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Clinical significance of lymph node metastasis in gastric cancer

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World Journal of Gastroenterology 2014年第14期20卷 3967-3975页

作者： jing-yu deng Han Liang Gastric Oncology Division Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer CenterNational Clinical Center of Cancer

Gastric cancer,one of the most common malignancies in the world,frequently reveals lymph node,peritoneum,and liver *** of gastric cancer patients present with lymph node metastasis when they were initially diagnosed or underwent surgical resection,which results in poor *** the depth of tumor invasion and lymph node involvement are considered as the most important prognostic predictors of gastric *** extended lymphadenectomy was not considered a survival benefit procedure and was reported to be associated with high mortality and morbidity in two randomized controlled European trials,it showed significant superiority in terms of lower locoregional recurrence and disease related deaths compared to limited lymphadenectomy in a 15-year followup *** all clinical investigators have reached a consensus that the predictive efficiency of the number of metastatic lymph nodes is far better than the extent of lymph node metastasis for the prognosis of gastric cancer worldwide,but other nodal metastatic classifications of gastric cancer have been proposed as alternatives to the number of metastatic lymph nodes for improving the predictive efficiency for patient *** is still controversial over whether the ratio between metastatic and examined lymph nodes is superior to the number of metastatic lymph nodes in prognostic evaluation of gastric ***,the negative lymph node count has been increasingly recognized to be an important factor significantly associated with prognosis of gastric cancer.

关键词： Stomach Neoplasm Lymph node Metastasis Prognosis

Advances in para-aortic nodal dissection in gastric cancer surgery: A review of research progress over the last decade

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World Journal of Clinical Cases 2020年第13期8卷 2703-2716页

作者： Yin-Ping Dong jing-yu deng Department of Gastroenterology Tianjin Medical University Cancer HospitalCity Key Laboratory of Tianjin Cancer Center and National Clinical Research Center for CancerTianjin 300060China

Approximately 17%-40%of para-aortic lymph node(PAN)metastasis occurs in patients with advanced gastric *** the third tier of lymphatic drainage of the stomach and the final station in front of the systemic circulation,PAN infiltration is defined as distant metastasis and plays a key role in the evaluation of the prognosis of advanced gastric *** clinical factors including tumor size≥5 cm,pT3 or pT4 depth of tumor invasion,pN2 and pN3 stages,the macroscopic type of Borrmann Ⅲ/Ⅳ,and the diffuse/mixed Lauren classification are indicators of PAN *** PAN dissection(PAND)should be performed on patients with or without the macroscopic PAN invasion remains unascertained,regardless of the numerous retrospective comparative studies reported on the improved prognosis over D2 *** paradoxical result from many other studies showed no significant difference in the overall survival between these two lymphadenectomies.A phase Ⅱ trial launched by the Japan Clinical Oncology Group indicated that two or three courses of S-1 and cisplatin preoperatively followed by radical surgery with D2+PAND and postoperative S-1 is the current standard strategy for the treatment of patients with extensive lymph node metastasis,and this regimen could be substituted by a promising strategy with effective combination chemotherapy or suitable chemotherapy *** review focuses on the advances in radical gastrectomy plus PAND with or without chemotherapy for patients with advanced gastric cancer.

关键词： Para-aortic lymph node Lymphadenectomy Stomach Neoplasm

Role of E3 ubiquitin ligases in gastric cancer

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World Journal of Gastroenterology 2015年第3期21卷 786-793页

作者： Ya-Chao Hou jing-yu deng Department of Gastroenterology Cancer Hospital of Tianjin Medical UniversityCity Key Laboratory of Tianjin Cancer Centerand National Clinical Research Center of Cancer

E3 ubiquitin ligases have an important role in carcinogenesis and include a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S *** far,E3 ubiquitin ligases have been reported to have a role in a variety of biological processes including cell cycle regulation,cell proliferation,and ***,several kinds of E3 ubiquitin ligases were demonstrated to be generally highly expressed in gastric cancer(GC) tissues and to contribute to *** this review,we summarize thecurrent knowledge and information about the clinical significance of E3 ubiquitin ligases in ***,a proteasome inhibitor,encouraged the evaluation of other components of the ubiquitin proteasome system for pharmaceutical *** clinical value of novel treatment strategies targeting aberrant E3 ubiquitin ligases for GC are discussed in the review.

关键词： E3 ubiquitin ligases Gastric cancer Oncogene Tumor

Bronchogenic cyst of the stomach:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1525-1531页

作者： Wen-Ting He jing-yu deng Han Liang Jian-yu Xiao Fu-Liang Cao Department of Gastroenterology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinand Tianjin’s Clinical Research Center for CancerTianjin 300060China Department of Radiology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinand Tianjin’s Clinical Research Center for CancerTianjin 300060China Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinand Tianjin’s Clinical Research Center for CancerTianjin 300060China

BACKGROUND Gastric bronchogenic cysts(BCs)are extremely rare cystic masses caused by abnormal development of the respiratory system during the embryonic *** bronchial cysts are rare lesions first reported in 1956;as of 2019,only 37 cases are available in the MEDLINE/PubMed online *** usually have no clinical symptoms in the early stage,and their imaging findings also lack ***,they are difficult to diagnose before histopathological *** SUMMARY A 55-year-old woman presented at our hospital with intermittent epigastric *** had a slightly high level of serum carbohydrate antigen 72-4(CA 72-4).Endoscopic ultrasound found that a cystic mass originated from the submucosa of the posterior gastric wall near the cardia,indicating a diagnosis of cystic hygroma of the ***,a computed tomography scan demonstrated a quasi-circular cystic mass closely related to the lesser curvature of the gastric fundus with a low *** the imaging examinations did not suggest a malignancy and the patient required complete resection,she underwent laparoscopic *** an intraoperative finding,this cystic lesion was located in the posterior wall of the fundus and contained some yellow viscous ***,the pathologists verified that the cyst in the fundus was a gastric *** patient recovered well with normal CA 72-4 levels,and her course was uneventful at 10 *** This is a valuable report as it describes an extremely rare case of gastric ***,this is the first case of BC to present with elevated CA 72-4 levels.

关键词： Bronchogenic cyst Stomach Submucosal lesion Endoscopic ultrasoundguided fine needle aspiration Endosonography Case report

Effects of extended lymphadenectomy and postoperative chemotherapy on node-negative gastric cancer

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World Journal of Gastroenterology 2013年第33期19卷 5551-5556页

作者： Qiang Xue Xiao-Na Wang jing-yu deng Ru-Peng Zhang Han Liang Department of Gastric Cancer Surgery Tianjin Medical University Cancer Hospital and City Key Laboratory of Cancer Prevention and Therapy

AIM:To investigate the effects of extended lymphadenectomy and postoperative chemotherapy on gastric cancer without lymph node ***:Clinical data of 311 node-negative gastric cancer patients who underwent potentially curative gastrectomy with more than 15 lymph nodes resected,from January 2002 to December 2006,were analyzed *** with pT4 stage or distant metastasis were *** analyzed the relationship between the D2 lymphadenectomy and the 5-year survival rate among different subgroups stratified by clinical features,such as age,tumor size,tumor location and depth of *** the same time,the relationship between postoperative chemotherapy and the5-year survival rate among different subgroups were also ***:The overall 5-year survival rate of the entire cohort was 63.7%.The 5-year survival rate was poor in those patients who were:(1)more than 65 years old;(2)with tumor size larger than 4 cm;(3)with tumor located in the upper portion of the stomach;and(4)with pT3 *** survival rate was improved significantly by extended lymphadenectomy only in patients with pT3 tumor(P=0.019),but not in other ***,there was no significant difference in survival rate between patients with and without postoperative chemotherapy among all of the subgroups(P>0.05).CONCLUSION:For gastric cancer patients without lymph node metastasis,extended lymphadenectomy could improve the survival rate of those who have pT3-stage ***,there was no evidence of a survival benefit from postoperative chemotherapy alone.

关键词： Gastric cancer Lymph node negative metastasis Extended lymphadenectomy D2 lymphadenectomy Chemotherapy

Examined lymph node count for gastric cancer patients after curative surgery

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World Journal of Clinical Cases 2023年第9期11卷 1930-1938页

作者： Yi Zeng Lu-Chuan Chen Zai-Sheng Ye jing-yu deng Department of Gastrointestinal Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Gastric Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300202China

Lymph node(LN)metastasis is the most common form of metastasis in gastric cancer(GC).The status and stage of LN metastasis are important indicators that reflect the progress of *** number of LN metastases is still the most effective index to evaluate the prognosis of patients in all stages of LN *** LN(ELN)count refers to the number of LNs harvested from specimens by curative gastrectomy for pathological *** review summarizes the factors that influence ELN count,including individual and tumor factors,intraoperative dissection factors,postoperative sorting factors,and pathological examination *** ELN counts will lead to prognosis-related stage *** LN sorting and regional LN sorting are the two most important LN sorting *** most direct and effective way to harvest a large number of LNs is for surgeons to perform in vitro fine LN sorting.

关键词： Stomach Neoplasm Lymph node Metastasis Prognosis

Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer

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World Journal of Gastroenterology 2014年第30期20卷 10537-10544页

作者： Nan Jiang jing-yu deng Xue-Wei Ding Bin Ke Ning Liu Ru-Peng Zhang Han Liang Key Laboratory of Cancer Prevention and Therapy Department of Gastrointestinal OncologyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy

AIM: To investigate the impact of prognostic nutritional index (PNI) on the postoperative complications and long-term outcomes in gastric cancer patients undergoing total gastrectomy.

关键词： Prognostic nutritional index gastric cancer postoperative complications total gastrectomy prognosis

Adenocarcinoma of esophagogastric junction

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Chinese Journal of Cancer Research 2014年第4期26卷 362-363页

作者： jing-yu deng Han Liang Department of Gastroenterology Tianjin Medical University Cancer HospitalCity Key Laboratory of Tianjin Cancer Center and National Clinical Research Center for Cancer

To date,there has been a dramatic increase in the incidence of adenocarcinomas of the esophagogastric junction （AEG）*** classification of AEG,defined by Siewert and Stein,was approved at the second International Gastric Cancer Congress in Munich in April *** accordance with the anatomic cardia,EGJC can be divided into three subtypes：type Ⅰ,adenocarcinoma of the distal esophagus with the center located within 1 cm above and 5 cm above the anatomic esophagogastric junction （EGJ）;type Ⅱ,true carcinoma of the cardia with the tumor center within 1 cm above and 2 cm below the EGJ;type Ⅲ,subcardial carcinoma with the tumor center between 2 and 5 cm below EGJ,which infiltrates the EGJ and distal esophagus from below （1）.

关键词： Adenocarcinoma of esophagogastric junction AEG

Effect of complication grade on survival following curative gastrectomy for carcinoma

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World Journal of Gastroenterology 2014年第25期20卷 8244-8252页

作者： Nan Jiang jing-yu deng Xue-Wei Ding Li Zhang Hong-Gen Liu yue-Xiang Liang Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy

AIM: To elucidate the potential impact of the grade of complications on long-term survival of gastric cancer patients after curative surgery.

关键词： Gastric cancer Complication grade Gastrectomy Overall survival Prognosis