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Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

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Chinese Journal of Integrative Medicine 2024年第6期30卷 507-514页

作者： zhao jing TIAN Xin-chen ZHANG Jia-qi HUANG Chen SUN Yan qiAO Sen JIANG Shu-long Clinical Medical Laboratory Center Jining First People’s HospitalJiningShandong Province272000China Cheeloo College of Medicine Shandong UniversityJinan250000China

Objective:To investigate the anti-liver cancer effects and aspartic acid(Asp)-related action mechanism of Euphorbia fischeriana Steud.(LD).Methods:The mice model of liver cancer was established by injection of H22 *** 5 days,mice were randomly divided into model group,sorafenib group(20 mg/kg),LD high-dose(LDH,1.36 g/kg) group,LD medium-dose(LDM,0.68 g/kg) group,and LD low-dose(LDL,0.34 g/kg)group,10 mice each *** were intragastrically administered to the mice once daily for 10 days,*** weight,tumor size and tumor weight were *** index was *** changes of liver cancer tissues were evaluated by hematoxylin and eosin staining and TUNEL *** chromatography-mass spectrometer was used to analyze different metabolites between the model and LDH ***:After LD treatment,tumor weight,tumor size and hepatic index were reduced compared with the model *** and karyorrhexis of tumor cells were ***,61 differential metabolites(18 up-regulated,43 down-regulated) were affirmed and 20 pathways of KEGG(P<0.05) were *** addition,Bel-7402,HepG2 and H22 cell viabilities were significantly increased after adding Asp into the *** then,the cell proliferation effect induced by Asp was ameliorated by ***:The anti-liver cancer efficacy of LD extract was validated in H22 mice model,and inhibition of Asp level might be the underlying mechanism.

关键词： liver cancer Euphorbia fischeriana Steud. aspartic acid metabolomics

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer

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National Science Review 2024年第1期11卷 107-119页

作者： Shuren Zhang Dongfan Song Wenhao Yu Ji Li Xiaoyu Wang Yachao Li Zihan zhao qi Xue jing zhao Jie P.Li Zijian Guo State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University Department of Urology Afflliated Drum Tower HospitalMedical SchoolNanjing University Nanchuang (Jiangsu)Institute of Chemistry and Health

Mounting evidence suggests that strategies combining DNA-damaging agents and stimulator of interferon genes(STING) agonists are promising cancer therapeutic regimens because they can amplify STING activation and remodel the immunosuppressive tumor microenvironment. However, a single molecular entity comprising both agents has not yet been developed. Herein, we designed two PtIV-MSA-2 conjugates(Ⅰand Ⅱ) containing the DNA-damaging chemotherapeutic drug cisplatin and the innate immuneactivating STING agonist MSA-2; these conjugates showed great potential as multispecific small-molecule drugs against pancreatic cancer. Mechanistic studies revealed that conjugate Ⅰ upregulated the expression of transcripts associated with innate immunity and metabolism in cancer cells, significantly differing from cisplatin and MSA-2. An analysis of the tumor microenvironment demonstrated that conjugate I could enhance the infiltration of natural killer(NK) cells into tumors and promote the activation of T cells, NK cells and dendritic cells in tumor tissues. These findings indicated that conjugate I, which was created by incorporating a Pt chemotherapeutic drug and STING agonist into one molecule, is a promising and potent anticancer drug candidate, opening new avenues for small-molecule-based cancer metalloimmunotherapy.

关键词： platinum drug STING agonist single-molecule multitarget metalloimmunology

Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4157-4165页

作者： jing-Song qi Peng zhao Xiao-Bo zhao Yong-Li zhao Ying-Chang Guo Department of Interventional The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina

BACKGROUND Liver cancer is a highly malignant tumor with significant clinical *** alone often yields suboptimal outcomes in both the short and long term,characterized by high rates of local recurrence and distant metastasis,leading to a poor long-term *** To evaluate the clinical efficacy of small particle drug-eluting beads-transarterial chemoembolization(DEB-TACE)combined with targeted therapy for the treatment of unresectable liver *** We analyzed clinical data from 74 patients with unresectable liver cancer admitted between January 2019 and December *** on the different treatment regimens administered,patients were divided into the control(36 patients receiving sorafenib alone)and joint(38 patients receiving small particle DEB-TACE combined with sorafenib)*** compared liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB)]and serum tumor markers[alpha fetoprotein(AFP)]before and after treatment in both ***-term efficacy measures[complete response(CR),partial response,progression disease,stable disease,objective response rate(ORR),and disease control rate(DCR)]were assessed ***-term follow-up evaluated median overall survival(OS),progression-free survival(PFS),and adverse reaction rates between the two *** One month post-treatment,the joint group demonstrated significantly higher rates of CR,ORR,and DCR compared to the control group(P<0.05).Three days after treatment,the joint group showed elevated levels of ALT,AST,and TBIL but reduced levels of ALB and AFP compared to the control group(P<0.05).The median OS was 18 months for the control group and 25 months for the joint group,while the median PFS was 15 months for the control group and 22 months for the joint group,with significant differences observed(log-rank:χ2=7.824,6.861,respectively;P=0.005,0.009,respectively).The incidence of adverse reactions was not s

关键词： Small particle Drug-eluting beads-transarterial chemoembolization Sorafenib Treatment Unresectable liver cancer

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闭合宇宙的新观测证据与宇宙学的危机

科学通报 2019年第36期64卷 3773-3775页

作者：祁景钊张鑫东北大学理学院物理系

宇宙学的研究已经进入到一个精确宇宙学时代.普朗克卫星以前所未有的精度精确测量了宇宙微波背景辐射(cosmic microwave background,CMB)上的微小温度涨落和极化,这些测量结果为宇宙学参数提供了强有力的限制[1].总体来说,普朗克观测结... 详细信息

宇宙学的研究已经进入到一个精确宇宙学时代.普朗克卫星以前所未有的精度精确测量了宇宙微波背景辐射(cosmic microwave background,CMB)上的微小温度涨落和极化,这些测量结果为宇宙学参数提供了强有力的限制[1].总体来说,普朗克观测结果明确支持一个仅含有6个基本宇宙学参数的宇宙学模型,即所谓的宇宙学常数冷暗物质(߉cold dark matter,߉CDM)模型.目前,空间平直的߉CDM模型被普遍视为一个宇宙学的标准模型,因为该模型的预言与几乎所有的宇宙学观测都符合得很好.

关键词：宇宙学宇宙微波背景辐射冷暗物质普朗克标准模型温度涨落

Distribution and Formation Causes of PM_(2.5) and O_(3) Double High Pollution Events in China during 2013–20

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Advances in Atmospheric Sciences 2024年第6期41卷 1235-1250,I0004-I0021页

作者： Zhixuan TONG Yingying YAN Shaofei KONG Jintai LIN Nan CHEN Bo ZHU jing MA Tianliang zhao Shihua qi Department of Atmospheric Science School of Environmental SciencesChina University of GeosciencesWuhan 430074China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research Centre for Complex Air Pollution of Hubei Province Wuhan 430074China Laboratory for Climate and Ocean–Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China Eco-Environmental Monitoring Centre of Hubei Province Wuhan 430074China Key Laboratory of Atmospheric Chemistry China Meteorological AdministrationBeijing 100081China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely *** this study,the spatiotemporal distribution of DHP events in China during 2013–20 is *** synoptic types affecting DHP events are identified with the Lamb–Jenkinson circulation classification *** meteorological and chemical causes of DHP events controlled by the main synoptic types are further *** show that DHP events(1655 in total for China during 2013–20)mainly occur over the North China Plain,Yangtze River Delta,Pearl River Delta,Sichuan Basin,and Central *** occurrence frequency increases by 5.1%during 2013–15,and then decreases by 56.1%during 2015–*** main circulation types of DHP events are“cyclone”and“anticyclone”,accounting for over 40%of all DHP events over five main polluted regions in China,followed by southerly or easterly flat airflow types,like“southeast”,“southwest”,and“east”.Compared with non-DHP events,DHP events are characterized by static or weak wind,high temperature(20.9℃ versus 23.1℃)and low humidity(70.0%versus 64.9%).The diurnal cycles of meteorological conditions cause PM_(2.5)(0300–1200 LST,Local Standard Time=UTC+8 hours)and O_(3)(1500–2100 LST)to exceed the national standards at different periods of the DHP *** pollutant conversion indices further indicate the rapid secondary conversions during DHP events,and thus the concentrations of NO_(2),SO_(2) and volatile organic compounds decrease by 13.1%,4.7%and 4.4%,*** results of this study can be informative for future decisions on the management of DHP events.

