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Metabolic profile analysis of free amino acids in experimental autoimmune uveoretinitis rat plasma

International Journal of Ophthalmology(English edition) 2019年第1期12卷 16-24页

作者： Jun-Guo Guo Xin-Miao Guo Xing-Rong Wang jing-zhen tian Hong-Sheng Bi College of Pharmacy Shandong University of Traditional Chinese Medicine Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases Eye Institute Shandong University of Traditional Chinese Medicine School of Management Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital Shandong University of Traditional Chinese Medicine

AIM: To determine the differences of amino acid(AA) levels in experimental autoimmune uveoretinitis(EAU). METHODS: AA analysis of the plasma samples in EAU rats induced by interphotoreceptor retinoid-binding protein emulsion were performed with high performance liquid chromatography(HPLC) and phenylisothiocyanate(PITC) pre-column derivation methods were performed. Using partial least squares discriminant analysis(PLS-DA), the potential biomarkers were identified in EAU rat plasma, and the metabolic pathways related to EAU were further analyzed. RESULTS: The method results showed that linear(r≥0.9957), intra-day reproducible [relative standard deviation(RSD)=0.04%-1.33%], inter-day reproducible(RSD=0.06%-2.07%), repeatability(RSD=0.03%-0.89%), stability(RSD=0.05%-2.48%) and recovery(RSD=1.98%-4.39%), with detection limits of 0.853-11.4 ng/mL. The metabolic profile in EAU rats was different from that in the control groups five AAs concentrations were increased and nine AAs were reduced. Moreover, five metabolic pathways were related to the development of EAU. CONCLUSION: The developed method is a simple, rapid and convenient for determination of AAs in EAU rat plasma, and these findings will provide a comprehensiveinsight on the metabolic profiling of the pathological changes in EAU.

关键词： experimental autoimmune uveoretinitis phenylisothiocyanate high performance liquid chromatography amino acid metabolic profile rat

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Numerical Analysis of Effect of Water on Explosive Wave Propagation in Tunnels and Surrounding Rock

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Journal of China University of Mining and Technology 2007年第3期17卷 368-371页

作者： XIA Chang-jing SONG zhen-duo tian Lu-lu LIU Hong-bin WANG Lu WU Xiao-fang School of Mechanics ＆ Civil Engineering China University of Mining ＆ Technology Beijing 100083 China

Based on the application of practical engineering,propagation processes of explosive waves in rock with water well and tunnel are simulated by ANSYS/LS-DYNA software. The evolution of damage in rock is presented. The effect of water on the damage of the concrete slab in a tunnel is compared with damage inflicted without water. The numerical simulation illustrates that water plays an important role in the evolution of damage of the concrete slab in a mine tunnel. In the presence of water in the rock the concrete slab is damaged more severely than without water in rock. The effect of water location in the rock is also considered. It is found that the concrete slab in the tunnel shows various degrees of damage as a function of the different locations of water. Attenuation laws of stress waves over time-space in rock with water are also obtained. Numerical results indicate that,under blast loading,there are three zones in the rock: a crushed zone nearby the explosive charge,a damaged zone and an elastic zone. The conclusions of numerical analysis may provide references for blasting designs and structure protection.

关键词： explosive wave numerical simulation concrete slab damage evolution

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普通混凝土和高性能混凝土泛碱试验研究

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中北大学学报（自然科学版） 2017年第2期38卷 243-248页

作者：刘晋艳田钰靖巩天真牛宁山西大学土木工程系山西太原030013 中国矿业大学(北京)力学与建筑工程学院北京100083 山西大学混凝土外加剂技术研究中心山西太原030006 山西诚达公路勘察设计有限公司山西太原030006

对晋北地区混凝土表面泛碱产物进行采样并分析其化学成分,得到泛碱产物90%以上是Na_2SO_4.分别制备普通混凝土试件和高性能混凝土试件各一批,半浸泡于Na_2SO_4溶液中并辅以干湿循环,分析两种试件的区别反应,得到如下结论:高性能混凝土... 详细信息

对晋北地区混凝土表面泛碱产物进行采样并分析其化学成分,得到泛碱产物90%以上是Na_2SO_4.分别制备普通混凝土试件和高性能混凝土试件各一批,半浸泡于Na_2SO_4溶液中并辅以干湿循环,分析两种试件的区别反应,得到如下结论:高性能混凝土和普通混凝土试块的的泛碱产物虽然都是硫酸钠晶体,但结晶形貌不同;高性能混凝土能延缓泛碱的发生,且其泛碱产物明显少于普通混凝土;高性能混凝土对于防止硫酸盐化学侵蚀方面有明显优势.

关键词：泛碱高性能混凝土干湿交替结晶形貌

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu jing Wu Guang Yin Fan‑zhen Jiao Zhong‑zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei Yang Yike jing zhen Zeng Xuesong Yi Wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing Li Zixuan He Weitai Chai Meng tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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美国公法域外适用机制及中国因应研究

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海南大学学报（人文社会科学版） 2025年第1期43卷 195-206页

作者：田静南开大学法学院天津300071

公法域外适用衍生于国际体系的结构性演变,有着经济全球化下独特的政治、经济与意识形态背景。其在公法域外适用需求的显现、国家主权观念的转换、公法禁忌原则的突破以及法律形式的嬗变上,具备了一定的存在基础。但是近年来,囿于美国... 详细信息

公法域外适用衍生于国际体系的结构性演变,有着经济全球化下独特的政治、经济与意识形态背景。其在公法域外适用需求的显现、国家主权观念的转换、公法禁忌原则的突破以及法律形式的嬗变上,具备了一定的存在基础。但是近年来,囿于美国国际法理念的转变,其由原先对严格属地主义的固守转为对国家利益至上的推崇,因而在公法域外适用上愈发地恣意与专断,使公法域外适用存在严重的法律、外交和道德张力。为应对美国公法域外适用,中国须秉承防御与建设共进的思路。一方面,加强国际合作共同抗衡美国公法域外适用制度的滥用,同时健全中国的反制法律体系;另一方面,梳理总结美国多年来在公法域外适用过程中形成的丰富经验,在此基础上构建完善符合国际法基本原则的中国法域外适用制度。

关键词：域外适用管辖权效果原则公法禁忌

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang tian-tian Meng Song Li jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang jing-Shui zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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2D phosphides heterostructures on titanium microfiltration membrane for enhanced ampere-level current density overall seawater splitting

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Nano Research 2025年第1期18卷 249-259页

作者： Wenjing Dai Xin Wang Yulong Ma Sisi He Ming Chen Zhaohui Yin Shuheng tian Maolin Wang Shixiang Yu Hang Zhang Yuanzhe Wang Hong Wang Jianxin Li Faming Gao Bowen Cheng Yun Wang zhen Yin Ding Ma tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China Haian Institute of High-Tech Research Nanjing UniversityHaian 226600China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Separation Membranes and Membrane Processes Separation Membrane Science and Technology International Joint Research CentreTiangong UniversityTianjin 300387China Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversitySouthportQueensland 4222Australia

The advancement of direct seawater electrolysis is a significant step towards sustainable hydrogen production,addressing the critical need for renewable energy sources and efficient resource ***,direct seawater electrolysis has to face several challenges posed by the corrosiveness of highly concentrated chloride and the competitive chlorine evolution reaction(ClER).To overcome these issues,we designed a novel NiP_(2)@CoP electrocatalyst on a porous titanium microfiltration(Ti MF)*** obtained bifunctional NiP_(2)@CoP catalyst outperforms the Pt/C and IrO_(2),as evidenced by its low overpotentials of 192 and 425 mV at a current density of 500 mA·cm^(-2) for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alkaline seawater(1 M KOH+0.5 M NaCl),***,only 231 and 569 mV overpotentials are required at the current density of 1500 mA·cm^(-2) towards HER and OER in alkaline seawater,*** importantly,no ClER was observed,demonstrating its excellent selectivity to *** selection of porous Ti MF membrane as an electrode substrate further enhances the performance by providing a robust structure that promotes the fast generation and release of gas *** promising outcomes obtained with NiP_(2)@CoP catalysts on Ti MF support,therefore,pave the way for the commercial viability of direct seawater electrolysis technologies at industrial-level current densities.

关键词： direct seawater electrolysis porous titanium microfiltration membrane phosphides heterostructures NiP_(2)@CoP electrocatalyst excellent selectivity to oxygen evolution reaction(OER)

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