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A NEW WELL TEST MODEL FOR STRESS-SENSITIVE AND RADIALLY HETEROGENEOUS DUAL-POROSITY RESERVOIRS WITH NON-UNIFORM THICKNESSES

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Journal of Hydrodynamics 2011年第6期23卷 759-766页

作者： ZHANG Lie-hui, guo jing-jing, LIU Qi-guo State Key Laboratory of Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, China State Key Laboratory of Reservoir Geology and Exploitation Southwest Petroleum University Chengdu China

This article presents a new well test model for stress-sensitive composite dual-porosity reservoirs based on the concept of permeability modulus, where the rock and fluid properties as well as the formation thickness vary in the radial direction. An analytical solution in the Laplace space for the pressure-transient behavior for a line-source, constant-rate well of this type of reservoir is obtained with the Laplace transformation and the perturbation technique. The pressure and its derivative in the reservoir and the effects of relevant parameters on the pressure-transient response are obtained. The model as well as the corresponding type curves may be used in predicting the production performance or analyzing the production data for this type of reservoir.

关键词： non-uniform thickness stress-sensitive composite dual-porosity well test model type curve

Contrast in vulnerability to freezing-induced xylem embolism contributes to divergence in spring phenology between diffuse-and ring-porous temperate trees

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Forest Ecosystems 2022年第6期9卷 734-744页

作者： Ai-Ying Wang Han-Xiao Cui Xue-Wei Gong jing-jing guo Nan Wu Guang-You Hao School of Life Sciences and Engineering Shenyang UniversityShenyang110044LiaoningChina Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security College of Life Science and BioengineeringShenyang UniversityShenyang110044LiaoningChina CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang110016China University of Chinese Academy of Sciences Beijing100049China Tree Laboratory Shenyang Academy of Landscape-gardeningShenyang110016LiaoningChina

Background:The spring phenology and growth strategy of temperate tree species can be strongly linked to their sensitivity to frosts,which deserve more profound investigations under the background of climate warming particularly considering the advancement of spring phenology as well as the increase in frequency and intensity of spring cold ***:Spring phenologies,stem radial growth characteristics,frost sensitivity of leaves and stem hydraulic systems were studied in five diffuse-porous and five ring-porous temperate tree species under a common garden ***:The results showed that the spring leaf phenology of the diffuse-porous species was one to two weeks earlier than that of the ring-porous *** ring-porous species had significantly higher stem hydraulic conductivity than the diffuse-porous species(1.81 and 0.95 kg·m^(-1)·s^(-1)·MPa^(-1),P<0.05)but were more vulnerable to freeze-thaw induced xylem embolism than the *** a simulated freeze-thaw event,the average percentage loss of hydraulic conductivity in the current year shoots increased from 26.0%(native embolism)to 86.7%in the ring-porous species,while it only increased from 21.3%to 38.3%in the diffuse-porous *** spring phenology was clearly correlated with vulnerability to freeze-thaw induced embolism,with the more vulnerable ring-porous species exhibited substantially delayed phenology to reduce risks of catastrophic hydraulic dysfunction during spring ***,ring-porous species can offset the postponed onset of growth and gained even higher annual growth due to significantly higher hydraulic efficiency and leaf gas exchange ***:Contrasts between ring-porous and diffuse-porous species in resistance to freeze-thaw induced embolism suggest that they face different selective pressures from early spring frosts,which may at least be partially responsible for their divergence in spring phenology and growth strategy and can potentially lead to di

关键词： Diffuse-porous trees Freeze-thaw cycle Frost damage Ring-porous trees Spring phenology Xylem embolism

Insights into in-situ imbibition behavior of fracturing fluid in propped shale fractures based on nuclear magnetic resonance:A case study from Longmaxi Formation shale,Sichuan Basin,China

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Petroleum Science 2024年第1期21卷 410-429页

作者： jing-jing guo Kai-Xiang Di Lie-Hui Zhang Yu-Long Zhao Hui-Ying Tang Rui-Han Zhang Ye Tian National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina

Shale gas is an important component of unconventional oil and gas *** the imbibition behavior is helpful to optimize flowback parameters and enhance gas *** imbibition studies have focused on shale matrix,and the pressure conditions discussed were mostly *** initial imbibition behavior begins from propped fractures to matrix,but there are few studies working on explaining the imbibition behavior in propped fractures or the phenomenon of many shale wells exhibit higher productivity after a“soaking”***,propped fracture samples were designed for imbibition and migration *** order to accurately study the mechanism and main influencing factors of fracturing fluid imbibition and migration in propped and unpropped shale fractures under high temperature and high pressure,a series of experiments based on nuclear magnetic resonance(NMR)were carried *** showed that NMR T_(2) spectra of all samples exhibited a bimodal *** final imbibition volume of fracturing fluid was positively related to pressure and fracture *** imbibition effect of fracturing fluid was more evident in matrix pores under high *** the migration during soaking stage,the fracturing fluid gradually migrated from large pores to small pores and gradually displaced the shale gas from the matrix,thus allowing the water blocking in propped fractures to self-unlock to some *** permeability decreased in the imbibition stage,while it recovered in the migration stage to some extent.

关键词： Forced imbibition Migration Soaking NMR T_(2)spectra Propped fracture Permeability recovery

An efficient synthesis of imidodicarbonic diamides from 1,3-thiazetidin-2-ones with NH_2OH·HCl via ring-opening reaction

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Chinese Chemical Letters 2015年第1期26卷 85-88页

作者： Wen-Yuan Tang jing-jing guo Xing-Xing Gui De-Man Han Jian-Jun Li College of Pharmaceutical and Chemical Engineering Taizhou University Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education College of Pharmaceutical SciencesZhejiang University of Technology

A ring-opening process of 4-imino-1,3-thiazetidin-2-ones with *** was described for the first time. Two different scaffolds of imidodicarbonic diamide were obtained selectively in good yields in the presence of organi... 详细信息

关键词： lmidodicarbonic diamides 1,3 -Thiazetidin-2 -one Hydroxylamine hydrochloride Ring-opening

Inter-layer interference for multi-layered tight gas reservoir in the absence and presence of movable water

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Petroleum Science 2024年第3期21卷 1751-1764页

作者： Tao Zhang Bin-Rui Wang Yu-Long Zhao Lie-Hui Zhang Xiang-Yang Qiao Lei Zhang jing-jing guo Hung Vo Thanh National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu60500SichuanChina Shaanxi Yanchang Petroleum(Group)Corp.Ltd. Xian710075ShaanxiChina Waseda Research Institute for Science and Engineering Waseda UniversityTokyoJapan

Due to the dissimilarity among different producing layers,the influences of inter-layer interference on the production performance of a multi-layer gas reservoir are ***,systematic studies of inter-layer interference for tight gas reservoirs are really limited,especially for those reservoirs in the presence of *** this work,five types of possible inter-layer interferences,including both absence and presence of water,are identified for commingled production of tight gas ***,a series of reservoir-scale and pore-scale numerical simulations are conducted to quantify the degree of influence of each type of *** field evidence from the Yan'an tight gas reservoir(Ordos Basin,China)is found to support the simulation ***,suggestions are proposed to mitigate the potential inter-layer *** results indicate that,in the absence of water,commingled production is favorable in two situations:when there is a difference in physical properties and when there is a difference in the pressure system of each *** reservoirs with a multi-pressure system,the backflow phenomenon,which significantly influences the production performance,only occurs under extreme conditions(such as very low production rates or well shut-in periods).When water is introduced into the multi-layer system,inter-layer interference becomes nearly *** both the gas-rich layer and water-rich layer for commingled production is not desirable,as it can trigger water invasion from the water-rich layer into the gas-rich *** gas-rich layer might also be interfered with by water from the neighboring unperforated water-rich layer,where the water might break the barrier(eg weak joint surface,cement in fractures)between the two layers and migrate into the gas-rich ***,the gas-rich layer could possibly be interfered with by water that accumulates at the bottom of the wellbore due to gravitational diff

关键词： Tight gas Comingled production Interference Two-phase flow Water blocking

Molecular Epidemiology and Vaccine Compatibility Analysis of Seasonal Influenza Viruses in Wuhan, 2016–2019

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Virologica Sinica 2020年第5期35卷 556-565页

作者： Liang-Jun Chen jing-jing guo Wei-Wei guo E-Xiang Shen Xin Wang Kai-Ji Li Jie Yan Mang Shi Yi-Rong Li Wei Hou Department of Laboratory Medicine Zhongnan HospitalState Key Laboratory of VirologyInstitute of Medical VirologySchool of Basic Medical SciencesWuhan UniversityWuhan 430071China School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Marie Bashir Institute for Infectious Diseases and Biosecurity Charles Perkins CentreSchool of Biological Sciences and Sydney Medical SchoolThe University of SydneySydneyNSW 2006Australia

Influenza viruses(FLUV)cause high morbidity and mortality annually in the world and pose a serious threat to the public ***,as an important transportation hub in China,has a dense population and suitable climate,which also lays a major hidden danger for the outbreak of *** survey and characterize the seasonal FLUV in Wuhan during 2016–2019,we collected 44,738 throat swabs,among which 15.5%were influenza A(FLUAV)positive,6.1%influenza B(FLUBV)and 0.3%*** monitoring FLUV in each month from June 2016 to May 2019,different with the previously seasonality pattern,only a single influenza peak was appeared in winter of 2017–2018 and 2018–2019,*** data indicated that the complex circulation pattern of seasonal influenza in *** addition,we found the age group was skewed towards 5–14 years group whose activity were mostly school based,which suggested school may be an important place for influenza ***,phylogenic analysis revealed that two subtypes(subclade 3C.2 a2 and 3C.2 a1b)of A(H3N2)were circulating in Wuhan and there was an obvious transition in 2018 because the two subclades were detected ***,by estimating the vaccine effectiveness,we found that the vaccine strain of FLUAV didn’t seem to match very well the current epidemic strain,especially A(H3N2).Hence,more accurate prediction of seasonal outbreak is essential for vaccine *** together,our results provided the current information about seasonal FLUV in Wuhan which form the basis for vaccine updating.

关键词： Seasonal influenza Molecular epidemiology Phylogenic analysis Vaccine effectiveness

Interstitial pneumonia combined with nocardia cyriacigeorgica infection:A case report

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World Journal of Clinical Cases 2023年第32期11卷 7920-7925页

作者： Dao-Da Qi Yi Zhuang Yang Chen jing-jing guo Ze Zhang Yan Gu Department of Geriatrics The Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210006Jiangsu ProvinceChina

BACKGROUND Nocardia infection is a relatively uncommon disease,with no reports among patients with interstitial *** to its atypical clinical symptoms and chest computed tomography(CT)findings and the frequent yielding of negative results by conventional cultures,it poses challenges for timely diagnosis and *** SUMMARY A 63-year-old female patient presented to our hospital in July 2022 with a 3-mo history of intermittent cough and poor appetite,accompanied by a 2-wk long duration of *** had a previous medical history of interstitial pneumonia and was on oral prednisone and *** CT revealed the presence of newly developed round *** diagnosis of Nocardia cyriacigeorgica infection was confirmed through metagenomic next-generation sequencing(mNGS)performed on bronchoalveolar lavage *** antiinfection therapy was initiated,resulting in symptom improvement and radiological resolution,further validating the mNGS *** Nocardia cyriacigeorgica infection is a clinically rare condition that is primarily observed in immunocompromised *** clinical and radiological manifestations lack specificity,but mNGS can aid in rapidly obtaining pathogenic *** initiation of targeted antimicrobial therapy based on mNGS results can improve patient prognosis.

关键词： Interstitial pneumonia Nocardia cyriacigeorgica infection Literature review Case report

Bronchobiliary fistula in a patient with liver cancer

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 523-525页

作者： Yao-Xin Chen Zhi-Hua Deng Hao Zhao Bi-Ying Zhou jing-jing guo Gang Zeng Jin-Xian Qian Department of Respiratory and Critical Care Medicine Suzhou Municipal Hospital Affiliated to Nanjing Medical UniversitySuzhou 215000China

Bronchobiliary fistula(BBF) is a pathologic channel between the biliary tract and bronchial tree. In general, congenital BBF is relatively rare in adult patients. There are a few case reports suggesting that BBF is mainly secondary to hepatobiliary diseases, such as biliary obstruction, tumor, surgery, or liver abscess, and liver tumor is the predominant causative factor [1]. In addition, with the increasing number of liver and biliary surgeries and interventional therapies in recent years, more cases of BBF were reported as a postoperative complication [ 2, 3 ]. In this case, we presented a patient who underwent interventional treatment for liver tumor and was treated for his respiratory symptoms but diagnosed with BBF finally. Here, we summarized the clinical features and main diagnostic procedures of the case, aiming to provide evidence for early identification and diagnosis of BBF.

关键词： biliary fistula diagnosis

PA-E18G substitution in influenza A virus confers resistance to ZX-7101,a cap-dependent endonuclease inhibitor

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Virologica Sinica 2023年第4期38卷 559-567页

作者： Dan Luo Qing Ye Rui-Ting Li Hang-Yu Zhou jing-jing guo Suo-Qun Zhao Sen Zhang Tao Jiang Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China State Key Laboratory of Medical Molecular Biology Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123China

Cap-dependent endonuclease(CEN)in the polymerase acidic protein(PA)of influenza A virus(IAV)represents a promising drug target due to its critical role in viral gene *** CEN inhibitor,baloxavir marboxil(BXM),was approved in Japan and the US in 2018 and several other countries *** with the clinical use of BXM,the emergence and spread of IAV variants with reduced susceptibility to BXM have aroused serious ***,we comprehensively characterized the in vitro and in vivo antiviral activities of ZX-7101A,an analogue of *** active form of prodrug ZX-7101 showed broad-spectrum antiviral potency against various IAV subtypes,including pH1N1,H3N2,H7N9 and H9N2,in MDCK cells,and the 50%effective concentration(EC_(50))was calculated to nanomole level and comparable to that of baloxavir acid(BXA),the active form of ***,in vivo assays showed that administration of ZX-7101A conferred significant protection against lethal pH1N1 challenge in mice,with reduced viral RNA loads and alleviated pulmonary ***,serial passaging of H1N1 virus in MDCK cells under selection pressure of ZX-7101 led to a resistant variant at the 15th *** genetic and sequencing analysis demonstrated that a single E18G substitution in the PA subunit contributed to the reduced susceptibility to both ZX-7101 and *** together,our results not only characterized a new CEN inhibitor of IAV but also identified a novel amino acid substitution responsible for CEN inhibitor resistance,which provides critical clues for future drug development and drug resistance surveillance.

关键词： Influenza virus Cap-dependent endonuclease(CEN) Baloxavir marboxil(BXM) Drug resistance