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Study of the pressure transient behavior of directional wells considering the effect of non-uniform flux distribution

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Petroleum Science 2024年第3期21卷 1765-1779页

作者： yan-Zhong Liang Bai-Lu Teng Wan-jing Luo School of Energy Resources China University of Geosciences(Beijing)Beijing100083China

During the production,the fluid in the vicinity of the directional well enters the wellbore with different rates,leading to non-uniform flux distribution along the directional ***,in all existing studies,it is oversimplified to a uniform flux distribution,which can result in inaccurate results for field ***,this paper proposes a semi-analytical model of a directional well based on the assumption of non-uniform flux ***,the direction well is discretized into a carefully chosen series of linear sources,such that the complex well trajectory can be captured and the nonuniform flux distribution along the wellbore can be considered to model the three-dimensional flow *** using the finite difference method,we can obtain the numerical solutions of the transient flow within the *** the aid of Green's function method,we can obtain the analytical solutions of the transient flow from the matrix to the *** complete flow behavior of a directional well is perfectly represented by coupling the above two types of transient ***,on the basis of the proposed model,we conduct a comprehensive analysis of the pressure transient behavior of a directional *** computation results show that the flux variation along the direction well has a significant effect on pressure *** addition,the directional well in an infinite reservoir may exhibit the following flow regimes:wellbore afterflow,transition flow,inclined radial flow,elliptical flow,horizontal linear flow,and horizontal radial *** horizontal linear flow can be observed only if the formation thickness is much smaller than the well ***,a dip region that appears on the pressure derivative curve indicates the three-dimensional flow behavior near the wellbore.

关键词： Directional well Pressure transient behavior Semi-analytical model Non-uniform flux

Advances in surface plasmon resonance for analyzing active components in traditional Chinese medicine

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1397-1406页

作者： jing Xie Xian-Deng Li Mi Li Hong-yan Zhu yan Cao Jian Zhang A-jing Xu Faculty of Pharmacy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200092China Department of Biochemical Pharmacy School of PharmacySecond Military Medical UniversityShanghai200433China

The surface plasmon resonance(SPR)biosensor technology is a novel optical analysis method for studying intermolecular *** to in-depth research on traditional Chinese medicine(TCM)in recent years,comprehensive and specific identification of components and target interactions has become key yet difficult *** has gradually been used to analyze the active components of TCM owing to its high sensitivity,strong exclusivity,large flux,and real-time monitoring *** review sought to briefly introduce the active components of TCM and the principle of SPR,and provide historical and new insights into the application of SPR in the analysis of the active components of TCM.

关键词： Surface plasmon resonance Traditional Chinese medicine Optical analysis techniques Multi-target molecular mechanism study Biosensor

Huangqin flavonoid extraction for spinal cord injury in a rat model

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Neural Regeneration Research 2018年第12期13卷 2200-2208页

作者： Qian Zhang Li-Xin Zhang jing An Liang yan Cui-Cui Liu jing-jing Zhao Hao yang Translational Medicine Center Hong Hui Hospital Xi'an Jiaotong University Department of Clinical Pharmacy Hong Hui Hospital Xi'an Jiaotong University Department of Spine Surgery Hong Hui Hospital Xi'an Jiaotong University

Flavonoids from Huangqin（dried roots of Scutellaria baicalensis Georgi） have anti-inflammatory effects, and are considered useful for treatment of spinal cord injury. To verify this hypothesis, the T9-10 spinal cord segments of rats were damaged using Allen＇s method to establish a rat spinal cord injury model. Before model establishment, Huangqin flavonoid extraction（12.5 g/kg） was administered intragastrically for 1 week until 28 days after model establishment. Methylprednisolone（30 mg/kg） was injected into the tail vein at 30 minutes after model establishment as a positive control. Basso, Beattie, and Bresnahan locomotor scale scores were used to assess hind limb motor function. Hematoxylin-eosin staining was used to detect pathological changes in the injured spinal cord. Immunofluorescence and western blot assays were performed to measure immunoreactivity and expression levels of brain-derived neurotrophic factor, neuronal marker neurofilament protein, microglial marker CD11 b and astrocyte marker glial fibrillary acidic protein in the injured spinal cord. Huangqin flavonoid extraction markedly reduced spinal cord hematoma, inflammatory cell infiltration and cavities and scars, and increased the Basso, Beattie, and Bresnahan locomotor scale scores; these effects were identical to those of methylprednisolone. Huangqin flavonoid extraction also increased immunoreactivity and expression levels of brain-derived neurotrophic factor and neurofilament protein, and reduced immunoreactivity and expression levels of CD11 b and glial fibrillary acidic protein, in the injured spinal cord. Overall, these data suggest that Huangqin flavonoid extraction can promote recovery of spinal cord injury by inducing brain-derived neurotrophic factor and neurofilament protein expression, reducing microglia activation and regulating reactive astrocytes.

