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Petroleum Science 2016年第3期13卷 507-516页

作者： Dai-Gang Wang Yong-Le Hu jing-jing sun Yong Li Research Institute of Petroleum Exploration & Development PetroChina School of Earth and Space Sciences Peking University College of Petroleum Engineering China University of Petroleum

Immiscible water-alternating-gas（WAG） flooding is an EOR technique that has proven successful for water drive reservoirs due to its ability to improve displacement and sweep ***,considering the complicated phase behavior and various multiphase flow characteristics,gas tends to break through early in production wells in heterogeneous formations because of overriding,fingering,and channeling,which may result in unfavorable recovery *** the basis of phase behavior studies,minimum miscibility pressure measurements,and immiscible WAG coreflood experiments,the cubic B-spline model（CBM） was employed to describe the three-phase relative permeability *** the Levenberg-Marquardt algorithm to adjust the vector of unknown model parameters of the CBM sequentially,optimization of production performance including pressure drop,water cut,and the cumulative gas-oil ratio was performed.A novel numerical inversion method was established for estimation of the water-oil-gas relative permeability curve during the immiscible WAG *** on the quantitative characterization of major recovery mechanisms,the proposed method was validated by interpreting coreflood data of the immiscible WAG *** proposed method is reliable and can meet engineering *** provides a basic calculation theory for implicit estimation of oil-water-gas relative permeability curve.

关键词： Cubic B-spline model Immiscible WAG flooding Relative permeability Numerical inversion

Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to a de novo ankyrin mutation: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5245-5251页

作者： Jun-Fang Wang Li Ma Xiao-Hui Gong Cheng Cai jing-jing sun Department of Neonatology Shanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062China NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction EngineeringShanghai 200062China

BACKGROUND Hereditary spherocytosis(HS)is a common type of hemolytic anemia caused by a red cell membrane *** type 1(HS1)is mostly caused by mutations in ankyrin(ANK1).Newborns with HS1 usually only exhibit anemia and mild *** herein report a case of HS1 and discuss its clinical *** SUMMARY A 2-d-old male full-term newborn was admitted to our hospital with severe,intractable neonatal *** investigations showed hemolytic anemia and hyperbilirubinemia and excluded immune-mediated *** patient underwent two exchange transfusions and one plasmapheresis resulting in significantly reduced serum *** analyses and genomic DNA sequencing studies were *** trio clinical exome sequencing revealed a de novo null heterozygous mutation in the patient's ANK1 gene:c.841C>T(***281Ter).This mutation results in the premature termination of the ANK1 *** Our case demonstrates that genetic analysis can be an essential method for diagnosing HS when a newborn has severe hyperbilirubinemia.

关键词： Hereditary spherocytosis Ankyrin Neonate Intractable neonatal jaundice Case report

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World Journal of Clinical Cases 2022年第15期10卷 5082-5087页

作者： Su-Fei Pan Yuan-Yuan Zhang Xiao-Zhen Wang jing-jing sun Shao-Ling Song Yu-Rong Tang Ji-Liang Wang Department of Laboratory Medicine Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina

BACKGROUND Mycobacterium abscessus(***)is a rapidly growing mycobacterium and ubiquitous in the environment,which infrequently causes disease in ***,it can cause cutaneous or respiratory infections among immunocompromised *** to the resistance to most antibiotics,the pathogen is formidable and *** SUMMARY Here,we present a case of catheter-related *** infections in a patient with motor neurone *** and peripheral blood cultures of the patient showed positive results during Gram staining and acid-fast *** alarm time of catheter blood culture was 10.6 h earlier than that of peripheral *** removal of the peripherally inserted central catheter,secretion and catheter blood culture were *** was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and 16S rDNA *** For catheter-related *** infection,rapid diagnosis and timely and adequate antimicrobial therapy are crucial.

关键词： Catheter-related infections Diagnosis Motor neurone disease Mycobacterium abscessus Case report

Propofol injection combined with bone marrow mesenchymal stem cell transplantation better improves electrophysiological function in the hindlimb of rats with spinal cord injury than monotherapy

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Neural Regeneration Research 2015年第4期10卷 636-643页

作者： Yue-xin Wang jing-jing sun Mei Zhang Xiao-hua Hou Jun Hong Ya-jing Zhou Zhi-yong Zhang First Department of Orthopedics Tangshan Worker’s Hospital Affiliated to Hebei Medical University Department of Neurology Tangshan Union Medical College Hospital Operating Room Tangshan Worker’s Hospital Affiliated to Hebei Medical University Department of Neurosurgery Tangshan Worker’s Hospital Affiliated to Hebei Medical University Department of Anesthesiology Xingtai People’s Hospital Affiliated to Hebei Medical University

The repair effects of bone marrow mesenchymal stem cell transplantation on nervous system damage are not satisfactory. Propofol has been shown to protect against spinal cord injury. Therefore, this study sought to explore the therapeutic effects of their combination on spinal cord injury. Rat models of spinal cord injury were established using the weight drop method. Rats were subjected to bone marrow mesenchymal stem cell transplantationvia tail vein injection and/or propofol injectionvia tail vein using an infusion pump. Four weeks after cell transplan-tation and/or propofol treatment, the cavity within the spinal cord was reduced. The numbers of PKH-26-positive cells and horseradish peroxidase-positive nerve ifbers apparently increased in the spinal cord. Latencies of somatosensory evoked potentials and motor evoked potentials in the hindlimb were noticeably shortened, amplitude was increased and hindlimb motor function was obviously improved. Moreover, the combined effects were better than cell transplantation or propofol injection alone. The above data suggest that the combination of propofol injection and bone marrow mesenchymal stem cell transplantation can effectively improve hindlimb electro-physiological function, promote the recovery of motor funtion, and play a neuroprotective role in spinal cord injury in rats.

关键词： nerve regeneration bone marrow mesenchymal stem cells propofol spinal cord injury cell transplantation electrophysiology motor function stem cells neuroprotection neural regeneration

XRD STUDY ON PIEZOELECTRIC CERAMIC OF PZSN SYSTEM

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Journal of Wuhan University of Technology(Materials Science) 1996年第3期11卷 14-21页

作者：崔万秋周静刘静孙文华 WUHAN UNIV TECHNOL INST MAT SCI & TECHNOL WUHAN 430070 PEOPLES R CHINA

The structure of piezoelectric ceramic in Pb [(Zn (1/3) Nb (2/3))(Sn-1/2 Nb-2/3](Zr,Ti) O-3 system is studied through XRD and TEM analysis. The effects of substitution of Ba2+Sr2+ for Pb2+ and small amount of dopants such cis MnO2 and Sb2O3 on the structure are investigated. The difference between unpolarized and polarized XRD patterns and the structure of ferroelectric domains is emphatically! studied. The result shows that the samples are of the tetragonal perovskite-type structure. The dopants change the tetragonal of samples and grain size but have no effect on the crystal phase. Tile effects of polarizing on the structure can be proved from the deformation of unit cell in microscopic state and rotation of 90 degrees ferroelectric domains in microscopic state.

关键词： piezoelectric ceramic PZSN systems XRD study

Transport of carbamazepine and drug interactions at blood-brain barrier

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Acta Pharmacologica Sinica 2006年第2期27卷 249-253页

作者： jing-jing sun Lin XIE Xiao-dong LIU~2 Center of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China CenterofDrugMetabolismandPharmacokinetics ChinaPharmaceuticalUniversityNanjing210009China

Aim:To investigate the characteristics of carbamazepine(CBZ)transport anddrug interactions at the blood-brain ***:Cultured rat brain microvas-cular endothelial cells(rBMEC)were used as an in vitro model of the blood-brainbarrier(BBB).When cells became confluent,CBZ uptake over time was recordedby incubation of the cells in a medium containing 10 mg/L CBZ at 37℃.Thesteady-state uptake of CBZ by rBMEC was tested for different CBZ concentra-tions at 37℃.The effects of various agents on the steady-state uptake of CBZand efflux of CBZ from rBMEC were also ***:The uptake of CBZ byrBMEC was time-and *** steady-state uptake oc-curred at 30 rain for *** steady-state uptake was significantly in-creased(P<0.01)by treatment with *** co-administration ofcyclosporine A significantly increased the steady-state uptake of CBZ by therBMEC,whereas co-administration of olanzapine significantly decreased the up-take in a concentration-and temperature-dependent *** efflux of CBZfrom rBMEC was inhibited by ***:The transport of CBZ at the BBBis mediated by many *** specific ABC(ATP-binding cassette,ABC)efflux transporters may be involved in the transport of *** influ-ence the transport of CBZ at the BBB in different ways.

关键词： carbamazepine blood-brain barrier cyclosporine A olanzapine rat brain microvascular endothelial cells drug interaction

玻璃温室环境下番茄叶绿素含量敏感光谱波段提取及估测模型

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光谱学与光谱分析 2017年第1期37卷 194-199页

作者：丁永军张晶晶孙红李修华兰州城市学院信息工程学院甘肃兰州730070 中国农业大学"现代精细农业系统集成研究"教育部重点实验室北京100083 广西大学电气工程学院广西南宁530004

为了快速、准确估测番茄叶片叶绿素含量,利用光谱分析技术研究了玻璃温室环境下番茄叶绿素含量敏感光谱波段提取及其估测模型。番茄以基质方式栽培,在结果期使用ASD FieldSpecTM HH型便携式光谱辐射仪采集叶片光谱,并采用752型紫外-可... 详细信息

为了快速、准确估测番茄叶片叶绿素含量,利用光谱分析技术研究了玻璃温室环境下番茄叶绿素含量敏感光谱波段提取及其估测模型。番茄以基质方式栽培,在结果期使用ASD FieldSpecTM HH型便携式光谱辐射仪采集叶片光谱,并采用752型紫外-可见分光光度计测定其叶绿素含量。从原始光谱、吸光度光谱、一阶微分光谱、去除包络线光谱出发,进行光谱预处理,分析了净化图谱信息、突出作物叶绿素含量光谱特征的有效性。其中,吸光度光谱在可见光部分增强了光谱响应特征,去除包络线光谱和一阶微分光谱均具有较强的蓝光、红光吸收谷和绿光反射峰。又结合波段间自相关分析和多重共线性诊断提取了番茄叶绿素含量敏感光谱波段,原始光谱特征波段为639,672,696,750,768nm;吸光度光谱特征波段为638,663,750,763nm;去包络线光谱特征波段为436,564,591,612,635,683,760nm;一阶微分光谱特征波段为516,559,778nm。最后,应用4种预处理下的番茄叶绿素含量敏感光谱波段分别建立多元线性回归模型,模型精度由高至低分别为去包络线、吸光度、原始、一阶微分,其中去包络线模型校正集决定系数R2c为0.88,验证集决定系数R2v达到0.82,具有较好的预测能力。

关键词：番茄光谱敏感波段叶绿素

Acousto-optic Q-switched Yb3+-doped all-fiber laser in MOPA configuration

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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作者： Wen-qi ZHANG,Ting-wu GE,Feng YU,jing-jing DAI,Chang sun,Zhi-yong WANG Beijing University of Technology,Beijing 100124,China

A pulsed acousto-optic Q-switched all-fiber laser in master-oscillator power amplifier(MOPA)configuration is *** seed source is using LD as pump source,ytterbium-doped fiber as the gain medium,fiber Bragg grating(FBG) as resonator mirrors,acousto-optic Q-switch(AOM)as a *** output of seed source is amplified by two stage *** second stage amplifier obtains the pulses of 10Waverage power,10-34kHz repetition rate,1064nm center *** the repetition rate is 23kHz,the pulse width is 275ns and the 3dB spectral width is 2.492nm.

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu Xiao-Li Li Xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors