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实时三维超声心动图在二尖瓣病变中的应用

中国医学影像技术 2010年第12期26卷 2398-2400页

作者：荆立华穆玉明新疆医科大学第一附属医院超声医学中心心脏超声诊断科新疆乌鲁木齐830054

二尖瓣特殊的解剖结构、功能特点使其成为研究热点。本文就实时三维超声心动图在二尖瓣狭窄、二尖瓣瓣叶脱垂、二尖瓣关闭不全及二尖瓣手术中的应用进行综述。

关键词：超声心动描记术,三维二尖瓣

Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong li li Dan jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

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World Journal of Gastroenterology 2007年第45期13卷 6048-6052页

作者： Ze-Yu Wu Jin Wan jing-hua li Gang Zhao Yuan Yao Jia-lin Du Quan-Fang liu lin Peng Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Department of Clinical Laboratory The First Affiliated Hospital Huangpu Division Sun Yat-Sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, in order to make the effective selection of patients who could benefit from lateral lymph node dissection, as well as the relationship of lateral lymph node metastasis with local recurrence and survival of patients with advanced low rectal cancer. METHODS： A total of 96 consecutive patients who underwent curative surgery with lateral pelvic lymphadenectomy for advanced lower rectal cancer were retrospectively analyzed. The relation of lateral lymph node metastasis with clinicopathologic characteristics, local recurrence and survival of patients was identified. RESULTS： Lateral lymph node metastasis was observed in 14.6% （14/96） of patients with advanced low rectal cancer. Lateral lymph node metastasis was detected in 10 （25.0%） of 40 patients with tumor diameter ≥ 5 cm and in 4 （7.1%） of 56 patients with tumor diameter 〈 5 cm. The difference between the significant （X^2 = 5.973, P = two groups was statistically 0.015）. Lateral lymph node metastasis was more frequent in patients with 4/4 diameter of tumor infiltration （7 of 10 cases, 70.0%）, compared with patients with 3/4, 2/4 and 1/4 diameter of tumor infiltration （3 of 25 cases, 12.0%; 3 of 45 cases, 6.7%; 1 of 16 cases, 6.3%）（X^2 = 27.944, P = 0.0001）. The lateral lymph node metastasis rate was 30.0% （9 of 30 cases）, 9.1% （4 of 44 cases） and 4.5% （1 of 22cases） for poorly, moderately and well-differentiated carcinoma, respectively. The difference between the three groups was statistically significant （X^2 = 8.569, P = 0.014）. Local recurrence was 18.8% （18 of 96 cases）, 64.3% （9 of 14 cases）, and 11.0% （9 of 82 cases） in patients with advanced low rectal cancer, in those with and without lateral lymph node metastasis, respectively. The difference between the two groups was statistically significant （X^2 = 22.308, P = 0.0001）. Kaplan-Meier survival analysis showed significant improvements in median sur

关键词： Low rectal cancer Lateral lymph nodemetastasis Local recurrence Prognosis

Study of circumferential resection margin in patients with middle and lower rectal carcinoma

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World Journal of Gastroenterology 2007年第24期13卷 3380-3383页

作者： Ze-Yu Wu Jin Wan jing-hua li Gang Zhao lin Peng Yuan Yao Jia-lin Du Quan-Fang liu Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Zhong Shan Medical-College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma. The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated. METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma. Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma. Twelve patients (21.4%) had positive circumferential resection margin. Local recurrence rate of patients with positive circumferential resection margin was 33.3% (4/12), whereas it was 6.8% (3/44) in those with negative circumferential resection margin (P = 0.014). Distant recurrence was observed in 50% (6/12) of patients with positive circumferential resection margin; conversely, it was 18.2% (8/44) in those with negative circumferential resection margin (P = 0.024). Kaplan-Meier survival analysis showed significant improvements in median survival (32.2 ± 4.1 mo, 95% CI: 24.1-40.4mo vs 23.0 ± 3.5 mo, 95% CI: 16.2-29.8 mo) for circumferential resection margin-negative patients over circumferential resection margin-positive patients (log-rank, P < 0.05). 37% T3 tumors examined were positive for circumferential resection margin, while only 0% T1 tumors and 8.7% T2 tumors were examined as circumferential resection margin. The difference between these three groups was statistically significant (P = 0.021). In 18 cancer specimens with tumor diameter ≥ 5 cm 7 (38.9%) were detected as positive c

关键词： Middle and lower rectal carcinoma Circumferential resection margin Prognosis

Treatment of 164 Cases of Thoracic Aortic Aneurysm

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Treatment of 164 Cases of Thoracic Aortic Aneurysm

The Mechanism of the Treatment of Tannery Wastewater by Micro-electrolysis

中华医学会第七次全国胸心血管外科学术会议暨2007中华医学会胸心血管外科青年医师论坛

作者： jing hua li De-min Dong Guo-hua Department of Cardiothoracic Surgery of General Hospital of Nanjing Command.Nanjing 210002,China

Objective To summarize the diagnosis methods,artificial vessel replacement techniques in thoracic aortic aneurysm and clinical application of endovascular stent graft exclusion. Methods From December 1995 to December 2006,164 patients(117 males and 47 females),aging from 27 to 77 years old(average 54),with thoracic aortic aneurysm undergoing surgical treatment were ***-nine of them were categorized as having Marfan syndrom,38 DeBakey type Ⅰ,18 DeBakey type Ⅱ,and 59 DeBakey type Ⅲ aortic *** to NYHA heart function classification,35 cases were in Grade 1,55 in Grade Ⅱ,58 in Grade Ⅲ and 16 in Grade Ⅳ.Forty-nine patients with Mafan syndrom recieved moderate hypothermia cardiopulmonary bypass operation via median thoracic incision,among whom Bentall procedure was applied in 44 cases and Wheat procedure in 5 *** of the 38 patients suffering from DeBakey type Ⅰ aortic dissection underwent ascending aorta and total aortic arch replacement and the left 8 underwent ascending aorta and semi- aortic arch *** the 38 patients,2 underwent total thoracic aortic artifical vessel replacement,25 underwent Wheat procedure,and 3 underwent aortic valvuloplasty.36 cases of the 59 patients with DeBakey type Ⅲ arotic dissection underwent desending aortic aneurysm resection and artificial vessel replacemint via left posterolateral thoracic incision,using left heart bypass or aorta to artery bypass(using Cott tubes).The other 23 patients underwent endovascular stent graft exclusion in descending aorta via femoral artery.

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The Mechanism of the Treatment of Tannery Wastewater by Micr...

Evaluation of efficacy and safety of sunitinib regimen in 22 patients with metastatic renal cell carcinoma： at least 12-month follow-up

The 12th Asian Pacific Confederation of Chemical Engineering Congress

作者： li Yan jing Guo-hua li Tian-Peng Zhou Zuo-Ming College of Material Science and Engineering,University of huaQiao,362021,Quanzhou,China

In this paper changes of pH value and Feconcentration were determined during the micro- electrolysis *** the removal of CODby micro- electrolysis method was compared to that by direct flocculation process with *** rem... 详细信息

关键词： micro-electrolysis tannery wastewater mechanism analysis

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Chinese Medical Journal 2013年第15期126卷 2826-2829页

作者： ZHANG Cui-jian ZHAO Peng-ju li Xue-song ZHAO jing huaNG li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian HE Zhi-song JIN Jie ZHOU li-qun Peking Univ Hosp 1 Dept Urol Beijing 100034 Peoples R China Peoples liberat Army Navy Gen Hosp Dept Urol Beijing 100037 Peoples R China Univ Pittsburgh Sch Med Dept Immunol Pittsburgh PA 15219 USA Scripps Res Inst Dept Metab & Aging Jupiter FL 33458 USA Peking Univ Inst Urol Natl Urol Canc Ctr Beijing 100034 Peoples R China

Background Sunitinib has been proved an effective new option for treatment of metastatic renal cell carcinoma （mRCC）. Analysis of clinical data of 22 patients, who were exposed to sunitinib for at least 1 year, was conducted to evaluate the long-term efficacy and safety of sunitinib for the treatment of mRCC. Methods A total of 54 patients with mRCC were treated with sunitinib malate, 50 mg/d orally, on a 4-weeks-on and 2-weeks-off dosing schedule in Peking University First Hospital. Treatment continued until disease progression, unacceptable adverse events （AEs）, or death. Among them, 22 patients continued treatment for at least I year. The clinical data of these 22 patients were prospectively collected for analysis. AEs were assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0. Tumor response was evaluated in accordance with the Response Evaluation Criteria in Solid Tumors. Results Median progression-free survival was 19.5 months until last follow-up. The best efficacy results achieved were complete response, partial response, and stable disease for 2, 9, and 11 patients, respectively. Objective response rate was 50%. The most common AEs were hand-foot syndrome （95%） and hypertension （91%）. Other common AEs were thyroid-stimulating hormone elevation （82%）, platelet decrease （77%）, and loss of appetite （77%）. Only one patient withdrew from treatment for cardiac infarction. Another nine patients experienced dose modifications or short-term suspensions. Conclusion Long-term exposure to sunitinib malate showed encouraging efficacy in the treatment of mRCC. At the same time, the tolerability was good.

关键词： sunitinib renal cell carcinoma metastatic safety efficacy

HBx-DNA probe preparation and its application in study of hepatocarcinogenesis

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World Journal of Gastroenterology 1998年第4期4卷 48-50页

作者： GAO FengGuang, SUN WenSheng, CAO Yinglin, ZHANG liNing, SONG jing, li huaFen and YAN ShiKunKeywords hepatitis B virus liver neoplasms/etiology carcinoma, hepatocellular/etiology DNA probe

AIM To study the role of HBV especially HBx Open Reading Frame (ORF) in the development of hepatocellular carcinoma (HCC).METHODS HBV 3.2kb fragment was retrieved by digesting recombinant plasmid pBR322-2HBV with EcoR Ⅰ, and HBx 0.59kb fragments by digesting HBV-DNA with BamHⅠ and BglⅡ. These fragments were labelled with digoxigenin to get HBV-DNA and HBx-DNA probes. HBV-DNA was detected in HCC by dot blot and Southern blot hybridization with HBV-DNA probe, so the positive specimens in which HBV-DNA were integrated were selected. HBx-DNA was subsequently detected in the selected specimens with HBx-DNA *** HBV-DNA was detected in 75% HCC, among which integrated type, integrated + free type covered 63.6% and 36.4%. There was no free type. HBx-DNA was detected in 90.5% specimens of integrated *** Hepatocarcinogenesis was highly related to HBV-DNA integration, and HBV-DNA mainly integrated into chromosome with incomplete virus DNA fragments among which HBx fragment was the predominant one.

关键词： DNA

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li jing li Yanqi Song Sujuan Qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing