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A new ent-labdane eiterpenoid lactone from Andrographis paniculata

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Chinese Chemical Letters 2009年第3期20卷 317-319页

作者： Xiao Chi Ma Bao jing Zhang Sha Deng Shan Shan Huang Ke Xin Liu jing ming jia School of Pharmaceutical Sciences Dalian Medical University Dalian 116027 PR China School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shengyang 110016 China

A new ent-labdane diterpenoid lactone with a new natural product was isolated from Andrographis paniculata. Their structures were elucidated on the basis of spectral evidences including 2D NMR.

关键词： Andrographis paniculata Ent-labdane diterpenoid Acanthaceae Lactone

ent-Pimarane Diterpenoid Dimers from Sigesbeckia glabrescens with Potent Anti-inflammatory Activities

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Chinese Journal of Chemistry 2021年第12期39卷 3315-3321页

作者： Xiao-Xu Gao Ying-Ying Zheng Xiao-Yu Zhang Gao-Sheng Hu jing-ming jia An-Hua Wang School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Chromatographic purification of Sigesbeckia glabrescens extracts led to three undescribed ent-pimarane diterpenoid dimers,named glabreside A—C(1-3).Their structures were confirmed by comprehensive spectroscopic analyses,and the structures of compound 1 and 3 were confirmed by X-ray *** results of anti-inflammatory activity assay showed that glabreside C(3)exhibited the most potent inhibition activity on nitric oxide(NO)production induced by lipopolysaccharide(LPS)in BV2 microglia compared with the other two *** C also increased the protein expression level of heme oxygenase-1(HO-1),and suppressed inducible nitric oxide synthase(iNOS)and cyclooxygenase 2(COX2)in LPS-stimulated BV2 ***,glabreside C exerts its anti-inflammatory effect by inhibiting AKT/MAPKs signaling *** findings indicate the vital role of ent-pimarane diterpenoid dimers in explaining the anti-inflammatory activity of *** and provide important evidence for further development and utilization of Sigesbeckiae *** results also suggest that glabreside C is a potential lead compound for anti-inflammatory drugs.

关键词： Siegesbeckia glabrescens Makino Terpenoids Biosynthesis Inflammatory Biological activity

Discovery of Highly Oxidized Abietane Diterpenoids from the Roots of Euphorbia fischeriana with Anti-tumor Activities

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Chinese Journal of Chemistry 2021年第11期39卷 2973-2982页

作者： jiang-Chun Wei Yu-Ning Gao Dong-Dong Wang Xiao-Yu Zhang San-Peng Fan Te-Ri-Gen Bao Xiao-Xu Gao Gao-Sheng Hu An-Hua Wang jing-ming jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning110016 China

Four previously undescribed ent-abietane diterpenoids(1—4),along with eleven known analogues(5—15),were isolated from the roots of wild Euphorbia *** gross structures were determined via extensive spectroscopic data,and the absolute configurations were elucidated by means of single-crystal X-ray diffraction analysis,Rh2(OCOCF3)4-induced CD spectrum and ECD *** cervical carcinoma inhibition activities counteract HeLa cells were screened by MTT assay,and the structure-activity relationships were further *** results demonstrated that 2(IC50 value at 3.75μmol/L)was more potent than *** underlying mechanism study revealed that 2 could distinctly induce apoptosis accompanied by increasing reactive oxygen species(ROS)production,Ca^(2+)influx and decreasing mitochondrial membrane ***,signal pathways including MAPKs/AKT might play a significant role in 2-induced cervical cancer cells death.

关键词： Euphorbia fischeriana Diterpenoids Structure elucidation Biological activity Anti-tumor

基于可持续发展视角下我国资源型城市经济发展态势分析

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安全与环境学报 2023年第3期23卷 962-970页

作者：张国兴景明佳华北水利水电大学管理与经济学院郑州450046 华北水利水电大学黄河流域生态经济系统可持续发展研究中心郑州450046

资源型城市可持续发展是我国经济新常态建设的重要环节,为理清资源型城市转型过程中存在的问题和发展现状,基于CiteSpace软件,对CNKI总库中1991—2021年4436篇中文核心文献构建共现图谱,从发文机构、发文作者、研究内容3个角度深入研究... 详细信息

资源型城市可持续发展是我国经济新常态建设的重要环节,为理清资源型城市转型过程中存在的问题和发展现状,基于CiteSpace软件,对CNKI总库中1991—2021年4436篇中文核心文献构建共现图谱,从发文机构、发文作者、研究内容3个角度深入研究了我国资源型城市可持续发展态势。结果表明:我国相关高校(研究所)均对资源型城市的可持续发展转型态势开展了研究,发文机构集中于东北地区和西部地区,具有较强的区域性特征,且机构间合作处于较低水平。该领域核心作者数量众多,其中绝大多数偏向单独研究,作者间合作水平较低,未能形成固定合作团队。从关键词时间分布来看,该领域的研究内容以2004年、2014年为界可划分为3个阶段,由此产生的重要关键词节点有“经济转型”“产业转型”“城市转型”“循环经济”“低碳经济”。目前对资源型城市可持续发展转型态势的研究则更关注“新常态”和“耦合协调”。

关键词：环境科学技术基础学科资源型城市可持续发展 CiteSpace 科学知识图谱

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我国煤矿领域安全经济研究态势分析

安全与环境学报 2021年第2期21卷 902-907页

作者：景明佳郭绍帅程磊华北水利水电大学财务处郑州450000 河南理工大学安全科学与工程学院河南焦作454000

为了了解我国煤矿安全经济领域的整体研究态势,基于中国知网(CNKI)文献数据,采用Cite Space V软件从研究机构、发文作者、热点关键词3个方面对我国煤矿安全经济领域的整体研究状况进行了汇总、分析。结果表明:在研究机构方面,大量的研... 详细信息

为了了解我国煤矿安全经济领域的整体研究态势,基于中国知网(CNKI)文献数据,采用Cite Space V软件从研究机构、发文作者、热点关键词3个方面对我国煤矿安全经济领域的整体研究状况进行了汇总、分析。结果表明:在研究机构方面,大量的研究机构在我国煤矿安全经济领域开展了研究,但各研究机构的发文量均处于比较低的水平,机构之间的合作关系较弱,在研究机构组成中,生产经营企业占据了较大的比例;在作者方面,作者之间的合作关系较弱,研究人员的发文量均处于比较低的水平;在热点关键词方面,我国在煤矿安全经济领域的研究态势处于不断发展变化中,2011—2015年研究热度达到最高,机电一体化是2016—2020年新增的主要研究热点。

关键词：安全社会工程煤矿经济中国知网(CNKI) CiteSpace

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吸烟对甲状腺相关眼病患者眶脂肪分化的影响

眼科 2016年第5期25卷 334-338页

作者：周哲高玉孙琰景明胡佳丽解放军第四一一医院眼科上海200081

目的确定吸烟对甲状腺相关眼病(TAO)患者眶脂肪分化的影响。设计回顾性病例系列。研究对象2012年6-12月在上海长征医院眼科行眶减压术的TAO患者40例,男性27例,女性13例。方法 40例TAO患者中,21例吸烟、8例曾吸烟但已戒烟,5例被动吸烟,6... 详细信息

目的确定吸烟对甲状腺相关眼病(TAO)患者眶脂肪分化的影响。设计回顾性病例系列。研究对象2012年6-12月在上海长征医院眼科行眶减压术的TAO患者40例,男性27例,女性13例。方法 40例TAO患者中,21例吸烟、8例曾吸烟但已戒烟,5例被动吸烟,6例非吸烟。运用RT-PCR检测所有患者眶脂肪CCAAT/增强结合蛋白(C/EBP)和过氧化物酶体增生物激活受体(PPARγ)mRNA表达量。用△Ct法进行其各基因表达的相对定量。多组间的总体比较采用单因素方差分析,随后用SNK-q检验进行两两比较。主要指标C/EBP和PPARγmRNA表达量。结果吸烟组患者的C/EBP(12.04±4.26)和PPARγmRNA表达量(4.82±1.41)明显高于非吸烟组(C/EBP:2.32±0.92;PPARγ:1.37±0.25)(P<0.001)。同时,曾吸烟组和被动吸烟组的C/EBP(4.29±1.26,5.76±1.03)和PPARγmRNA表达量(2.91±1.23,3.22±0.50)对比非吸烟组的差异也具有统计学意义(曾吸烟组C/EBP P=0.039,PPARγP=0.047;被动吸烟组C/EBP P=0.002,PPARγP=0.002)。吸烟指数≥100年支的TAO患者眶脂肪C/EBP(14.28±3.61)和PPARγmRNA(5.65±1.02)高于吸烟指数<100年支的患者(C/EBP:8.42±2.30;PPARγ:3.48±0.74)(P均<0.01)。结论眶脂肪C/EBP和PPARγmRNA的表达量与吸烟史有关。

关键词：吸烟甲状腺相关眼病 CCAAT/增强结合蛋白过氧化物酶体增生物激活受体

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang jia jing Wen Xue-Lin Cheng Yan Han ming-Hui Peng jing Zhou Yao Liu Sun-Fang jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang jing Ren Chenguang Zheng jiajia Yang Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation