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The BEL1-like transcription factor GhBLH5-A05 participates in cotton response to drought stress

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The Crop Journal 2024年第1期12卷 177-187页

作者： jing-Bo Zhang Yao Wang Shi-Peng Zhang fan Cheng Yong Zheng yang Li Xue-Bao Li Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina College of Life Sciences Xinjiang Normal UniversityUrumqi 830017XinjiangChina

Drought stress impairs crop growth and ***1-like family transcription factors may be involved in plant response to drought stress,but little is known of the molecular mechanism by which these proteins regulate plant response and defense to drought *** we show that the BEL1-like transcription factor GhBLH5-A05 functions in cotton(Gossypium hirsutum)response and defense to drought *** of GhBLH5-A05 in cotton was induced by drought *** of GhBLH5-A05 in both Arabidopsis and cotton increased drought tolerance,whereas silencing GhBLH5-A05 in cotton resulted in elevated sensitivity to drought ***5-A05 binds to cis elements in the promoters of GhRD20-A09 and GhDREB2C-D05 to activate the expression of these ***5-A05 interacted with the KNOX transcription factor ***-expression of GhBLH5-A05 and GhKNAT6-A03 increased the transcription of GhRD20-A09 and *** conclude that GhBLH5-A05 acts as a regulatory factor with GhKNAT6-A03 functioning in cotton response to drought stress by activating the expression of the drought-responsive genes GhRD20-A09 and GhDREB2C-D05.

关键词： Cotton(Gossypium hirsutum) BEL1-like transcription factor Drought stress Transcriptional regulation Drought tolerance

In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4102-4117页

作者： Yuan Li fan Tong Yufan Wang jing Wang Manqi Wu Hanmei Li Hongyan Guo Huile Gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Tumor vaccine,a promising modality of tumor immunotherapy,needs to go through the process of tumor antigen generation and loading,antigen drainage to lymph nodes(LNs),antigen internalization by dendritic cells(DCs),DC maturation,and antigen cross-presentation to activate ***,tumor vaccines are often unable to satisfy all the steps,leading to the limitation of their application and ***,based on a smart nanogel system,an in situ nano-vaccine(CpG@Man-P/Tra/Gel)targeting LNs was constructed to induce potent anti-tumor immune effects and inhibit the recurrence and metastasis of ovarian *** CpG@Man-P/Tra/Gel exhibited MMP-2-sensitive release of trametinib(Tra)and nano-adjuvant CPG@Man-P,which generated abundant in situ depot of whole-cell tumor antigens and formed in situ nano-vaccines with CpG@*** from mannose(Man)modification,the nano-vaccines targeted to LNs,promoted the uptake of antigens by DCs,further inducing the maturation of DCs and activation of T ***,CpG@Man-P with different particle sizes were prepared and the effective size was selected to evaluate the antitumor effect and immune response in ***,combined with PD-1 blocking,the vaccine effectively inhibited primary tumor growth and induced tumor-specific immune response against tumor recurrence and metastasis of ovarian cancer.

关键词： In situ nano-vaccine Lymph node targeting MMP-2 responsive PD-1 Combination therapy CpG Ovarian cancer Metastases

Comparison on the Origin and Development of Sophora flavescens in China and Japan

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Agricultural Biotechnology 2024年第2期13卷 58-63页

作者： jing yan Zheng fan Yuling XU Chenyu ZHOU Rongchun HAN School of pharmacy Anhui University of Chinese MedicineHefei 230012China Antagen Pharmaceutics IncMassachusetts Canton 02021USA The Affiliated Taihe Hospital of Traditional Chinese Medicine Anhui University of Chinese MedicineTaihe 236600China

Sophora flavescens , which was first recorded in Shen Nong s Herbal Classic , has the functions of clearing away heat, drying dampness, killing parasites and promoting urination. In its long-term application, traditional Chinese medicine has gradually deepened its understanding of the origin and efficacy of S. flavescens . In order to explore changes in the origin and efficacy of traditional Chinese herb S. flavescens in the history of China and Japan, in this paper, the origin and development of S. flavescens in China and Japan were compared from three aspects: the origin, medicinal efficacy, and processing methods of S. flavescens in China and Japan, hoping to provide clear understanding of the medicinal plant S. flavescens .

关键词： Sophora flavescens Japan Herbalogical study Processing

Myocardial injury caused by Amanita pseudoporphyria Hongo

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World Journal of Emergency Medicine 2024年第5期15卷 401-403页

作者： Junliang Xiao Chengliang Liao Xiquan yan Xiaotong Han Maiying fan Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University(People's Hospital of Hunan Province)Changsha 410005China Clinical Research Center For Emergency and Critical Care in Hunan Province Changsha 410005China Hunan Provincial Institute of Emergency Medicine Changsha 410005China Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics Changsha 410005China

Amanita pseudoporphyria Hongo(APH)is a toxic mushroom containing Amanita toxin that is notably associated with liver and kidney function impairment.[1]Acute myocardial infarction(AMI)is a severe stage of coronary heart disease that can cause sudden death and is the leading cause of mortality and morbidity across the world.[2]The incidence rate of myocardial injury caused by accidental ingestion of APH is very *** this study,we aimed to report 11 patients who had varying degrees of myocardial injury,reduced heart function,and even cardiac arrest after accidental ingestion of APH.