关键词： nerve regeneration spinal cord injury flavonoids Scutellaria baicalensis neurofilament brain-derived neurotrophic factor astrocytes rnicroglia neural regeneration

Boosting energy storage performance of low-temperature sputtered CaBi_(2)Nb_(2)O_(9) thin film capacitors via rapid thermal annealing

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Journal of Advanced Ceramics 2021年第3期10卷 627-635页

作者： jing yan yanling WANG Chun-Ming WANG Jun OUyanG Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Advanced Energy Materials and Chemistry School of Chemistry and Chemical EngineeringShandong Provincial Key Laboratory of Molecular EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250013China Amperex Technology Limited Ningde 352100China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

CaBi_(2)Nb_(2)O_(9) thin film capacitors were fabricated on SrRuO_(3)-buffered Pt(111)/Ti/Si(100)substrates by adopting a two-step fabrication *** process combines a low-temperature sputtering deposition with a rapid thermal annealing(RTA)to inhibit the grain growth,for the purposes of delaying the polarization saturation and reducing the ferroelectric *** using this method,CaBi_(2)Nb_(2)O_(9) thin films with uniformly distributed nanograins were obtained,which display a large recyclable energy density Wrec≈69 J/cm^(3) and a high energy efficiencyη≈82.4%.A superior fatigue-resistance(negligible energy performance degradation after 10^(9) charge-discharge cycles)and a good thermal stability(from-170 to 150℃)have also been *** two-step method can be used to prepare other bismuth layer-structured ferroelectric film capacitors with enhanced energy storage performances.

关键词： bismuth layer-structured ferroelectrics(BLSFs) calcium bismuth niobate(CaBi_(2)Nb_(2)O_(9)) nanograin films rapid thermal annealing(RTA) energy storage fatigue-resistance

Statistical Entropy of the Kaluza-Klein Black Hole from the Horizon Conformal Field Theory

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Chinese Physics Letters 2001年第3期18卷 331-333页

作者： jing Ji-Liang yan Mu-Lin Institute of Physics and Department of Physics Hunan Normal UniversityChangsha 410081 Department of Astronomy and Applied Physics University of Science and Technology of ChinaHefei 230026

The statistical entropy of the Kaluza-Klein black hole is studied by counting the black hole states which form an algebra of diffeomorphism at Killing horizon with a central *** is shown that the entropy yielded by the standard Cardy formula agrees with the Bekenstein-Hawking entropy only if we take period T of function u as the periodicity of the Euclidean black *** the other hand,the first-order quantum correction to the entropy is proportional to logarithm of the Bekenstein-Hawking entropy with a factor-1/2.

关键词： horizon periodicity entropy

Leaf hydraulics coordinated with leaf economics and leaf size in mangrove species along a salinity gradient

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Plant Diversity 2023年第3期45卷 309-314页

作者： jing-jing Cao jing Chen Qing-Pei yang yan-Mei Xiong Wei-Zheng Ren De-Liang Kong College of Forestry Henan Agricultural UniversityZhengzhou450002China Research Institute of Tropical Forestry Chinese Academy of ForestryGuangzhou510520China

Independence among leaf economics,leaf hydraulics and leaf size confers plants great capability in adapting to heterogeneous ***,it remains unclear whether the independence of the leaf traits revealed across species still holds within species,especially under stressed ***,a suite of traits in these dimensions were measured in leaves and roots of a typical mangrove species,Ceriops tagal,which grows in habitats with a similar sunny and hot environment but different soil salinity in southern *** with *** under low soil salinity,*** under high soil salinity had lower photosynthetic capacity,as indicated directly by a lower leaf nitrogen concentration and higher water use efficiency,and indirectly by a higher investment in defense function and thinner palisade tissue;had lower water transport capacity,as evidenced by thinner leaf minor veins and thinner root vessels;and also had much smaller single leaf *** economics,hydraulics and leaf size of the mangrove species appear to be coordinated as one trait dimension,which likely stemmed from covariation of soil water and nutrient availability along the salinity *** intraspecific leaf trait relationship under a stressful environment is insightful for our understanding of plant adaption to the multifarious environments.

关键词： Leaf hydraulics Leaf economics Plant size Salty stress Ecophysiology Mangrove Intraspecific

Research on pricing,service and logistic decision-making of E-supply chain with‘Free Shipping’strategy

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Journal of Control and Decision 2018年第4期5卷 319-337页

作者： Yu-yan Wang jing Li school of Management science and engineering shandong university of finance and economicsJinanChina school of international Business administration shanghai university of finance&economicsshanghaiChina

Considering the cost of logistic service and the‘Free Shipping’strategy,two models of E-supply chain,respectively dominated by e-commerce platform or manufacturer are constructed,and the optimal decisions for each model is calculated in this *** research indicates that:the sales price is lower and the profit of manufacturer is higher in the mode dominated by *** the other hand,the platform’s service-level is lower and the profit of platform is higher in the mode dominated by dominant ***,the sales price,platform’s service and platform’s profit will increase with the growth of commission and decrease with the service cost elasticity ***,the profit of manufacturer will decrease with the growth of commission but increase with elasticity ***,the logistic price and profit of logistic enterprise are higher in the mode dominated by manufacturer,moreover,they will decrease with the growth of commission.

关键词： e-supply chain free shipping dominant model

Thermal-water-salt coupling process of unsaturated saline soil under unidirectional freezing

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Journal of Mountain Science 2023年第2期20卷 557-569页

作者： LUO Chong-liang YU Yun-yan ZHANG jing TAO jing-yan OU Qing-jie CUI Wen-hao School of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730070China School of Civil Engineering Hexi UniversityZhangye 734000China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Salinization and desertification are closely related to water-salt migration caused by a temperature *** on the Darcy Law of unsaturated soils,the law of energy conservation and the law of mass conservation,the thermal-water-salt coupling mathematical model of unsaturated frozen saline soil was *** model considered the latent heat of phase change,crystallization impedance,crystallization consumption and complete precipitation of solute crystallization in *** order to verify the rationality of the model,the unidirectional freezing test of unsaturated saline soil was carried out in an open system with no-pressure water supplement to obtain the spatial distribution of temperature,moisture and salt in the saline ***,numerical simulations are implemented with the assistance of COMSOL *** of the model is illustrated by comparisons between the simulation and experimental *** results demonstrated that the temperature within saline soil changes with time and can be divided into three stages,namely quick freezing stage,transitional stage and stable *** water and salt contents in the freezing zone are layered,with peak values at the freezing *** coupled model could reveal the heat-mass migration mechanism of unsaturated frozen saline soil and dynamically describe the freezing depth and the movement law of the freezing front,ice and salt crystal formation mechanism,and the change law of thermal conductivity and permeability coefficient.

关键词： Unsaturated sulfate saline soil Watersalt migration Crystallization latent heat Crystallization impedance Mathematical model

Propofol Brings on the Light for Depression Therapy

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Neuroscience Bulletin 2023年第12期39卷 1891-1894页

作者： Yun yan Hongli Ma jing Zhao Department of Anesthesiology China-Japan Friendship HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100029China

Major depressive disorder(MDD)is a major cause of global disability,with a global prevalence of 4.4%[1].Anhedonia is a core feature of MDD,and is associated with the longer treatment-resistant course:a third to half of patients with MDD had no response to multiple antidepressants[2].It is crucial to search the more effective target therapeutics for anhedonia to develop new *** is currently the most popular intravenous agent used for general clinical anesthesia and exerts its effect by activating-aminobutyric acid type A(GABAA)receptors.

关键词： anesthesia drugs Therapy