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Liquid metal biomaterials: translational medicines,challenges and perspectives

National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu Jincheng Lu Yikuang Xi Xuelin wang jing Liu Department of Biomedical Engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics

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Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： Zi-han wang jing Guo Han-jie Guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

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MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

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Current Medical Science 2024年第1期44卷 195-211页

作者： Xiang-li PANG Jie LI jing wang Si-si YAN jing YANG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Clinic Research Center for Assisted Reproductive Technology and Embryonic Development in Hubei Province Wuhan 430060China

Objective Innate lymphoid cells(ILCs)are a class of newly discovered *** 1 ILCs(ILC1s)are identified in the decidua of humans and *** mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related ***,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling *** study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling *** Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different *** targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were *** addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,***,changes of the NF-κB signaling pathway in ILC1s were examined in the different *** the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling *** The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion

关键词： maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p abortion

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Coherence analysis of noise-like pulses generated by an erbium-doped fiber mode-locked laser

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Optoelectronics Letters 2024年第4期20卷 205-210页

作者： ZHANG Ziyi wang Chuncan LI jing wang Peng Key Laboratory of All Optical Network and Advanced Telecommunication Network Ministry of EducationInstitute of Lightwave TechnologyBeijing Jiaotong University Beijing 100044China

The noise-like pulses(NLPs)with tunable fraction of the pedestal height in the whole intensity autocorrelation(AC)trace are numerically demonstrated in the designed erbium-doped fiber(EDF)mode-locked laser,which contains the saturable absorber(SA)with nonlinear polarization rotation(NPR),sinusoidal-shaped or Gaussian-shaped filter,two segments of EDFs,and two pieces of single-mode fibers(SMFs)with normal dispersion and anomalous dispersion,*** pedestal ratio of the intensity AC trace can be tuned by changing the gain saturation energies of *** results show that when the net cavity dispersion is 1.06 ps^(2),the tuning range of the pedestal ratio for the NLPs can reach its maximum values,which are 0.51—0.89 and 0.58—0.88 for the sinusoidal-shaped and Gaussian-shaped filters,*** addition,an appropriate choice of filter bandwidth is also conducive to obtain a wide range of the tuning pedestal ratio for the intensity AC trace.

关键词： fiber tuning polarization

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Phylogenetic Analysis of Homologous Proteins Encoded by UL2 and UL23 genes of Herpesviridae

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中国病毒学 2007年第3期22卷 207-211页

作者： Long-ding LIU　 Wen-juan WU　 Min HONG　 Hai-jing SHI　 Shao-hui MA　 jing-jing wang　 Hong-ling ZHAO　 Yun LIAO　 Qi-han LI　 Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Kunming 650118 China

The proteins encoded by the Herpesviridae β-gene play a critical role in the replication stage of the *** this paper,phylogenetic analyses provided evidence that some β-gene products,such as UL2 and UL23 from HSV1,have their homologous genes in its family,and also exist in prokaryotic organisms,indicating that these viruses appear to have been assembled over evolutionary time by numerous independent events of horizontal gene transfer.

关键词：系统分析同源蛋白质编码疱疹病毒 UL2基因 β蛋白质 UL23基因

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Flexible Load Participation in Peaking Shaving and Valley Filling Based on Dynamic Price Incentives

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Energy Engineering 2024年第2期121卷 523-540页

作者： Lifeng wang jing Yu Wenlu Ji Nanjing Power Supply Company Nanjing210019China State Grid Jiangsu Electric Power Co. Ltd.Nanjing211103China

Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various moments or motivating users,the design of a reasonable dynamic pricing mechanism to actively engage users in demand response becomes imperative for power grid *** this purpose,a power grid-flexible load bilevel model is constructed based on dynamic pricing,where the leader is the dispatching center and the lower-level flexible load acts as the ***,an upper-level day-ahead dispatching model for the power grid is established,considering the lowest power grid dispatching cost as the objective function and incorporating the power grid-side ***,the lower level comprehensively considers the load characteristics of industrial load,energy storage,and data centers,and then establishes a lower-level flexible load operation model with the lowest user power-consuming cost as the objective ***,the proposed method is validated using the IEEE-118 system,and the findings indicate that the dynamic pricing mechanism for peaking shaving and valley filling can effectively guide users to respond actively,thereby reducing the peak-valley difference and decreasing users’purchasing costs.

