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[Recent progress in mass spectrometry imaging using nanospray desorption electrospray ionization]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 43-49页

作者： jing-Bo Wang xiao-Lan Li Rui-Xia Fan Ping Lü Rui-Chuan Yin West China School of Pharmacy Sichuan University Chengdu 610041 China.

Ambient mass spectrometry imaging (MSI) enables hundreds of analytes in tissue sections to be directly mapped at atmospheric pressure with minimal sample preparation. This field is currently experiencing rapid growth, with numerous reported ambient ionization techniques resulting in a "hundred flowers bloom" situation. Nanospray desorption electrospray ionization (nano-DESI), developed by the Laskin group in 2010, is a widely used liquid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012. The nano-DESI probe comprises a primary capillary and a nanospray capillary, with the latter efficiently transferring analyte-containing droplets via a tiny liquid bridge formed between the probe and sample surface, thereby enabling nanoelectrospray ionization (nano-ESI) in front of the inlet of a mass spectrometer. The advantages of nano-DESI MSI include minimal sample preparation, high spatial resolution, and high sensitivity. These features are well-suited for imaging various sample types, including frozen tissue sections, microbial communities, and environmental samples. A PubMed-database search using the "nano-DESI" keyword revealed 72 related articles in the 2010-2024 period, with 34 of them published between 2021 and 2024, which indicates that nano-DESI has rapidly developed as an ambient ionization technique over recent years. Herein, we briefly introduce key nano-DESI-MSI research progress reported in the past three years with the aim of better understanding and facilitating the use of this technology. We first discuss advances in ion-source development. Since no commercial nano-DESI source exists, designing and constructing ion sources remain technical challenges that limit its development. Nano-DESI has been successfully coupled with various types of mass spectrometer, including LTQ Orbitrap, quadrupole-Orbitrap (Q Exactive), 6560 IM QTOF, timsTOF Pro2, triple quadrupole, and FTICR. These couplings have signi

关键词： ambient mass spectrometry imaging nanospray desorption electrospray ionization spatial proteomics structural characterization of lipid

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu yu Li-yun Zhou xiao Huang Xin-yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

A Comparative Study on Emulsion Polymerization Processes of Styrene Initiated by Water-soluble and Oil-soluble Initiators

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Chinese Journal of Polymer Science 2019年第2期37卷 142-148页

作者： xiao-jing Liu yu-He Tian Yang-Cheng Lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University

The solubility of initiator determines its distribution and the roles played in emulsion polymerization as well as the final products, but this is still lack of systematic investigation. The present work focuses on this issue by comparing the kinetic behaviors and product properties of styrene emulsion polymerization initiated by 2,2-azoisobutyronitrile(AIBN) and potassium persulphate(KPS).Compared to KPS-initiated emulsion polymerization, the AIBN-initiated polymerization was found to be insensitive to the type of emulsifier, and have high polymerization rate as well as narrow molecular weight distribution and particle size distribution. This result indicates the effective free radicals are generated in micelles or colloids, which could decrease the proportion of homogeneous nucleation and make the process and product more controllable. As a consequence, there is a linear relationship between molecular weight of product and AIBN concentration in lg-lg coordinate. It provided a reference for the preparation of latexes with specified molecular weight and supported the possibility of the coexistence of multiple free radicals in one micelle or colloid when using oil-soluble initiator.

关键词： Emulsion polymerization Oil-soluble initiator Water-soluble initiator Styrene Reaction mechanism

An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

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Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-Da Zhu yu-Zhe Han xiao-Bi jing School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using H_(2)O_(2)as the green *** was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb,Cu,Pd,Ag and *** of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material,which might facilitate its absorption to *** work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis,*** Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions,*** discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Surfaces Porous materials Rare metal concentration Adsorption Catalysis

单孔与双孔胸腔镜手术切除后纵隔肿瘤的对比研究

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中国血液流变学杂志 2017年第3期27卷 298-300页

