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Journal of Iron and Steel Research International 2022年第4期29卷 677-686页

作者： Wei Li jing-huan chang Bao-feng Wen Rui Cao State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metal Lanzhou University of TechnologyLanzhou 730050GansuChina Department of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050GansuChina

A galvanized steel is used to join Mg AZ31B alloy and Al A6061-T6 alloy as a joining transition layer by cold metal transfer(CMT)***,to optimize the process variables,extensive welding tests were performed by a design of experiment ***,microstructures,joining mechanisms and tensile properties were characterized and *** indicated that Mg and Al alloys can be joined by using galvanized steel as a joining transition layer and cold metal transfer welding *** formed joint is called as a Mg–steel–Al CMT *** using galvanized steel transition joining layer,Mg–Al brittle intermetallics Al12Mg17 and Al3Mg2 were *** properties of Mg–steel–Al CMT joints have been improved after optimizing the welding *** strength of Mg–steel–Al CMT joint is comparable to those of Al–Al joint and Mg–Mg *** strength of Mg–steel–Al CMT joint can reach 100%that of Al–Al joint and Al–steel joint,and reach 90%that of Mg–Mg joint and Mg–steel *** optimized Mg–steel–Al CMT welded joint with galvanized steel transition layer is fractured at the heat affected zone of Al base metal rather than at the weld-brazed interface,due to softening of Al base metal.

关键词： Cold metal transfer Mg alloy Al alloy Galvanized steel Transition joining layer Dissimilar metal joining

Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

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Science China Life Sciences 2025年第1期 306-308页

作者： Aziz Ul Ikram Yanping jing huan Chen Jian Chen International Genome Center Jiangsu University Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma jing Wei chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Social bots’ role in climate change discussion on Twitter: Measuring standpoints, topics, and interaction strategies

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Advances in Climate change Research 2021年第6期12卷 913-923页

作者： CHEN chang-Feng SHI Wen YANG jing FU Hao-huan School of Journalism and Communication Tsinghua UniversityBeijing100084China School of Journalism and Communication Jinan UniversityGuangzhou510632China Department of Earth System Science Tsinghua UniversityBeijing100084China

This study aims to explore social bots' role in online climate change discussions. By analyzing 491,279 climate-change-related tweets, we found that social bots were actively engaged in climate change discussions on Twitter and contributed up to 1.5.4% of related contents. Bots promote the saliency of energy, climate actions and climate strikes on public agenda. 83.1% of tweets posted by social bots support climate change activism, and 16.9% support climate change skepticism. However, social bot skeptics are more strategical than social bot activists in terms of launching conversations with opposing-minded humans, and avoiding amplification of opposing voices. They are also more successful in inciting opposing-minded humans' initiative conversation and like-minded humans' amplification. Based on the above findings, we suggest cultivating individuals’ media literacy in terms of distinguishing malicious social bots as a potential solution to deal with social bot skeptics disguised as humans, as well as making use of benign social bots for science popularization.

关键词： Climate change Social media Social bots Climate skeptics

数字经济赋能养老服务业跨越“低水平均衡陷阱”

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河北学刊 2025年第1期45卷 152-161页

作者：夏杰长罗敬蔚中国社会科学院财经战略研究院中央财经大学法学院

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的... 详细信息

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的重要力量。借力数字经济推动养老服务实现高水平均衡,进而实现养老服务业高质量发展,需要综合施策:适当延长老年群体工作年限;对老年人口进行数字技术培训,助力他们跨越数字鸿沟;利用数字技术优化养老服务的资源配置;多渠道降低养老服务业成本;提升从业人员数字素养。

关键词： “低水平均衡陷阱” 老龄化数字经济养老服务业

Icariin protects vascular endothelial cells from oxidative stress through inhibiting endoplasmic reticulum stress

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Journal of Integrative Medicine 2019年第3期17卷 205-212页

作者： Fang-yuan Wang Jian Jia huan-huan Song Cheng-ming Jia chang-bo Chen jing Ma Department of Traditional Chinese Medicine Army Medical Center in Traditional Chinese MedicineXijing HospitalForth Military Medical University

