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Protocol for evaluating the effects of Danggui Shaoyao Powder in the treatment of DPN with qi deficiency and blood stasis pattern based on routine therapy:a randomized controlled trial

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Clinical Research Communications 2022年第2期5卷 9-14页

作者： Shi-Guang Qiu Kai Li Hong Gao Wen-Bin He Chang Liu Xian Wang Yi-Wei Gui jing-yu zhao Gao-An Wang Yi-Qiang Xie Second affiliated Hospital of Hainan Medical University Haikou 570311China College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610081China Affiliated Hospital of Shanxi University of Traditional Chinese Medicine Taiyuan 030024China

Background:Diabetic peripheral neuropathy(DPN)has high *** present,the treatment for DPN mainly focuses on controlling of blood sugar,nourishment of nerves and symptomatic treatment of pain which face some limitations,such as poor effects and adverse reactions of drugs and so *** Chinese Medicine(TCM)has certain curative effect in the prevention and treatment of *** Shaoyao powder,one of the famous classic prescriptions in TCM,has been often used clinically in the treatment of DPN in China,which without any relevant evidence-based medical research *** protocol was designed to evaluate the effects of Danggui Shaoyao Powder in the treatment of DPN with qi deficiency and blood stasis pattern based on routine ***:This protocol is designed as a three-arms parallel-group,outcome-assessor blinded RCT.303 Patients with DPN,from outpatient and inpatient departments of four clinical centers in China,will be randomly allocated into 3 groups(routine group,treatment group and control group).The course of treatment was designed as 1 month and followed up for 3 *** TCSS scale,TCM syndrome scale,nerve conduction function,serum indexes will be tested to provide more clinical evidences for the effect of Danggui Shaoyao Powder on prevention and treatment of ***,we will make statistics and analyse the data to draw a ***:Danggui Shaoyao Powder is the ideal drug which is an agent acting on multiple targets related to DPN’s *** hope to find more clinical evidences for the effect of Danggui Shaoyao Powder on prevention and treatment of DPN through this RCT experiment.

关键词： protocol Danggui Shaoyao Powder diabetic peripheral neuropathy RCT

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing Xue yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

水孔蛋白-5在机械通气致急性肺损伤大鼠肺组织中的表达研究

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中国现代医学杂志 2021年第3期31卷 1-5页

作者：陈美羽赵毓静张新日山西医科大学第一医院呼吸与危重症学科山西太原030001

目的探讨水孔蛋白-5(AQP-5)在不同机械通气时间致大鼠急性肺损伤(ALI)肺组织中的表达。方法将30只SD大鼠,按照机械通气时间不同,完全随机分为对照组、0.5 h组、1.0 h组、1.5 h组和2.0 h组,每组6只。通过肺组织大体标本图、肺系数、HE染... 详细信息

目的探讨水孔蛋白-5(AQP-5)在不同机械通气时间致大鼠急性肺损伤(ALI)肺组织中的表达。方法将30只SD大鼠,按照机械通气时间不同,完全随机分为对照组、0.5 h组、1.0 h组、1.5 h组和2.0 h组,每组6只。通过肺组织大体标本图、肺系数、HE染色,观察肺组织水肿及损伤程度;采用病理切片染色评分法评估各组肺组织中AQP-5表达量。结果 5组肺系数、AQP-5染色强度评分和AQP-5阳性细胞占比评分比较,经方差分析,差异有统计学意义(P <0.05)。肺系数与AQP-5染色强度评分呈负相关(rs=-0.925,P <0.05);肺系数与AQP-5染色阳性细胞占比评分之间呈负相关(rs=-0.951,P <0.05)。结论随着机械通气时间延长,肺水肿程度逐渐加重,肺组织中AQP-5表达量逐渐减少,表明AQP-5参与机械通气致肺水肿的发生、发展。

关键词：急性肺损伤肺水肿水孔蛋白-5 机械通气

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浅析高校贫困生抑郁症的成因及对策

现代预防医学 2007年第21期34卷 4135-4136页

作者：喻静昭胡昌标林梅怀化医学高等专科学校怀化学院

[目的]调查分析某高校贫困生抑郁症的现患状况及其影响因素,并探讨相应的教育对策。[方法]用抑郁自评量表(SDS)调查某高校442名贫困生,并访谈其中部分对象;资料的分析用SPSS11统计软件包。[结果]贫困生的SDS标准评分为59.49±6.234,高... 详细信息

[目的]调查分析某高校贫困生抑郁症的现患状况及其影响因素,并探讨相应的教育对策。[方法]用抑郁自评量表(SDS)调查某高校442名贫困生,并访谈其中部分对象;资料的分析用SPSS11统计软件包。[结果]贫困生的SDS标准评分为59.49±6.234,高于非贫困生的55.42±5.838,差异有统计学意义(P﹤0.01);贫困生和非贫困生抑郁症患病率分别为34.8%和9.0%,差异也有统计学意义(P﹤0.01)。专业对SDS标准评分和抑郁症患病率也有一定影响。但父母职业、家庭居住环境却没有影响。[结论]贫困生抑郁症明显高于非贫困生,高校应加大对贫困生的心理健康教育工作。

关键词：高校贫困生抑郁症对策

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黄土高原一次超级单体短时强降水中尺度分析

气象科学 2016年第6期36卷 742-751页

作者：王楠李萍云井宇赵强陕西省气象台西安710015

2012年盛夏陕西绥德县出现短时强降水,4 h雨量超过100 mm。利用NCEP 1°×1°再分析资料进行诊断分析发现,在陕北东北部对流层中下层有一中α尺度气旋存在,且随高度向东北倾斜,垂直方向上形成次级环流,使强降水区的上升运动加剧。分析... 详细信息

2012年盛夏陕西绥德县出现短时强降水,4 h雨量超过100 mm。利用NCEP 1°×1°再分析资料进行诊断分析发现,在陕北东北部对流层中下层有一中α尺度气旋存在,且随高度向东北倾斜,垂直方向上形成次级环流,使强降水区的上升运动加剧。分析地面观测、卫星资料发现,西路冷空气引导干侵入加强层结不稳定性,东路冷空气楔形抬升作用,使得不稳定能量释放;同时,在东西两路干冷空气的夹击作用下,绥德县内形成中气旋,暖湿空气在当地得以聚集上升;2个中β尺度对流云团在东西路风场作用下合并后迅速增强。多普勒雷达资料显示,2个中γ尺度的超级单体回波在绥德先后发展形成列车效应;2个超级单体中的中气旋特征各有不同,是回波结构演变的主要原因。

关键词：强降水超级单体中气旋干侵入次级环流

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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一种基于RSL的协议形式化描述技术的研究

计算机科学 2003年第1期30卷 97-98页

作者：赵静屈玉贵赵保华中国科学技术大学计算机系合肥230027

This paper presents a formal technique of protocols based on RSL,which can efficiently connect the formaldescription ,validation,implementation and testing of protocols. It mainly discusses the formal description of protocolsbased on RSL,and also provides an algorithm about this. Finally,taking the protocol AB as an example,a formal de-scription based on RSL is given.

关键词： RSL 形式化描述技术通信协议协议工程学计算机网络

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-Jun Zhang Wen-Wei Wang jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury