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Combination of Toric and multifocal intraocular lens implantation in bilateral cataract patients with unilateral astigmatism

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1766-1771页

作者： jing-li liang Fang Tian Hong Zhang He Teng Tianjin Medical University Eye Hospital Tianjin 300384China

AIM： To assess the binocular visual function in bilateral cataract patients with unilateral astigmatism after combined implantations of Toric with multifocal intraocular lens （IOL）, and to compare with that of Toric and monofocal IOL ***： All the 30 patients with unilateral astigmatism suffered bilateral cataract were randomly divided into two groups： Toric plus multifocal IOL group and Toric plus monofocal IOL group. Uncorrected and corrected visual acuity at distance （5.0 m）, intermediate distance （0.6 m）, and near （0.33 m）, contrast sensitivity, and stereopsis were assessed 6mo after surgery. Patients were also surveyed for visual disturbances and spectacle ***： Binocular uncorrected visual acuity （LogMAR） of Toric/multifocal IOL eyes at distance, intermediate, near were 0.05±0.05, 0.24±0.10, and 0.14±0.06 respectively. The values of Toric plus monofocal IOL eyes were 0.06±0.07, 0.26±0.08, and 0.37±0.10 respectively. These values did not indicate significant differences between two groups with exception of near visual acuity. In the photopic condition （with or without glare）, the contrast sensitivity of multifocal IOL eyes was significant lower than the monofocal IOL eyes in 18 cpd. In the mesopic condition, the contrast sensitivity of multifocal group was significant lower than monofocal group in 12 cpd, and in mesopic glare condition, this significant difference was found both in 6 cpd and 12 cpd. The stereopsis of Toric/multifocal IOL eyes decreased slightly （100±80 seconds of arc, t=2.222, P=0.136）. Mean near vision for patient satisfaction was statistically significantly higher in Toric/multifocal IOL group patients versus than that in Toric/monofocal IOL group （80% vs 25.5%, P=0.000）. Visual disturbance was not noticed in either ***： Although the combination of Toric and multifocal IOL implantation results in compromising stereoacuity, it can still provide patients with high levels of spectacle freedom and good o

关键词： Toric multifocal intraocular lens binocular cataract unilateral astigmatism

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Changes in the peripapillary vasculature and macular thickness after cataract surgery using two phacoemulsification systems with optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 932-939页

作者： liang-Zhang Tan Fang Tian Lu Chen li-Na Sun Xue Gong jing-li liang Hong Zhang Xiao-Rong li Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

AIM:To assess the changes in the peripapillary vasculature and macular thickness after cataract surgery using two phacoemulsification systems with optical coherence tomography angiography(OCTA).METHODS:Fifty-two eyes of 52 patients with agerelated cataract were randomized into two groups for phacoemulsification:Infiniti group(26 patients)using the Infiniti phacoemulsification system with gravity-fluidics and Centurion group(26 patients)using the Centurion phacoemulsification system with *** peripapillary vessel density(PVD)and macular thickness were examined using OCTA at baseline and at 1d,1 and 3mo after cataract ***:In the Infiniti group,the PVD was significantly reduced at 1d after the cataract surgery(P0.05).In the Centurion group,the VD and thickness in the optic papilla and macula did not significantly change in all regions during the follow-up(all P>0.05).The best-corrected visual acuity(BCVA)significantly improved in both groups postoperatively(P<0.001).CONCLUSION:Using the Infiniti phacoemulsification system,OCTA provides a promising analysis of retinal vascular alterations,demonstrating a reduction of the PVD and an increase in the macular *** Centurion phacoemulsification system can provide better retinal vasculature preservation during cataract surgery.

关键词： cataract surgery phacoemulsification system retinal vasculature optical coherence tomography angiography

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Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes

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Communications in Theoretical Physics 2019年第7期71卷 887-902页

作者： Zhi-Xiong Deng jing-liang li Bing Yuan Kai Yang Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology Soochow UniversitySuzhou 215006China Institute for Frontier Materials Deakin UniversityGeelongAustralia

Pore-forming peptides have promising potentials for biomedical uses due to their ability to permeabilize cell ***,to molecularly engineer them for practical applications is still blocked by the poor understanding of the specific roles of individual residues in peptides’***,using an advanced computational approach that combines Coarse-Grained molecular dynamics and well-tempered metadynamics,the membrane activities of melittin,a representative pore-forming peptide,and its gain-of-function variants,are characterized from the kinetics and thermodynamics *** simulations elucidate the molecular details of peptide-induced membrane poration;during which,some vital intermediate states,including the aggregation and U-shape configuration formation of peptides in the membrane,are observed and further applied as collective variables to construct the multi-dimensional free energy landscapes of the peptide-membrane *** a combination of kinetic and thermodynamic descriptions of the interaction process provides crucial information of residue-specialized contribution in chain conformation and consequently membrane perforation ability of the *** is found that residues at the kink part(***)determine the chain flexibility and U-shape bending of the peptide,while residues near the C-terminus(*** and Lys)are responsible for recruiting neighboring peptides for inter-molecular cooperation;the probable reaction pathway and the poration efficiency are consequently *** results are helpful for a comprehensive understanding of the complicated molecular mechanism of pore-forming peptides and pave the way to rationally design and/or engineer the peptides for practical applications.

关键词： pore-forming peptide lipid membrane melittin molecular dynamics simulations free energy landscape

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Treatment of Hiccup by Finger-pressing Yifeng (TE 17): A Report of 148 Cases

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Journal of Acupuncture and Tuina Science 2003年第3期1卷 59-60页

作者： li jing-liang CUI Yi-jun TCM Department of Huaihe Hospital Affiliated to Henan University Zhengzhou 475000 China

Theauthor treated 148 cases of hiccup by finger-pressing Yifeng (TE 17). After one treatment, 97cases were cured; 34 cases were cured after 2-3 treatments, 6 cases were cured after over 4 treatments; and 11 cases obta... 详细信息

关键词： Hiccup Acupressure Acupuncture-mox ibustion Point TE 17 (Yifeng)

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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing li Xiaoge Wang Xiaofan Cao Zhiqun He Chunjun liang Mingxing Chen jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing Yao Yuan li Xi liu Wenping liang Yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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Protective effects of L-arginine on reperfusion injury after pancreaticoduodenal transplantation in rats

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 349-354页

作者： Chun-Hui Yuan, Yong-Feng liu, Ying Cheng, Ning Zhao, Gui-Chen li,jing liang and San-Guang He Department of Organ Transplantation, First Affiliated Hospital of China Medical University, Shenyang 110001 , China Department of Organ Transplantation First Affiliated Hospital of China Medical University Shenyang 110001 China. ychdoctor@***

BACKGROUND: Post-transplantation pancreatitis andgraft thrombosis are two major complications of pancreastrans-plantation that contribute to morbidity, mortality, andgraft loss. Nitric oxide (NO) is a potent vasodilator agentformed when L-arginine ( L-Arg) is converted to L-citrul-line by the action of NO synthase (NOS), and plays a ma-jor role in microcirculatory changes. We therefore investi-gated the effect of L-Arg on reperfusion injury followingpancreaticoduodenal transplantation in ***: The homologous male Wistar rat model ofheterotopic total pancreaticoduodenal transplantation wasused. The L-Arg-treated rats received the intravenous in-jection of L-Arg 5 minutes before and after reperfusion at adose of 200 mg/kg while the N-Nitro-L-arginine methyl es-ter (L-NAME) -treated rats at a dose of 10 mg/kg. Theamount of NO in the pancreas graft was measured. Serumconcentration of cytokine-induced neutrophil chemoattrac-tant ( CINC) was determined by enzyme-linked immu-nosorbant assay, the expression of CINC mRNA was detect-ed by Northern blot assay in the pancreas graft, and the ac-tivity of myeloperoxidase (MPO) was measured. Histolo-gical examination was ***: The amount of NO was higher in the L-Arggroup than in the control group, while it was lower in theL-NAME group than in the control group (P liorated when L-Arg was administered, whereas the panc-reas damage was aggravated whe

关键词： pancreas transplantation reperfusion L-arginine

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： jingyi liang Fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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基于多变量混沌时间序列的航班运行风险预测模型

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工程科学学报 2020年第12期42卷 1664-1673页

作者：王岩韬李景良谷润平中国民航大学空管学院天津300300

为了提升航班运行风险预测精度,基于某航空公司2016—2018年航班运行风险数据,在验证15个风险时间序列的混沌特性后,构建基于多变量混沌时间序列的风险预测模型.首先,对15个风险时间序列进行多变量相空间重构,采用主成分分析法(PCA)对... 详细信息

为了提升航班运行风险预测精度,基于某航空公司2016—2018年航班运行风险数据,在验证15个风险时间序列的混沌特性后,构建基于多变量混沌时间序列的风险预测模型.首先,对15个风险时间序列进行多变量相空间重构,采用主成分分析法(PCA)对相空间进行降维处理;然后,基于迭代预测的方式,分别采用极限学习机、RBF神经网络、回声状态网络和Elman神经网络建立风险短期预测模型;最后,以降维后的相空间作为输入,计算并比较分析未来1~7 d的风险预测结果.结果表明:多变量相空间重构后总维数为62维,经PCA降维处理,降至31维;在不同的预测模型中,降维后RBF模型预测效果最佳;其中,预测第1天结果相对误差<25%出现频数为82.62%,至第5天仍达75%以上;该模型第1天预测结果的修正平均绝对百分比误差(MAPE)值为11.32%,且前5 d均低于20%,满足航空公司使用要求.1~5 d预测结果对航班风险管控具有实践操作价值,证明基于多变量混沌时间序列的风险预测方案可行、有效.

关键词：航班运行风险风险预测多变量混沌时间序列相空间重构神经网络

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基于栅格空间数据的粤北山区土地可持续利用评价

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测绘通报 2008年第1期 40-43页

作者：黎景良后斌武汉大学遥感信息工程学院湖北武汉430079

土地可持续利用是区域发展的立足之本,是可持续发展战略的核心内容之一,进行科学的土地可持续利用评价具有十分重要的意义。选择粤北山区的韶关市作为研究区域,利用遥感和G IS技术,构建一套适合研究区域的土地可持续利用评价指标体系,... 详细信息

土地可持续利用是区域发展的立足之本,是可持续发展战略的核心内容之一,进行科学的土地可持续利用评价具有十分重要的意义。选择粤北山区的韶关市作为研究区域,利用遥感和G IS技术,构建一套适合研究区域的土地可持续利用评价指标体系,并提出一个土地可持续利用定量评价模型。然后对评价指标数据进行标准化和空间化处理,对研究区域进行基于栅格空间数据的土地可持续利用评价。最后总结研究区的土地可持续利用状况,提出适合研究区域土地可持续利用的可行性建议。

关键词：栅格空间数据粤北山区土地可持续利用评价

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