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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu zhao Juan-Han yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

负载TiO_2改性粉煤灰处理垃圾渗滤液实验研究

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东北师大学报（自然科学版） 2017年第1期49卷 148-153页

作者：王占华周兵孙雪景赵玉鑫王鑫壹吉林建筑大学市政与环境工程学院吉林长春130118 吉林建筑大学松辽流域水环境教育部重点实验室吉林长春130118 吉林省中实环保工程开发有限公司吉林长春130118

采用凝胶法制备负载TiO_2改性粉煤灰,将其作为光催化剂投加到实验室卫生填埋场模型产生的垃圾渗滤液中,在紫外光源照射下,分析探讨了负载条件、渗滤液体系pH、光照时间、负载TiO_2改性粉煤灰投加量对渗滤液中污染物去除效率的影响.结果... 详细信息

采用凝胶法制备负载TiO_2改性粉煤灰,将其作为光催化剂投加到实验室卫生填埋场模型产生的垃圾渗滤液中,在紫外光源照射下,分析探讨了负载条件、渗滤液体系pH、光照时间、负载TiO_2改性粉煤灰投加量对渗滤液中污染物去除效率的影响.结果表明:在温度范围20℃~30℃、光照120min、pH=2、500℃焙烧的负载TiO_2的2mol/L盐酸改性粉煤灰光催化剂的投加量为30g/L时,渗滤液体系中污染物的去除率较高.

关键词：负载 TiO2 改性粉煤灰垃圾渗滤液

HPLC法测定通舒口爽胶囊中3种成分的含量

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沈阳药科大学学报 2010年第3期27卷 231-235页

作者：崔玉芹张洪霞李晶门金玉赵怀清沈阳药科大学药学院辽宁沈阳110016

目的建立测定通舒口爽胶囊中柚皮苷，橙皮苷和新橙皮苷含量的HPLC方法。方法采用Diamonsil C18（200mm×4．6mm，5μm）色谱柱，流动相：甲醇-乙腈-体积分数为0．05％的磷酸水溶液（体积比为20：10：65），流速：1．0mL·min^-1，柱温... 详细信息

目的建立测定通舒口爽胶囊中柚皮苷，橙皮苷和新橙皮苷含量的HPLC方法。方法采用Diamonsil C18（200mm×4．6mm，5μm）色谱柱，流动相：甲醇-乙腈-体积分数为0．05％的磷酸水溶液（体积比为20：10：65），流速：1．0mL·min^-1，柱温：30℃，检测波长：280nm。结果柚皮苷在8．88～88．8mg·L^-1内呈线性关系（r=0．9997），平均回收率为100．5％；橙皮苷在7．60—76．0mg·L^-1内呈线性关系（r=0．9996），平均回收率为100．5％；新橙皮苷在10．56-105．6mg·L^-1内呈线性关系（r=0．9999），平均回收率为100．5％。结论本实验建立的方法可作为通舒口爽胶囊质量控制方法之一。

关键词：通舒口爽胶囊柚皮苷橙皮苷新橙皮苷高效液相色谱法

Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： yuxun Lu Weisi Wang Le yu yuqiang zhao Ying Chen yunhai Guo Bingrong Luo yuhua Liu Shizhu Li Liping Duan Ying Zhou yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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高效液相色谱法测定多烯磷脂酰胆碱软胶囊中磷脂酰胆碱和溶血磷脂酰胆碱的含量

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中南药学 2017年第9期15卷 1304-1306页

作者：姚泽李云晶马越韩静赵宇明沈阳药科大学制药工程学院辽宁本溪117000

目的建立HPLC法测定多烯磷脂酰胆碱软胶囊中磷脂酰胆碱和溶血磷脂酰胆碱的含量以及有关物质方法。方法采用蒸发光散射检测器SEDEX55,MERCK的Li Chrospher 100 Diol-5色谱柱(125mm×4.0 mm,5μm);流动相A为正己烷-异丙醇-冰醋酸-三乙胺(... 详细信息

目的建立HPLC法测定多烯磷脂酰胆碱软胶囊中磷脂酰胆碱和溶血磷脂酰胆碱的含量以及有关物质方法。方法采用蒸发光散射检测器SEDEX55,MERCK的Li Chrospher 100 Diol-5色谱柱(125mm×4.0 mm,5μm);流动相A为正己烷-异丙醇-冰醋酸-三乙胺(814∶170∶15∶0.8),流动相B为异丙醇-超纯水-冰醋酸-三乙胺(844∶140∶15∶0.8),梯度洗脱。结果磷脂酰胆碱在0.912~2.736mg·mL^(-1),溶血磷脂酰胆碱在0.072~0.216 mg·mL^(-1)内与峰面积线性关系良好(R^2均为0.999)。磷脂酰胆碱的平均回收率为101.2%,RSD为1.3%;溶血磷脂酰胆碱的平均回收率为100.5%,RSD为1.9%。溶血磷脂酰胆碱的检测限为0.57μg。结论本检测方法专属性强,结果可靠,专属性强,重复性良好,可用于多烯磷脂酰胆碱软胶囊的质量评价。

关键词：多烯磷脂酰胆碱软胶囊磷脂酰胆碱溶血磷脂酰胆碱高效液相色谱法含量测定

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On P-sober Spaces

Acta Mathematica Sinica,English Series 2023年第9期39卷 1768-1780页

作者： yu jing Zhang Bin zhao School of Mathematics and Statistics Shaanxi Normal UniversityXi’an710119P.R.China

In this paper,we focus on p-sober spaces and prove that(1)the To space X is p-sober if and only if the Smyth power space of X is p-sober;(2)the space X has a p-sober dcpo model if and only if X is T_(1)and p-sober;(3)every non-p-sober T_(0)space does not have a p-sobrification;(4)the T_(0)space X is sober if and only if X is p-sober and PD.

关键词： P-sober dcpo poset model of topological space p-sobrification

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干细胞抗卵巢颗粒细胞衰老的作用机制及进展

中国组织工程研究 2025年第25期29卷 5414-5421页

作者：林美玉赵玺龙高景赵晶阮光萍解放军联勤保障部队第九二〇医院基础医学实验室云南省昆明市650032 干细胞与免疫细胞生物医药技术国家地方联合工程研究中心云南省昆明市650032 云南省细胞治疗技术转化医学重点实验室云南省昆明市650032

背景:干细胞疗法作为一种新兴的治疗手段,有望改善卵巢环境,延缓卵巢颗粒细胞的衰老,为高龄妊娠女性带来新的希望。目的:综述干细胞抗卵巢颗粒细胞衰老的机制及研究进展。方法:检索中国知网和PubMed数据库中关于干细胞抗卵巢颗粒细胞衰... 详细信息

背景:干细胞疗法作为一种新兴的治疗手段,有望改善卵巢环境,延缓卵巢颗粒细胞的衰老,为高龄妊娠女性带来新的希望。目的:综述干细胞抗卵巢颗粒细胞衰老的机制及研究进展。方法:检索中国知网和PubMed数据库中关于干细胞抗卵巢颗粒细胞衰老的文献,以“干细胞,卵巢颗粒细胞,衰老”为中文检索词,以“stem cells,ovary granulosa cells,aging”为英文检索词,最终纳入67篇文献进行分析。结果与结论:①总结了5种卵巢颗粒细胞衰老的机制:DNA损伤和修复能力下降、氧化应激、线粒体功能受损、炎症反应、激素水平变化;②整理了当前干细胞治疗卵巢颗粒细胞衰老的5种机制:促进增殖和抑制凋亡、分化潜能及再生能力、分泌因子、抗氧化、抗炎症反应和免疫调节;③目前有多种类型的干细胞可通过多种方式协同治疗卵巢颗粒细胞衰老,干细胞疗法在恢复女性生育能力方面具有广阔前景。

关键词：干细胞卵巢颗粒细胞衰老机制氧化应激抑制凋亡细胞因子抗氧化抗炎症反应

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning yu Hua-Tao Wu jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年

作者： Yang LI yuzhe GU Sheng QIAN yuncong PANG Aoxi yu Shuwen ZHENG Wenjie XIA yuan LIAO Baoguang LIU Shujuan LIU Qiang zhao College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance. In contrast, ionically conductive electrodes offer potential advantages such as transparency, stability, and low impedance, making them a promising alternative to existing electrically conductive electrodes [3]. Acrylic acid (AA)and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) are commonly used in the synthesis of ionic gels, as they ionize in water to produce a large number of ions, helping to maintain moisture balance and reduce impedance caused by dehydration [4]. However, the presence of freely moving ions in the gel network can interfere with conductivity, highlighting the need to introduce new conductive networks to enhance performance [5].

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