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LD-pumped Ho,Tm:YLF microchip laser

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Journal of Marine Science and Application 2003年第1期2卷 71-75页

作者： SUN jing-hua, ZHANG Xin-lu College of Science, Harbin Engineering University, Harbin 150001,China College of Science Harbin Engineering University Harbin 150001 China

A simple rate equation model for 2μm Tm,Ho:YLF laser is given to study laser dynamics. Under low pump power, the explicit formulae for the threshold pump power and the relation between output power and incident power are obtained. The present model provides a straightforward procedure to design the laser resonator and the optical coupling system for optimization. At the same time, the experimental results are reported. At room temperature the slope efficiency is 22.4% and the typical lasing threshold is about 328mW. The theory is in good agreement with experiment.

关键词： Tm,Ho:YLF room temperature laser diode rate equation.

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功能梯度梁在轴向移动载荷作用下的动态响应

科学技术与工程 2016年第34期16卷 1-5页

作者：张靖华吕亚丽兰州理工大学理学院兰州730050

研究了功能梯度材料梁在沿轴向移动的集中力作用下的动态响应特性,其中考虑功能梯度材料的物理性能参数沿厚度方向以幂指数形式连续变化。首先基于经典Euler梁理论建立动态响应控制方程,并求解获得功能梯度两端简支梁的固有频率及主振型... 详细信息

研究了功能梯度材料梁在沿轴向移动的集中力作用下的动态响应特性,其中考虑功能梯度材料的物理性能参数沿厚度方向以幂指数形式连续变化。首先基于经典Euler梁理论建立动态响应控制方程,并求解获得功能梯度两端简支梁的固有频率及主振型,同时推导证明了其主振型的正交性。然后采用模态叠加法研究梁在轴向移动载荷作用下的动态响应及共振特性,求解获得了中点最大挠度随时间的变化及共振速度的解析解,并采用数值结果分析了共振速度及其影响因素。

关键词：功能梯度材料 Euler梁移动载荷动态响应

Human M1 receptor cDNA transferred to Chinese Hamster Ovary (CHO) cells as a drug target

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Human M1 receptor cDNA transferred to Chinese Hamster Ovary ...

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

2002全国青年药理学英文学术会议

作者： LIU Yong-Xue WANG Qiong ZHAO jing-hua lu Xiao-QinGAO Yue TAN Hong-Ling GAO Pei-Yong (Beijing Institute of Radiation Medicine, Beijing 100850)

G protein-coupled receptors (GPCR) have been always contributing to the drug discovery as the most important targets. Muscarinic acetyicholine receptors are members of GPCR superfamily. Five subtypes (M1-M5) of muscarinic acetylcholine receptors have been discovered. Of the five subtypes, M1 receptor mainly contribute to a variety of centrally mediated functions. With the completion of human genome project (HGP), a lot of orphan GPCRs (oGPCR), whose ligands have been not discovered till now, appeared as potential targets for new drug screening. It is very important to establish the effective drug screening system for the oGPCR. Subjects: to establish the genetically engineering cells for further delineating pharmacologically M1 receptors and trying to provide help in the establishment of screening methods targeted oGPCR. Methods: 1) cloning the human M1 cDNA by

关键词： Muscarinic acetylcholine receptors Chinese Hamster Ovary (CHO) cells orphan GPCRs

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

即时检测肌钙蛋白I在院外急救中的应用情况分析

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中国急救复苏与灾害医学杂志 2017年第1期12卷 37-39页

作者：姜华陆向辉邵瑜上海市浦东新区医疗急救中心上海201206 上海市浦东新区医疗急救中心医教科

目的探讨院外即时检测（Point of Care Test，POCT）肌钙蛋白I在院外急救中对急性心肌梗死（Acute Myocardial Infarction，AMI）的早期诊断价值。方法收集由本中心3个分站转送的“胸痛”疑似AMI患者在急救车上进行常规心电图（Electroc... 详细信息

目的探讨院外即时检测（Point of Care Test，POCT）肌钙蛋白I在院外急救中对急性心肌梗死（Acute Myocardial Infarction，AMI）的早期诊断价值。方法收集由本中心3个分站转送的“胸痛”疑似AMI患者在急救车上进行常规心电图（Electrocardiograph，ECG）检测及心肌肌钙蛋白I（cardiac TroponinI，cTnI）POCT检测，观察检测结果并与院内回访数据相结合，比较单项心电图检查、cTnI检测及二者联合检测的阳性检出率。结果院外心肌标志物cTnI即时定性检测比心电图法在院外急救“胸痛”病人中对AMI的诊断有明显较高的灵敏度（P=0．00028）。在医院确诊的31例AMI患者中，POCT法检测为24例（77％），心电图法检测为15例（48％）。结论在AMI患者的院外急救中引入院外及时检测肌钙蛋白可提高诊断率，缩短诊断时间，适合在院外快速筛选出AMI患者，对AMI早期诊断和再灌注治疗有重要价值，并适用于临床推广。

关键词：院外即时检测肌钙蛋白I 急性心肌梗死院外急救心电图

308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病疗效观察

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中国皮肤性病学杂志 2010年第1期24卷 42-43页

作者：王乖娟侯新江刘卫兵荆鲁华解放军第404医院皮肤科山东威海264200 威海职业技术学院生化系山东威海264200

目的探讨308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病的临床疗效。方法所有参加研究的患者均接受308nm准分子激光照射2次/w,共6周,且皮损处外搽0.1%他克莫司软膏,早、晚各1次,疗程6周。每2周根据皮损进行治疗前及治疗后的PAS... 详细信息

目的探讨308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病的临床疗效。方法所有参加研究的患者均接受308nm准分子激光照射2次/w,共6周,且皮损处外搽0.1%他克莫司软膏,早、晚各1次,疗程6周。每2周根据皮损进行治疗前及治疗后的PASI评分比较。结果308nm准分子激光照射平均次数为7.31(5～11)次,外搽0.1%他克莫司软膏平均次数为79.2(69～91)次,治疗6周结束后平均PASI评分为3.15(3.34±1.98),治疗前平均PASI评分为15.31(17.59±3.67),有效率81.40%,治疗前、后2次PASI评分比较,差异有统计学意义(P<0.05)。不良反应轻微,发生率为20.93%。结论308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病疗效好,不良反应少。

关键词：银屑病准分子激光他克莫司寻常性

吸附无细胞百白破-重组乙型肝炎(CHO细胞)联合疫苗的中试工艺

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中国生物制品学杂志 2009年第10期22卷 990-992,1001页

作者：陈静蒋强华卢宏波项美娟吴季南曾令冰武汉生物制品研究所细菌类疫苗室武汉430060

目的探讨吸附无细胞百白破-重组乙型肝炎(CHO细胞)联合疫苗(DTaP-HBV)的中试工艺。方法通过不同的配比条件,探索DTaP-HBV联合疫苗的最佳中试工艺。以此工艺制备3批DTaP-HBV,进行各项指标的检定及稳定性试验。结果配方以无细胞百日咳疫... 详细信息

目的探讨吸附无细胞百白破-重组乙型肝炎(CHO细胞)联合疫苗(DTaP-HBV)的中试工艺。方法通过不同的配比条件,探索DTaP-HBV联合疫苗的最佳中试工艺。以此工艺制备3批DTaP-HBV,进行各项指标的检定及稳定性试验。结果配方以无细胞百日咳疫苗原液18μgPN/ml,精制白喉类毒素25Lf/ml,精制破伤风类毒素7Lf/ml,重组乙肝疫苗原液20μg/ml为宜;DTaP-HBV的稀释液选用0.85%NaCl溶液吸附效果较好,各抗原间无干扰作用;不同配合方式对四联疫苗的效力影响不大。3批DTaP-HBV的各项检定指标均符合《中国药典》三部(2005版)要求,且稳定性良好。结论已筛选出DTaP-HBV联合疫苗的最佳中试工艺,以此工艺制备的疫苗安全、稳定、有效。

关键词：无细胞百白破三联疫苗乙肝疫苗联合疫苗中试

润燥止痒胶囊联合依巴斯汀治疗慢性荨麻疹疗效观察

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中国皮肤性病学杂志 2009年第5期23卷 I0001-I0002页

作者：陈洪晓荆鲁华刘卫兵荀乙峰解放军404医院(济南军区皮肤性病诊疗中心整形美容中心)山东威海264200

目的观察润燥止痒胶囊联合依巴斯汀治疗慢性荨麻疹的疗效。方法86例患者随机分成两组,治疗组44例口服润燥止痒胶囊4粒,3次/d,依巴斯汀10mg 1次/d,连续治疗4周;对照组42例单独口服依巴斯汀,方法疗程同治疗组。结果治疗组有效率为90.91%,... 详细信息

目的观察润燥止痒胶囊联合依巴斯汀治疗慢性荨麻疹的疗效。方法86例患者随机分成两组,治疗组44例口服润燥止痒胶囊4粒,3次/d,依巴斯汀10mg 1次/d,连续治疗4周;对照组42例单独口服依巴斯汀,方法疗程同治疗组。结果治疗组有效率为90.91%,对照组为71.43%。两组比较差异有显著性(P<0.05)。结论润燥止痒胶囊联合依巴斯汀治疗慢性荨麻疹疗效确切。

关键词：润燥止痒胶囊依巴斯汀慢性荨麻疹

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics