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Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu Liu Si Yin Tee Guijian Guan Ming‑Yong han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhanced applications

A Kind of Plant Small Molecular Chaperones Enhance the Tolerance to Biotic and Abiotic Stresses

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A Kind of Plant Small Molecular Chaperones Enhance the Toler...

Intestinal microbiota and type 2 diabetes:from mechanism insights to therapeutic perspective

中国植物病理学会2019年学术年会

作者： Guo Liuming Li jing He jing Liu han Yuan Zhengjie Zhang Hengmu Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences College of Chemistry and Life Science Zhejiang Normal University

Small heat shock proteins（sHSPs） have thought to function as chaperones,protecting their targets from denaturation and aggregation when organisms are subjected to various biotic and abiotic stresses（Haslbeck et al.,2019）.In our previous study,a sHSP from Oryza sativa（OsHSP20） and its homolog（NbHSP20） from *** were cloned and found to self-interact and forms granules within the ***,they could interact in vitro and vivo with RNA-dependent RNA polymerase（RdRp） of Rice stripe virus（RSV）,which causes a severe disease of rice in Eastern *** analysis showed that RSV infection could alter the expression pattern or sub-cellular distribution of HSP20 s by their hetero-interaction in protoplasts of rice and epidermal cells of ***（Li et al.,2015）.However,their functions remain largely *** deep insight into their roles,here we investigated their expression pattern,molecular chaperone activity,and effects on tolerance to various biotic and abiotic stresses in ***（a prokaryote）,yeast,and plants（eukaryotes） overexpressing the HSP20 *** expressions were significantly up-regulated by viral infection,heat shock and high *** purified recombinant proteins were shown to inhibit the thermal aggregation of the mitochondrial malate dehydrogenase（MDH） enzyme in vitro,suggesting their molecular chaperone *** expression of HSP20 in Escherichia coli or Pichia postoris cells enhanced heat and salt stress tolerance compared with the control *** plants had longer roots and higher germination rates than those of control plants when exposed to heat and salt treatments,consistently supporting the viewpoint that HSP20 s confer heat and salt tolerance by its molecular chaperone activity in different *** the other hand,the transgenic plants were artificially inoculated with Tomato mosaic virus（ToMV）,Turnip Mosaic Virus（TuMV） and RSV,and were found to delay the symptom development,indicating

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World Journal of Gastroenterology 2014年第47期20卷 17737-17745页

作者： Jun-Ling han Hui-Ling Lin Department of Endocrinology and Metabolism the 187~(th) Hospital of PLA

The incidence of type 2 diabetes(T2DM)is rapidly increasing ***,the pathogenesis of T2DM has not yet been well *** evidence suggests that the intestinal microbiota composition is associated with obesity and *** this review,we provide an overview about the mechanisms underlying the role of intestinal microbiota in the pathogenesis of *** is clear evidence that the intestinal microbiota influences the host through its effect on body weight,bile acid metabolism,proinflammatory activity and insulin resistance,and modulation of gut *** gut microbiota with the use of probiotics,prebiotics,antibiotics,and fecal microbiota transplantation may have benefits for improvement in glucose metabolism and insulin resistance in the *** studies are required to increase our understanding of the complex interplay between intestinal microbiota and the host with *** studies may be able to boost the development of new effective therapeutic approaches for T2DM.

关键词： Intestinal microbiota Type 2 diabetes Body weight Bile-acid metabolism Insulin resistance Intestinal microbiota modulation

Four Types of Percolation Transitions in the Cluster Aggregation Network Model

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Chinese Physics Letters 2018年第1期35卷 59-62页

作者： Wen-Chen han Jun-Zhong Yang School of Science Beijing University of Posts and Telecommunications

We study the percolation transition in a one-species cluster aggregation network model, in which the parameter α describes the suppression on the cluster sizes. It is found that the model can exhibit four types of percolation transitions, two continuous percolation transitions and two discontinuous ones. Continuous and discontinuous percolation transitions can be distinguished from each other by the largest single jump. Two types of continuous percolation transitions show different behaviors in the time gap. Two types of discontinuous percolation transitions are different in the time evolution of the cluster size distribution. Moreover, we also find that the time gap may also be a measure to distinguish different discontinuous percolations in this model.

关键词： Four Types of Percolation Transitions in the Cluster Aggregation Network Model

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小麦深色啤酒生产工艺研究

安徽农业科学 2009年第21期37卷 10147-10147,10236页

作者：韩小龙济宁学院生命科学与工程系山东济宁273155

[目的]研制深色小麦啤酒的生产工艺。[方法]以小麦麦芽、大麦麦芽、焦香大麦芽为原料，按1：1：0．25的比例混合增湿粉碎后，在65℃下进行糖化，在78℃下进行过滤，所得麦芽汁（14。Bx）冷却后按0．8：100的体积比添加酵母，在接种温度1... 详细信息

[目的]研制深色小麦啤酒的生产工艺。[方法]以小麦麦芽、大麦麦芽、焦香大麦芽为原料，按1：1：0．25的比例混合增湿粉碎后，在65℃下进行糖化，在78℃下进行过滤，所得麦芽汁（14。Bx）冷却后按0．8：100的体积比添加酵母，在接种温度14℃和最高发酵温度18℃条件下发酵48h，之后加压至0．1MPa。12℃下发酵72h，然后以4℃／d的速度降温．降至4和0℃时，分别排第1和2次酵母，最后在-1-0℃下贮酒10d，出酒时残糖浓度应控制在2．7％以下。[结果]成品啤酒原麦汁浓度12。P，色度为25EBC，苦味值20BU，酒精含量为4．2％（WIW），外观发酵度为75．3％；酒液清亮透明，泡沫洁白细腻，挂杯持久，具有明显的水果香味，口感纯正，柔和爽口。[结论]研制的深色小麦啤酒完全可以达到微型啤酒的生产标准。

关键词：小麦啤酒上面发酵酵母深色啤酒

Rabies Virus Neutralizing Activity,Safety,and Immunogenicity of Recombinant Human Rabies Antibody Compared with Human Rabies Immunoglobulin in Healthy Adults

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Biomedical and Environmental Sciences 2022年第9期35卷 782-791页

作者： ZhanG Jun Nan MENG Ya Juan BAI Yun Hua LI Yu Feng YANG Li Qing SHI Nian Min han Hui Xia GAO Jian ZHU Li Juan LI Shu Ping ZhanG jing ZHAO Qin Hua WANG Xiu Qin WEI jing Shuang REN Le Min CAO Chen Hua CHEN Chen ZHAO Wei LI Li Center for Disease Control and Prevention of Chaoyang District Beijing 100021China NCPC New Drug Research and Development Co. Ltd.State Key Laboratory of Antibody Research&DevelopmentShijiazhuang 050015HebeiChina Beijing Institute of Biological Products Beijing 100021China Xiaohongmen Community Healthcare Center Beijing 100023China

Objective Preliminary assessment of rabies virus neutralizing activity,safety and immunogenicity of a recombinant human rabies antibody(NM57)compared with human rabies immunoglobulin(HRIG)in Chinese healthy *** Subjects were randomly(1:1:1)allocated to Groups A(20 IU/kg NM57),B(40 IU/kg NM57),or C(20 IU/kg HRIG).One injection was given on the day of *** samples were collected on days-7 to 0(pre-injection),3,7,14,28,and *** events(AEs)and serious AEs(SAEs)were recorded over a period of 42 days after *** All 60 subjects developed detectable rabies virus neutralizing antibodies(RVNAs)(>0.05 IU/mL)on days 3,7,14,28,and *** RVNA levels peaked on day 3 in all three groups,with a geometric mean concentration(GMC)of 0.2139 IU/mL in Group A,0.3660 IU/mL in Group B,and0.1994 IU/mL in Group *** each follow-up point,the GMC in Group B was significantly higher than that in Groups A and *** areas under the antibody concentration curve over 0-14 days and 0-42 days in Group B were significantly larger than those in Groups A and *** AEs were *** for one grade 2 myalgia in Group C,the other 14 were all grade *** SAEs were *** The rabies virus neutralizing activity of 40 IU/kg NM57 was superior to that of 20 IU/kg NM57 and 20 IU/kg HRIG,and the rabies virus neutralizing activity of 20 IU/kg NM57 and 20 IU/kg HRIG were *** was comparable between NM57 and HRIG.

关键词： Recombinant human rabies antibody NM57 Human rabies immunoglobulin Rabies virus neutralizing activity Safety Immunogenicity

World Integrated Medicine Master han Jisheng

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World Journal of Integrated Traditional and Western Medicine 2018年第3期4卷 1-10页

作者： zou jianhua han jisheng wjim 不详

Interview Time:April.24th,2018 Location:Home of Academician han Jisheng Interviewer:Professor Zou Jianhua,Associate Editor-in-Chief of WJIM Interviewee:Academician han Jisheng Introduction of han Jisheng Academician han Jisheng,male,born in 1928,graduated from Shanghai Medical College as M.D.(1947-1953),and specialized in physiology at Dalian Medical *** served many organizations as follows:Professor and Head,*** Physiology,Peking Medical University,Director of the Neuroscience Research Institute(1993-),Peking University,Member of Chinese Academy of Sciences(1993-),founding president of the Chinese Association for the Study of Pain(CASP)since 1989,and Editor-in-Chief of the Chinese Journal of Pain Medicine,Editor-in-Chief of 7 books including the comprehensive textbook Principles of Neuroscience in Chinese,Grantee of NIDA/NIH,USA(DA 03983)for acupuncture research(1987-2000),Scientific Advisor for WHO(1990-),Consultant of Scientific Review Committee,NIH and ADAMHA,USA,and member of Executive Committee,International Narcotic Research Conference(INRC)(2002-2006).

关键词： Academician han Dalian Medical Neuroscience Research

Distortion minimization for multimedia transmission in NOMA HAP-UAV integrated aerial access networks

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Chinese Journal of Aeronautics 2022年第9期35卷 81-94页

作者： Guobin ZhanG Zhu han hang XIN Xin WEI Boya DI School of Electrical Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Electrical and Computer Engineering and Department of Computer Science University of HoustonTX77004USA School of Computer Science and Technology Dongguan University of TechnologyDongguan 523808China Department of Computing Imperial CollegeLondon SW72AzUK

Aerial access networks have been envisioned as a promising 6G solution to enhance the ground communication systems in both coverage and capacity. To better utilize the spectrum and fully explore different channel characteristics, this paper constructs an integrated network comprising the High Altitude Platform(HAP) and Unmanned Air Vehicles(UAVs) with the NonOrthogonal Multiple Access(NOMA) technology. In order to improve the transmission quality of images and videos, a power management scheme is proposed to minimize the distortion of the transmissions from the HAP and UAVs to the terminals. The power control is formulated as a non-convex problem constrained by the maximal transmit power and the minimal terminal rate requirements. The variable substitution and the first-order Tailor’s expansion is used to transform it into a sequence of convex problems, which are subsequently solved through the gradient projection method. Simulation demonstrates the signal distortion and error rate improvement achieved by the proposed algorithm.

关键词： Aerial Access Networks High Altitude Platform Non-Orthogonal Multiple Access Sixth-Generation Unmanned Air Vehicles

Asynchronous Observer Design for Switched Linear Systems: A Tube-Based Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 70-81页

作者： Minghao han Ruixian Zhang Lixian Zhang Ye Zhao Wei Pan School of Astronautics Harbin Institute of TechnologyHarbin 150080China School of Mechanical Engineering Georgia Institute of TechnologyAtlanta GA 30332 USA Department of Cognitive Robotics Delft University of TechnologyDelft 2628 CDNetherlands

This paper proposes a tube-based method for the asynchronous observation problem of discrete-time switched linear systems in the presence of amplitude-bounded *** stability conditions of the nominal observer error system under mode-dependent persistent dwell-time(MPDT)switching are first established. Taking the disturbances into account, a novel asynchronous MPDT robust positive invariant(RPI) set and an asynchronous MPDT generalized RPI(GRPI)set are determined for the difference system between the nominal and disturbed observer error systems. Further, the global uniform asymptotical stability of the observer error system is established in the sense of converging to the asynchronous MPDT GRPI set, i.e., the cross section of the tube of the observer error system. Finally, the proposed results are validated on a space robot manipulator example.

关键词： Asynchronous observer design generalized robust positive invariant(GRPI) set mode-dependent persistent dwell-time(MPDT) switched linear systems

Engineering DNA logic systems with non-canonical DNA-nanostructures:basic principles,recent developments and bio-applications

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Science China Chemistry 2022年第2期65卷 284-297页

作者： Daoqing Fan Jun Wang Jiawen han Erkang Wang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQ

Engineering DNA logic systems is considered as one of the most promising strategies for next-generation molecular *** to the inherent features of DNA,such as low cost,easy synthesis,and controllable hybridization,various DNA logic devices with different functions have been developed in the recent ***,a variety of logic-programmed biological applications are also explored,which initiates a new chapter for DNA logic *** this field has gained rapid developments,a systematical review that could not only elaborate the logic principles of diverse DNA logic devices but also outline recent representative works is urgently *** this review,we first elaborate the general classification and logical principle of diverse DNA logic devices,in which the operating strategy of these devices and representative examples are selectively ***,we review state-of-the-art advancements in DNA computing based on different non-canonical DNA-nanostructures during the past decade,in which some classical works are *** that,the innovative applications of DNA computing to logic-controlled bioanalysis,cell imaging,and drug load/delivery are selectively ***,we analyze current obstacles and suggest appropriate prospects for this area.

关键词： DNA logic systems molecular logic non-canonical DNA-nanostructures arithmetic/non-arithmetic functions logical bio-applications