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Preparation of hydrophilic molecularly imprinted polymers for tetracycline antibiotics recognition

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Chinese Chemical Letters 2011年第5期22卷 611-614页

作者： Peng Wang xiao Fang Fu jing Li, jing Luo xiao Ya Zhao Ming Jun Sun Yin Zhu Shang Cheng Ye Hubei Entry-Exit Inspection and Quarantine Bureau of PRC Wuhan 430022 China

Hydrophilic molecularly imprinted polymers（MIPs） were prepared using tetracycline as template,methacrylic acid as monomer and glycidilmethacrylate as pro-hydrophilic *** with common MIPs,the imprinting effect and adsorption amounts of hydrophilic MIPs for tetracycline（TC） were greatly improved in water ***,the electrochemical sensor fabricated by modifying hydrophilic MIPs on glassy carbon electrode was developed for the determination of TC in foodstuff samples.

关键词： Hydrophilic molecularly imprinted polymers Electrochemical sensor Tetracycline antibiotics Foodstuff samples

Mapping of QTL Associated with Drought Tolerance in a Semi-Automobile Rain Shelter in Maize (Zea mays L.)

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Agricultural Sciences in China 2011年第7期10卷 987-996页

作者： ZHU jing-jing WANG xiao-peng SUN Cui-xia ZHU Xiu-miao LI Meng ZHANG Guo-dong TIAN Yan-chen WANG Ze-li National Key Laboratory of Crop Biology Ministry of Science and Technology/College of Life Sciences Shandong Agricultural University Tai＇an 271018 P.R.China

Drought is a major constraint in maize production worldwide. We studied quantitative trait loci （QTL） underlying drought tolerance for maize plants grown in two different environments. Traits investigated included ASI, plant height, grain yield, ear height, and ear setting. A genetic linkage map was constructed with 120 simple sequence repeat （SSR） markers based on an F2 population derived from a cross between D5 （resistant parent） and 7924 （susceptible parent）. Correlation and heritability were calculated. QTLs of these traits were identified by composite interval mapping combined with a linkage map covering 1 790.3 cM. The markers were arranged in ten linkage groups. QTL mapping was made of the mean trait performance of the 180 F2：3 population. The results showed five, five, six, four, and five QTLs for ASI, plant height, grain yield, ear height, and ear setting under full irrigation condition, respectively, and four, seven, six, four, and four QTLs for ASI, plant height, grain yield, ear height, and ear setting under severe late stress conditions, respectively. Especially the four QTLs detected for five traits in 2008 and 2009. The universal QTLs information generated in this study will aid in undertaking an integrated breeding strategy for further genetic studies in drought tolerance improvement in maize.

关键词： maize drought tolerance simple sequence repeat quantitative trait loci

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing Zhang jing Yang jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

Fluorescence in situ hybridization-based confirmation of acute graftvs-host disease diagnosis following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1102-1109页

作者： jing-jing xiao Jin-Yu Ma Jun Liao Di Wu Chao Lv Hai-Yang Li Shi Zuo Hai-Tao Zhu Hua-Jian Gu School of Clinical Medicine Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Hepatobiliary Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Pediatric Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Although acute graft-vs-host disease(aGvHD)is a rare complication of liver transplantation,it is poorly understood and has an extremely high mortality *** standardized diagnostic criteria or treatment regimens currently *** SUMMARY The present study investigated the etiology,diagnosis,and treatment of aGvHD following liver ***,diagnosis,disease course,histology,and treatment of an aGvHD case are reported,and associated literature is reviewed.A 64-year-old female required LTx due to primary biliary *** donor was a 12-year-old *** weeks following liver transplantation,the recipient developed pyrexia,diarrhea,rashes,and antibiotic-unresponsive *** symptoms together with laboratory investigations suggested a diagnosis of aGvHD,which was confirmed via peripheral blood fluorescent in situ *** XY chromosome fluorescent in situ hybridization indicating early chimerism achieved 93%sensitivity in the detection of *** immunosuppressants were discontinued,and high-dose intravenous methylprednisolone was initiated along with *** diarrhea resolved,the patient’s general condition continued to deteriorate until demise due to multi-system organ failure at 37 d post-liver *** case illustrates the life-threatening nature of *** Herein,we have summarized a post-LTx aGvHD case and reviewed associated literature in order to increase awareness and provide potentially risk-mitigating recommendations.

关键词： Liver transplantation Graft-vs-host disease Fluorescence in situ hybridization cytogenetics Chimerism Diagnosis Case report

Molecular mechanism of icariin on rat asthmatic model

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Chinese Medical Journal 2011年第18期124卷 2899-2906页

作者： XU Chang-qing LE jing-jing DUAN xiao-hong DU Wei-jing LIU Bao-jun WU jing-feng CAO Yu-xue DONG jing-cheng Integrative Department Huashan Hospital Affiliated to FudanUniversity Shanghai 200040 China

Background Effects of icariin on airway inflammation in asthmatic rats and the intervention of LPS induced inflammation are interfered with the machanism of icariin. Our study aimed to observe the effect of icariin on ovalbumin-induced imbalance of Th1/Th2 cytokine expression and its mechanism. Methods Sixty male SD rats were randomly divided into control group （PBS）, asthma group （ovalbumin （OVA）-induced） dexamethasone group, and OVA＋icariin low, medium and high dose groups （5, 10, 20 mg/kg, respectively）. Each group had ten rats. The model of OVA sensitization was a rat asthma model. Enzyme-linked immunosorbent assay （ELISA） method was used to observe the effects of icariin on interleukin-4 （IL-4） and inerferon y （IFN-y） in rats＇ lung tissue. Immunohistochemical staining was applied to detect the intervention effects of icadin on T cells （T-bet） and gatabinding protein 3 （GATA-3） in rat pulmonary tissue. Realtime RT-PCR was used to observe the intervention effects of icariin on T-bet and GATA-3 mRNA expression in rat pulmonary tissue and spleen lymphocytes. Western blotting was used to observe the icariin intervention effects on T-bet, GATA-3 and nuclear factor-Kappa B （NF-KB） p65 protein expressions in rat pulmonary tissue. Results The ELISA results from pulmonary tissue showed that IL-4 expression was significantly reduced （P 〈0.05）, while the IFN-y expression increased but not significantly when we compared OVA＋icariin medium and high dose groups with the asthma group. Immunohistochemical staining of pulmonary tissue showed that the GATA-3 decreased significantly while the T-bet staining did not change in the OVA＋icariin high dose group. In pulmonary tissue and spleen lymphocytes T-bet and GATA-3 mRNA expressions were significantly reduced （P 〈0.05） in icariin treatment groups compared with the asthma model group. GATA-3 and T-bet mRNA in rat spleen lymphocytes in the asthma group were higher than in the control group. GATA-3 mRNA expression in pulmonary tissue

关键词： icariin Th1/Th2 T-bet/GATA-3 nuclear factor Kappa B p65

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考虑实时停车场信息的出行方式选择仿真模型

交通运输系统工程与信息 2018年第2期18卷 52-59页

作者：梁晶晶张小宁同济大学经济与管理学院上海200092

停车App在交通出行中的广泛应用,使实时获取各类停车场信息更加便捷.然而,实时停车场信息在优化交通系统方面的作用机理尚无理论基础,其应用效果也缺乏量化分析.本文将实时剩余停车位信息和停车诱导信息作为研究对象,基于点队列模型、... 详细信息

停车App在交通出行中的广泛应用,使实时获取各类停车场信息更加便捷.然而,实时停车场信息在优化交通系统方面的作用机理尚无理论基础,其应用效果也缺乏量化分析.本文将实时剩余停车位信息和停车诱导信息作为研究对象,基于点队列模型、学习理论和Logit选择模型,建立了实时停车场信息提供下的出行方式选择行为的仿真模型.然后,设计3种出行情景并结合仿真实验结果,对实时停车场信息提供影响出行者出行行为的机理进行分析,从而评估其对交通系统的优化效果.最后,基于对2类主要参数(学习因子和扩容因子)的敏感性分析,进一步讨论了提升实时停车场信息提供对交通系统优化作用的可行方式.

关键词：智能交通仿真模型学习行为理论出行方式选择点队列模型

Comparison of efficacy and safety of nab-paclitaxel and oxaliplatin+S-1 and standard S-1 and oxaliplatin chemotherapy regimens for treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3224-3238页

作者： Yi-Cong Wang Long Feng Gong-Ping Wang Peng-Jie Yu Can Guo Bao-Jia Cai Yan Song Ting Pan Bo-Hao Lin Yuan-Dong Li jing-jing xiao Department of Gastrointestinal Oncology The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Interventional Medicine Xi’an No.3 HospitalThe Affiliated Hospital of Northwestern UniversityXi’an 710018Shaanxi ProvinceChina Department of RadiologyLuoyang No.6 People's Hospital Luoyang 471000Henan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND Gastric cancer(GC)is a relatively frequent clinical phenomenon,referring to ma-lignant tumors emerging in the gastric mucosal epithelial *** has a high mor-bidity and mortality rate,posing a significant threat to the health of ***,how to diagnose and treat GC has become a heated topic in this research *** To discuss the effectiveness and safety of nab-paclitaxel in combination with oxaliplatin and S-1(P-SOX)for the treatment of GC,and to analyze the factors that may influence its *** A total of 219 eligible patients with advanced GC,who were treated at Qinghai University Affiliated Hospital Gastrointestinal Oncology between January 2018 and March 2020,were included in the *** them,149 patients received SOX regimen and 70 patients received S-1 *** patients underwent both preoperative and postoperative chemotherapy consisting of 2-4 cycles each,totaling 6-8 cycles,along with parallel D2 radical surgical *** patients were followed up for a period of three years or until reaching the event *** The short-term and long-term efficacy of the P-SOX group was significantly higher than that of the SOX group,and the safety was *** multivariate analysis revealed that progression-free survival was associated with perioperative chemotherapy efficacy,tumor diameter≤2cm,high differentiation,and early cTNM(T stands for invasion depth;N stands for node metastasis;M stands for distant invasion)*** In comparison to the SOX regimen,the P-SOX regimen demonstrates improved short-term and long-term efficacy with tolerable adverse *** is anticipated that the P-SOX regimen will emerge as a first-line chemotherapy option for *** with GC who receive effective perioperative chemotherapy(Response Evaluation Criteria in Solid Tumors 1.1,Tumor Regression Grade),have a tumor diameter≤2cm,exhibit high degree of differentiation,and are at an early cTNM stage show better prognos

关键词： Nab-paclitaxel Gastric cancer Efficacy Safety

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei xiao Zhiyong Kan jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors