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Clinical Characteristics, Radiological Features and Gene Mutation in 10 Chinese Families with Spinocerebellar Ataxias

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Chinese Medical Journal 2015年第13期128卷 1714-1723页

作者： Jian-Wen Chen Li Zhao Feng Zhang Lan Li Yu-Hang Gu jing-yuan zhou Hui Zhang Ming Meng Kai-Hua Zhang Wei-Dong Le Chun-Bo Dong Department of Neurology The First Affiliated Hospital of Dalian Medical University Dalian 116011 China Department of Neurology The Second Affiliated Hospital of Dalian Medical University Dalian 116023 China Center for Translational Research of Neurology Diseases 1st Affiliated Hospital of Dalian Medical University Dalian 116021 China

Background： Spinocerebellar ata^ias （SCAs） are a group ofneurodegenerative disorders that primarily cause the degeneration in the cerebellum, spinal cord, and brainstem. We study the clinical characteristics, radiological features and gene mutation in Chinese families with SCAs. Methods： In this study, we investigated 10 SCAs Chinese families with SCAI, SCA3/Machado-Joseph disease （MJD}, SCA7, SCAB. There were 27 people who were genetically diagnosed as SCA, of which 21 people showed clinical symptoms, and 6 people had no clinical phenotype that we called them presymptomatic patients. In addition, 3 people with cerebellar ataxia and cataracts were diagnosed according to the Harding diagnostic criteria but tailed to be recognized as SCAs on genetic testing. Clinical characteristic analyses of each type of SCAs and radiological examinations were perlbrmed. Results： We found that SCA3/MJD was the most common subtype in Hart population in China, and the ratio of the pontine tegmentum and the posterior fossa area was negatively con＇elated with the number of cytosine-adenine-guanine （CAG） repeats： the disease duration was positively correlated with the International Cooperative Ataxia Rating Scale score; and the CAG repeats number of abnormal alleles was negatively correlated with the age of onset. Conchlsions： Collectively our study is a systematic research on SCAs in China, which may help for the clinical diagnosis and prenatal screening of this disease, and it may also aid toward better understanding of this disease.

关键词： Genetic Testing Radiological Features: Spinocerebellar Ataxias Trinucleotide Repeat Expansion

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考虑加速蠕变的岩石蠕变过程损伤模拟方法

湖南大学学报（自然科学版） 2013年第2期40卷 15-20页

作者：曹文贵袁靖周王江营翟友成湖南大学土木工程学院湖南长沙410082

针对岩石蠕变的阶段性特征,在深入研究岩石蠕变力学机理基础上,将岩石蠕变过程视为线性与非线性蠕变过程的迭加,通过引入损伤理论和Kachanov损伤演化规律,构建出可反映岩石非线性蠕变过程即加速蠕变过程特征的弹塑性损伤体元件模型,将... 详细信息

针对岩石蠕变的阶段性特征,在深入研究岩石蠕变力学机理基础上,将岩石蠕变过程视为线性与非线性蠕变过程的迭加,通过引入损伤理论和Kachanov损伤演化规律,构建出可反映岩石非线性蠕变过程即加速蠕变过程特征的弹塑性损伤体元件模型,将其与可较好地反映岩石线性蠕变过程即减速蠕变过程特征的Kelvin元件模型进行串联复合,建立出可反映岩石蠕变全过程尤其是加速蠕变特点的岩石蠕变模型,并提出了简单可行的模型参数确定方法,从而建立出岩石蠕变全过程的新型模拟方法;该模型或方法不仅能较好地模拟岩石从减速到加速的蠕变全过程,而且,模型参数少,易于确定.最后,通过理论与实测曲线的对比分析,表明了该模型的合理性与可行性.

关键词：岩石力学加速蠕变减速蠕变损伤弹塑性损伤体 Kelvin体蠕变模型

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珠江口水域航标灯塔桩设计与施工刍议

中国海事 2021年第3期 62-67页

作者：袁靖周南海航海保障中心广州航标处广东广州510320

文中根据交通运输部南海航海保障中心广州航标处(以下简称“广州航标处”)辖区航标灯塔桩建设情况,结合笔者建设管理经验,对常用的几类航标灯塔桩材质特性及结构设计进行了总结分析,并提出了基础设计及施工管理方面的一些建议。

关键词：航标灯塔桩设计施工

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一种新的岩石长期强度确定方法

筑路机械与施工机械化 2018年第3期35卷 74-78页

作者：袁靖周交通运输部南海航海保障中心广州航标处广东广州510320

从岩石蠕变过程中的变形特点出发,引入流变损伤概念,对岩石蠕变过程中变形、损伤及长期强度之间的关系进行了分析;在经典岩石流变H-K模型的基础上,得到了岩石长期强度与损伤变形阈值及屈服应力的理论计算公式。定性分析及实例验证结果证... 详细信息

从岩石蠕变过程中的变形特点出发,引入流变损伤概念,对岩石蠕变过程中变形、损伤及长期强度之间的关系进行了分析;在经典岩石流变H-K模型的基础上,得到了岩石长期强度与损伤变形阈值及屈服应力的理论计算公式。定性分析及实例验证结果证明,该理论计算公式可反映岩石长期强度随岩性变化的规律,且参数少、求解过程简便,具有较好的工程应用参考价值。

关键词：流变损伤流变模型岩石长期强度屈服应力

浅谈综采工作面复杂条件下变频技术的研究与应用

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价值工程 2016年第16期35卷 141-142页

作者：袁京洲平顶山天安煤业股份有限公司八矿平顶山467000

本文基于八矿综采工作面生产情况,通过引进变频技术来提高综采工作面设备控制效率和安全性能,取得了不错的成效。本文将就这种变频控制技术进行重点解析。

关键词：综采工作面变频技术设备控制节能安全高效

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基于离散型荧火虫算法的高校智能排课的研究

数学的实践与认识 2016年第19期46卷 23-30页

作者：沈桂芳李敬明周园园安徽新华学院信息工程学院安徽合肥230088 合肥工业大学管理学院安徽合肥230009

针对传统排课方法排课效率低、成功率低、冲突率高等无法满足现代高校教务管理要求的现状,提出一种基于离散型荧火虫算法的智能排课模型.首先,根据教师、班级、课程、教室及授课时间要求建立一个多目标、多约束的排课数学模型,采用二分... 详细信息

针对传统排课方法排课效率低、成功率低、冲突率高等无法满足现代高校教务管理要求的现状,提出一种基于离散型荧火虫算法的智能排课模型.首先,根据教师、班级、课程、教室及授课时间要求建立一个多目标、多约束的排课数学模型,采用二分图完美匹配操作初始可行排课方案;然后,利用离散型荧火虫优化算法在可行方案中寻找最优排课方案;最后,通过Matlab仿真实验验证其可行性与有效性.

关键词：智能排课离散型荧火虫算法二部图完美匹配

基于CMAQ-ISAM模型对石家庄市臭氧污染过程模拟分析

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环境科学 2024年第9期45卷 5106-5116页

作者：耿雅娴郭婧涵葛宇轩王树桥袁京周张丁超王欣河北科技大学环境科学与工程学院石家庄050018 挥发性有机物与恶臭污染防治技术国家地方联合工程研究中心石家庄050018

石家庄市历年6月皆为臭氧(O_(3))污染高发阶段,2023年6月O_(3)8h浓度平均值(O_(3)-8h)污染超标天数占该月天数的80%,O_(3)为首要污染物占比达100%.针对6月11~18日的一次O_(3)重污染过程,利用空气质量模型WRF-CMAQ模拟,平均误差数据MFB为... 详细信息

石家庄市历年6月皆为臭氧(O_(3))污染高发阶段,2023年6月O_(3)8h浓度平均值(O_(3)-8h)污染超标天数占该月天数的80%,O_(3)为首要污染物占比达100%.针对6月11~18日的一次O_(3)重污染过程,利用空气质量模型WRF-CMAQ模拟,平均误差数据MFB为−10.47%和MFE为17.96%,处于理想误差水平范围内.利用CMAQ过程分析模块进行石家庄市物理和化学过程模拟,得到干沉降(DDEP)浓度贡献为−23.88μg·m^(−3),是消耗O_(3)的主要过程,而输送过程(TRAN)是O_(3)的主要来源,其中贡献较大为垂直输送(VTRA).同时利用CMAQ中源解析模块(ISAM)对石家庄市本地与周边区域的O_(3)贡献进行了详细分析.结果表明,石家庄市本地行业贡献源的贡献率大小为:交通源(12.54%)>工业源(6.94%)>居民源(6.56%)>电力源(4.75%).而远距离传输源(BCON)持续处于高贡献首位,贡献率为63.31%.平稳天气下的重污染时段,嵌套域D02层中BCON低于标记区域对石家庄市的浓度贡献总和,周边城市中,保定市在平稳天气下贡献率最高,为26.21%.后期邢台市在高值西南风作用下,浓度贡献也迅速升高.要切实减轻O_(3)污染,不仅要对本市减排,还需要对上风向城市进行提前控制,实行区域间联防联控才是关键.

关键词：臭氧(O3) CMAQ-ISAM模型过程分析源解析石家庄市

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin yuan Weicheng Kong Pengcheng Xia yuanrong Li Yuewei Chen Nian Liu jing He Jue Shi Zihe Hu Yanyan zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods