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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan jing-jing zhao Liang Liu Dong-Sheng Zhang Li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains poor.This phase 3 trial(ClinicalTrials.gov:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and bevacizumab.The main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 months.Median PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths reported.The addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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Multiple indicators and analytic hierarchy process(AHP)for comprehensive performance evaluation of exhaust hood

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Building Simulation 2022年第6期15卷 1097-1110页

作者： jing-jing zhao Ruo-ning Chen Jia-hua Wang Xue-yi You Tianjin Key Lab of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjinChina Ningbo FOTILE Kitchen Ware Co. Ltd.NingboChina

Indicators are the basis for judging the working performance of exhaust hood and capture performance are usually used as the only indicator.An evaluation index system including three factors of cooking oil fumes(COF)instantaneous capture,health risk impact and thermal comfort was proposed to assess the comprehensive performance of exhaust hood in the present study.The primary capture efficiency(PCE)of formaldehyde,the PCE of particulate matter with the diameter less than or equal to 2.5μm(PM_(2.5)),the incremental lifetime cancer risk(ILCR)of formaldehyde,the ILCR of PM_(2.5)and the predicted mean vote(PMV),which can all be quantified with the aid of computational fluid dynamics(CFD),were selected as the indicators.And the analytic hierarchy process(AHP)method was introduced to perform the comprehensive performance evaluation of exhaust hood.The performance of two exhaust hood structures(grille and orifice type)with three exhaust rates(3000,4000,and 5000 m^(3)/h)in two cooking zones of a university canteen kitchen were evaluated.The result showed that the reduction of ILCR of COF exposure is the most important to the performance of exhaust hood.The comprehensive performance of orifice exhaust hood with exhaust rate of 4000 and 5000 m^(3)/h are optimal;the orifice exhaust hood with exhaust of 3000 m^(3)/h and grille exhaust hood with exhaust rate of 5000 m^(3)/h are moderate;the grille exhaust hood with exhaust rate of 3000 and 4000 m^(3)/h are low.Decision-making priorities based on comprehensive and individual performance are not exactly the same in the two cooking zones.It is necessary to use the index system to evaluate the comprehensive performance of exhaust hood that considers the impact on human health and thermal comfort.

关键词： evaluation index system analytic hierarchy process comprehensive performance exhaust hood computational fluid dynamics

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Corneal histomorphology and electron microscopic observation of R124L mutated corneal dystrophy in a relapsed pedigree

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1416-1422页

作者： Meng-Jun Fu jing zhao Shan Duan Hao-Run Zhang jing-jing zhao Li Zeng Rui Wang Xing-Tao Zhou Department of Refractive Surgery Center Weifang Eye HospitalWeifang 261000Shandong ProvinceChina State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200000China Laboratory of Molecular Medicine Institute of Maternal and Child MedicineShenzhen Maternity and Child HealthcareHospitalSouthern Medical UniversityShenzhen 518040Guangdong ProvinceChina

·AIM:To investigate the histological characteristics and ultrastructure of recurrent Chinese R124 L mutated corneal dystrophy after keratoplasty.·METHODS:The subjects were enrolled from a Chinese family of corneal dystrophy with R124 L heterozygous gene mutation and with a history of consanguineous marriage.Normal corneal samples were used as controls.·RESULTS:In this family,2 patients(3 eyes)underwent penetrating keratoplasty(PKP)and 2 patients(4 eyes)underwent lamellar keratoplasty(LKP).They had recurrence at 33.5±3.0(range 30-36)mo after keratoplasty.Among them,1 patient(1 eye)underwent PKP again and 1 patient(2 eyes)underwent LKP again.In the R124 L mutated recurrent corneal dystrophy,the corneal turbidity was mainly distributed from the upper corneal cortex to the anterior stroma;the corneal epithelium surface was rougher and more uneven;and,the corneal erosions were larger.Hematoxylin-eosin staining showed that the thickness of the corneal epithelium was uneven;the arrangement of the epithelial cells was disordered;and,some corneal epithelial cells were swollen.The results of Congo red staining,Masson’s trichrome staining and Periodic acid-Schiff staining were positive,while that of Alcian blue staining was negative.Under a transmission electron microscope,deposition of high electron density substances between epithelial and basal cells,and,apoptosis of basal cells were observed.Many high electron density depositions were observed in the sub-epithelial and anterior corneal matrix.·CONCLUSION:In the Chinese family of recurrent corneal dystrophy with R124 L gene mutation,the corneal epithelia of the recurrent cases are rougher,and the corneal depositions are extra cellular amyloid fibrin.

关键词： corneal dystrophy R124L mutation electron microscope observation pathology

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Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPAR_γ and NF-_κB

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World Journal of Gastroenterology 2012年第14期18卷 1680-1688页

作者： Hui Yang Long-Feng zhao Zhong-Fu zhao Yan Wang jing-jing zhao Li Zhang Department of Infectious Diseases the First AffiliatedHospital of Shanxi Medical University Taiyuan 030001 ShanxiProvince China Institute of Hepatopathy Changzhi MedicalCollege Changzhi 046000 Shanxi Province China

AIM:To investigate the effects of heme oxygenase(HO)-1 on liver fibrosis and the expression of peroxisome proliferator-activated receptor gamma(PPARγ) and nuclear factor-kappa B(NF-κB) in rats.METHODS:Sixty Wistar rats were used to construct liver fibrosis models and were randomly divided into 5 groups:group A(normal,untreated),group B(model for 4 wk,untreated),group C(model for 6 wk,untreated),group D [model for 6 wk,treated with zinc protoporphyrin Ⅸ(ZnPP-Ⅸ) from week 4 to week 6],group E(model for 6 wk,treated with hemin from week 4 to week 6).Next,liver injury was assessed by measuring serum alanine aminotransferase(ALT),aspartate aminotransferase(AST) and albumin levels.The degree of hepatic fibrosis was evaluated by measuring serum hyaluronate acid(HA),type Ⅳ collagen(Ⅳ-C) and by histological examination.Hydroxyproline(Hyp) content in the liver homogenate was determined.The expres-sion levels of alpha-smooth muscle actin(α-SMA) in liver tissue were measured by real-time quantitative polymerase chain reaction(RT-PCR).The expression levels of PPARγ and NF-κB were determined by RT-PCR and Western blotting.RESULTS:The expression of HO-1 increased with the development of fibrosis.Induction of HO-1 by hemin significantly attenuated the severity of liver injury and the levels of liver fibrosis as compared with inhibition of HO-1 by ZnPP-Ⅸ.The concentrations of serum ALT,AST,HA and Ⅳ-C in group E decreased compared with group C and group D(P < 0.01).Amount of Hyp and α-SMA in the liver tissues in group E decreased compared with group C(0.62 ± 0.14 vs 0.84 ± 0.07,1.42 ± 0.17 vs 1.84 ± 0.17,respectively,P < 0.01) and group D(0.62 ± 0.14 vs 1.11 ± 0.16,1.42 ± 0.17 vs 2.56 ± 0.37,respectively,P < 0.01).The expression of PPARγ at levels of transcription and translation decreased with the development of fibrosis especially in group D;and it increased in group E compared with groups C and D(0.88 ± 0.15 vs 0.56 ± 0.19,0.88 ± 0.15 vs 0.41 ± 0.11,respectively,P < 0.01).The expression of NF-κB increased with the development o

关键词：血红素氧合酶-1 Wistar大鼠肝纤维化过氧化物酶体增殖物激活受体 α-平滑肌肌动蛋白 Western印迹核因子-κB RT-PCR

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Linking satellite-based spring phenology to temperate deciduous broadleaf forest photosynthesis activity

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International Journal of Digital Earth 2014年第11期7卷 881-896页

作者： jing-jing zhao Liang-Yun Liu Key Laboratory of Digital Earth Science Center for Earth Observation and Digital EarthUniversity of Chinese Academy of SciencesBeijingChina

Satellite-based remote sensed phenology has been widely used to assess global climate change.However,it is constrained by uncertain linkages with photo-synthesis activity.Two dynamic threshold methods were employed to retrieve spring phenology metrics from four Moderate Resolution Imaging Spectro-radiometer(MODIS)products,including fraction of Absorbed Photosyntheti-cally Active Radiation(fAPAR),Leaf Area Index(LAI),Normalized Difference Vegetation Index(NDVI),and Enhanced Vegetation Index(EVI)for three temperate deciduous broadleaf forests in North America between 2001 and 2009.These MODIS-based spring phenology metrics were subsequently linked to the photosynthetic curves(daily gross primary productivity,GPP)measured by an eddy covariance flux tower.The 20% dynamic threshold spring onset metrics from MODIS products were closer to the photosynthesis onset metrics at the date of 2% GPP increase for NDVI and fAPAR,and closer to the date of 5%and 10% increase of GPP for EVI and LAI,respectively.The 50% dynamic threshold onset metrics were closer to the photosynthesis onset metrics at the date of 10%GPP increase for NDVI,and closer to the date of 20% GPP increase for fAPAR,LAI and EVI,respectively.These results can improve our knowledge on the photosynthesis activity status of remotely sensed spring phenology metrics.