关键词： double high pollution events PM_(2.5) ozone spatiotemporal distribution meteorological causes chemical composition characteristics

Influence of high-pressure heat treatment on magnetocaloric effects and magnetic phase transition in single crystal Gd3Ga5O12

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Journal of Rare Earths 2024年第11期42卷 2112-2118页

作者： Xiang Jin jing zhao Lei Gao Huaijin Ma Haschuluu Oimod Hongwei Zhu qi Li Taichao Su Hongyu Zhu Tegus O Jianjun zhao Inner Mongolia Key Laboratory for Physics and Chemistry of Functional Materials Inner Mongolia Normal University School of Physical Science and Technology Baotou Teachers' CollegeKey Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region National Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare Earths College of Science Guilin University of Technology

The magnetic properties and magnetic phase transition critical behavior of Gd3Ga5O12single crystals subjected to high-pressure heat treatment were *** results show that high-pressure heat treatment reduces the Curie temperature and magnetization of the *** a magnetic field change of 5 T,the maximum isothermal magnetic entropy of the sample is approximately 19.73 J/（kg·K）.High-pressure heat treatment increases the phase transition temperature range and leads to an increase in the magnetic refrigeration *** Gd3Ga5O12single crystals and the high-pressure heat-treated sample undergo a second-order phase *** critical behavior of the samples aligns with the mean field model acquired via critical model *** indicates that the samples exhibit long-range exchange interactions in the system near the Curie ***,this material can be used as a magnetic refrigerant for low-temperature applications.

关键词： High-pressure heat treatment Magnetic phase transition Magnetic refrigeration Magnetocaloric effect Rare earths

Transition metal clusters with precise numbers of atoms anchored on graphdiyne as multifunctional electrocatalysts for OER/ORR/HER:a computational study

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Rare Metals 2024年第7期43卷 3107-3117页

作者： Xin-Yang Liu jing-Wei Liu Gang Li jing-Xiang zhao College of Chemistry and Chemical Engineering Harbin Normal UniversityHarbin 150025China

Subnanometer metal clusters play an increasingly important role in heterogeneous catalysis due to their high catalytic activity and *** this work,by means of the density functional theory(DFT) calculations,the catalytic activities of transition metal clusters with precise numbers of atoms supported on graphdiyne(TM_(1-4)@GDY,TM=V,Cr,Mn,Fe,Co,Ni,Cu,Ru,Rh,Pd,Ir,Pt) were investigated for oxygen evolution reactions(OER),oxygen reduction reactions(ORR) and hydrogen evolution reactions(HER).The computed results reveal that the Pd_(2),Pd_(4) and Pt_(1) anchored graphdiyne can serve as trifunctional catalysts for OER/ORR/HER with the overpotentials of 0.49/0.37/0.06,0.45/0.33/0.12 and 0.37/0.43/0.01 V,respectively,while Pd_(1) and Pt_(2)@graphdiyne can exhibit excellent catalytic performance for water splitting(OER/HER) with the overpotentials of 0.55/0.17 and 0.43/0.03 *** addition,Ni_(1) and Pd_(3) anchored GDY can perform as bifunctional catalysts for metal-air cells(OER/ORR) and fuels cells(ORR/HER) with the overpotentials of 0.34/0.32 and 0.42/0.04 V,***,by precisely controlling the numbers of atoms in clusters,the TM_(1-4) anchored graphdiyne can serve as promising multifunctional electrocatalysts for OER/ORR/HER,which may provide an instructive strategy to design catalysts for the energy conversation and storage devices.

