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Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics

Protein & Cell 2024年第5期15卷 364-384页

作者： Huifen Lu Ying jing Chen Zhang Shuai Ma Weiqi Zhang Daoyuan Huang Bin Zhang Yuesheng zuo Yingying Qin Guang-Hui Liu Yang Yu jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration CASBeijing 100101China China National Center for Bioinformation Beijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking UniversityThird HospitalBeijing 100191China Clinical Stem Cell Research Center Peking UniversityThird HospitalBeijing 100191China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthJinan 250012China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Biomarker Consortium Beijing 100101China

The ovary is indispensable for female reproduction,and its age-dependent functional decline is the primary cause of ***,the molecular basis of ovarian aging in higher vertebrates remains poorly ***,we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these to aged primate *** a global view,somatic cells within the non-follicle region undergo more pronounced transcriptional fluctuation relative to those in the follicle region,likely constituting a hostile microenvironment that facilitates ovarian ***,we uncovered that inflammation,the senescent-associated secretory phenotype,senescence,and fibrosis are the likely primary contributors to ovarian aging(PCOA).Of note,we identified spatial co-localization between a PCOA-featured spot and an unappreciated MT2(Metallothionein 2)highly expressing spot(MT2^(high))characterized by high levels of inflammation,potentially serving as an aging hotspot in the primate ***,with advanced age,a subpopulation of MT2^(high)accumulates,likely disseminating and amplifying the senescent signal *** study establishes the first primate spatiotemporal transcriptomic atlas,advancing our understanding of mechanistic determinants underpinning primate ovarian aging and unraveling potential biomarkers and therapeutic targets for aging and age-associated human ovarian disorders.

关键词： spatial transcriptome primate ovary aging senescence inflammation

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Surface-targeted functionalization of nickel-rich cathodes through synergistic slurry additive approach with multi-level impact using minimal quantity

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Nano Research 2024年第1期17卷 333-343页

作者： jing Zhang Jiapei Li Longhao Cao Wenhua Cheng Ziyin Guo Xiuxia zuo Chao Wang Ya-Jun Cheng Yonggao Xia Yudai Huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China School of Materials Science and Engineering Tongji UniversityShanghai 200240China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

LiNi0.8Co0.1Mn0.1O_(2)(NCM811),a Ni-rich layered oxide,is a promising cathode material for high-energy density lithium-ion batteries(LIBs).However,its structural instability,caused by adverse phase transitions and continuous oxygen release,as well as deteriorated interfacial stability due to excessive electrolyte oxidative decomposition,limits its widespread *** address these issues,a new concept is proposed that surface targeted precise functionalization(STPF)of the NCM811 cathode using a synergistic slurry additive(SSA)*** approach involves coating the NCM811 particle surface with 3-aminopropyl dimethoxy methyl silane(3-ADMS),followed by the precise deposition of ascorbic acid via an acid-base *** slurry additives induce the formation of an ultra-thin spinel surface layer and a stable cathode–electrolyte interface(CEI),which enhances the electrochemical kinetics and inhibits crack *** STPF strategy implemented by the SSA approach significantly improves the cyclic stability and rate performance of the NCM811 cathode in both half-cell and full-cell *** work establishes a promising strategy to enhance the structural stability and electrochemical performance of nickel-rich cathodes and provides a feasible route to promote practical applications of high-energy density lithium-ion battery technology.

关键词： nickel-rich cathode slurry additive lithium-ion battery cathode–electrolyte interface ascorbic acid phase transition

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2:17-type SmCo permanent magnets with controllable remanence temperature coefficients via substitution of heavy rare earth elements

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Rare Metals 2024年第8期43卷 3990-3996页

作者： Jia-Yi Huang Shu-Lan zuo Qi Zhang Hong-Yang Dai Lei Yang jing-Hua Liu Cheng-Bao Jiang Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and EngineeringBeihang University

Permanent magnets that can maintain a constant magnetic flux over a wide temperature range are highly desirable in certain applications such as precision instruments.2:17-type SmCo permanent magnets are promising for such instruments owing to their excellent high-temperature magnetic properties that can be further manipulated byadding heavy rare earth elements (HREs).

关键词： Rare earths

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Intermediate phase-assisted growth of CsPbBr_(3) for high performance of carbon-based perovskite solar cells

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Rare Metals 2024年第5期43卷 2222-2229页

作者： Bo-Yan Liu He-Ming Yang Yu-Dong zuo Zhi-Hao Tao Jun-Chun Li Ya-jing Chang Guo-Qing Tong Yang Jiang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037China

CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against *** high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar ***,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as *** TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[***]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high *** combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.

关键词： CsPbBr_(3) Perovskite solar cells Carbon electrode Hole transport layer free Intermediate phase

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Recent development of aspiration pump in the aspiration thrombectomy system

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Medicine in Novel Technology and Devices 2024年第2期22卷 1-8页

作者： Chen Wei jing Dong Hongyi Yang jinghong Shi Huihui Fang Yangjie zuo Yubing Shi The Second Clinical College of Medicine Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Department of Cardiology the Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Institute of Integrative Medicine Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina School of Medical Technology Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina School of Engineering Staffordshire UniversityStoke-on-TrentStaffordshireUK

Vascular embolic diseases are associated with blockage of blood supply to vital organs and thus are *** thrombectomy is becoming the primary choice for revascularization in the treatment of vascular occlusions *** the power source in the aspiration thrombectomy procedure,the aspiration pump directly influences the outcome of the *** research surveyed the current technical developments of the aspiration pump in China through reviewing information obtained from the patent database and technical literatures,commented on the issues in the current patent designs,and gave suggestions for future design *** study can be used as a reference for researchers and developers of medical devices besides the neurosurgeons.

关键词： Aspiration pump Thrombus Thrombectomy Vascular embolic diseases Aspiration thrombectomy

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Unraveling magnetic properties and martensitic transformation in Mn-rich Ni-Mn-Sn alloys:first-principles calculations and experiments

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Rare Metals 2024年第4期43卷 1769-1785页

作者： Yu Zhang jing Bai Ke-Liang Guo Jia-Xin Xu Jiang-Long Gu Nicola Morley Qui-Zhi Gao Yu-Dong Zhang Claude Esling Xiang Zhao Liang zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao066004China Department of Material Science and Engineering University of SheffieldSheffieldS13JDUK State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China Laboratoire d’Étude des Microstructures Et de Mécanique des Matériaux University of Lorraine57045MetzFrance

We have investigated the phase stability,magnetic properties,and martensitic transformation thermodynamics/kinetics of the Ni_(24-x)Mn_(18+x+y)Sn_(6-y)(x,y=0,1,2)system by combining the first-principles calculations and *** calculation results show that the optimized lattice parameters are consistent with the experimental ***,we obtain the relation equation for the austenite formation energy(E_(form-A))and Mn content(X_(Mn)):E_(form-A)=507.358X_(Mn)-274.126,as well as for the six-layer modulated(6M)martensite formation energy(E_(form-6M))and Ni content(X_(Ni)):E_(form-6M)=-728.484X_(Ni)+*** ternary phase diagram of the total magnetic moment was *** excess Mn will reduce the total magnetic moment of 6M(Mag6M)and non-modulated(NM)(MagNM)martensites,with the following equations relating the total magnetic moment and Mn content:Mag_(6M)=-15.905X_(Mn)+7.902and Mag_(NM)=-14.781X_(Mn)+7.411,while the effect on austenite is *** variation of total magnetic moment is mainly dominated by the Mn atomic magnetic *** 3d electrons of Mn_(Sn)(Mn at Sn sublattice)play an important role in magnetic properties from the perspective of the electronic density of *** on the thermodynamics of martensitic transformation,the alloys will likely undergo austenite?6M?NM transformation *** the thermodynamic and kinetic results,the martensitic transformation temperature decreases with x increasing and increases with y *** results are expected to provide reference for predicting the phase stability and magnetic properties of NiMn-Sn alloys.

关键词： Ni-Mn-Sn First-principles calculations Martensitic transformation Magnetic property Kinetics

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A review of research progress on continuous cropping obstacles

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 253-270页

作者： Kunguang WANG Qiaofang LU Zhechao DOU Zhiguang CHI Dongming CUI jing MA Guowei WANG Jialing KUANG Nanqi WANG Yuanmei zuo College of Resources and Environmental Sciences State Key Laboratory of Nutrient Use and ManagementNational Academy of Agriculture Green DevelopmentChina Agricultural UniversityBeijing 100193China College of Resources and Environmental Sciences Southwest UniversityChongqing 400715China Yunnan ICL YTH Phosphate Research and Technology Co. Ltd.Kunming 650228China

Due to the increasing global population and limited land resources, continuous cropping has become common. However, after a few years of continuous cropping, obstacles often arise that cause soil degeneration, decreased crop yield and quality, and increased disease incidence, resulting in significant economic losses. It is essential to understand the causes and mitigation mechanisms of continuous cropping obstacles(CCOs) and then develop appropriate methods to overcome them. This review systematically summarizes the causes and mitigation measures of soil degradation in continuous cropping through a meta-analysis. It was concluded that not all continuous cropping systems are prone to CCOs. Therefore, it is necessary to grasp the principles governing the occurrence of diseases caused by soilborne pathogens in different cropping systems, consider plant–soil-organisms interactions as a system, scientifically regulate the physical and chemical properties of soils from a systems perspective, and then regulate the structure of microbial food webs in the soil to achieve a reduction in diseases caused by soilborne pathogens and increase crop yield ultimately. This review provides reference data and guidance for addressing this fundamental problem.

关键词： Continuous cropping obstacles rhizosphere regulation soil microecological environment

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Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA Koen ZHANG jing Xian XIE Wei ZONG Wen Qi zuo Hui ZHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

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Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang jing Wang Ji-Sheng Zhong Ai-Hua Li Ya-jing Yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

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Spatial continuous modeling of early Cenozoic carbon cycle and climate

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National Science Review 2024年第4期11卷 30-32页

作者： Yonggang Liu Jian Zhang Haoyue zuo Zhilin He Jiaqi Guo Qifan Lin Haonan Yu Jiawenjing Lan jing Han Zhihong Song Zihan Yin Liang Zhao Yongyun Hu Zhengtang Guo Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic Sciences School of Physics Peking University Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences

The partial pressure of atmospheric CO2（pCO2） is determined by the carbon cycle that involves climate, biogeochemistry, and plate tectonics. In this cycle,atmospheric CO2is converted into organic carbon and carbonates by biological activities and silicate weathering, and buried as sediments. The sediments on the ocean floor are subducted into the Earth’s interior, and subsequently converted back into CO2and outgassed into the atmosphere.

关键词： ATMOSPHERIC CO2

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