关键词： MODIS spring phenology deciduous broadleaf forest GPP eddy covariance flux tower photosynthesis activity period

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Huangqin flavonoid extraction for spinal cord injury in a rat model

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Neural Regeneration Research 2018年第12期13卷 2200-2208页

作者： Qian Zhang Li-Xin Zhang jing An Liang Yan Cui-Cui Liu jing-jing zhao Hao Yang Translational Medicine Center Hong Hui Hospital Xi'an Jiaotong University Department of Clinical Pharmacy Hong Hui Hospital Xi'an Jiaotong University Department of Spine Surgery Hong Hui Hospital Xi'an Jiaotong University

Flavonoids from Huangqin（dried roots of Scutellaria baicalensis Georgi） have anti-inflammatory effects, and are considered useful for treatment of spinal cord injury. To verify this hypothesis, the T9-10 spinal cord segments of rats were damaged using Allen＇s method to establish a rat spinal cord injury model. Before model establishment, Huangqin flavonoid extraction（12.5 g/kg） was administered intragastrically for 1 week until 28 days after model establishment. Methylprednisolone（30 mg/kg） was injected into the tail vein at 30 minutes after model establishment as a positive control. Basso, Beattie, and Bresnahan locomotor scale scores were used to assess hind limb motor function. Hematoxylin-eosin staining was used to detect pathological changes in the injured spinal cord. Immunofluorescence and western blot assays were performed to measure immunoreactivity and expression levels of brain-derived neurotrophic factor, neuronal marker neurofilament protein, microglial marker CD11 b and astrocyte marker glial fibrillary acidic protein in the injured spinal cord. Huangqin flavonoid extraction markedly reduced spinal cord hematoma, inflammatory cell infiltration and cavities and scars, and increased the Basso, Beattie, and Bresnahan locomotor scale scores; these effects were identical to those of methylprednisolone. Huangqin flavonoid extraction also increased immunoreactivity and expression levels of brain-derived neurotrophic factor and neurofilament protein, and reduced immunoreactivity and expression levels of CD11 b and glial fibrillary acidic protein, in the injured spinal cord. Overall, these data suggest that Huangqin flavonoid extraction can promote recovery of spinal cord injury by inducing brain-derived neurotrophic factor and neurofilament protein expression, reducing microglia activation and regulating reactive astrocytes.

关键词： nerve regeneration spinal cord injury flavonoids Scutellaria baicalensis neurofilament brain-derived neurotrophic factor astrocytes rnicroglia neural regeneration

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Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle

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Chinese Medical Journal 2016年第7期129卷 881-882页

作者： jing-jing zhao Ming Xie Ruo-Kun Huang Kai Xiao Department of Orthopedics Wuhan Pu'ai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430033 China

To the Editor： Tenosynovial giant cell tumor （TSGCT） has a localized and a diffuse form. Localized form, in 80-90% of cases, occurs in the hand joints, and infrequently in the knee and the ankle and around the lateral malleolus, without adhesion to the skin [Figure la], moreover, the patient＇s gait pattern and mobility of the ankle showed no abnormalities. X-ray images of

关键词： lateral malleolus adhesion

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Peripapillary retinal nerve fiber layer thickness distribution in Chinese with myopia measured by 3D-optical coherence tomography

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 626-631页

作者： jing-jing zhao Wen-Juan Zhuang Xue-Qiu Yang Shan-Shan Li Wei Xiang Weifang Eye Hospital Department of Ophthalmology General Hospital of Ningxia Medical University Shandong Eye Hospital Shandong Eye Institute Shangdong Acadeny of Medical Sciences Yinchuan Health Inspection Bureau

AIMTo assess the effect of myopia on the thickness of retinal nerve fiber layer (RNFL) measured by 3D optical coherence tomography (3D-OCT) in a group of nonglaucomatous Chinese subjects.

关键词： optical coherence tomography myopia retinal nerve fiber layer

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Effect of anti-asthma Chinese medicine Chuankezhi on the anti-tumor activity of cytokine-induced killer cells

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Chinese Journal of Cancer 2013年第10期32卷 553-560页

作者： jing-jing zhao Ke Pan Qi-jing Wang Zheng-Di Xu De-Sheng Weng Jian-Jun Li Yong-Qiang Li Jian-Chuan Xia State Key Laboratory of Oncology in South China Department of Experimental Research Sun Yat-sen University Cancer Center Department of Biotherapy Center Sun Yat-sen University Cancer Center Guangzhou ImVin Pharmaceuticals Co. Ltd

Chuankezhi(CKZ),a new Chinese medicine,plays an important role in immunoregulation.Cytokineinduced killer(CIK)cells have been commonly used for immunotherapy in recent years.In this study,we aimed to investigate the immunoregulatory effect of CKZ on CIK cells.Peripheral blood monocytes were isolated from healthy donors,and CIK cells were generated by culturing monocytes with interferon-gamma(IFN-γ)and interleukin 2.Different concentrations of CKZ were added on day 2.After incubation for 14days in culture,the antitumor effects of CIK cells were measured by cytotoxicity assay.Flow cytometry was used to explore the effect of CKZ on CIK cell immunophenotype,intracellular cytokine production,and apoptosis.The effect of CKZ on the antitumor activity of CIK cells in nude mice was also investigated.CKZ increased the percentage of CD3+CD56+CIK cells but did not significantly change the percentage of CD4+,CD8+,or CD4+CD25+CIK cells.CKZ-conditioned CIK cells showed a greater ability to kill tumor cells,as well as a higher frequency of IFN-γand TNF-αproduction,compared with the CIK cells in the control group.CKZ also suppressed the apoptosis of CIK cells in vitro.Furthermore,CKZ combined with CIK cells had a stronger suppressive effect on tumor growth in vivo than the CIK,CKZ,or normal saline control groups.Our results indicate that CKZ enhances the antitumor activity of CIK cells and is a potential medicine for tumor immunotherapy.

关键词：抗肿瘤活性杀伤细胞中国医药细胞因子外周血单核细胞抗哮喘免疫调节作用 IFN-γ

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Remote Ischemic Postconditioning for Ischemic Stroke： A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Chinese Medical Journal 2018年第8期131卷 956-965页

作者： jing-jing zhao Hui Xiao Wen-Bo zhao Xiao-Pei Zhang Yu Xiang Zeng-Jie Ye Miao-Miao Mo Xue-Ting Peng Lin Wei Department of Nursing Chongqing Medical and Pharmaceutical College Chongqing 401331 China Nursing Department Guangdong Province Hospital of Chinese Medicine Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China Department of Nephrology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 510632 China Department of Neurology Guangdong Province Hospital of Chinese Medicine Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China Department of Neurology Huaihua Hospital of Traditional Chinese Medicine Huaihua Hunan 418000 China Department of Economics and Management Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China The Second Clinical Medical College Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China

Background：Remote ischemic postconditioning （RIPostC） appears to protect distant organs from ischemia-reperfusion injury （IRI）. However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC.Methods：CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, risk ratio （RR） and mean difference （MD） with 95% confidence interval （CI） were calculated.Results：A total of 13 randomized controlled trials that enrolled a total of 794 study participants who suffered from or are at risk for brain IRI were selected. Compared with controls, RIPostC significantly reduced the recurrence of stroke or transient ischemic attacks （RR = 0.37; 95% CI： 0.26–0.55; P 〈 0.00001）. Moreover, it can reduce the levels of the National Institutes of Health Stroke Scale score （MD： 1.96; 95% CI： 2.18–1.75; P 〈 0.00001）, modified Rankin Scale score （MD： 0.73; 95% CI： 1.20–0.25; P = 0.00300）, and high-sensitivity C-reactive protein （MD： 4.17; 95% CI： 4.71–3.62; P 〈 0.00001） between the two groups. There was no side effect of RIPostC using tourniquet cuff around the limb on ischemic stroke treating based on different intervention duration.Conclusion：The present meta-analysis suggests that RIPostC might offer cerebral protection for stroke patients suffering from or are at risk of brain IRI.

关键词： Ischemic Stroke Meta-Analysis Remote Ischemic Postconditioning

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