关键词： Density functional theory Graphdiyne Single-cluster catalysts Multifunctional electrocatalysts Overpotential

Uncertain knowledge graph embedding:an effective method combining multi-relation and multi-path

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Frontiers of Computer Science 2024年第3期18卷 73-89页

作者： qi LIU qinghua ZHANG Fan zhao Guoyin WANG Key Laboratory of Tourism Multisource Data Perception and Decision Ministry of Culture and TourismChongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Big Data Intelligent Computing Chongqing University of Posts and TelecommunicationsChongqing 400065China

Uncertain Knowledge Graphs(UKGs)are used to characterize the inherent uncertainty of knowledge and have a richer semantic structure than deterministic knowledge *** research on the embedding of UKG has only recently begun,Uncertain Knowledge Graph Embedding(UKGE)model has a certain effect on solving this ***,there are still unresolved *** the one hand,when reasoning the confidence of unseen relation facts,the introduced probabilistic soft logic cannot be used to combine multi-path and multi-step global information,leading to information *** the other hand,the existing UKG embedding model can only model symmetric relation facts,but the embedding problem of asymmetric relation facts has not be *** address the above issues,a Multiplex Uncertain Knowledge Graph Embedding(MUKGE)model is proposed in this ***,to combine multiple information and achieve more accurate results in confidence reasoning,the Uncertain ResourceRank(URR)reasoning algorithm is ***,the asymmetry in the UKG is *** embed asymmetric relation facts of UKG,a multi-relation embedding model is ***,experiments are carried out on different datasets via 4 tasks to verify the effectiveness of *** results of experiments demonstrate that MUKGE can obtain better overall performance than the baselines,and it helps advance the research on UKG embedding.

关键词： knowledge representation uncertain knowledge graph multi-relation embedding uncertain reasoning

Degradation of warm permafrost and talik formation on the qinghai-Tibet Plateau in 2006-2021

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Advances in Climate Change Research 2024年第2期15卷 275-284页

作者： qi-Hang MEI Ji CHEN You-qian LIU Shou-Hong ZHANG jing-Yi zhao Tian-Chun DONG Jun-Cheng WANG Yao-Jun zhao Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environmental and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway qinghai-Tibet Group Co.Ltd Xining 810007China University of Chinese Academy of Sciences Beijing 100049China

Permafrost is degrading globally,particularly those with low thermal stability on the qinghai-Tibet Plateau,owing to climate ***,the inadequacy of direct research on permafrost degradation based on in-situ monitoring limits the prediction of permafrost degradation and engineering *** study explored the processes and modes of permafrost degradation into talik by analyzing ground temperature data from five points in the hinterland of the qinghai-Tibet Plateau from 2006 to *** results showed that the degradation of the warm permafrost layer with a geothermal gradient of zero occurred simultaneously in the top and bottom *** rate of permafrost degradation from the top down and bottom up increase during the degradation process,but the increase of the former is more drastic after the formation of thawed ***,the construction of the qinghai-Tibet Railway changed the degradation modes of the permafrost in adjacent natural sites through horizontal heat transfer,particularly after through talik formation under the *** findings suggest that taking countermeasures before or immediately after forming thawed interlayer is more *** evaluating the thermal impact of projects in warm permafrost regions,special attention should be given to the horizontal heat transfer process that may result from the formation of a through talik.

关键词： Warm permafrost Degradation Talik qinghai-Tibet Plateau Climate change