检索结果-南通市图书馆

Food Bioscience 2022年第2期46卷 468-476页

作者： jing-kun yan Ting-Ting Chen Xu Chen Yujia Liu Chenghong Liu Lin Li Key Laboratory of Healthy Food Development and Nutrition Regulation of China National Light Industry School of Chemical Engineering and Energy TechnologyDongguan University of TechnologyDongguan523808China School of Food&Biological Engineering Jiangsu UniversityZhenjiang212013China Biotech Research Institute Shanghai Academy of Agricultural Sciences Shanghai Key Laboratory of Agricultural Genetics and BreedingShanghai201106China

Barley(Hordeum vulgare L.)grasses(BG)have attracted considerable interest due to their multiple physiological activities and health *** this paper,eight BG at four different growth stages were collected:seedling,tillering,stem elongation,and heading,and their product qualities and biological activities were examined and *** demonstrated that harvest time obviously influenced proximate composition,surface color,and amino acid profile.Z21 and Z23 harvested at the seedling and early tillering stages,respectively,had higher total phenolic content(TPC)and total flavonoid content(TFC)than the other ***,Z21 and Z23 possessed better DPPH radical-scavenging ability,antioxidant capacity,andα-glucosidase inhibitory activity,which were positively correlated with TPC,TFC,and protein and total amino acid *** findings suggested that the early tillering stages were the preferable harvest times for BG with good product quality and biological properties.

关键词： Hordeum vulgare L. Barley grass Harvest time Phytochemicals Product quality Biological activity

Preparation,physicochemical and structural characterizations,and bioactivities of polysaccharides from Corbicula fluminea industrial distillate

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Bioscience 2022年第3期47卷 928-937页

作者： jing-kun yan Chun Wang Yun-Bo Yu Zi-Wei Wang Xu Chen Jie Zhu Lin Li Key Laboratory of Healthy Food Development and Nutrition Regulation of China National Light Industry School of Chemical Engineering and Energy TechnologyDongguan University of TechnologyDongguan523808China School of Food & Biological Engineering Jiangsu UniversityZhenjiang212013China

Corbicula fluminea distillate(CFD),as an industrial sub-product of the steaming process of ***,is rich in polysaccharides,proteins,and amino acids and has important developmental *** this study,therefore,three water-soluble polysaccharides(CFDPs:CFDP-D,CFDP-U,and CFDP-T)were extracted and separated from CFD through direct ethanol precipitation,ultrasound-assisted extraction,and three-phase partitioning(TPP),*** demonstrated that the three extraction methods had important influences on extraction yields,chemical compositions,molecular weights,monosaccharide and amino acid constituents,structural characteristics,and microstructures as well as biological activities of ***,CFDP-T had higher yield(60.92%±3.58%),carbohydrate content(91.05%±1.22%),and uronic acid content(8.55%±0.18%)and lower protein content(7.15%±0.15%)than CFDP-D and *** three CFDPs were acidic proteoheteroglycans combined through O-glycosidic bonds and had high molecular weights of 1.93–2.41×10^(7) Da and the same monosaccharide and amino acid compositions but different *** with CFDP-D and CFDP-U,CFDP-T exhibited more excellent free radical scavenging and stimulating(1.57±0.03μM,500μg/mL)activities on RAW264.7 macrophages in ***,our findings suggested that CFDP-T obtained from CFD by TPP had the potential to be a functional food ingredient in food industry.

关键词： Corbicula fluminea Industrial sub-product Polysaccharide Extraction methods Physicochemical characteristics Biological activity

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

在线全文

学校读者我要写书评

暂无评论

大蒜对铜绿微囊藻的化感抑制作用

江西农业大学学报 2016年第6期38卷 1167-1173页

作者：董龙香胡利静胡鲲肖艳翼杨先乐上海海洋大学国家水生动物病原库上海201306

通过人工培养箱培养的方法,利用分光光度计、酶标仪及相关试剂盒等分别测定铜绿微囊藻在不同浓度(0,0.2,0.4,0.8,1.6,3.2,6.4 g/L)大蒜作用下的生理生化指标变化情况,以期探讨大蒜对铜绿微囊藻的抑制机理。结果表明:大蒜对铜绿微囊藻表... 详细信息