作者：唐兴张晨何靖康于晓军苏州大学附属第一医院胸外科江苏苏州215006

目的对比单孔与双孔胸腔镜手术切除后纵隔肿瘤的疗效.方法 2011年3月—2017年2月,苏州大学附属第一医院共收治后纵隔肿瘤54例,按手术方法不同分为两组,A组为单孔胸腔镜手术组,共11例患者;B组为双孔胸腔镜手术组,共43例患者,分析比较两... 详细信息

目的对比单孔与双孔胸腔镜手术切除后纵隔肿瘤的疗效.方法 2011年3月—2017年2月,苏州大学附属第一医院共收治后纵隔肿瘤54例,按手术方法不同分为两组,A组为单孔胸腔镜手术组,共11例患者;B组为双孔胸腔镜手术组,共43例患者,分析比较两组的手术时间、术中出血量、术后拔胸管时间、术后住院时间和手术后并发症.结果 A组患者平均手术时间较B组短[（59.7±16.3）min vs（91.6±58.4）min];出血量少[（20.2±10.9）mL vs（82.6±40.3）mL],两组间差异有统计学意义（P〈0.05）;A组患者平均胸腔引流时间、手术后住院时间较B组短,分别为[（2.5±1.8）d vs（3.0±1.1）d,（3.6±2.7）d vs（5.5±2.3）d],两组间并发症发生率等数据差异无统计学意义（P〉0.05）.结论单孔与双孔胸腔镜手术切除后纵隔肿瘤疗效相当.

关键词：外科手术胸腔镜纵隔肿瘤

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao xiao Yi-Fan Wang Tian-yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Experimental study on the effects of sediment size and porosity on contaminant adsorption/desorption and interfacial diffusion characteristics

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Journal of Hydrodynamics 2013年第1期25卷 20-26页

作者： FAN jing-yu HE xiao-yan WANG Dao-zeng Shanghai Institute of Applied Mathematics and Mechanics Shanghai University

The joint effects of the sediment size and porosity on the contaminant adsorption/desorption and interfacial diffusion characteristics were experimentally investigated. The adsorption of Phosphorus （P） on the natural and artificial sediment suspensions was measured with respect to the P adsorption isotherms and kinetics in the experiment. The obtained adsorption isotherms for different grain-sized sediment suspensions fit well with the Langmuir equation, dependent on the initial aqueous concentration and sediment content. The P kinetic adsorption behaviors for cohesive fine-grained and non-cohesive coarse-grained sediment suspensions clearly show the size-dependent feature. On the other hand, the P kinetic release feature of a porous sediment layer is affected by not only the direct desorption of the uppermost sediments, but also the diffusivity in the pore-water within the underlying sediment layer, characterized by the sediment size and porosity, respectively. Furthermore, the temporal contaminant release from the permeable sediment layer into the overlying water column increases with the increasing flow velocity, while this enhancement in mediating the interfacial diffusion flux is somewhat insignificant in an immediate release stage, largely due to the resistance of the diffusive boundary layer on the hydrodynamic disturbance.

关键词： sediment contaminant adsorption desorption interfacial diffusion

Pricing VIX options with stochastic skew and asymmetric jumps

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Applied Mathematics(A Journal of Chinese Universities) 2020年第1期35卷 33-56页

作者： jing Bo LI Sheng-hong TAN xiao-yu Department of Mathematics Zhejiang UniversityHangzhou 310027China

This paper performs several empirical exercises to provide evidence that the stochas-tic skew behavior and asymmetric jumps exist in VIX *** order to adequately capture all of the features,we develop a general valuation model and obtain quasi-analytical solutions for pricing VIX *** addition,we make comparative studies of alternative models to illustrate the e ects after taking into account these features on the valuation of VIX options and investigate the relative value of an additional volatility factor and jump *** empirical results indicate that the multi-factor volatility structure is vital to VIX option pricing due to providing more exibility in the modeling of VIX dynamics,and the need for asymmetric jumps cannot be eliminated by an additional volatility factor.

关键词： VIX options stochastic skew multi-factor volatility jumps