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The Triangle-relationship of β-lactam Antitiotics

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Chinese Chemical Letters 1991年第8期2卷 653-654页

作者： jing jiang liu Ji Wei TANG Min Hui ZHU Xiao Ling FAN Department of Chemistry Nankai UniversityTianjin300071 Institute of Electronics Academia SinicaBeijing100080

The geometric parameters for D-Ala-D-Ala are optimized by MM, the most and next two stable conformations are obtained. According to the interaction model with target emzyme suggested by us, the traingle-relationship of it is obtained. This triangle-relationship could be found in the pharmaceuticals belong to different classes of β-actams also.

关键词： The Triangle-relationship of lactam Antitiotics

THE ELECTRIC PROPERTY OF SINGLET CARBENE AND ITS ISOELECTRONIC SYSTEM^1——Electrophilic and Nucleophilic Directions of an Atom in the Molecule

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Chinese Chemical Letters 1990年第1期1卷 9-12页

作者： jing jiang liu Lian De LU Department of Chemistry,Nankai University,Tianjin,300071

The electrostatic potential of carbene and nitrene,have been calculated by AB INITIO method with 6-31G** basis set,there are positive potential regions in the directions of vacant P orbitals,and negative regions in the directions of lone-pair electrons. Therefore,atoms in these molecules have different electric properties in different *** idea of electrophilic and nucleophilic directions of an atom in molecules should be introduced.

关键词： Atom Electrophilic and Nucleophilic Directions of an Atom in the Molecule THE ELECTRIC PROPERTY OF SINGLET CARBENE AND ITS ISOELECTRONIC SYSTEM~1 ITS

Divertor Modification and Stress Analysis of HL-2A Tokamak

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2005年第1期 47-48页

作者： jiang jing liu Dequan CHENG Fayin RAN Hong

With the development of the fusion technology, the functions of the divertor have extended from single impurity control to multi-task. Many main tokamak devices in the world such as JET, JT-60U, ASDEX-U, DⅢ-D have modified their divertor systems in recent years and many experiments have been performed on them. They have the opened divertor systems which have relatively simplified the divertor structure. The plasma configuration with large minor radius, proper elongation and triangularity is easy to shape. So the opened divertor system is also adopted in the HL-2A modification.

关键词： Divertor Modification Stress analysis

Identification of novel nuclear localization signal within the ErbB-2 protein

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Cell Research 2005年第7期15卷 504-510页

作者： Qiao Qiao CHEN, Xiao Ying CHEN, Yun Yun jiang, jing liu*School of Life Science, University of Science and Technology of China, Hefei 230027, China School of Life Science University of Science and Technology of China Hefei 230027 China. jliu@***.

ErbB2, a member of the receptor tyrosine kinase family, is frequently over-expressed in breast cancer. Proteolysis ofthe extracellular domain of ErbB2 results in constitutive activation of ErbB2 kinase. Recent study reported that ErbB2is found in the nucleus. Here, we showed that ErbB2 is imported into the nucleus through a nuclear localization signal(NLS)-mediated mechanism. The NLS sequence KRRQQKIRKYTMRR (aa655-668) contains three clusters of basicamino acids and it is sufficient to target GFP into the nucleus. However, mutation in any basic amino acid cluster of thisNLS sequence significantly affects its nuclear localization. Furthermore, it was found that this NLS is essential for thenuclear localization of ErbB2 since the intracellular domain of Erb2 lacking NLS completely abrogates its nucleartranslocation. Taken together, our study identified a novel nuclear localization signal and reveals a novel mechanismunderlying ErbB2 nuclear trafficking and localization.

关键词： ErbB2 NLS intracellular domain.

AN AB INITIO STU DY ON THE CORELATION BETWEEN THE ABSOLUTE CONFIGURATION AND THE CD SPECTRA OF ORGANIC PEROXIDES

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Chinese Chemical Letters 1991年第3期2卷 245-248页

作者： jing jiang liu Gua Lin DUAN Chemistry Dept.,Nankai Univ.,Tianjin,300071 Xiao Tian Liang Institute of Materia Medica,Beijing,100050

Correlation between the absolute configuration and the CD spectra of organic peroxides was studied by ab initio method with a mo- d el moleeule CH_3-O-O-CH_*** P form when 0°≤θ(twist angle of C-O-O-C) <90°, there ... 详细信息

关键词： STU AN AB INITIO STU DY ON THE CORELATION BETWEEN THE ABSOLUTE CONFIGURATION AND THE CD SPECTRA OF ORGANIC PEROXIDES AB CD

AROMATIC BOND INCLUDING METALLIC ATOM IN COORDINATE COMPOUNDS AND SOME OF ITS PROPERTIES

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Chinese Chemical Letters 1992年第5期3卷 363-366页

作者： jing jiang liu Yun Ti CHENDepartment of Chemistry,Nankai University,Tianjin,300071R.Kent MURMANNDepartment of Chemistry,University of Missouri Columbia MO 65211,U.S.A

Aromatic bond including metallic atom (Ni) is investigated by EHMO *** NMR spectra and the mechanism for hydrolysis are discussed on the ground of results of computation.

关键词： Ni PN AROMATIC BOND INCLUDING METALLIC ATOM IN COORDINATE COMPOUNDS AND SOME OF ITS PROPERTIES ITS

A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH_4

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Chinese Chemical Letters 1991年第4期2卷 269-272页

作者： Ru Yu CHEN Jian Wu WANG The Institute of Elemento-Organic Chemistry,Nankai University,Tianjin,300071jing jiang liu Gui Lin DUAN The Chemistry Department of Nankai University,Tianjin,300071

In the synthesis of l-phenyl-5-substituted amino-4-pyrazole N-alkyl amide, it was found for the first time that one of the two aromatic amido groups in the molecule of 1-phenyl-5-benzoyl amino-4-pyrazole N-alkyl amide was reduced selectively by LiAlH_4. new conclusion was drawn after several experiments have been done that ortho-amino(or substituted amino)aryl amide or the aryl amide with its ortho substituent which can be reduced into an amino group(or substituted amino group)can not be reduced by LiAlH_4. It was further rationalized by quantum chemical calculation.

关键词： A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4 PI

STUDY ON THE STRUCTURES OF COORDINATION COMPOUNDS OF N-(ortho-METHYL)-AND N-(ortho-METHOXY)-PHENYL IMINODIACETATO-Cu(Ⅱ)

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Chinese Chemical Letters 1991年第4期2卷 317-321页

作者： Yun Ti CHEN Heng Qian liu jing jiang liu Xian He BU (Department of Chemistry,Nankai University,Tianjin,300071)Jin Ling WANG Li Juan ZHANG Fang Ming MIAO (Department of Chemistry,Tianjin Normal University,Tianjin,300074)

The coordination compounds,{Cu[CH_3C_6H_4N(CH_2COO)_2]}.2H_2O and {Cu[CH_3OC_6H_4N(CH_2COO)_2]}.2H_2O,have been prepared and its crystal struc- tures *** final discrepancy factors are R=0.052,R_w=0.061 for (I)and R=0.052,R_w=0.039 for(Ⅱ).The geometry of the coordination poly- hedron with Cu(Ⅱ)is a distorted tetragonal pyramid for(Ⅰ)and an unsym- metrical and extended tetragonal bipyramid for(Ⅱ),*** re- sults of EHMO calculations indicate that the ligand mainly provided the field with very few of its electrons being coordinated to the central atom.

关键词： PHENYL IMINODIACETATO-Cu AND N STUDY ON THE STRUCTURES OF COORDINATION COMPOUNDS OF N ortho-METHOXY ortho-METHYL EHMO

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视雪综合征的研究进展

国际眼科杂志 2020年第11期20卷 1924-1926页

作者：李欢刘静江王伟河北省眼科医院河北省邢台市054001

本文系统介绍了视雪综合征(visual snow syndrome,VSS),这是一种无明确原因,表现为无数闪烁的小点持续存在于整个视野中,并可能伴有后像、内视、畏光、夜盲的视觉现象。目前已经有文献对该疾病进行了临床及病理生理学研究,最新的文献资... 详细信息

本文系统介绍了视雪综合征(visual snow syndrome,VSS),这是一种无明确原因,表现为无数闪烁的小点持续存在于整个视野中,并可能伴有后像、内视、畏光、夜盲的视觉现象。目前已经有文献对该疾病进行了临床及病理生理学研究,最新的文献资料中,更倾向于视雪综合征是一种视觉处理功能障碍,需与偏头痛等疾病相鉴别。在治疗方面,目前多是试验性研究,有病例报道显示抗癫痫、抗抑郁药、乙酰唑胺等和有色滤光片对缓解患者症状可能有积极作用。

关键词：视雪视雪综合征原发性持续性视觉干扰偏头痛