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Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study

World Journal of Emergency Medicine 2021年第2期12卷 117-123页

作者： Wen Gao Yu-ping Zhang jing-fen jin Nursing Department School of MedicineZhejiang UniversityHangzhou 310058China Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND: Delirium in patients in intensive care units(ICUs) is an acute disturbance and fluctuation of cognition and consciousness. Though increasing age has been found to be related to ICU delirium, there is limited evidence of the effect of age on delirium outcomes. The aim of this study is to investigate the relationship between age categories and outcomes among ICU delirium ***: Data were extracted from the electronic ICU(e ICU) Collaborative Research Database with records from 3,931 patients with delirium. Patients were classified into non-aged(<65 years), youngold(65–74 years), middle-old(75–84 years), and very-old(≥85 years) groups. A Cox regression model was built to examine the role of age in death in ICU and in hospital after controlling covariates. RESULTS: The sample included 1,667(42.4%) non-aged, 891(22.7%) young-old, 848(21.6%) middle-old, and 525(13.3%) very-old patients. The ICU mortality rate was 8.3% and the hospital mortality rate was 15.4%. Compared with the non-aged group, the elderly patients(≥65 yeras) had higher mortality at ICU discharge(χ2=13.726, P=0.001) and hospital discharge(χ2=56.347, P<0.001). The Cox regression analysis showed that age was an independent risk factor for death at ICU discharge(hazard ratio [HR]=1.502, 1.675, 1.840, 95% confidence interval [CI] 1.138–1.983, 1.250–2.244, 1.260–2.687;P=0.004, 0.001, 0.002 for the young-, middle-and very-old group, respectively) as well as death at hospital discharge(HR=1.801, 2.036, 2.642, 95% CI 1.454–2.230, 1.638–2.530, 2.047–3.409;all P<0.001).CONCLUSIONS: The risks of death in the ICU and hospital increase with age among delirious patients.

关键词： Intensive care Delirium Aging Mortality

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Death and do-not-resuscitate order in the emergency department:A single-center three-year retrospective study in the Chinese mainland

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World Journal of Emergency Medicine 2020年第4期11卷 231-237页

作者： Chuan-qi Ding Yu-ping Zhang Yu-wei Wang Min-fei Yang Sa Wang Nian-qi Cui jing-fen jin Department of Nursing the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina

BACKGROUND:Consenting to do-not-resuscitate(DNR)orders is an important and complex medical decision-making process in the treatment of patients at the end-of-life in emergency departments(EDs).The DNR decision in EDs has not been extensively studied,especially in the Chinese ***:This retrospective chart study of all deceased patients in the ED of a university hospital was conducted from January 2017 to December *** patients with out-of-hospital cardiac arrest were ***:There were 214 patients’deaths in the ED in the three *** them,132 patients were included in this study,whereas 82 with out-of-hospital cardiac arrest were *** were 99(75.0%)patients’deaths after a DNR order medical decision,64(64.6%)patients signed the orders within 24 hours of the ED admission,68(68.7%)patients died within 24 hours after signing it,and 97(98.0%)patients had DNR signed by the family *** analysis showed that four independent factors infl uenced the family surrogates’decisions to sign the DNR orders:lack of referral(odds ratio[OR]0.157,95%confi dence interval[CI]0.047–0.529,P=0.003),ED length of stay(ED LOS)≥72 hours(OR 5.889,95%CI 1.290–26.885,P=0.022),acute myocardial infarction(AMI)(OR 0.017,95%CI 0.001–0.279,P=0.004),and tracheal intubation(OR 0.028,95%CI 0.007–0.120,P<0.001).CONCLUSIONS:In the Chinese mainland,the proportion of patients consenting for DNR order is lower than that of developed *** decision to sign DNR orders is mainly affected by referral,ED LOS,AMI,and trachea intubation.

