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Cellular microparticles and pathophysiolog, of traumatic brain injury

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Protein & Cell 2017年第11期8卷 801-810页

作者： Zilong Zhao Yuan Zhou Ye Tian Min Li jing-fei dong Jianning Zhang Department of Neurosurgery Tianjin Institute of Neurology Tianjin Medical University General Hospital Tianjin 300052 China BloodWorks Northwest Research Institute Seattle WA 98102 USA Institute of Pathology School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China Institute of Pathology School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China Division of Hematology Department of Medicine School of Medicine University of Washington Seattle WA 98195 USA

Traumatic brain injury （TBI） is a leading cause of death and disability worldwide. The finding that cellular microparticles （MPs） generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.

关键词： traumatic brain injury cellularmicroparticles coagulopathy inflammation

Potential evaluation and implementation strategy for pocket park construction in high-density urban areas: A case study in Dalian, China

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Frontiers of Architectural Research 2024年第2期13卷 319-334页

作者： jing dong Ruonan Guo fei Guo Jun Cai School of Architecture and Fine Art Dalian University of TechnologyDalian 116024China

As an important element of urban renewal in highly urbanized areas, pocket parks with small size, flexible layout and daily accessibility are becoming a major component of green infrastructure and the mainstay of outdoor recreation space expansion in high-density urban centers. Nevertheless, the absence of a comprehensive framework for evaluating the potential of pocket park construction (PPC), one that integrates diverse influencing factors on a macro scale, has resulted in the random installation of such spaces, often failing to optimize the utilization of urban land. Addressing this critical lacuna, we propose an approach to evaluate PPC potential from a city-scale perspective, which is used to support the determination of which land units should be prioritized for PPC. A complete and feasible workflow was also established to identify potential land units, construct an index system for PPC combining demand and supply levels, quantitatively calculate indices based on remote sensing (RS) and geographic information system (GIS), accurately evaluate PPC potential using an entropy-weighted TOPSIS model, and develop targeted renewal strategies. A case study in Dalian, China, demonstrated the applicability and implications of the workflow. The results showed that it is flexible and easy to adapt to different local contexts, allowing evaluators to introduce parameters considering the availability of local data, and will help decision makers to build pocket parks in the most effective plots, providing a strong reference for high-quality development in other high-density urban centers facing the contradiction between ecological construction and land scarcity.

关键词： Pocket park Potential evaluation Urban renewal High-density urban areas

Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury

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Neural Regeneration Research 2019年第6期14卷 984-990页

作者： Hui-Jie Wei Li Liu Fang-Lian Chen dong Wang Liang Wang Zeng-Guang Wang Rong-Cai Jiang jing-fei dong Jie-Li Chen Jian-Ning Zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous System Department of Neurosurgery Peking University International Hospital Thrombosis Research Section Department of MedicineBaylor College of Medicine Department of Neurology Henry Ford Health System

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their ***, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury,and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels(r =-0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China(approval No. 200501) in January 2015.

关键词： nerve regeneration endothelial progenitor cells vascular repair vascular remodeling angiogenesis neovascularization blood glucose hyperglycemia traumatic brain injury mobilization suppression senescence alternative therapy brain damage neural regeneration

The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism

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Genes & Diseases 2024年第4期11卷 220-233页

作者： jing Zhang Wenhui Hu Zhi Zou Yuheng Li fei Kang Jianmei Li Shiwu dong College of Bioengineering Chongqing UniversityChongqing 400044China Department of Biomedical Materials Science College of Biomedical EngineeringArmy Medical University(Third Military Medical University)Chongqing 400038China State Key Laboratory of Trauma and Chemical Poisoning Army Medical University(Third Military Medical University)Chongqing 400038China

In recent years,researchers have become focused on the relationship between lipids and bone metabolism ***,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic *** has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone ***,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal *** lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards ***,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of ***,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism *** also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关键词： Bone homeostasis Cross-organ communication Lipid metabolism Osteoclast Osteoporosis

Characteristics and stability of oxide+carbonitride in H13 steel at 1250℃

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Journal of Iron and Steel Research International 2024年第1期31卷 134-142页

作者： Xiao-lin Sun Han-jie Guo jing Guo fei Wang dong Xu Gao-yang Song Shuai Wang School of Materials Science and Engineering Hebei University of EngineeringHandan056038HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China High Temperature Materials Research Institute Central Iron and Steel Research Institute Co.Ltd.Beijing100081China Technology Innovation Center for High Quality Cold Heading Steel of Hebei Province Hebei University of EngineeringHandan056038HebeiChina

The morphology,size,quantity,and composition of complex oxide+carbonitride in H13 steel held at 1250℃for 5,10,and 15 h were *** results show that the ratio and number of complex carbonitrides with cores in H13 steel are gradually increased when holding at 1250℃compared with those in the original H13 steel,and the core size *** are one or more oxide cores in(Ti_(x),V_(1-x))(Cy,N_(1-y)),including xCaO·zAl_(2)O_(3),xCaO·yMgO·zAl_(2)O_(3),and CaO after holding at 1250℃,in addition to MgO·Al_(2)O_(3)and Al_(2)O_(3)in the original *** equilibrium temperature for(Ti_(x),V_(1-x))(Cy,N_(1-y))precipitation at the solidification front and decomposition in the solid state was theoretically analyzed,which was affected by the x value and the product of Ti and N contents in H13 ***,the composition of(Ti_(x),V_(1-x))(Cy,N_(1-y))is influenced by the oxide *** is convinced that(Ti_(x),V_(1-x))(Cy,N_(1-y))with oxide cores has a higher stability,especially for oxides with a high Al_(2)O_(3)*** treatment at high temperature facilitates a more reasonable analysis of oxide+carbonitride,and the generation mechanism of oxide+carbonitride was discussed.

关键词： Complex carbonitride Decomposition Oxide core Characteristic Stability

Fusion of Spiral Convolution-LSTM for Intrusion Detection Modeling

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Computers, Materials & Continua 2024年第5期79卷 2315-2329页

作者： fei Wang Zhen dong School of Cyberspace Security Gansu University of Political Science and LawLanzhou73000China

Aiming at the problems of low accuracy and slow convergence speed of current intrusion detection models,SpiralConvolution is combined with Long Short-Term Memory Network to construct a new intrusion detection *** dataset is first preprocessed using solo thermal encoding and normalization *** the spiral convolution-Long Short-Term Memory Network model is constructed,which consists of spiral convolution,a two-layer long short-term memory network,and a *** is shown through experiments that the model is characterized by high accuracy,small model computation,and fast convergence speed relative to previous deep learning *** model uses a new neural network to achieve fast and accurate network traffic intrusion *** model in this paper achieves 0.9706 and 0.8432 accuracy rates on the NSL-KDD dataset and the UNSWNB-15 dataset under five classifications and ten classes,respectively.

关键词： Intrusion detection deep learning spiral convolution long and short term memory networks 1D-spiral convolution

Nanocavity enriched CuPd alloy with high selectivity for CO_(2) electroreduction toward C_(2)H_(4)

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Rare Metals 2024年第4期43卷 1513-1523页

作者： Ze-Yu Zhang Hai-Bin Wang fei-fei Zhang jing-Wei Li Xin-Zhuo Hu Si-Wei Yan Yi-Ming Bai Xun Zhang Gu-Rong Shen Peng-fei Yin jing Yang Cun-Ku dong jing Mao Hui Liu Xi-Wen Du Institute of New-Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China

Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy barrier of C-C ***,a viable catalyst design strategy to decrease energy barrier of C-C coupling should be put ***,a nanocavity-enriched CuPd single atom alloy(CuPd SAA)catalyst is designed to promote CC coupling *** faradaic efficiency of CuPd SAA for ethylene and C_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RHE),*** on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*CO,thus enhancing the faradaic efficiency for *** functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring Cu atoms to decrease the energy barrier of C-C coupling,further improving the faradaic *** work provides a new idea for designing catalyst with high selectivity for ethylene.

关键词： Adsorption configuration C-C coupling CO_(2) electrocatalysis Ethylene Single atom alloy

Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese Chemical Letters 2024年第2期35卷 352-357页

作者： Yingli Zhu Jie Qian Kunqian Yu jing Hou Yeshuo Ma fei Chen Jie dong Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National Engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

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Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： Han Yin Xiao-jing Liu Teng-fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3