Objective: To investigate the protective effect and underlying mechanism(s) of icariin(ICA) in preventing hydrogen peroxide(H_2O_2)-induced vascular endothelial cell injury via endoplasmic reticulum stress(ERS).Methods: To study the effects of ICA on H_2O_2-induced damage, we used the cell counting kit-8 assay to detect cell viability and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay to determine cell adhesion and apoptosis, respectively. Spectrophotometry and enzyme-linked immunosorbent assay were used to measure the expression levels of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px). Subsequently, glucose-regulated protein 78(GRP78), activating transcription factor-4(ATF4) and eukaryotic initiation factor-2 a(eIF2 a) were detected using Western ***: In human umbilical vein endothelial cells, different concentrations of ICA exhibited multiple effects, including reduced H_2O_2 damage, improved cell viability and adhesion, reduced cell apoptosis and increased SOD and GSH-Px activity. Among the ICA concentrations used, only the H_2O_2+ 100 lmol/L ICA group had significant differences compared to the H_2O_2 group. ERS activators H_2O_2 and DL-dithiothreitol(DTT) significantly increased GRP78, ATF4 and eIF2 a expressions, decreased cell activity and reduced SOD and GSH-Px activity. In contrast, the H_2O_2+ 100 lmol/L ICA and H_2O_2+ 100 lmol/L ICA + DTT groups had significant inhibitory effects on the expressions of GRP78,ATF4 and eIF2 a proteins, showing enhanced cell viability and SOD and GSH-Px ***: The results showed the dose-dependent effects of ICA against H_2O_2-induced injury in vascular endothelial cells. The inhibition of GRP78, ATF4 and eIF2 a protein expressions in the ERS, and the subsequent alleviation of oxidative stress damage, might be the molecular mechanism.

关键词： Icariin Endoplasmic reticulum stress Human umbilical vein endothelial cells Oxidative stress

Numerical investigation on dynamic response of the screen mesh in vibrating screening through DEM-FEM co-simulation

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Particuology 2024年第4期87卷 205-217页

作者： huan Zhang Xiao Zheng Weimin jing Key Laboratory of MetallurgicalEquipment and Control Technology Ministry of EducationWuhan University of Science and TechnologyWuhan430081 China Hubei Key Laboratory of Mechanical Transmssion and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan430081China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044China

Dynamic response of the screen mesh is of great significance in the optimum vibrating screen *** this paper,based on the DEM-FEM co-simulation method,the effect of screening parameters on the dynamic response of the screen mesh is explored and the mechanism is revealed on the particle ***,a virtual experiment on a linear vibrating screen was carried out to analyze the screening pa-rameters'effect with both impact load and sustained stress inflicted on the screen ***,the time-domain evolution regularity of the screen mesh LVA(Local Vibration Amplitude)under different particle plugging conditions was investigated based on the ***,the influence of screening parameters on LVA and its distribution was *** results show that the screening parameters can greatly affect the screen mesh LVA and its distribution by changing the movement of the granular material and the particle penetration probability,which provides an important basis for the optimal design of the screen mesh and its supporting structure.

关键词： Vibrating screen Dynamic response DEM-FEM Screening parameters Local vibration amplitude

Line Aging Assessment in Distribution Network Based on Topology Verification and Parameter Estimation

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1658-1668页

作者： Zhi Wu huan Long chang Chen School of Electrical Engineering Southeast UniversityNanjing China IEEE Maintenance Branch Company State Grid Jiangsu Electric Power Company Ltd.Nanjing China

The aging of lines has a strong impact on the economy and safety of the distribution *** paper proposes a novel approach to conduct line aging assessment in the distribution network based on topology verification and parameter *** topology verification,the set of alternative topologies is firstly generated based on the switching *** best-matched topology is determined by comparing the difference between the actual measurement data and calculated voltage magnitude curves among the alternative ***,a novel parameter estimation approach is proposed to estimate the actual line parameters based on the measured active power,reactive power,and voltage magnitude *** includes two stages,i.e.,the fixed-step aging parameter(FSAP)iteration,and specialized Newton-Raphson(SNR)*** theoretical line parameters of the best-matched topology are taken as a warm start of FSAP,and the fitted result of FSAP is further renewed by the *** on the deviation between the renewed and theoretical line parameters,the aging severity risk level of each line is finally quantified through the risk assessment *** experiments on the modified IEEE 33-bus and 123-bus systems demonstrate that the proposed approach can effectively conduct line aging assessment in the distribution network.

关键词： Line aging topology verification parameter estimation risk assessment Newton-Raphson iteration

Study on Magnetic Domain Structure of Co/Pt Dots Array

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Chinese Journal of Electronics 2017年第3期26卷 654-657页

作者： ZHU Xifu jing Xiaojun DU huan Teacher's colleage Beijing Union University School of Information and Communication Engineering Beijing University of Posts and Telecommunications Institute of Microelectronics of the Chinese Academy of Sciences

Co/Pt multilayer dots arrays with 580-nm periodicity were fabricated using Laser interference lithography(LIL)and an ion-beam milling *** obtained uniform dots arrays with a large area by optimizing the exposure parameters and improving exposure *** obtained their shapes and magnetic domain structures and investigated using an Atomic force microscope(AFM)and Magnetic force microscope(MFM).The AFM and MFM images show:1)when their size is smaller than 400nm,the dots are in single-domain state and their shape tends to be circular;and 2)when their size is greater than 400nm,the dots are in multi-domain state and they tend to form *** dots arrays possibly can be used in nano-scale magnetic storage.

关键词： Magnetic domain structures Co/Pt dots arrays AFM and MFM images Single domain state Multi-domain state