通过人工培养箱培养的方法,利用分光光度计、酶标仪及相关试剂盒等分别测定铜绿微囊藻在不同浓度(0,0.2,0.4,0.8,1.6,3.2,6.4 g/L)大蒜作用下的生理生化指标变化情况,以期探讨大蒜对铜绿微囊藻的抑制机理。结果表明:大蒜对铜绿微囊藻表现为低促高抑的作用效果,与对照相比,0.2 g/L的大蒜浓度对铜绿微囊藻生长反而略有促进作用;6.4 g/L浓度的大蒜则可有效地抑制铜绿微囊藻的生长,而且随着作用时间的延长其抑制效果愈加明显,在第96小时时铜绿微囊藻的生长抑制率可达53.42%;另外,高浓度大蒜能有效抑制铜绿微囊藻的叶绿素a含量并能影响铜绿微囊藻藻胆蛋白各组分的构成及可溶性蛋白的含量。由此可以得出,一定浓度的大蒜对铜绿微囊藻具有化感抑制作用,且高浓度下的大蒜能通过影响铜绿微囊藻叶绿素a的含量来影响其光合作用,最终导致藻类繁殖受阻。可见,藻类叶绿素a(即PSⅡ)是大蒜抑制铜绿微囊藻生长繁殖的一个作用位点。

关键词：大蒜铜绿微囊藻化感抑制作用作用位点

基于可见近红外光谱玉米种子活力的无损检测方法

在线全文

学校读者我要写书评

暂无评论

食品安全质量检测学报 2016年第11期7卷 4472-4477页

作者：白京彭彦昆王文秀中国农业大学工学院国家农产品加工技术装备研发分中心北京100083

目的：基于近红外漫反射技术,初步探讨玉米种子活力的快速、无损检测方法。方法本研究利用实验室自行搭建的近红外光谱检测系统获取60粒表面平整无明显损伤的M017玉米种子450~900 nm光谱曲线,其中校正集和验证集比例为3：1。利用红墨水... 详细信息

目的：基于近红外漫反射技术,初步探讨玉米种子活力的快速、无损检测方法。方法本研究利用实验室自行搭建的近红外光谱检测系统获取60粒表面平整无明显损伤的M017玉米种子450~900 nm光谱曲线,其中校正集和验证集比例为3：1。利用红墨水染色法判定玉米种子样品是否具有活力。通过进行 SG-5点平滑（Savitzky-Golay smoothing, SG）预处理方法减小曲线噪声,基于主成分分析（principal component analysis, PCA）方法提取主要判别成分,并依据测定的种子活力情况和其光谱曲线应用支持向量机（support vector machine, SVM）建立判别模型进行分析。结果当累计贡献率达到96%时,选取6个主成分,建立的模型判别正确率最高,近红外漫反射光谱数据能够较好的判别种子活力的有无,其中校正集和预测集判别正确率分别为95.56%和86.67%。结论证明该方法可行,基本能够满足快速无损检测判别玉米种子活力的要求,为今后快速无损检测玉米种子活力奠定了基础。

关键词：近红外光谱玉米种子活力

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan yang Xinxin yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词：

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

赤峪矿沿空留巷方式数值模拟研究

煤炭技术 2017年第5期36卷 3-5页

作者：崔景昆闫泽红洛锋游小伟张浩孙守新河北工程大学河北邯郸056038 河北省煤炭矿井建设工程技术研究中心河北邯郸056038

以赤峪矿C0202工作面的实际地质条件为背景,针对该工作面沿空留巷方式提出了原位沿空留巷、半原位沿空留巷和破底半原位沿空留巷3种留巷方式。应用UDEC数值模拟软件对上述3种留巷方式条件下巷道周围主应力、位移、塑性破坏等情况进行了... 详细信息

以赤峪矿C0202工作面的实际地质条件为背景,针对该工作面沿空留巷方式提出了原位沿空留巷、半原位沿空留巷和破底半原位沿空留巷3种留巷方式。应用UDEC数值模拟软件对上述3种留巷方式条件下巷道周围主应力、位移、塑性破坏等情况进行了数值模拟分析,并进行了可行性对比。

关键词：破底半原位沿空留巷充填体 UDEC数值模拟

Solar cycles during the seventeenth century revealed by equatorial aurora records

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2025年第1期9卷 182-187页

作者： Yong Wei LiMei yan Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Solar cycles are fundamental to astrophysics,space exploration,technological infrastructure,and Earth's climate.A better understanding of these cycles and their history can aid in risk mitigation on Earth,while also deepening our knowledge of stellar physics and solar system *** the solar cycles between 1600 and 1700-especially the post-1645 Maunder Minimum,characterized by significantly reduced solar activity-poses challenges to existing solar activity *** study utilizes a new red equatorial auroral catalog from ancient Korean texts to establish solar cycle patterns from 1623 to ***,a further reevaluation of the solar cycles between 1610 and 1755 identified a total of 13 cycles,diverging from the widely accepted record of 12 cycles during that *** research enhances our understanding of historical solar activity,and underscores the importance of integrating diverse historical sources into modern analyses.

关键词： solar cycle Maunder Minimum solar activity red equatorial aurora West Pacific geomagnetic anomaly