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现代预防医学 2012年第6期39卷 1502-1503+1505页

作者：饶若金丽华王述文姚红霞海南省人民医院血液病研究室

目的探讨CD117在急性髓系白血病病程中表达及其临床意义。方法应用CD45/SSC设门,直接荧光标记法,经流式细胞术对122例不同病程急性髓系白血病(AML)和47例急性淋巴细胞白血病(ALL)进行CD117的检测。结果对照组、ALL及AML3组CD117的表达... 详细信息

目的探讨CD117在急性髓系白血病病程中表达及其临床意义。方法应用CD45/SSC设门,直接荧光标记法,经流式细胞术对122例不同病程急性髓系白血病(AML)和47例急性淋巴细胞白血病(ALL)进行CD117的检测。结果对照组、ALL及AML3组CD117的表达阳性率和表达率差异有统计学意义(χ2=41.681,F=35.753,P﹤0.01)。AML组CD117的表达阳性率(58.9%)及表达率[(29.4±19.7)%]均明显高于对照组[(0,(4.2±1.2)%)]及ALL组(8.5%,8.9%±6.3%);在AML中,初治病例、CR病例及复发病例CD117的阳性率分别为58.9%、6.5%、72.2%,表达率分别为(29.4±19.7)%、(11.5±7.9)%、(34.2±20.1)%。3组间CD117的阳性率及表达率差异均有统计学意义(χ2=28.103,F=14.864,P﹤0.01)。CR组的CD117阳性率及表达率均明显低于初治组和复发组。结论 CD117阳性表达可作为AL髓系免疫表型依据;单独或联合其他抗体检测AML患者骨髓中CD117的表达可以作为预测复发及监测MRD的指标之一。

关键词：急性白血病 CD117 流式细胞术

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Deactivation of IKK by Protein Phosphatase

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Deactivation of IKK by Protein Phosphatase

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

2008年全国生物化学与分子生物学学术大会

作者： Hui-yan li Hui liu Chen-hui Wang Ji-yan Zhang Jiang-hong Man Yan-fei Gao Pei-jing Zhang Wei-hua li Jie Zhao Xin Pan Tao Zhou Wei-li Gong Ai-ling li Xue-min Zhang (Institute of Basic Medical Sciences,National Center of Biomedical Analysis,Beijing 100850 China)

Regulation of IKK activity is a key step modulating the signaling events leading to the activation of NF-κB by extracellular *** is believed that IKK activity is controlled by the opposing action of kinases and *** i...

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo liu Xin li Guangsheng Luo Naixin Zhai Ruizhe Hu jing lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing Yang Shuo Zhang Mengjie li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing Yang Hui Peng Sheng-Ke Tu Min li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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数字散斑干涉技术在振动分析中的应用

山东电子 2000年第1期 22-23页

作者：张静华李田泽山东淄博学院 255013 山东工程学院淄博市 255012

本文分析了散斑干涉的原理，采用双光束激光散斑干涉法，设计了一种数字散斑干涉的振动测量系统，给出了实验结果并对实验结果进行了讨论。

关键词：激光振动分析数字散斑干涉

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遭受攻击的生态系统应急恢复机理分析与研究

生物数学学报 2016年第4期31卷 505-519页

作者：燕慧娟华静李医民江苏大学理学院江苏镇江212013

土地利用、气候变化、氮沉积和大气浓度CO_2等导致生境丧失以及外来物种入侵都可以看成是对生态系统的各种攻击,在外界干扰下研究生态系统应急恢复策略对保护生态系统具有重要的现实意义.本文首先建立生态系统的网络模型,将生态系统遭... 详细信息

土地利用、气候变化、氮沉积和大气浓度CO_2等导致生境丧失以及外来物种入侵都可以看成是对生态系统的各种攻击,在外界干扰下研究生态系统应急恢复策略对保护生态系统具有重要的现实意义.本文首先建立生态系统的网络模型,将生态系统遭受攻击时的响应问题归结为生态网络模型发生级联失效过程中的网络抗毁性和崩溃问题.其次,利用物种负载、容量、最大承载量和恢复概率等指标研究在应急恢复条件下大规模网络级联失效,以及这些指标与网络抗毁性和网络崩溃速度之间的关联.最后,针对特定的阔叶混交林生态系统,通过数值仿真给出了该生态系统发生级联失效的系统稳定性阈值r_h和β_h均为0.35,当r>r_h或β>β_h时,关键物种的灭绝不会引起大规模网络级联失效而崩溃,当r

关键词：生态网络临界阈值级联故障抗毁性崩溃速度

双源CT对冠脉搭桥术后桥血管评价的Meta分析

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CT理论与应用研究（中英文） 2017年第3期26卷 285-290页

作者：杨涛顾静华李新明上海健康医学院附属周浦医院影像科上海201318 上海健康医学院附属周浦医院心内科上海201318

目的:利用循证医学方法,对双源CT评价冠状动脉搭桥术(CABG)后桥血管狭窄程度的价值进行Meta分析。方法:检索CNKI、万方、维普数据库以及Cochrance library、Pub Med、OVID、Embase等外文数据库,搜索双源CT诊断桥血管狭窄程度的诊断性试... 详细信息

目的:利用循证医学方法,对双源CT评价冠状动脉搭桥术(CABG)后桥血管狭窄程度的价值进行Meta分析。方法:检索CNKI、万方、维普数据库以及Cochrance library、Pub Med、OVID、Embase等外文数据库,搜索双源CT诊断桥血管狭窄程度的诊断性试验。对纳入资料使用Meta-disc 1.4软件进行分析计算,计算合并敏感度、特异度和诊断比值比。结果:最终入选5篇文献,其合并敏感度、特异度和诊断比值比分别为99%、99%、4 984,受试者工作特征曲线下面积为99.84%。结论:双源CT对于CABG后桥血管的评价具有很高的诊断效能和临床意义。

关键词：双源CT 冠状动脉搭桥术 Meta分析