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角膜屈光手术后人工晶状体度数计算公式的选择

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国际眼科杂志 2017年第7期17卷 1275-1277页

作者：陈丽静王锐张浩润付梦军赵静静滨州医学院研究生院中国山东省烟台市264003 潍坊眼科医院屈光手术中心中国山东省潍坊市261000

角膜屈光手术后的患者发生白内障并行人工晶状体置换手术时,如果按常规计算公式选择人工晶状体的度数,往往会在术后产生不同程度的屈光不正,主要来源于角膜屈光力的测算误差和计算公式的误差,以及眼轴长度测量和有效人工晶状体位置计算... 详细信息

角膜屈光手术后的患者发生白内障并行人工晶状体置换手术时,如果按常规计算公式选择人工晶状体的度数,往往会在术后产生不同程度的屈光不正,主要来源于角膜屈光力的测算误差和计算公式的误差,以及眼轴长度测量和有效人工晶状体位置计算的准确性降低等方面的原因。因此,对于曾行角膜屈光手术的白内障患者,术前应运用适当的方法估算角膜屈光力,并正确地选择合适的人工晶状体度数计算公式,从而减少晶状体置换术后引起的屈光误差。

关键词：人工晶状体计算公式角膜屈光手术屈光不正白内障

自体CIK、DC-CIK与半合子DC-CIK抗肿瘤免疫反应的比较研究(英文)

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Chinese Journal of Cancer 2010年第7期29卷 641-648页

作者：王其京王慧潘科 State Key Laboratory of Oncology in Southern China Department of Experimental Research Sun Yat-sen University Cancer Center

Background and Objective:Cytokine-induced killer(CIK) cells and autologous dendritic cells-CIK(DCCIK) cells co-cultured with autologous dendritic cells(DCs) and CIK cells are commonly used for immunotherapy *** compared the anti-tumor immune response of CIK cells,autologous DC-CIK cells,and semi-allogeneic DC-CIK cells to explore a more effective anti-tumor adoptive immunotherapy *** hods:Peripheral monocytes were isolated from patients with renal carcinoma,lung cancer,or maxillary squamous cell carcinoma and their healthy adult *** cells were cultured and induced as DCs and CIK cells in *** cells from patients were co-cultured with autologous DCs and DCs from their children respectively,generating DC-CIK cells and semi-allogeneic DC-CIK *** anti-tumor activities of autologous CIK cells,autologous DC-CIK cells,and semi-allogeneic DC-CIK cells were measured by LDH *** staining was used to test the secretion of *** cytometry was applied for detecting the phonotype changes of these three types of *** proliferation and cell apoptosis were detected by 5,6carboxyfluorescein diacetate succinimidyl ester(CFSE) and Annexin V/PI *** s:Compared with autologous CIK cells and DC-CIK cells,semi-allogeneic DC-CIK cells significantly enhanced the anti-tumor activity and IFN-γ secretion,reduced IL-4 secretion,increased the ratio of CD3+CD56+ cells and CD3+CD8+ cells,decreased the number of CD4+CD25+ cells,promoted cell proliferation,and lessened cell ***:Semi-allogeneic DC-CIK cells had a stronger anti-tumor effect than did autologous CIK cells and DC-CIK *** results provided experimental evidence for clinical application of DC-CIK cells.

关键词：抗肿瘤活性细胞免疫反应细胞因子树突状细胞体外诱导 CIK DC 自体

鼠妇提取物可抑制ILK调节骨桥蛋白诱导的血管平滑肌细胞增殖

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中国组织工程研究 2017年第16期21卷 2582-2586页

作者：段哲萍于新江李菁菁赵娟河北省人民医院肿瘤二科河北省石家庄市050051 河北省人民医院心脏外科河北省石家庄市050051 河北医科大学细胞生物教研室河北省石家庄市050017

背景:前期实验通过MTT法及细胞划痕实验检测出鼠妇可影响血管平滑肌细胞的增殖和迁移过程,但其相关作用机制尚不清楚。目的:探讨鼠妇对于骨桥蛋白诱导的血管平滑肌细胞增殖影响的相关分子机制。方法:按常规方法培养SD大鼠胸腹主动脉血... 详细信息

背景:前期实验通过MTT法及细胞划痕实验检测出鼠妇可影响血管平滑肌细胞的增殖和迁移过程,但其相关作用机制尚不清楚。目的:探讨鼠妇对于骨桥蛋白诱导的血管平滑肌细胞增殖影响的相关分子机制。方法:按常规方法培养SD大鼠胸腹主动脉血管平滑肌细胞,选取3-5代细胞用于实验。实验分为8组:对照组、骨桥蛋白组、鼠妇水提取物(0.5,1.0,2.0 g/L)+骨桥蛋白组、鼠妇乙酸乙酯提取物(0.25,0.5,1.0 g/L)+骨桥蛋白组。加入相应药物培养24 h后,收集细胞,采用Western bolt检测PCNA、ILK蛋白表达水平。结果与结论:(1)在鼠妇水提取物及乙酸乙酯提取物的作用下血管平滑肌细胞PCNA蛋白表达下降,其中0.5 g/L的鼠妇水提取物组和1.0 g/L的鼠妇乙酸乙酯提取物组抑制作用最明显,分别为骨桥蛋白组的77.8%和74.1%;(2)低质量浓度(0.5 g/L)的鼠妇水提取物抑制ILK表达作用明显,是骨桥蛋白组的81.4%;鼠妇乙酸乙酯提取物作用下血管平滑肌细胞ILK的表达水平没有明显改变;(3)结果表明,鼠妇水提取物及乙酸乙酯提取物均可抑制骨桥蛋白诱导的血管平滑肌细胞增殖,且鼠妇水提取物该作用可能与ILK蛋白通路有关。

关键词：甲虫骨桥蛋白质增殖细胞核抗原组织工程组织构建鼠妇骨桥蛋白 PCNA ILK

Leader-follower: Human-centered intention-guided controller for novel SuperLimb with application to load-carrying scenarios

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Science China Technological Sciences 2025年第1期 325-338页

作者： Qinghua ZHANG Xianglong LI Hongwei jing Kerui SUN Yuancheng LI Sikai zhao Lele LI Haotian JU Ziqi WANG Rui WU Tianjiao ZHENG Jie zhao Yanhe ZHU The State Key Laboratory of Robotics and System Harbin Institute of Technology The Learning Algorithms and Systems Laboratory School of Engineeringécole Polytechnique Fédérale de Lausanne

Supernumerary robotic arms(SuperLimb) are a new type of wearable robot that works closely with humans as a third hand to augment human operation capability. Accurate conveyance of wearers' intentions, allocation of roles, and humancentered interaction considerations are the key points in the process of human–SuperLimb collaboration. This paper proposes a human-centered intention-guided leader–follower controller that relies on the dynamic modeling of SuperLimb with application to load-carrying scenarios. The proposed leader–follower controller takes the human as the leader and the SuperLimb as the follower, achieving effective information communication, autonomous coordination, and good force compliance between SuperLimb, humans, and the environment under human safety assurance. First, the human–SuperLimb dynamic system is modeled to achieve force interaction with the environment and wearer. Second, to achieve the precise intention extraction of humans, pose data from five visual odometry sensors are fused to capture the human state, the generalized position, the velocity of hands, and the surface electromyography signals from two myoelectric bracelets sensors are processed to recognize the natural hand gestures during load-carrying scenarios by a designed Swin transformer network. Then, based on the real-time distance detection between human and mechanical limbs, the security assurance and force-compliant interaction of the human–SuperLimb system are realized. Finally, the human hand muscle intention recognition, human–robot safety strategy verification,and comparative load-carrying experiments with and without the proposed method are conducted on the SuperLimb *** showed that the task parameters are well estimated to produce more reasonable planning trajectories, and SuperLimb could well understand the wearer's intentions to switch different SuperLimb actions. The proposed sensor-based human–robot communication framework motivates future studies of o

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing Xue Yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

飞秒激光与机械板层刀制瓣的LASIK术后干眼的临床对比研究

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国际眼科杂志 2015年第2期15卷 215-218页

作者：付梦军王锐张浩润赵静静潍坊眼科医院中国山东省潍坊市261000

目的:应用Oculus干眼分析仪观察飞秒激光与机械板层刀制瓣的LASIK术后干眼情况。方法:收集2014-01/04在潍坊眼科医院行飞秒激光制瓣的准分子激光原位角膜磨镶术(FS-LASIK)及机械板层刀制瓣准分子激光原位角膜磨镶术(LASIK)的患者60例120... 详细信息