关键词： Demand response fixed time-of-use electricity price mechanism dynamic price incentives mechanism bi-level model flexible load

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Complete Genomic Sequence Analysis of a New SV40 Isolate

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中国病毒学 2007年第1期22卷 41-45页

作者： Xue-mei ZHANG Yan-chun CHE jing-jing wang Long-ding LIU Ming-xue XIE Qi-han LI Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan Province 650118 China

从恒河猴孤立的一个新 SV40 种类(SV-IMB ) 的染色体完全被定序并且与其它相比孤立。结果证明整个染色体包含 5246bp，并且 SV-IMB 的 aver 年龄身份作为与另外的 SV40 相比是 98.1% 孤立。它的规章的区域由完全的 enhancer 和有缺点的 ... 详细信息

从恒河猴孤立的一个新 SV40 种类(SV-IMB ) 的染色体完全被定序并且与其它相比孤立。结果证明整个染色体包含 5246bp，并且 SV-IMB 的 aver 年龄身份作为与另外的 SV40 相比是 98.1% 孤立。它的规章的区域由完全的 enhancer 和有缺点的 e enhancer 组成。氨基酸变化在大 T 抗原(标签) 和 VP1 区域发生了到某程度。调查结果证明 SV-IMB 是新 SV40 孤立。关键词 SV40 - 标签 - 规章的区域 CLC 数字 S852.65 基础条款：国家自然科学成立(30570081 )

关键词： SV40 T-Ag Regulatory region

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ConvNeXt-UperNet-Based Deep Learning Model for Road Extraction from High-Resolution Remote Sensing Images

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Computers, Materials & Continua 2024年第8期80卷 1907-1925页

作者： jing wang Chen Zhang Tianwen Lin Geographic Information and Tourism College Chuzhou UniversityChuzhou239000China Anhui Province Key Laboratory of Physical Geographic Environment Chuzhou UniversityChuzhou239000China

When existing deep learning models are used for road extraction tasks from high-resolution images,they are easily affected by noise factors such as tree and building occlusion and complex backgrounds,resulting in incomplete road extraction and low *** propose the introduction of spatial and channel attention modules to the convolutional neural network ***,ConvNeXt is used as the backbone network,which cooperates with the perceptual analysis network UPerNet,retains the detection head of the semantic segmentation,and builds a new model ConvNeXt-UPerNet to suppress noise *** on the open-source DeepGlobe and CHN6-CUG datasets and introducing the DiceLoss on the basis of CrossEntropyLoss solves the problem of positive and negative sample *** results show that the new network model can achieve the following performance on the DeepGlobe dataset:79.40%for precision(Pre),97.93% for accuracy(Acc),69.28% for intersection over union(IoU),and 83.56% for mean intersection over union(MIoU).On the CHN6-CUG dataset,the model achieves the respective values of 78.17%for Pre,97.63%for Acc,65.4% for IoU,and 81.46% for *** with other network models,the fused ConvNeXt-UPerNet model can extract road information better when faced with the influence of noise contained in high-resolution remote sensing *** also achieves multiscale image feature information with unified perception,ultimately improving the generalization ability of deep learning technology in extracting complex roads from high-resolution remote sensing images.

关键词： Deep learning semantic segmentation remote sensing imagery road extraction

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Enhancing CO_(2)capture of an aminoethylethanolamine-based non-aqueous absorbent by using tertiary amine as a proton-transfer mediator:From performance to mechanism

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Journal of Environmental Sciences 2024年第6期140卷 146-156页

作者： Xiaobin Zhou Danwang Chao Liu Guohua jing Bihong Lv Dunqiu wang College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541004China The Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin 541004China College of Chemical Engineering Huaqiao UniversityXiamen 361021China

Non-aqueous absorbents(NAAs)have attracted increasing attention for CO_(2)capture because of their great energy-saving *** diamines which can provide high CO_(2)absorption loading are promising candidates for formulating NAAs but suffer disadvantages in *** this study,a promising strategy that using tertiary amines(TAs)as proton-transfer mediators was proposed to enhance the regenerability of an aminoethylethanolamine(AEEA,diamine)/dimethyl sulfoxide(DMSO)(A/D)***,some employed TAs such as N,N-diethylaminoethanol(DEEA),N,N,N’,N’’,N’’-pentamethyldiethylenetriamine(PMDETA),3-dimethylamino-1-propanol(3DMA1P),and N,N-dimethylethanolamine(DMEA)enhanced not only the regenerability of the A/D NAA but also the CO_(2)absorption ***,the CO_(2)absorption loading and cyclic loading were increased by about 12.7%and 15.5%-22.7%,*** TA-enhanced CO_(2)capture mechanism was comprehensively explored via nuclear magnetic resonance technique and quantum chemical *** CO_(2)absorption,the TA acted as an ultimate proton acceptor for AEEA-zwitterion and enabled more AEEA to form carbamate species(AEEACOO-)to store CO_(2),thus enhancing CO_(2)*** CO_(2)desorption,the TA first provided protons directly to AEEACOO-as a proton donor;moreover,it functioned as a proton carrier and facilitated the low-energy step-wise proton transfer from protonated AEEA to AEEACOO-.Consequently,the presence of TA made it easier for AEEACOO-to obtain protons to decompose,resulting in enhanced CO_(2)*** a word,introducing the TA as a proton-transfer mediator into the A/D NAA enhanced both the CO_(2)absorption performance and the regenerability,which was an efficient way to“kill two birds with one stone”.

关键词： Carbon dioxide capture Non-aqueous absorbent Tertiary amine Proton-transfer mediator Enhanced mechanism

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Development and application of multi-field coupled high-pressure triaxial apparatus for soil

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地下水科学与工程:英文版 2023年第3期11卷 308-316页

作者： Xiu-yan wang Lin Sun Shuai-wei wang Ming-yu wang Jin-qiu Li Wei-chao Sun jing-jing wang Xi Zhu He Di Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China SuperMap Software Co. Ltd.Beijing 100000China

The increasing severity of ground subsidence,ground fissure and other disasters caused by the excessive exploitation of deep underground resources has highlighted the pressing need for effective management.A significant contributing factor to the challenges faced is the inadequacy of existing soil mechanics experimental instruments in providing effective indicators,creating a bottleneck in comprehensively understanding the mechanisms of land *** is urgent to develop a multi-field and multi-functional soil mechanics experimental system to address this *** soil mechanics theories,the existing manufacturing capabilities of triaxial apparatus and the practical demands of the test system,a set of multi-field coupled high-pressure triaxial system is developed tailored for testing deep soils(at depths of approximately 3000 m)and soft *** system incorporates specialized design elements such as high-pressure chamber and horizontal deformation testing *** addition to the conventional triaxial tester functions,its distinctive feature encompass a horizontal deformation tracking measuring device,a water release testing device and temperature control device for the *** ensemble facilitates testing of horizontal and vertical deformation water release and other parameters of samples under a specified stress conditions,at constant or varying temperature ranging from-40℃–90℃.The accuracy of the tested parameters meets the requirements of relevant current *** test system not only provides scientifically robust data for revealing the deformation and failure mechanism of soil subjected to extreme temperature,but also offers critical data support for major engineering projects,deep exploration and mitigation efforts related to soil deformation-induced disaster.

关键词： Multi-field coupled triaxial test High and low temperature Horizontal deformation Compressed water release

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