关键词： Emergency service Do-not-resuscitate Death patients Retrospective analysis Emergency departments

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Arginine vasopressin reversed Aβ25-35-induced depression of hippocampal long-term potentiation in rat in vivo

Arginine vasopressin reversed Aβ25-35-induced depression of...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Wei jing,fen GUO,jin-Shun QI Department of neurobiology,Shanxi medical University,Taiyuan 030001,China

The main pathological characteristics of Alzheimer’s disease(AD) is the high density of senile plaques(SPs) in the brain which constitute of amyloid β-peptide(Aβ).However,the possible mechanisms by which Aβimpairs neurons are still uncertain and there is still no effective method in the prevention and treatment of *** Long term potentiation(LTP) is a persistent enhancement of excitatory synaptic transmission induced by preceding operations of high-frequency stimulation(HFS) and has long been thought to be a suitable model for not only the study of synaptic plasticity but also the elucidation of mechanisms underlying cognitive and memory disorders,such as *** vasopressin(AVP) is a neuropeptide,which plays an important role,as a central neurotransmitter,in the regulation of some central nervous functions including learning and *** decreased level of AVP in AD suggests that AVP-containing neurons may also be one of the targets of Aβbesides acetylcolinergic neurons;the improvement of memory by AVP suggests that AVP may protect neurons against neurotoxicity of Aβ,and be probably usefull in the prevention and treatment of ***,up to now,the most experiments regarding AVP mainly focused on the observation of animal *** studies on the mechanisms of the effects of AVP on hippocampal LTP are rarely reported or even controversial. In addition,although it has been shown that Aβcan impair LTP while AVP can enhance it,whether AVP can reverse A β-induced LTP suppression after co-application of AVP and Aβhas not been reported ***,the purposes of the present study were:(1) to further clarify the effects of AVP on rat hippocampal LTP in vivo;(2) to investigate the possible protective action of AVP on AP-induced LTP *** using extracellular electrophysiological technique,we recorded field excitatory postsynaptic potential(fEPSP) from the stratum radiatum of hippocampal CA1 area through applying stimulation to presynaptic Scha

关键词： Alzheimer’s disease(AD) Amyloidβ-protein(Aβ) Aβ25-35 long term potentiation(LTP) Arginine vasopressin(AVP) hippocampus

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低温等离子体对小鼠皮肤伤口愈合的影响

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西安交通大学学报（医学版） 2017年第5期38卷 643-648页

作者：蔡晶芬刘进仁任鸿斌许桂敏陈思乐孙养信石兴民张冠军西安交通大学公共卫生学院卫生毒理与卫生检验系陕西西安710061 西安交通大学电力设备电气绝缘国家重点实验室陕西西安710049 陕西省疾病预防控制中心消毒与病媒生物防控所陕西西安710054

目的比较不同剂量的大气压低温等离子体对BALB/c小鼠伤口愈合的影响,探讨低温等离子体处理小鼠伤口的最佳剂量以及影响伤口愈合的机制。方法采用介质阻挡放电方法产生大气压低温等离子体射流,对小鼠皮肤伤口进行处理,按处理时间分为10s... 详细信息

目的比较不同剂量的大气压低温等离子体对BALB/c小鼠伤口愈合的影响,探讨低温等离子体处理小鼠伤口的最佳剂量以及影响伤口愈合的机制。方法采用介质阻挡放电方法产生大气压低温等离子体射流,对小鼠皮肤伤口进行处理,按处理时间分为10s、20s、30s、40s、50s实验组,以不处理的自然愈合的伤口作为阴性对照组,以人重组表皮生长因子处理伤口作为阳性对照组,每天处理1次,连续观察14d。每天记录各组的伤口尺寸变化;取处理第7天的伤口组织行HE染色观察组织病理学变化;免疫荧光染色技术检测伤口组织中Ⅰ型胶原蛋白的表达;发射光谱分析低温等离子体射流的成分。结果 10s、20s、30s、40s实验组的小鼠伤口愈合速度较快,分别在第12、10、7、13天均基本愈合,而50s实验组的小鼠伤口在第14天尚未愈合;阳性对照组的小鼠伤口在第7天全部愈合,30s实验组可以达到阳性对照组小鼠伤口愈合效果。HE染色与免疫荧光染色技术表明,30s的等离子体处理剂量可以最大限度的促进伤口表皮再生,肉芽组织增生和胶原沉淀。光谱诊断发现低温等离子体中含有OH、NO、激发态N2分子以及激发态O原子。结论适量的低温等离子体可促进小鼠的伤口愈合,而过量则会抑制小鼠伤口的愈合;伤口的愈合过程可能和低温等离子体中的活性氧、活性氮的作用相关。

关键词：等离子体射流 BALB/c小鼠创伤愈合

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Cu/Mo2C synthesized through Anderson-type polyoxometalates modulate interfacial water structure to achieve hydrogen evolution at high current density

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Nano Research 2024年第4期17卷 2546-2554页

作者： Dunyuan jin fen Qiao Yan Zhou Junfeng Wang Kecheng Cao jing Yang Jikang Zhao Lei Zhou Haitao Li School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China School of Physical Science and Technology and Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China

The development of efficient non-precious metal catalysts is important for the large-scale application of alkaline hydrogen evolution reaction(HER).Here,we synthesized a composite catalyst of Cu and Mo_(2)C(Cu/Mo_(2)C)using Anderson-type polyoxometalates(POMs)synthesized by the facile soaking method as *** electronic interaction between Cu and Mo_(2)C drives the positive charge of Cu,alleviating the strong adsorption of hydrogen at the Mo site by modulating the d-band center of Mo_(2)*** studying the interfacial water structure using in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS),we determined that the positively charged Cu crystals have the function of activating water molecules and optimizing the interfacial water *** interfacial water of Cu/Mo_(2)C contains a large amount of free water,which could facilitate the transport of reaction *** to activated water molecules and optimized interfacial water structure and hydrogen adsorption energy,the overpotential of Cu/Mo_(2)C is 24 mV at a current density of 10 mA·cm^(-2) and 178 mV at a current density of 1000 mA·cm^(-2).This work improves catalyst performance in terms of interfacial water structure optimization and deepens the understanding of water-mediated catalysis.

关键词： electrocatalytic hydrogen production interfacial water charge transport d band center in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS)

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Infliximab treatment in two Chinese patients with psoriatic arthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 779-782页

作者： Xi XIE jin-wei CHEN fen LI jing TIAN Jie-sheng GAO David ZHANG Department of Rheumatology the Second Xiangya Hospital Central South University Changsha 410011 China Department of Bioengineering University of Washington Seattle Washington 98195 USA

Psoriatic arthritis(PsA) is a rheumatoid factor(RF)-seronegative systemic inflammatory disorder associated with *** treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs(DMARDs).In this paper,we report two Chinese patients with active longstanding PsA treated with infliximab,a human-mouse chimeric monoclonal antibody against tumor necrosis factor alpha(TNF-α).The results show that infliximab acted quickly and effectively in relieving peripheral and axial symptoms and refractory skin lesions,even in recombinant human TNF-α receptor(rhTNFR)-resistant *** take-home message from our cases is that infliximab is a useful therapeutic option for refractory PsA,especially when a patient has a combination of psoriasis and psoriatic *** local evidence and experience must be accumulated in order to make anti-TNF-α therapy more accessible to PsA patients in China.

关键词： Refractory psoriatic arthritis Skin lesions Infliximab Anti-tumor necrosis factor alpha (TNF-α) treatment

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PAHs in aquatic sediment in Hangzhou, China: Analytical methods, pollution pattern, risk assessment and sources

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Journal of Environmental Sciences 2005年第5期17卷 748-755页

作者： ZHU Li-zhong CAI Xue-fen WANG jing Department of Environmental Science Zhejiang University Hangzhou 310028 China Women＇s Hospital School of Medicine Zhejiang University Hangzhou 310006 China Zhejiang Provincial Environmental Monitoring Centre Hangzhou 310012 China

Eleven surface sediment samples, from Hangzhou section of Qiantang River and jinghang Canal, west Lake the inland river were collected to investigate 17 polycycUc aromatic hydrocarbons（PAHs） pollution in aquatic sediments of Hangzhou. Accelerated solvent extraction（ASE） was used to extract PAHs from sediments with satisfactory recoveries. It was found that the total PAHs in the sediments ranged from 308.4 to 3037 ng/g dw, and PAHs pollution in sediments from jinghang Canal were the heaviest. Lowest effect level（LEL） and severe effect level （SEL） sediment quality guidelines were introduced to perform risk assessment for PAHs pollution in aquatic sediments. Only one sample in jinghang Canal had adverse impact on benthic organism. 2-3 ring PAHs had a noticeable contribution to total PAHs, especially NA, PHEN. A quantity method was used to determine the major source, the results showed petroleum origin was the chief source to PAHs pollution in all sediments with the exception of sediments from jinghang Canal where combustion sources had a larger contribution.

关键词： PAHs ASE sediment source risk assessment

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Efficacy of one-day quadruple therapy for H pylori infection in Chinese patients

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World Journal of Gastroenterology 2006年第19期12卷 3105-3107页

作者： Xiao-Hui Huo Jian-Kun Chu Xiu-fen Yang jing Wang Li-jing Zhang jin-Cheng Ma Jun Yu Department of Gastroenterology First Affiliated Hospital of Hebei Medical University Shijiazhuang Hebei Province China Department of Medicine and Therapeutics Prince of Wales Hospital Chinese University of Hong Kong Hong Kong China

AIM： TO compare the efficacies of one-day quadruple therapy and seven-day triple therapy in Chinese patients. METHODS： Sixty consecutive patients with nonulcer dyspepsia and confirmed H pylori infection were randomized to receive either omeprazole 40 mg, amoxycillin 1 g, and furazolidone 100 mg, all twice a day for 7 d or omeprazole 20 mg （at breakfast and dinner）, amoxicillin 1 g, furazolidone 200 mg, and colloidal bismuth subcitrate 220 mg four times for only one day. H pylori status was determined before and at least 5 weeks after therapy by endoscopy with antral and corpus biopsies for rapid urease test and histology. RESULTS： Hpyloi eradication was successful in 66.67% （20/30） patients in the 7-d group and in 36.67% （11/30） patients in the 1-day group （P = 0.037）. Side effects were induced by the treatment in 13.3% （4/30） patients of each group, but these were all self-limiting, shortlasting, and did not require any specific treatment. CONCLUSION： The one-day quadruple therapy is less effective than the one-week regimen in curing H pylori infection in Chinese patients.

关键词： H pylori Quadruple therapy Antibiotics Gastritis Side effects

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Influence of dissolved organic carbon on multimedia distribution and toxicity of fipronil and its transformation products in lotic waterways

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Journal of Environmental Sciences 2023年第8期130卷 52-64页

作者： Weizong Li Hao Hu fen Liu Huizhen Li jing You School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health Jinan UniversityGuangzhou 511443China

Environmental fate and ecological impacts of fipronil and its transformation products(FIPs)in aquatic environment have caused worldwide attention,however,the influence of dissolved organic carbon(DOC)on multimedia distribution,bioavailability,and toxicity of FIPs in field waterways was largely ***,we collected 11 companion water and sediment samples along a lotic stream in Guangzhou,South *** were ubiquitous with total water concentrations ranging from 1.22 to 43.2 ng/L(14.8±12.9 ng/L)and fipronil sulfone was predominant in both water and *** than 70%of FIPs in aqueous phase were bound to DOC and the KDOC values of FIPs were approximately 1–2 orders of magnitude higher than K_(d-s)/K_(OC),emphasizing the significance of DOC in phase partitioning and transport of FIPs in aquatic *** and sediment samples were more toxic to Chironomus dilutus than Hyallela azteca,and FIPs(especially fipronil sulfone)pronouncedly contributed toxicity to *** units(TU)based on freely dissolved concentrations in water determined by solid phase microextraction significantly improved toxicity estimation of FIPs to the invertebrates compared to TUs based on aqueous *** present study highlights the significance of DOC association on fate and ecological risk of hydrophobic insecticides in lotic ecosystem.

关键词： Hydrophobic organic contaminant Bioavailability Partitioning Aquatic toxicity Passive sampler

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Magnetoelectric coupling effect of polarization regulation in BiFeO_(3)/LaTiO_(3)heterostructures

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Chinese Physics B 2021年第7期30卷 387-393页

作者： Chao jin feng-Zhu Ren Wei Sun jing-Yu Li Bing Wang Qin-fen Gu Institute for Computational Materials Science School of Physics and ElectronicsInternational Joint Research Laboratory of New Energy Materials and Devices of Henan ProvinceHenan UniversityKaifeng 475004China Australian Synchrotron ANSTO800 Blackburn RdClaytonVIC3168Australia

An effective regulation of the magnetism and interface of ferromagnetic materials is not only of great scientific significance,but also has an urgent need in modern *** this work,by using the first-principles calculations,we demonstrate an effective approach to achieve non-volatile electrical control of ferromagnets,which proves this idea in multiferroic heterostructures of ferromagnetic La TiO_(3)and ferroelectric Bi FeO_(3).The results show that the magnetic properties and two-dimensional electron gas concentrations of La TiO_(3)films can be controlled by changing the polarization directions of Bi FeO_(3).The destroyed symmetry being introduced by ferroelectric polarization of the system leads to the transfer and reconstruction of the Ti-3 d electrons,which is the fundamental reason for the changing of magnetic *** multiferroic heterostructures will pave the way for non-volatile electrical control of ferromagnets and have potential applications.

关键词： first-principles calculations BiFeO_(3)/LaTiO_(3)heterostructures magnetoelectric coupling effect polarization regulation

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