目的:应用Oculus干眼分析仪观察飞秒激光与机械板层刀制瓣的LASIK术后干眼情况。方法:收集2014-01/04在潍坊眼科医院行飞秒激光制瓣的准分子激光原位角膜磨镶术(FS-LASIK)及机械板层刀制瓣准分子激光原位角膜磨镶术(LASIK)的患者60例120眼,年龄27.46±6.65岁。其中LASIK组28例56眼,FS-LASIK组32例64眼。应用Oculus干眼分析仪观察患者术前、术后1wk及术后1mo时泪河高度、首次泪膜破裂时间、平均泪膜破裂时间随时间的变化。结果:Oculus干眼分析仪检查术前泪河高度为0.25±0.10mm,首次泪膜破裂时间为6.70±3.86s,平均泪膜破裂时间为10.14±4.51s。术后1wk泪河高度为0.19±0.04mm,首次泪膜破裂时间为4.87±1.71s,平均泪膜破裂时间为7.77±2.30s,两组患者术后1wk与术前相比差异有统计学意义(P0.05)。结论:机械板层刀制瓣LASIK和FS-LASIK术后患者均有不同程度的干眼,泪液分泌量及泪膜的稳定性均有不同程度的下降,加用人工泪液干眼症状有所改善。Oculus干眼分析仪非侵入性的反映泪液量及泪膜稳定性,有利于LASIK术后干眼的快速诊断及严重程度的判断。

关键词：角膜屈光手术准分子激光原位角膜磨镶术飞秒激光干眼

Simulation of Shielding Effectiveness Test with Bounded-Wave EMP Simulator

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Simulation of Shielding Effectiveness Test with Bounded-Wave...

2011 4th IEEE International Symposium on Microwave,Antenna,Propagation and EMC Technologies for Wireless Communications

作者： Wang Wei jing-jing zhao Bin Chen Bi-hua Zhou ey Laboratory on Electromagnetic Environmental Effects and Electro-optical Engineering PLA Univ. of Sci. & Tech. Nanjing 210007 China

The shielding effectiveness （SE） test is usually implemented in the bounded-wave ***,numerical simulating the SE of a shielding enclosure is mostly modeled with plane wave *** this paper we present the parallel FDTD method to analyze the SE of a shielding enclosure in bounded-wave *** improved formalism for thin slot is *** result shows that the result obtained in the simulator is higher than the plane wave simulating *** the numerical results,we can find the law of the results between bounded-wave simulator model and the plane wave model.

关键词： Bounded-wave simulator FDTD thin slot shielding effectiveness

来源： cnki会议评论

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胶粉改性沥青的老化及再生

现代化工 2017年第1期37卷 75-78页

作者：方彬彬周晶晶赵基钢叶园园周晓龙华东理工大学石油加工所上海200237

制备了胶粉改性沥青(CRMA)并在实验室中进行老化,并在老化后的CRMA中添加苯乙烯—丁二烯—苯乙烯三嵌段共聚物(SBS)、橡胶油、胶粉进行再生。以SBS质量分数、橡胶油质量分数、胶粉质量分数以及再生温度作为四因素进行正交实验,并对结果... 详细信息

制备了胶粉改性沥青(CRMA)并在实验室中进行老化,并在老化后的CRMA中添加苯乙烯—丁二烯—苯乙烯三嵌段共聚物(SBS)、橡胶油、胶粉进行再生。以SBS质量分数、橡胶油质量分数、胶粉质量分数以及再生温度作为四因素进行正交实验,并对结果进行极差和方差分析,探究各因素对再生CRMA性质的影响,并对其进行了优化。实验结果表明,各因素对再生CRMA性质影响程度大小依次为:温度、SBS质量分数、橡胶油质量分数、胶粉质量分数;优化结果为:SBS的质量分数为1%,橡胶油的质量分数为6%,胶粉的质量分数为7%,再生温度为200℃,在此方案下制备的再生CRMA各项性质符合中石化CRMA-Ⅲ类标准。

关键词： CRMA 正交实验再生优化

Decreased Expression of the ARID1A Gene is Associated with Poor Prognosis in Primary Gastric Cancer

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Decreased Expression of the ARID1A Gene is Associated with P...