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World Journal of Clinical Cases 2019年第21期7卷 3562-3568页

作者： Yin-Qiao Du jing-yang sun Ming Ni Yong-Gang Zhou Department of Orthopedics General Hospital of Chinese People’s Liberation Army

BACKGROUND A recurrent valgus deformity was a common complication after total knee arthroplasty(TKA)in patients with valgus ***,re-revision surgery for re-recurrent valgus deformity after revision TKA in patients with valgus deformity before primary TKA was *** SUMMARY We reported a 72-year-old female patient with two recurrent valgus deformities after TKA for a valgus knee deformity who underwent two revision surgeries to rectify the *** the re-revision surgery,bone defects were successfully reconstructed by the augments and cement in combination with screws and a *** appropriate neutral alignment of the lower limb was restored by the perfect femoral entry point and the long diaphyseal cementless *** fixation of the metaphysis and diaphysis of the femur was obtained by the sleeve and long diaphyseal cementless *** patient was pain-free and deformityfree for 2.5 *** The management of bone defects,the choice of the stem and the femoral entry point were of vital importance in the revision or re-revision TKA for a recurrent valgus deformity.

关键词： Revision total knee arthroplasty Valgus deformity Bone defects Recurrent Case report

Reconstruction of Paprosky type ⅢB acetabular bone defects using a cup-on-cup technique: A surgical technique and case series

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World Journal of Clinical Cases 2020年第7期8卷 1223-1231页

作者： Yin-Qiao Du Yu-Ping Liu jing-yang sun Ming Ni Yong-Gang Zhou Department of Orthopedics Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Orthopedics Tengzhou Central People’s HospitalTengzhou 277500Shandong ProvinceChina

BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to *** severe defects,we developed our own cup-on-cup *** defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup *** To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup *** We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January *** acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 *** The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last *** mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm *** trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 *** was no evidence of component migration at the last *** The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.

关键词： Total hip arthroplasty Trabecular metal Cup-on-cup Bone defect

Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulatedpelvic-fracture combined with massive bleeding

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Journal of Medical Colleges of PLA(China) 2016年第2期31卷 80-86页

作者： Bing Xie Ming Liang Da-Peng Zhou Wen Zhao jing-yang sun jing-jing Rong jing Tian Department of Orthopedics General Hospital of Shenyang Military Region Department of Cardiology General Hospital of Shenyang Military Region

Background: Pelvic fracture combined with massive bleeding(PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the systemic inflammatory response syndrome(SIRS) in dogs with simulated-pelvic-fracture combined with massive ***: Twenty adult dogs were randomly divided into an embolization group(EG) and a control group(CG). For the two groups, heart rate, respiratory rate and body temperature and other physiological variables were measured, and IL-6, TNF-α and arterial blood gas levels were monitored. These variables were assayed every 30 min until death in the CG, while dogs in the EG underwent arterial angiography after 60 min of modeling. The internal iliac artery was embolized on the injured ***: The average time to SIRS in the CG was 3.56 h, occurring at a rate of 90%(9/10) within 24 h, with a mortality rate of 50%(5/10); the average time to SIRS for the EG was 5.33 h, occurring at a rate of 30%(3/10) within 24 h, with a mortality rate of 10%(1/10). When SIRS occurred in the EG, the mean plasma IL-6 level was 52.66±7.38pg/ml and the TNF-ps, tα level was 11.45±2.72ng/ml, showing a significant difference with those of the CG(P<0.05). In the two grouhe respiratory rate and leukocyte levels were higher at each monitored time after modeling than those before modeling; the mean arterial pressure, levels of hemoglobin and oxygen partial pressure were significantly lower at each time point after modeling than those before modeling except for the mean arterial pressure at 0h in EG; the platelet levels at 4 and 8h were higher than those before modeling; and the differences were statistically significant(P<0.05). In the EG, the mean arterial pressure, heart rate, respiratory rate and hemoglobin levels at 2, 4 and 8h were lower than those at 0h; the levels of leukocy

关键词： Internal iliac artery embolization Systemic inflammatory response syndrome Interventional treatment cabin

Early patellar tendon rupture after total knee arthroplasty: A direct repair method

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World Journal of Clinical Cases 2022年第31期10卷 11349-11357页

作者： Tie-Jian Li jing-yang sun Yin-Qiao Du Jun-Min Shen Bo-Han Zhang Yong-Gang Zhou Department of Orthopedics The First Medical Center of PLA General HospitalBeijing 100048China Department of Orthopedics The Fourth Medical Center of PLA General HospitalNational Clinical Research Center for OrthopedicsSports Medicine and RehabilitationBeijing 100853China

BACKGROUND Patellar tendon rupture after total knee arthroplasty(TKA)is a catastrophic *** the occurrence of this injury is rare,it can lead to significant dysfunction for the patient and is very tricky to deal *** has been no standard treatment for early patella tendon rupture after TKA,and long-term follow-up data are *** To introduce a direct repair method for early patella tendon rupture following TKA and determine the clinical outcomes and complications of this *** During the period of 2008 to 2021,3265 consecutive TKAs were retrospectively *** patients developed early patellar tendon rupture postoperatively and were treated by a direct repair *** follow-up was 5.7 ***,operative,and clinical data were *** clinical outcomes were assessed using the Western Ontario and McMaster Universities(WOMAC)score,the Hospital for Special Surgery(HSS)score,knee range of motion,extensor lag,and surgical *** statistics and paired t test were employed to analyze the *** For all 12 patients who underwent direct repair for early patellar tendon rupture,3 patients failed:One(8.3%)for infection and two(17.6%)for *** two patients with re-fracture both underwent reoperation to reconstruct the extensor mechanism and the patient with infection underwent revision *** range of motion was 109.2°±10.6°preoperatively to 87.9°±11°postoperatively,mean extensor lag was 21°at follow-up,and mean WOMAC and HSS scores were 65.8±30.9 and 60.3±21.7 points,*** This direct repair method of early patellar tendon rupture is not an ideal *** is actually ineffective for the recovery of knee joint function in patients,and is still associated with severe knee extension lag and high complication *** with the outcomes of other repair methods mentioned in the literature,this direct repair method shows poor clinical outcomes.

关键词： Direct repair Patellar tendon fracture Total knee arthroplasty Reconstruction High complication rates

Jumbo cup in hip joint renovation may cause the center of rotation to increase

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World Journal of Clinical Cases 2021年第22期9卷 6300-6307页

作者： Ya-Wen Peng Jun-Min Shen Yan-Chao Zhang jing-yang sun Yin-Qiao Du Yong-Gang Zhou Department of Orthopedics The First Medical CentreChinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Utilizing the large jumbo cup in revision total hip arthroplasty is an effective approach to cure many lacunar and segmental peripheral bone ***,with the use of the jumbo cup,the center of the hip joint may become elevated relative to the primary acetabulum,and the diameter of the large cup is *** To study the height and the significance of the elevation of the hip joint *** Eighty-eight patients matched the criteria for this condition and were included in the *** center height of the hip joint was measured relative to the opposite normal hip *** diameter of the jumbo cup was measured and checked according to operation notes,and the diameter of the jumbo cup was measured with a prosthesis ***,the horizontal and vertical centers of rotation were measured on the surgical side and opposite *** average center height of the hip joint on the renovated side and the opposite side and the position of the hip cup relative to the teardrop were compared using a paired *** Radiometric analysis showed that the average hip joint center was elevated by 7.6 *** rotational center height delta of the renovated hip was 7.6±5.6 mm,and there was an obvious difference between the two groups(P=0.00).The difference in horizontal distance was 0.5±5.1 mm(-11.5-14.0 mm),and there was no obvious difference between the two groups(P=0.38).According to the foreign standard,the rotational center height delta of the renovated hip was 7.5±6.2 mm,and there was a significant difference between the two groups(P=0.00).There was no obvious difference between the domestic and foreign standards(P>0.05)between the two *** The application of the jumbo cup elevates the rotational center of the hip joint,but it is feasible and effective to use the jumbo cup.

关键词： Hip revision surgery Jumbo cup Center of rotation Hip joint renovation Hip joint

Different squatting positions after total knee arthroplasty: A retrospective study

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World Journal of Clinical Cases 2022年第23期10卷 8107-8114页

作者： Tie-Jian Li jing-yang sun Yin-Qiao Du Jun-Min Shen Bo-Han Zhang Yong-Gang Zhou Department of Orthopedics The First Medical Center of PLA General HospitalBeijing 100048China

BACKGROUND Total knee arthroplasty(TKA)has been shown to improve quality of life and reduce ***-flexion activities such as squatting,kneeling,and floor transfers are mainly listed as demanding *** them,squatting is an important *** To provide a new squat position classification and evaluate the different squatting positions of a series of patients after primary *** From May 2018 to October 2019,we retrospectively reviewed 154 video recordings of the squatting-related motions of patients after *** the included patients,119 were women and 35 were *** mean age at the index surgery was 61.4 years(range,30 to 77).RESULTS The median follow-up was 12 mo(range,6 to 156 mo).We classified those squatting-related motions into three major variations according to squatting depth:Half squat,parallel squat,and deep *** angles of hip flexion,knee flexion,and ankle dorsiflexion were measured in the screenshots captured from the videos at the moment of squatting nadir.A total of 26 patients were classified as half squats,75 as parallel squats,and 53 as deep *** angles of hip flexion,knee flexion,and ankle dorsiflexion all differed significantly among the three squatting positions(P0.05).Our squatting position classification offers a pragmatic approach to evaluating patients’squatting ability after TKA.

关键词： High flexion Outcome Squat Squatting position Total knee arthroplasty

Feasibility study of emergency intervention for vascular injury outside the hospital

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Military Medical Research 2017年第2期4卷 80-85页

作者： Ming Liang jing-jing Rong jing-yang sun Xiao-Zeng Wang Fei Li Geng Wang Yan-Chun Liang Ya-Ling Han Department of Cardiology General Hospital of Shenyang Military Region

Background: Minimally invasive surgery in the field of traumatic vascular injury diagnosis and treatment has achieved good results. This study was designed to determine whether pre-hospital emergency intervention is feasible for vascular injury in a field intervention cabin under the condition of war or a disaster ***: Different types of animal experiments of vascular injury intervention were performed in a field intervention cabin. Treatment capacity was evaluated by data collection, including duration of surgery, clinical evaluation, image clarity, and equipment handling. Environmental adaptability and mobility were evaluated by maneuverability and long-distance ***: A total of 56 surgeries(7 types) were performed in the field intervention cabin. Digital subtraction angiography(DSA) had good imaging performance. A total of 4800 km of long-distance mobility was performed, and all the equipment operated normally without any equipment failure. We participated in the medical service maneuver twice. The cabin unfolded and worked properly. There was no equipment damage during the medical service ***: Use of a field intervention cabin under the conditions of war or disaster is feasible for pre-hospital emergency intervention of vascular injury.

关键词： Vascular injury Pre-hospital emergency Intervention Cabin

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu Xiao-Li Li Xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Effect of Progressive Substitution of Cement and Lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： sun yang WANG Faxin SU Yaying LI Yiwei HE Feng College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an Research Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment Corp.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in Lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unconfined compressive strength(UCS)

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents