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Malignant myopericytoma originating from the colon: A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1918-1925页

作者： Heng-Li Zhang Min Zhang jing-Qiang Guo Fang-Nan Wu Jin-De Zhu Chao-Yong Tu Xin-Liang Lv Kun Zhang Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Myopericytoma is a benign tumor that typically occurs within subcutaneous tissue and most often involves the distal extremities,followed by the proximal extremities,neck,thoracic vertebrae and oral *** resection is often *** myopericytoma is extremely rare and has a poor ***,we report for the first time a case of malignant myopericytoma originating from the *** SUMMARY A 69-year-old male was admitted to our hospital with right upper quadrant pain for five *** suggested a liver mass with hemorrhage.A malignant hepatic tumor was the initial *** resection was performed after a complete preoperative work *** postoperative pathology suggested that the mass was a malignant myoblastoma unrelated to the *** months after the first surgery,an enhanced computed tomography(CT)scan revealed a recurrence of the *** diagnosis of malignant myopericytoma derived from the colon was confirmed on histopathological examination of the specimen from the second *** patient did not return to the hospital regularly for *** first postoperative abdominal CT examination six months after the second surgery demonstrated multiple liver *** time between the diagnosis of the tumor to death was approximately one *** Malignant myopericytoma is a rare *** diagnosis may be *** to a lack of treatment options,prognosis is poor.

关键词： Malignant myopericytoma Liver tumor Colonic neoplasms Abdominal pain

“大思政课”视域下高校红色文化资源育人的路径研究

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黑龙江教师发展学院学报 2024年第1期43卷 38-42页

作者：卢凯彭慧洁江峰宜春职业技术学院宜春336000 湖北师范大学黄石435000

全面推进“大思政课”的背景下,要求调动一切育人资源。红色文化资源是党带领人民团结奋斗形成的宝贵育人资源,充分发挥好红色文化资源的育人功能意义重大。基于此,“大思政课”视域下,构建起“大课堂”“大资源”“大师资”协同发力的... 详细信息

全面推进“大思政课”的背景下,要求调动一切育人资源。红色文化资源是党带领人民团结奋斗形成的宝贵育人资源,充分发挥好红色文化资源的育人功能意义重大。基于此,“大思政课”视域下,构建起“大课堂”“大资源”“大师资”协同发力的红色文化资源育人路径,落实好高校立德树人的根本任务。

关键词：大思政课高校红色文化育人路径

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang Minjae Do Michael Christopher Stark Qiwen peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou Ling-Yu Zhang An-Ni Lin Yang Zhang jing Jiang Xin Che Yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity

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Chinese Journal of Natural Medicines 2024年第9期22卷 854-863页

作者： MO Jisong TAN Yufen AI Wenjing LI Yunyun YUAN Yiyun JIANG Yueping XU Kangping TAN Guishan WANG Wenxuan LI jing LIU Shao Department of Pharmacy National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410008China

Four novel macrocyclic trichothecenes,termed mytoxins D-G(1-4),along with four known analogs(5-8),were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria *** compound features a tricyclic 12,13-epoxytrichothec-9-ene(EPT)***,mytoxin G(4)represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene *** structures of the newly identified compounds were elucidated through comprehensive spectroscopic analysis combined with quantum chemical *** isolated compounds demonstrated cytotoxic activity against the CAL27 and HCT116 cell lines,which are models for human oral squamous cell carcinoma and colorectal cancer,***,mytoxin D(1)and mytoxin F(3)exhibited pronounced cytotoxic effects against both cancer cell lines,with IC_(50)values ranging from 3 to 6 nmol·L~(-1).Moreover,compounds 1 and 3 were found to induce apoptosis in HCT116 cells by activating caspase-3.

关键词： Macrocyclic trichothecenes Myrothecium verrucaria Cytotoxicity Secondary metabolite Soil fungi

Analysis of a Typical Case of Meteorological Service in Tangpu Reservoir

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Meteorological and Environmental Research 2024年第2期15卷 44-47页

作者： Quan SHAN Yuxin DING Tingting GU Jinxin WANG kai TANG Zhejiang Meteorological Service Center Hangzhou 310017China

The continuous rainy precipitation process from February to March in 2019 was selected to analyze the effect of meteorological service in Tangpu Reservoir basin,so as to sum up service experience and then lay a better foundation for subsequent *** response to the rainy weather from December 2018 to early 2019,three rounds of flood discharge were carried out in Tangpu *** February-March in 2019,the hit rate of short-term area rainfall forecast for Tangpu Reservoir was 80.0%.Compared with the median of forecast interval,the average absolute error was 7.6 mm,and the relative error was 32.7%.The large deviation in the forecast from March 27 to 28 was deeply analyzed,and it is found that the main reasons were excessive reliance on and trust in a single model,insufficient correction of the actual situation,and insufficient judgment of the nature of *** the future reservoir meteorological service,three aspects of thinking were put forward,such as further strengthening the sharing of hydrological and meteorological information,improving the forecasting ability,and deepening the research of runoff forecast models.

关键词： Tangpu Reservoir Meteorological service Continuous rain Analysis of a typical case

基于数学方法的破碎煤岩体注浆加固效果评价研究

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数学的实践与认识 2024年第7期54卷 220-227页

作者：王晓蕾王晶姬治岗蒋大鹏吕梁学院资源与机械工程系山西吕梁033000

针对破碎煤岩体注浆加固效果如何受多种因素的影响,运用改进的层次分析法确定指标权重,灰色关联确定参评与标准序列关联度,最大关联度对应的向量等级即为破碎煤岩体注浆加固效果评价效果等级.建立了以注浆施工效果评价为目标层的GRA和I... 详细信息

针对破碎煤岩体注浆加固效果如何受多种因素的影响,运用改进的层次分析法确定指标权重,灰色关联确定参评与标准序列关联度,最大关联度对应的向量等级即为破碎煤岩体注浆加固效果评价效果等级.建立了以注浆施工效果评价为目标层的GRA和IAHP的综合评价体系,改进的层次分析法采用“三标度”确定判断矩阵,保证了矩阵的一致性,并对煤矿注浆施工工程进行了效果评价.研究结果表明,破碎煤岩体注浆加固工程效果为“良好”;人员和设备对破碎煤岩体注浆加固效果的影响较大,是破碎煤岩体注浆加固效果评价重点关注的对象;注浆后两帮移近量降低了606mm,降低比达到86.57%,底鼓量降低了928mm,降低比达到了84.36%.基本上达到了治理的目的与评价结果良好基本吻合,为提高注浆效果提供了科学依据.

关键词：矿业工程破碎煤岩体注浆加固效果评价

木质素改性方法及其制备碳纤维的应用研究进展

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复合材料学报 2024年第4期41卷 1764-1775页

作者：沈聪浩章沈翀李靖郭大亮李静沙力争浙江科技大学环境与资源学院杭州310023

木质素作为自然界最丰富的芳香族化合物,其含碳量达30%~40%,是制备碳纤维的优质原料。然而由于存在非晶态化学结构、低分子量、宽分子量分布和排列不良等特性,其复杂的非均质结构和固有的易絮凝特质需通过改性以克服。本文介绍了木质素... 详细信息

木质素作为自然界最丰富的芳香族化合物,其含碳量达30%~40%,是制备碳纤维的优质原料。然而由于存在非晶态化学结构、低分子量、宽分子量分布和排列不良等特性,其复杂的非均质结构和固有的易絮凝特质需通过改性以克服。本文介绍了木质素的基本结构单元与特征,并在此基础上详细描述了物理混合、化学改性、生物作用等改性过程工艺条件及其对木质素结构及木质素基碳纤维的强度、电化学、过滤、透气等性能影响,并在此基础上对碳纤维在交通建筑、航空航天、生命健康及新能源等领域应用进行了拓展探讨。此外,拓展概述了木质素的定向官能团改性、绿色改性方法及改性过程表达等可行性,为木质素基碳纤维复合材料的进一步研究和开发提供思考,并推动其实现工业化应用。

关键词：木质素物化改性碳纤维力学性能电化学性能

Evaluating short-term and long-term liver fibrosis improvement in hepatitis C patients after DAA treatment

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The Journal of Biomedical Research 2024年第05期 464-472页

作者： Yifan Wang Xinyan Ma Yanzheng Zou Ming Yue Meiling Zhang Rongbin Yu Hongbo Chen peng Huang Department of Infectious Disease Jurong Hospital Affiliated to Jiangsu University Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Department of Infectious Diseases the First Affiliated Hospital of Nanjing Medical University

Despite achieving a high cure rate with the direct-acting antivirals(DAAs) in hepatitis C treatment, further research is needed to identify additional benefits of the DAA therapy. The current study evaluated liver fibrosis improvement in 848 hepatitis C patients treated with DAAs, who also achieved sustained virologic response. By the fibrosis-4(FIB-4) index, patients were categorized based on their baseline fibrosis levels, and the improvement in fibrosis was analyzed in both short-term(9–26 weeks) and long-term(≥ 36 weeks) *** results showed a significant decrease in the FIB-4 index, indicating an improvement in liver fibrosis, in63.0% and 67.6% of the patients during the short-term and long-term follow-up, respectively. Short-term improvement was associated with factors including ribavirin usage, blood cholinesterase levels, alanine transaminase levels, albumin levels, and the baseline FIB-4 index, while long-term improvement was associated with factors such as aspartate transaminase levels, total protein level, and the baseline FIB-4 index. The current study emphasizes the importance of continuous assessment and post-treatment monitoring of liver fibrosis, which will provide crucial insights for enhancing patient care in hepatitis C management.

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