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Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis

International Journal of Ophthalmology(English edition) 2024年第1期17卷 66-72页

作者： Yan-Qiao Huang Qian-Zhong Cao yi-Yao Wang yi-jing zhou Dan-ying Zheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of preschool children with congenital ectopia lentis(CEL).METHODS:A prospective self-controlled study was conducted in Zhongshan Ophthalmic Center.Children aged from 5 to 7y whom were diagnosed with CEL and underwent phacoemulsification with scleral-fixated posterior chamber intraocular lens implantation and their parents were enrolled in this study.All of them completed the child and proxy(parental)PedsQL™4.0 before and after the surgery.Their preoperative scores were compared to their postoperative ones.Subgroup analyses were performed based on gender and preoperative bilateral presenting visual acuity of the children.RESULTS:Thirty-two children with CEL successfully underwent surgery without any complications,among whom 8 had monocular surgery and 24 had binocular surgery.Preoperative and postoperative questionnaires were completed by 32 child-parent pairs.Surgical intervention could significantly improve the vision of affected children(P<0.001).The medians of physical,psychosocial and total health scores self-reported by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)preoperatively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)postoperatively.The preoperative scores of the affected children were significantly lower in all scales than age-matched healthy children(P<0.001).All the postoperative scores were significantly higher than the preoperative scores in affected children and their parents(P<0.001).In the physical functioning evaluation,the preoperative score reported by parents of girls was higher than parents of boys(P=0.041),and the postoperative score of girls was higher than that of boys(P=0.036).CONCLUSION:CEL is associated with significantly worse quality of life in preschool children.Surgical intervention can significantly improve the HRQoL in affected children from both personal and family perspective.

关键词： congenital ectopia lentis surgical intervention health-related quality of life preschool children

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Complementary monogamy and polygamy properties among multipartite systems

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Chinese Physics B 2024年第3期33卷 207-213页

作者：李陶周静怡孙琪靳志祥梁登峰罗婷 School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China School of Computer Science and Techonology Dongguan University of TechnologyDongguan 523808China People's Public Security University of China Academy of Information Network SecurityBeijing 100038China

Monogamy and polygamy relations are essential properties of quantum entanglement,which characterize the distributions of entanglement in multipartite systems.In this paper,we establish the general monogamy relations forγ-th(0≤γ≤α,α≥1)power of quantum entanglement based on unified-(q,s)entanglement and polygamy relations forδ-th(δ≥β,0≤β≤1)power of entanglement of assistance based on unified-(q,s)entanglement of assistance,which provides a complement to the previous research in terms of different parameter regions ofγandδ.These results are then applied to specific quantum correlations,e.g.,entanglement of formation,Renyi-q entanglement of assistance and Tsallis-q entanglement of assistance to get the corresponding monogamy and polygamy inequalities.Moreover,typical examples are presented for illustration.

关键词： monogamy relation polygramy relation

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Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway

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Chinese Medical Journal 2016年第10期129卷 1154-1160页

作者： Yuan Yang jing-yi zhou Li-Jun Zhao Bao-Rong Gao Xiao-Ping Wan Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China Department of Gynecology Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital Shanghai 200126 China

Background： Previously, we reported that dual-specificity adenocarcinoma （EEA）. However, the role of DUSP1 medroxyprogesterone （MPA） are still unclear. phosphatase I （DUSPI） was differentially expressed in endometrioid in EEA progression and the relationship between DUSPI and Methods： The expression of DUSPI in EEA specimens was detected by immunohistochemical analysis. The effect of DUSPI on cell proliferation was analyzed by Cell Counting Kit 8 and colony formation assay, and cell migration was analyzed by transwell assay. MPA-induced DUSPI expression in EEA cells was measured by Western blot. Results： DUSPI expression was deficient in advanced International Federation of Gynecology and Obstetrics stage, high-grade and myometrial invasive EEA. In EEA cell lines （HeclA, Hecl B, RL952, and Ishikawa）, the DUSP1 expression was substantially higher in lshikawa cells than in other cell lines （P 〈 0.05）. Knockdown ofDUSP I promoted lshikawa cells proliferation, migration, and activation of mitogen-activated protein kinases/extracellular signal-regulated kinase （MAPK/Erk） pathway. MPA-induced DUSP1 expression and inhibited MAPK/Erk pathway in Ishikawa cells. Conclusions： Our data suggest that DUSP1 deficiency promotes EEA progression via MAPK/Erk pathway, which may be reversed by MPA, suggesting that DUSP I may serve as a potential therapeutic target for the treatment of EEA.

关键词： Dual-specificity Phosphatase 1 Endometrioid Adenocarcinoma Medroxyprogesterone Phospho-extracellular Signal-regulated Kinase 1/2

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Effect of Optimized Concentrations of Basic Fibroblast Growth Factor and Epidermal Growth Factor on Proliferation of Fibroblasts and Expression of Collagen： Related to Pelvic Floor Tissue Regeneration

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Chinese Medical Journal 2018年第17期131卷 2089-2096页

作者： Yuan-Yuan Jia jing-yi zhou Yue Chang Fang An Xiao-Wei Li Xiao-Yue Xu Xiu-Li Sun Chun-Yang Xiong Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China Beijing Key Laboratory of Female Pelvic Floor Disorders Beijing 100044 China Department of Mechanics and Bioengineering College of Engineering Peking University Beijing 100871 China

Background： Fibroblasts were the main seed cells in the studies of tissue engineering of the pelvic floor ligament. Basic fibroblast growth factor （bFGF） and epidermal growth factor （EGF） were widely studied but at various concentrations. This study aimed to optimize the concentrations of combined bFGF and EGF by evaluating their effects on proliferation and collagen secretion of fibroblasts. Methods： Fibroblasts were differentiated from rat adipose mesenchymal stem cells （ADSCs）. Flow cytometry and immunohistochemistry were used for cell identification. The growth factors were applied at concentrations of 0, 1, 10, and 100 ng/ml as three groups：（1） bFGF alone, （2） EGF alone, and （3） bFGF mixed with EGF. Cell proliferation was evaluated by Cell Counting Kit-8 assays. Expression of Type I and III collagen （Col-I and Col-1II） mRNAs was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Statistical analysis was performed with SPSS software and GraphPad Prism using one-way analysis of variance and multiple t-test. Results： ADSCs were successfully isolated from rat adipose tissue as identified by expression of typical surface markers CD29, CD44, CD90, and CD45 in flow cytometry. Fibroblasts induced from ADSC, compared with ADSCs, were with higher mRNA expression levels of Col I and Col III （F = 1.29, P = 0.0390）. bFGF, EGF, and the mixture ofbFGF with EGF can enhanced fibroblasts proliferation, and the concentration of 10 ng/ml of the mixture ofbFGF with EGF displayed most effectively （all P 〈 0.05）. The expression levels of Col-I and Col-Ill mRNAs in fibroblasts displayed significant increases in the 10 ng/ml bFGF combined with EGF group （all P 〈 0.05）. Conclusions： The optimal concentration of both bFGF and EGF to promote cell proliferation and collagen expression in fibroblasts was 10 ng/ml at which fibroblasts grew faster and secreted more Type I and III collagens into the extracellular matrix, which might contribute to the stability of the pelvic floor microenvironment.

关键词： Adipose Mesenchymal Stem Cells Basic Fibroblast Growth Factor Epidermal Growth Factor Fibroblasts Tissue Engineering

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Identification of new fusion genes and their clinical significance in endometrial cancer

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Chinese Medical Journal 2019年第11期132卷 1314-1321页

作者： Tian Yao Jin-Jin Liu Li-Jun Zhao jing-yi zhou Jia-Qi Wang Yue Wang Zhi-Qi Wang Li-Hui Wei Jian-Liu Wang Xiao-Ping Li Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China

Background:Fusion genes may play an important role in tumorigenesis, prognosis, and drug resistance;however, studies on fusion genes in endometrial cancer (EC) are rare. This study aimed to identify new fusion genes and to explore their clinical significance in EC. Methods: A total of 28 patients diagnosed with EC were enrolled in this study. RNA sequencing was used to obtain entire genomes and transcriptomes. STAR-comparison and STAR-fusion prediction were applied to predict the fusion genes. Chi-square tests and Student t tests were used to verify the clinical significance with SPSS 13.0 software. Results: New fusion genes were found, and the number of fusion genes varied from 3 to 110 among all patients with EC. The type of fusion genes varied and included messenger RNA (mRNA)-mRNA, long non-coding RNA (lncRNA)-lncRNA, and lncRNAmRNA. There were six fusion genes with high fusion rates, namely, RF11-123010.4-GRIP1-RP11-444D3.1-SOXS,RP11-680G10.1-GSE1,NRIP1-AF127936.7,RP11-96H19.1-RP11-446N19.1,andDPH7-PTP4A3. Further studies showed that these fusion genes are related to stage, grade, and recurrence, in which NRIP1-AF127936.7andDPH7-PTP4A3 were found only in stage Ⅲ patients with EC. DPH7-PTP4A3was found in grades 2 and 3, and recurrent patients with EC. Conclusion: Fusion genes play an essential role in EC. Six genes that are overexpressed with high fusion rates are identified. NRIP1-AF127936.7and DPH7-PTP4A3 might be related to stage, and DPH7-PTP4A3 be related to grade and recurrence.