关键词： mortality injury coronary

Room-temperature Self-healing and Recyclable PDMS Elastomers with Superior Mechanical Properties for Triboelectric Nanogenerators

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Chinese Journal of Polymer Science 2024年第10期42卷 1566-1577,I0014页

作者： Shu-Juan Wang Lu Wang Hong-Zhe Su Zhi-Cheng Wu Qiao-Gen Zhang Wei fan Xin-Li jing School of Chemistry Joint Innovation Center of Thermal Protection MaterialsXi’an Jiaotong UniversityXi’an710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an710048China

Polydimethylsiloxane(PDMS)is an electron-withdrawing material that is widely used in triboelectric nanogenerators(TENGs).However,PDMS has poor mechanical properties after curing and is easily damaged when subjected to long-term ***,the long-term stable operation of TENGs under mechanical deformation cannot be *** this work,multiple hydrogen bonds and aromatic disulfide bonds were introduced into PDMS *** elastomers exhibited high toughness(a tensile strength of 1.91 MPa and an elongation at break of 340%),good recyclability,and room-temperature self-healing properties(healing efficiency of 96.4%in 24 h).Recyclable sandwich-like triboelectric nanogenerators with excellent electrical output performance(13.5 V)and room-temperature self-healing performance(24 h,98%recovery of self-generating performance)were prepared by utilizing the hydrogen bonding between the PDMS elastomer and *** work reported herein offers theoretical guidance and a compelling strategy for developing high-performance TENG negative friction layers.

关键词： Polydimethylsiloxane Aromatic disulfide bonds Hydrogen bonds Room temperature self-healing Triboelectric nanogenerator

EBSD analysis of grain boundary evolution and dynamic recrystallization of Inconel 625 superalloy at various hot spinning feed rates

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Progress in Natural Science:Materials International 2024年第1期34卷 56-65页

作者： Zhanjie jing Jiangkun fan Xudong Liu Yuelin Song Zixiao Wang Kai Cao Yuetan Chen Heng Fu Jianing Zhang Jinshan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Chongqing Innovation Center Northwestern Polytechnical University National&Local Joint Engineering Research Center for Precision Thermoforming Technology of Advanced Metal Materials

Hot spinning can make the material withstand shear stress, so that the shape of the material has a great change,which is one of the main processing methods of nickel-based alloy plate members. Inconel 625 alloy, which has excellent high temperature mechanical properties and can be used as the main candidate material for aerospace applications, needs further study on its hot spinning deformation behavior and deformation mechanism. In this paper, the effect of feed rate on the microstructure evolution of Inconel 625 superalloy was studied by the electron backscattered diffraction technology. The microstructure with necklace-like structures composed of dynamic recrystallization(DRX) grains was observed after hot spinning. It was found that at the low feed rate, the promotion of DRX degree and grain refinement happened, where the grain size reached the trough of 10.99 μm under a feed rate of 300 mm/min. However, with the further feed rate rising, the degree of DRX was suppressed to a certain extent and grain size increased to 14.26 μm. On balance, the feed rate of 300 mm/min was the most efficient condition for grain refinement. Besides, it was revealed that both discontinuous dynamic recrystallization(DDRX) and continuous dynamic recrystallization(CDRX) occurred during hot spinning. DDRX includes the initial grain boundary nucleation by bulging and the annealing twin boundary assisted nucleation, while the CDRX mechanism is related to the continuous subgrain rotation within the deformed grain. DDRX is the main DRX mechanism.

关键词： Inconel 625 superalloy Hot spinning Grain boundary evolution DRX mechanism

Miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： jing Cheng Zhang Mu Ku Chen Yubin fan Qinmiao Chen Shufan Chen Jin Yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： Yu-fan yang Hai-Lu Ma Xi Wang Min Nie Jiang-Feng Mao Xue-yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited

Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 703-715页

作者： Li Xu Yu-Hong fan Xiao-jing Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000China School of Basic Medical Sciences Wuhan UniversityWuhan 430060China

Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary *** complexity stems from genetic predisposition,environmental influences,and metabolic *** processes govern various cellular functions such as transcription,chromatin structure,and cell *** NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the *** methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to *** early-stage NAFLD is reversible,its progression to severe stages becomes almost ***,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关键词： Non-alcoholic fatty liver disease Mechanism Histone methylation Methyltransferases Demethytrasferases Epigenetic modification Adipogenesis