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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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基于仿真方法的共享换电站价值量化分析

北京工业大学学报 2025年第1期51卷 22-31页

作者：沙玲汪静张海峰王岱上海工程技术大学机械与汽车工程学院上海201620 上海蔚来汽车有限公司上海201800

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个... 详细信息

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个模拟用户换电行为的仿真器,通过量化用户的平均排队时间和换电站数量,评估电动汽车用户在不同电动汽车规模和换电站渗透率下的换电体验。结果表明,电动汽车品牌共享换电站资源,能够显著减少电动汽车用户的排队时间,以及将排队时间保持在期望阈值内所需的换电站数量,从而提高用户的充电体验并节省换电站建设成本。

关键词：电动汽车换电站共享排队论换电体验仿真

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美国侦探小说之渊源、发展与叙事

佳木斯大学社会科学学报 2025年第1期43卷 125-129页

作者：邓景茹朝阳师范学院辽宁朝阳122000

侦探小说因其惊悚悬疑的情节和紧张刺激的审美体验在美国文学中占有举足轻重的地位。侦探小说以传统文学积淀为要素,以心理推理和逻辑破案为媒介,经过作者的渲染和布局,描述故事的发展和结局。美国文学中,自爱伦·坡开创了美国侦探小说... 详细信息

侦探小说因其惊悚悬疑的情节和紧张刺激的审美体验在美国文学中占有举足轻重的地位。侦探小说以传统文学积淀为要素,以心理推理和逻辑破案为媒介,经过作者的渲染和布局,描述故事的发展和结局。美国文学中,自爱伦·坡开创了美国侦探小说先河之后,经历了安娜·凯瑟琳的过渡时期,创建了侦探小说的写作原理和程式,而范达因和奎恩的写作使美国侦探文学达到黄金时期,而至后来发展为20世纪的硬汉派小说,从情节、叙事、意境和效价都日臻完善,在美国文学中独树一帜。

关键词：侦探小说原型叙事范式

铜基催化剂在乙炔氢氯化反应中的工业应用评估

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现代化工 2025年第1期45卷 72-76页

作者：代元元杨京林牛强内蒙古鄂尔多斯电力冶金集团股份有限公司内蒙古鄂尔多斯016064

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通... 详细信息

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通过严格控制工艺指标可避免铜工业应用的安全风险问题。

关键词：乙炔氢氯化铜催化剂工业化应用安全性

Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays

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Nano Research 2021年第3期14卷 620-627页

作者： jing dai Yuan Yao School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Matrix adaptation reconstructs the architecture of cell,and has important implication in proper biological ***,how the network of cytoskeleton filament undergoes reconstruction,reordering,and surface adaptation,requires a systematic ***,we show that surface sensing and adaptation occur correspondingly with related reorganization of cytoskeleton filaments(actin,tubulin,and vimentin).The microstructure of filament network is built by adaptive change of chemical polymerization on cytoskeleton *** transition of cellular morphology,from spheroidal architecture on nanoarray to extending structure with stress fibers on flat surface,involves spatial reorganization and polymerization modulation of *** dimension of filaments(diameter,orientation,and density)are changed accordingly to spatiotemporal distribution of cytoskeleton *** addition,our findings elucidate how cell can tune their architecture at nanoscale by matrix adaptation,and provide a novel information on interplay between cytoskeleton and pathophysiology.

关键词： adaptation cytoskeleton polymerization reordering

Inspection interval optimization for aircraft composite structures with dent and delamination damage

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Journal of Systems Engineering and Electronics 2021年第1期32卷 252-260页

作者： CAI jing dai Dingqiang College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The optimization of inspection intervals for composite structures has been proposed,but only one damage type,dent damage,has been addressed so *** present study focuses on the two main damage types of dent and delamination,and a model for optimizing the inspection interval of composite structures is proposed to minimize the total maintenance cost on the premise that the probability of structure failure will not exceed the acceptable *** order to analyze the damage characteristics and the residual strength of the composite structure,the frequency,energy,size,and depth of the damage are studied,and the situation of missing detection during the inspection is *** structural residual strength and total maintenance cost are quantified corresponding to different inspection *** proposed optimization method relieves the constraints in previous simulation methods,and is more consistent with the actual ***,the outer wing of aircraft is taken as an example,and with the historical cases and experimental data,the optimization method is *** optimal inspection interval is shorter than the actually implemented inspection interval,and the corresponding maintenance cost is reduced by 23.3%.The result shows the feasibility and effectiveness of the proposed optimization method.

关键词： civil aircraft composite structure accidental impact damage failure probability inspection interval

COLLABORATIVE DESIGN OF RFID SYSTEMS FOR MULTI-PURPOSE SUPPLY CHAIN APPLICATIONS

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Journal of Systems Science and Systems Engineering 2013年第2期22卷 152-170页

作者： Hongyan dai jing XU School of Business Central University of Finance and Economics Department of Industrial Engineering Tsinghua University

One of the key challenges for implementing RFID systems in supply chain management is the difficulty in economic justification. Such difficulty is further amplified by its public participation nature as multiple self-interest beneficiaries may receive diverse paybacks, and their incentives to join the system are difficult to align. This paper aims to address these problems by a collaborative design from two aspects. First, we propose to introduce a centralized planning mechanism in the chain to facilitate the participation, so that the cost of the overall system can be minimized. Second, we propose to analyze the multi-facet economic return from multi-purpose applications to achieve the full potential of RFID systems. To illustrate our approach, its application for inventory inaccuracy and product recall in RFID system is presented.

关键词： RFID collaborative design economic justification centralized planning

Hydrothermal Synthesis and Characterization of Perovskite PbTiO_(3) Powders from Different Precursors

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Chemical Research in Chinese Universities 1998年第3期14卷 3-7页

作者： CHEN dai-rong XU ru-ren Department of Chemistry Jilin UniversityChangchun130023

Perovskite type of PbTiO 3 fine powders which are homogeneous in physic chemical properties has been hydrothermally synthesized from the different precursors. The borderline reaction conditions, such as temperature and time, for the formation of PbTiO 3 were established and the effect of the precursor on the particle properties was investigated. As a precursor, Pb Ti alko carbonate xerogel dispersed in 2 methoxyethanol was found to be effective for the synthesis of the PbTiO 3 powders with a lower agglomeration and a simple mode of particle size.

关键词： Hydrothermal synthesis PbTiO 3 powders Precursor