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Efficacy and safety of individually tailored antiplatelet therapy in patients with acute coronary syndrome after coronary stenting： a single center, randomized, feasibility study

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Journal of Geriatric Cardiology 2015年第1期12卷 23-29页

作者： hong-Chang ZHU Yi LI Shao-Yi guan jing LI Xiao-Zeng WANG Quan-Min jing Zu-Lu WANG Ya-Ling HAN Second Affiliated Hospital of Dalian Medical University Dalianl 16023 Shandong Province China Cardiovascular Institute General Hospital of Shenyang Military Region Shenyang 110016 Liaoning Province China

Background Low responsiveness to clopidogrel （LRC） is associated with increased risk of ischemic events. This study was aimed to explore the feasibility of tailored antiplatelet therapy according to the responsiveness to clopidogrel. Methods A total of 305 clopidogrel naive patients with acute coronary syndromes （ACS） undergoing coronary stenting were randomly assigned to receive standard （n = 151） or tailored （n = 154） antiplatelet therapy. The ADP-induced platelet aggregation tests by light transmission aggregometry were performed to identify LRC patients assigned to the tailored group. The standard antiplatelet regimen was dual antiplatelet therapy with aspirin and clopidogrel. The tailored antiplatelet therapy was standard regimen for non-LRC patients and an additional 6-month cilostazol treatment for LRC patients. The primary efficacy outcome was the composite of cardiovascular death, myocardial infarction or stroke at one year. Results LCR was present in 26.6% （41/154） of patients in the tailored group. The percentage platelet aggregation for LCR patients was significantly decreased at three days after adjunctive cilostazol treatment （77.5% ± 12.1% vs. 64.5% ± 12.1%, P 〈 0.001）. At one year follow-up, a non-significant 37% relative risk reduction of primary events were observed in the tailored group as compared to the standard group （5.8% vs. 9.3%, P = 0.257）. There were no differences in the rates of stent thrombosis and hemorrhagic events between the two groups. Conclusions Tailored antiplatelet therapy for ACS patients after coronary stenting according to responsiveness to clopidogrel is feasible. However, its efficacy and safety need further confirmation by clinical trials with larger sample sizes.

关键词： Acute coronary syndrome Antiplatelet therapy Clopidogrel Coronary stenting

Osteoprotegerin,interleukin and hepatocyte growth factor for prediction of diabetes and hypertension in the third trimester of pregnancy

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World Journal of Clinical Cases 2020年第22期8卷 5529-5534页

作者： Su-jing Huang hong-Wei Wang Hai-Fang Wu Qiu-Yuan Wei Shu Luo Lin Xu hong-Qiong guan Department of Obstetrics The Second Affiliated Hospital of Hainan Medical CollegeHaikou 570311Hainan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)raises the risk of high blood pressure and may cause a series of life-threatening complications in pregnant *** and management of GDM and gestational hypertension(GH)in pregnancy helps to control and reduce these risks and prevent adverse effects on mothers and their ***,the majority criteria used for screening of diabetes mellitus is oral glucose tolerance tests,and blood pressure test is usually used for the screening and diagnosis of ***,these criteria might not anticipate or detect all GDM or GH ***,new specific predictive and diagnostic tools should be evaluated for this *** study selected three biomarkers of osteoprotegerin(OPG),interleukin(IL)and hepatocyte growth factor(HGF)for GDM and GH predication and *** To explore the feasibility of changes in placental and serum OPG,IL and HGF as tools for prediction and diagnosis of diabetes and hypertension in pregnant *** From January 2018 to January 2019,44 pregnant women with GDM and GH were selected as an observation group,and 44 healthy pregnant women were selected as a control group in the same *** OPG,IL and HGF were compared between the two *** The levels of OPG and HGF in the observation group were lower than in the control group,and the level of IL-1βwas higher in the observation group than in the control group(all P<0.05).Furthermore,OPG and HGF were negatively associated with gestational diabetes and gestational hypertension,while IL-1βwas positively associated with GDM complicated with GH(all P<0.05).CONCLUSION The evaluation of serum OPG,HGF and IL-1βlevels in patients with coexistent gestational diabetes complicated with hypertension can predict the degree of disease and play an important role in the follow-up treatment and prognosis prediction.

关键词： Third trimester of pregnancy Osteoprotegerin Interleukin Hepatocyte growth factor Gestational diabetes mellitus Gestational hypertension

Communication-Aware Formation Control of AUVs With Model Uncertainty and Fading Channel via Integral Reinforcement Learning

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 159-176页

作者： Wenqiang Cao jing Yan Xian Yang Xiaoyuan Luo Xinping guan the Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004China IEEE the Institute of Information Science and Engineering Yanshan UniversityQinhuangdao 066004China the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China

Most formation approaches of autonomous underwater vehicles(AUVs)focus on the control techniques,ignoring the influence of underwater *** paper is concerned with a communication-aware formation issue for AUVs,subject to model uncertainty and fading *** integral reinforcement learning(IRL)based estimator is designed to calculate the probabilistic channel parameters,wherein the multivariate probabilistic collocation method with orthogonal fractional factorial design(M-PCM-OFFD)is employed to evaluate the uncertain channel *** the estimated signal-to-noise ratio(SNR),we employ the IRL and M-PCM-OFFD to develop a saturated formation controller for AUVs,dealing with uncertain dynamics and current *** the proposed formation approach,an integrated optimization solution is presented to make a balance between formation stability and communication *** innovations lie in three aspects:1)Construct an integrated communication and control optimization framework;2)Design an IRL-based channel prediction estimator;3)Develop an IRL-based formation controller with ***,simulation results show that the formation approach can avoid local optimum estimation,improve the channel efficiency,and relax the dependence of AUV model parameters.

关键词： Autonomous underwater vehicles(AUVs) communication-aware formation reinforcement learning uncertainty

Electrospun Nanofibers for New Generation Flexible Energy Storage

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Energy & Environmental Materials 2021年第4期4卷 502-521页

作者： Yonghui Yan Xiangye Liu jing Yan Cao guan John Wang Frontiers Science Center for Flexible Electronics Institute of Flexible ElectronicsNorthwestern Polytechnical UniversityXi’an 710072China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

As one of the essential components for flexible electronics,flexible electrochemical energy storage(EES)has garnered extensive interests at all levels of materials,devices,and *** successful implementation of high-performance flexible EES devices relies on exploring of suitable electrode/electrolyte materials that have both superior electrochemical and mechanical *** this function,one-dimensional electrospun nanofibers have emerged as a class of promising building blocks for the key components of flexible EES *** this overview,the fundamental principles and technical advances of electrospinning are examined,for both their successes and challenges in controllable fabrication of nanofibers with the desirable chemical compositions,micro/meso-/nanostructures,and therefore resultant *** advances in applications of electrospun nanofibers for various key flexible EES devices are critically looked into,including those in supercapacitors,metal-ion batteries,and metal-air *** existing challenges and prospects of these electrospun nanofiber-based flexible EES are discussed,aiming to inspire continued efforts in developing the optimal high-performance and low cost flexible EES devices for long-awaited practical applications.

关键词： 1D nanofibers electrochemical energy storage electrospinning flexible electronics

Natural Compound Curcumin—a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of △F508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator

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Chemical Research in Chinese Universities 2008年第2期24卷 200-203页

作者： LIU Xin guan Li HE Cheng-yan ZHANG Xiao-jing XU Li-na SHANG De-jing MA Tong-hui YANG hong Membrane Channel Research Laboratory Northeast Normal University Changchun 130024 P. R. China China-Japan Union Hospital Jilin University Changchun 130033 P. R. China Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery Liaoning Normal University Dalian 116029 P. R. China

Cystic fibrosis（CF） is a severe genetic disease caused by the gene mutation of the cystic fibrosis transmembrane conductance regulator（CFTR） chloride channel. The most common point mutation AF508, which leads to impaired intracellular processing and channel gating of CFTR, appears in about 90% CF patients. The natural compound curcumin was reported to correct the processing defect of AF508-CFTR and proposed as a potential therapeutic drug to cure CF. In the present study, we analyzed the effect of curcumin on AF508-CFTR and demonstrated that curcumin can restore the impaired chloride conductance of AF508 mutant CFTR. The activity is rapid, reversible and cAMP-dependent. However, we couldn＇t reproduce the previously reported correction of the defective membrane trafficking of AF508-CFTR by curcumin. Therefore, curcumin may not be a superior lead compound for developing anti-CF drugs.

关键词： Cystic tibrosis CFTR Mutation Natural compound Drug discovery

Is it necessary to use the entire root as a donor when transferring contralateral C7 nerve to repair median nerve？

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Neural Regeneration Research 2018年第1期13卷 94-99页

作者： Kai-ming Gao Jie Lao Wen-jie guan jing-jing Hu Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Key Laboratory of Hand Reconstruction Ministry of Health Shanghai China Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai China Nursing Department Huashan Hospital Fudan University Shanghai China

