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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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基于外表面修饰的固态纳米通道用于生物标志物分析的研究进展

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应用化学 2024年第1期41卷 87-99页

作者：袁丽珍林妮娅张云帆胡晶晶娄筱叮夏帆中国地质大学(武汉)生物地质与环境地质国家重点实验室纳米矿物材料及应用教育部工程研究中心材料与化学学院武汉430074

生物标志物,如离子、小分子、蛋白质、多糖、核酸和细胞,参与生物体的构建,在生命过程中发挥重要作用。准确检测这些生物标志物对于疾病研究、早期诊断、药物评估和人类健康监测具有重要意义。外表面功能化固态纳米通道在纳米通道的外... 详细信息

生物标志物,如离子、小分子、蛋白质、多糖、核酸和细胞,参与生物体的构建,在生命过程中发挥重要作用。准确检测这些生物标志物对于疾病研究、早期诊断、药物评估和人类健康监测具有重要意义。外表面功能化固态纳米通道在纳米通道的外表面进行修饰,消除了对靶标分子的限制,通过基于离子信号的变化,提升了检测的速度和灵敏度。本文从外表面修饰的固态纳米通道在生物标志物检测方面进行综述,简要介绍了固态纳米通道外表面功能化的方法,重点总结了外表面修饰的固态纳米通道在生物标志物分析上的研究进展,简要展望外表面修饰的固态纳米通道所面临的挑战与发展机遇。

关键词：纳米通道外表面生物标志物

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Multifunctional aggregates for precise cellular analysis

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Science China Chemistry 2021年第11期64卷 1938-1945页

作者： jing-jing hu Xiaoqi Dong Wenlian Jiang Fan Xia Xiaoding Lou State Key Laboratory of Biogeology and Environmental Geology Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430074China

Precisely analyzing the target materials in living cells can reveal the essence and mystery of life at a deeper level,which will provide reliable theoretical basis for the occurrence,development,treatment and prognosis of major ***,because living cells are in the dynamic process of metabolism,there are several challenges existed in accurate analysis,including subcellular compartment heterogeneity,plasma membrane interface barrier,and cell cycle *** this regard,our group has designed and synthesized a series of multifunctional aggregates by mainly integrating the peptide elements,nucleic acid elements and aggregation elements to overcome the *** article summarizes the latest developments of multifunctional aggregates for precise cell analysis by our group,and systematically introduces them according to different design concepts and targeting dimensions,such as space,efficiency as well as *** hope this work could contribute to analyzing the biomarkers in cells through constructing the multifunctional aggregates,understanding the operation mechanism of cells,finally inspiring technology breakthroughs in biomedical fields.

关键词： precise cellular analysis aggregation induced emission peptide nucleic acid aggregate

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Evaluation of nerve transfer options for treating total brachial plexus avulsion injury： a retrospective study of 73 participants

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Neural Regeneration Research 2018年第3期13卷 470-476页

作者： Kai-ming Gao jing-jing hu Jie Lao Xin Zhao Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Nursing Department Huashan Hospital Fudan University Shanghai China Key Laboratory of Hand Reconstruction Ministry of Health Shanghai China Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai China

Despite recent great progress in diagnosis and microsurgical repair, the prognosis in total brachial plexus-avulsion injury remains *** number of donors and unreasonable use of donor nerves might be key factors. To identify an optimal treatment strategy for this condition, we conducted a retrospective review. Seventy-three patients with total brachial plexus avulsion injury were followed up for an average of 7.3 years. Our analysis demonstrated no significant difference in elbow-flexion recovery between phrenic nerve-transfer （25 cases）, phrenic nerve-graft （19 cases）, intercostal nerve （17 cases）, or contralateral C7-transfer （12 cases） groups. Restoration of shoulder function was attempted through anterior accessory nerve （27 cases）, posterior accessory nerve （10 cases）, intercostal nerve （5 cases）, or accessory ＋ intercostal nerve transfer （31 cases）. Accessory nerve ＋ intercostal nerve transfer was the most effective method. A significantly greater amount of elbow extension was observed in patients with intercostal nerve transfer （25 cases） than in those with contralateral C7 transfer （10 cases）. Recovery of median nerve function was noticeably better for those who received entire contralateral C7 transfer （33 cases） than for those who received partial contralateral C7 transfer （40 cases）. Wrist and finger extension were reconstructed by intercostal nerve transfer （31 cases）. Overall, the recommended surgical treatment for total brachial plexus-avulsion injury is phrenic nerve transfer for elbow flexion, accessory nerve ＋ intercostal nerve transfer for shoulder function, intercostal nerves transfer for elbow extension, entire contralateral C7 transfer for median nerve function, and intercostal nerve transfer for finger extension. The trial was registered at *** （identifier： NCT03166033）.

关键词： nerve regeneration brachial plexus-avulsion injury nerve transfer phrenic nerve accessary nerve contralateral C7 nerve intercostal nerve shoulder function elbow function median nerve radial nerve neural regeneration

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Is it necessary to use the entire root as a donor when transferring contralateral C7 nerve to repair median nerve？

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Neural Regeneration Research 2018年第1期13卷 94-99页

作者： Kai-ming Gao Jie Lao Wen-jie Guan jing-jing hu Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Key Laboratory of Hand Reconstruction Ministry of Health Shanghai China Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai China Nursing Department Huashan Hospital Fudan University Shanghai China

If a partial contralateral C7 nerve is transferred to a recipient injured nerve, results are not satisfactory. However, if an entire contralateral C7 nerve is used to repair two nerves, both recipient nerves show good recovery. These findings seem contradictory, as the above two methods use the same donor nerve, only the cutting method of the contralateral C7 nerve is different. To verify whether this can actually result in different repair effects, we divided rats with right total brachial plexus injury into three groups. In the entire root group, the entire contralateral C7 root was transected and transferred to the median nerve of the affected limb. In the posterior division group, only the posterior division of the contralateral C7 root was transected and transferred to the median nerve. In the entire root ＋ posterior division group, the entire contralateral C7 root was transected but only the posterior division was transferred to the median nerve. After neurectomy,the median nerve was repaired on the affected side in the three groups. At 8, 12, and 16 weeks postoperatively, electrophysiological examination showed that maximum amplitude, latency, muscle tetanic contraction force, and muscle fiber cross-sectional area of the flexor digitorum superficialis muscle were significantly better in the entire root and entire root ＋ posterior division groups than in the posterior division group. No significant difference was found between the entire root and entire root ＋ posterior division groups. Counts of myelinated axons in the median nerve were greater in the entire root group than in the entire root ＋ posterior division group, which were greater than the posterior division group. We conclude that for the same recipient nerve, harvesting of the entire contralateral C7 root achieved significantly better recovery than partial harvesting, even if only part of the entire root was used for transfer. This result indicates that the entire root should be used as a dono

关键词： nerve regeneration peripheral nerve injury brachial plexus injury avulsion injury contralateral C7 transfer nerve root entire root partial root median nerve ulnar nerve animal experiment neural regeneration

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Nanopores/Nanochannels Based on Electrical and Optical Dual Signal Response for Application in Biological Detection

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Chinese Journal of Chemistry 2023年第11期41卷 1374-1384页

作者： Guangwen Lu Niya Lin Zhaojun Chen Wenlian Jiang jing-jing hu Fan Xia Xiaoding Lou State Key Laboratory of Biogeology and Environmental Geology Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanHubei430078 China

Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.

关键词： Biomolecules Nanopores nanochannels Electrical and optical Fluorescence lon current

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Survival trends in gastric cancer patients of Northeast China

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World Journal of Gastroenterology 2011年第27期17卷 3257-3262页

作者： HaoZhang Ling-Ling Sun Yan-Li Meng Guang-Yu Song jing-jing hu PingLu BinJi Department of Hematology Fourth Affili-ated Hospital of China Medical UniversityShenyang110032Liaoning ProvinceChina Departmem of Oncology First Affiliated Hospital of China Medical UniversityShenyang110032Liaoning ProvinceChina

AIM: To describe survival trends in patients in Northeast China diagnosed as gastric cancer. METHODS: A review of all inpatient and outpatient records of gastric cancer patients was conducted in the First Affiliated Hospital of China Medical University. All the gastric cancer patients who satisfied the inclusion criteria from January 1, 1980 through December 31, 2003 were included in the study. The main outcomes were based on median survival and 3-year and 5-year survival rates, by decade of diagnosis. RESULTS: From 1980 through 2003, the median survival for patients with gastric cancer (n = 1604) increased from 33 mo to 49 mo. The decade of diagnosis was not significantly associated with patient survival for gastric cancer (P = 0.084 for overall survival, and P = 0.150 for 5-year survival); however, the survival rate of the 2000s was remarkably higher than that of the 1980s (P = 0.019 for overall survival, and P = 0.027 for 5-year survival).CONCLUSION: There was no significant difference of survival among each period; however, the survival rate of the 2000s was remarkably higher than that of the 1980s.

关键词： Survival trends Gastric cancer Northeast China

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Total synthesis of a putative yuzurimine-type Daphniphyllum alkaloid C_(14)–epi-deoxycalyciphylline H

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Chinese Chemical Letters 2024年第4期35卷 336-339页

作者： jingping hu jing Xu Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhen 518055China

One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contiguous stereogenic centers, and vicinal all-carbon quaternary centers make these alkaloids formidable challenge for synthetic chemists. Recently, synthesis of these alkaloids has received extensive attention from our community. Herein, we wish to report the total synthesis of C_(14)–epideoxycalyciphylline H, a putative member of yuzurimine-type alkaloid subfamily. Key transformations employed in our approach include an intramolecular Prins reaction and a Pd-catalyzed enyne cycloisomerization. In addition, synthesis of a daphnezomine L-type alkaloid, paxdaphnidine A, was also studied.

关键词： Total synthesis Daphniphyllum alkaloids Yuzurimine-type alkaloids Prins reaction Enyne cycloisomerization

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Recent advances in stimuli-responsive theranostic systems with aggregation-induced emission characteristics

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聚集体(英文) 2021年第1期2卷 48-65页

作者： jing-jing hu Wenlian Jiang Lizhen Yuan Chong Duan Qiming Yuan Zi Long Xiaoding Lou Fan Xia Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanChina

Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into one platform have attracted numerous attentions from worldwide *** the great developments,their clinical application is still in the nascent stage,owing to the unsatisfied imaging quality and limited therapeutic ***,the emerging of aggregation-induced emission(AIE)molecules with unique fluorescence property offers an opportunity to solve the imaging ***,further utilizing the tumor microenvironments and external triggers to design the stimuli-responsive imaging-guided therapy could enhance the therapeutic efficacy and reduce the side *** this review,the advancements in stimuli-responsive theranostic systems with AIE characteristics are *** systems are first classified according to their treatment modes,and then subdivided based on various stimuli,including pH,redox,enzyme,and *** each section,the design strategies and application examples are *** last,the current state of the art,limitations,as well as prospects are also discussed.

关键词： aggregation induced emission imaging stimuli-responsive theranostics tumor therapy

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Surface reconstruction of heterostructures in alkaline medium towards enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第6期43卷 2636-2647页

作者： Ming-Yang Yang Ji Yuan Xue-Lian Fu jing-jing Chen jing hu Zhou-Guang Lu Chen Liu Guangdong Research Center for Interfacial Engineering of Functional Materials Shenzhen Key Laboratory of Polymer Science and TechnologyShenzhen Key Laboratory of Energy Electrocatalytic MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Constructing heterostructures has proved to be a successful strategy to fabricate electrocatalysts with high efficiency for water ***,the structure evolution in alkaline hydrogen evolution reaction lacks investigation and the specific active center remains ***,we take the well-designed Ni_(3)S_(2)@VO_(2) heterostructures as a model to investigate the electrocatalytic activity and the surface reconstruction process of heterostructure catalysts in alkaline *** Ni_(3)S_(2)@VO_(2) heterostructures,with Ni_(3)S_(2) nanorods as the core and VO_(2) nanoflakes as the shell,coupled with the high conductive Ni_(3)S_(2),the hydrophilic VO_(2) and modulated electronic structures at the interfaces,exhibited prominent activity and superior stability at various current ***,the ex-situ characterizations confirmed that the surface reconstruction from Ni_(3)S_(2)@VO_(2) into Ni_(3)S_(2)@amorphous-Ni(OH)_(2) in alkaline media could optimize the water dissociation barrier and exposed large active area,thereby contributing to improved electrocatalytic *** study not only introduces novel high-performance electrocatalysts for hydrogen evolution reaction(HER),but also provides a new avenue for re-examining hetero-structural catalysts in alkaline solutions.

关键词： Heterostructures Ni_(3)S_(2)@VO_(2) Surface reconstruction Water dissociation Alkaline hydrogen evolution

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