关键词： Fusion genes Endometrial cancer Drug resistance Prognosis

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Intra-tumor heterogeneity for endometrial cancer and its clinical significance

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Chinese Medical Journal 2019年第13期132卷 1550-1562页

作者： Fu-Fen yin Li-Jun Zhao Xiao-Yu Ji Ning Duan Yan-Kui Wang jing-yi zhou Li-Hui Wei Xiang-Jun He Jian-Liu Wang Xiao-Ping Li Department of Obstetrics and Gynecology Peking University People's HospitalBeijing 100044China Department of Obstetrics and Gynecology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China

Background:Management of tumors has become more complex owing to tumor heterogeneity.Fewer studies have been performed on intra-tumor heterogeneity of endometrial cancer(EC)until now.Therefore,it is of great clinical value to explore the intra-tumor heterogeneity of EC based on clinical features and gene expression profiles.Methods:A total of 1688 patients with EC were screened and 114 patients were finally selected,including specimens from 84 patients with primary EC without relapse(PE)and the paired metastases(P-M)specimens,as well as specimens from 30 patients with primary EC with relapse(RPE)and the paired relapsed EC(P-RE)specimens.Microarray and RNA-seq were used to detect gene expression of EC samples.Clinicopathological characteristics and molecular data were compared between PE and P-M groups and between RPE and P-RE groups to explore the intra-tumor heterogeneity of EC.Results:The clinical intra-tumor spatial heterogeneity of pathological type,grade,ER status,and PR status between PE and P-M were 17.9%,13.1%,28.6%,and 28.6%,respectively.The clinical intra-tumor spatiotemporal heterogeneity of pathological type,grade,ER status,and PR status between RPE and P-RE were 16.7%,33.3%,25.0%,and 37.5%,respectively.Cluster analysis sorts EC samples based on progression type of lesion and their pathological type.There were differentially expressed genes between PE and P-M and between RPE and P-RE,of which gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis were mainly enriched in cell proliferation,the p53 signaling pathway,etc.Conclusions:Clinical and molecular data showed that there was spatiotemporal heterogeneity in intra-tumor of EC,which may add to the complexity of diagnosis and therapeutics for EC.Considering the intra-tumor heterogeneity,sequential chemotherapy and precision medicine may be a more suitable treatment plan for EC.

关键词： Cancer Endometrial cancer Heterogeneity

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Emerging roles of exosomes in oral diseases progression

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International Journal of Oral Science 2024年第1期16卷 36-51页

作者： Jiayi Wang Junjun jing Chenchen zhou yi Fan State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine.

关键词： diseases diagnosis salivary

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Evolution of tribo-magnetization during sliding of ferromagnetic materials

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Friction 2024年第5期12卷 906-918页

作者： Fumin GAO Laibin ZHANG Jin zhou yi XIONG jing WU Jianchun FAN China University of Petroleum-Beijing Beijing102249China Key Laboratory of Oil and Gas Safety and Emergency Technology Ministry of Emergency ManagementBeijing102249China

Sliding-induced subsurface microstructure evolution is believed to be decisive for determining the friction and wear performance of metallic contacts as well as the development of tribo-magnetization.This expects to develop a new prediction method of wear state by elucidating the correlation between subsurface microstructure evolution and corresponding magnetic domain changes.Herein,subsurface microstructure evolution including crystal and magnetic domain under tribological action is investigated experimentally.Our results demonstrate that dislocation mediated plastic deformation decisively influences microstructural changes during tribological contact,further determining the magnetic domain structure.Specifically,sliding-induced plastic deformation causes an increase in the width of magnetic domains,but depth-dependent derived microstructure formed under severe plastic deformation such as the refined grains and sub-grains,in turn,promoted the refinement of magnetic domains and their discontinuity,forming depth-dependent magnetic domain structure.These results are helpful to clarify the evolution of tribo-magnetization and the pinning effect of dislocations on magnetic domains.

关键词： tribology magnetic domain microstructure tribo-magnetization dislocations

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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu jing Yang Wen-jing Zhang yi-Ling zhou Gui-Jun Zhao Ya Huang Shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to date.While several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately described.Here,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated spermatozoa.The analysis revealed a novel homozygous c.520A>G(p.Thr174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and sperm.Multiple algorithms predicted this variant to be a damaging mutation.Consistent with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental carriers.To investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy control.Immunoblot analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the spermatozoa.Our findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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Cordyceps as potential therapeutic agents for atherosclerosis

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Journal of Integrative Medicine 2024年第2期22卷 102-114页

作者： yi Zhang Si-jing Liu School of Marxism Chengdu University of Traditional Chinese MedicineChengdu 61137Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases with Integrated Chinese and Western Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina

Atherosclerosis is a leading cause of mortality and morbidity worldwide.Despite the challenges in managing atherosclerosis,researchers continue to investigate new treatments and complementary therapies.Cordyceps is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for atherosclerosis.Numerous studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions,including anti-inflammatory and antioxidant activities,lowering cholesterol,inhibiting platelet aggregation,and modulating apoptosis or autophagy in vascular endothelial cells.Notably,the current misuse of the terms cordyceps and Ophiocordyceps sinensis has caused confusion among researchers,and complicated the current academic research on cordyceps.This review focuses on the chemical composition,pharmacological actions,and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of Ophiocordyceps spp.This review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.

关键词： Atherosclerosis Cordyceps Ophiocordyceps sinensis

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