If a partial contralateral C7 nerve is transferred to a recipient injured nerve, results are not satisfactory. However, if an entire contralateral C7 nerve is used to repair two nerves, both recipient nerves show good recovery. These findings seem contradictory, as the above two methods use the same donor nerve, only the cutting method of the contralateral C7 nerve is different. To verify whether this can actually result in different repair effects, we divided rats with right total brachial plexus injury into three groups. In the entire root group, the entire contralateral C7 root was transected and transferred to the median nerve of the affected limb. In the posterior division group, only the posterior division of the contralateral C7 root was transected and transferred to the median nerve. In the entire root ＋ posterior division group, the entire contralateral C7 root was transected but only the posterior division was transferred to the median nerve. After neurectomy,the median nerve was repaired on the affected side in the three groups. At 8, 12, and 16 weeks postoperatively, electrophysiological examination showed that maximum amplitude, latency, muscle tetanic contraction force, and muscle fiber cross-sectional area of the flexor digitorum superficialis muscle were significantly better in the entire root and entire root ＋ posterior division groups than in the posterior division group. No significant difference was found between the entire root and entire root ＋ posterior division groups. Counts of myelinated axons in the median nerve were greater in the entire root group than in the entire root ＋ posterior division group, which were greater than the posterior division group. We conclude that for the same recipient nerve, harvesting of the entire contralateral C7 root achieved significantly better recovery than partial harvesting, even if only part of the entire root was used for transfer. This result indicates that the entire root should be used as a dono

关键词： nerve regeneration peripheral nerve injury brachial plexus injury avulsion injury contralateral C7 transfer nerve root entire root partial root median nerve ulnar nerve animal experiment neural regeneration

Immune mechanisms of Concanavalin A model of autoimmune hepatitis

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World Journal of Gastroenterology 2012年第2期18卷 119-125页

作者： Hai-Xia Wang Man Liu Shun-Yan Weng jing-jing Li Chao Xie hong-Lin He Wen guan Yun-Sheng Yuan Jin Gao College of Sciences Anhui Science and Technology UniversityFengyang 233100Anhui ProvinceChina Shanghai Municipality Key Laboratory of Veterinary Biotechnology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Laboratory of Regeneration School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China

As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining *** the only viable treatments of AIH are immunosuppressant application and liver *** is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient *** Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so *** this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal *** go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine ***,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development.

关键词： Autoimmune hepatitis Animal models Concanavalin A

Tough Double Metal-ion Cross-linked Elastomers with Temperature-adaptable Self-healing and Luminescence Properties

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Chinese Journal of Polymer Science 2021年第5期39卷 554-565,I0005页

作者： Qi-Yan Yin Cheng-Hao Dai Huan Chen Kai Gou hong-Zhou guan Peng-Han Wang jing-Tao Jiang Geng-Sheng Weng School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Ningbo Key Laboratory of Specialty Polymers State Key Laboratory Base of Novel Functional Materials and Preparation ScienceNingbo UniversityNingbo 315211China

Smart materials with a combination of tough solid-like properties,fast self-healing and optical responsiveness are of interests for the development of new soft machines and wearable *** this work,tough physically cross-linked elastomers that show high mechanical strength,intriguing temperature-adaptable self-healing and fluorochromic response properties are designed using aluminum(Al)and fluorescent europium(Eu)ions as *** ionic Al-COOH binding is incorporated to construct the strong polymer network which mainly contributes to the mechanical robustness of the elastomer consisting of two interpenetrated *** Eu-iminodiacetate(IDA)coordination is mainly used to build the weaker but more dynamic network which dominate the elasticity,self-healing and luminescence of the *** Eu^(3+) and Al^(3+) contents give these supramolecular elastomers high *** temperature-sensitive Eu-IDA coordination enables tunable self-healing rate and efficiency along with fast Eu-centered"ON/OFF"switchable red *** mechanical,self-healing and luminescence properties of these elastomers can be adjusted by tuning the ratio of the two types of metal *** elastomer is potentially applicable for biosensors,wearable optoelectronics and anticounterfeiting materials.

关键词： Elastomer Tough Self-healing Luminescence Temperature-sensitive

Lom： Discovering Logic Flaws Within MongoDB-based Web Applications

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International Journal of Automation and computing 2017年第1期14卷 106-118页

作者： Shuo Wen Yuan Xue jing Xu Li-Ying Yuan Wen-Li Song hong-Ji Yang guan-Nan Si Institute of Machine Intelligence College of Computer and Control Engineering Nankai University Tianjin 300350 China Department of Electrical Engineering and Computer Science Vanderbilt University Nashville Tennessee 37212 USA Centre for Creative Computing Bath Spa University Bath BA2 9BN UK School of Information Science and Electrical Engineering Shandong Jiaotong University Ji'nan 250357 China

Logic flaws within web applications will allow malicious operations to be triggered towards back-end database. Existing approaches to identifying logic flaws of database accesses are strongly tied to structured query language （SQL） statement construction and cannot be applied to the new generation of web applications that use not only structured query language （NoSQL） databases as the storage tier. In this paper, we present Lom, a black-box approach for discovering many categories of logic flaws within MongoDB- based web applications. Our approach introduces a MongoDB operation model to support new features of MongoDB and models the application logic as a mealy finite state machine. During the testing phase, test inputs which emulate state violation attacks are constructed for identifying logic flaws at each application state. We apply Lom to several MongoDB-based web applications and demonstrate its effectiveness.

关键词： Logic flaw web application security not only structured query language (NoSQL) database black-box MougoDB.