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Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

World Journal of Hepatology 2024年第6期16卷 920-931页

作者： De-Liang Huang Qin-Xian Cai Guang-De Zhou Hong Yu Zhi-Bin Zhu jing-han peng Jun Chen Department of Liver Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously *** To assess the liver histological changes in the indeterminate phase CHB patients using liver *** The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December *** significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression *** Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate *** liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate *** liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate *** logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;Phanges in CHB patients in the indeterminate *** Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.

关键词： Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors

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Investigating core axial power distribution with multiconcentration gadolinium in PWR

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Nuclear Science and Techniques 2022年第11期33卷 22-32页

作者： jing-Gang Li jing-han peng Chao Wang Jun Chen Fei Xu Yun-Fan Ma China Nuclear Power Technology Research Institute Shenzhen 518000China

Core axial power distribution is an essential topic in pressurized water reactor(PWR)reactivity *** PWRs limit stability against axial core power oscillations at a high-cycle *** the‘‘camel’’peak power shape typically occurs with increasing depletion,the approaches used for the axial power control deserve special *** study aims to investigate the performance of different gadolinium rod design schemes in core axial power control during power operation based on the reactivity balance strategy,and to propose new multiconcentration gadolinium rod design *** the new design schemes,low-concentration gadolinium pellets are filled in the axial hump part of the gadolinium rod,and high-concentration gadolinium pellets are filled in the other *** impact of different gadolinium rod design schemes on the main core characteristics was evaluated using the nuclear design code package PCM developed by *** results show that the new gadolinium rod design significantly impacts the core axial power *** new design schemes can efficiently improve the core axial power distribution along the entire cycle by reducing the core axial power peak at the end of a cycle,enhancing the reactor operation stability,and achieving a better core safety margin,revealing a sizeable potential application.

关键词： Gadolinium PCM software package Fuel assembly Core axial power distribution Reactivity

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How the enhanced East Asian summer monsoon regulates total gross primary production in eastern China

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Advances in Climate Change Research 2024年第2期15卷 244-252页

作者： Ming-Yu han Yong ZhanG jing peng China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China China Meteorological Administration Institute for Development and Programme Design Beijing 100081China CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of Sciences(CAS)Beijing 100029China

Recognizing the relationship between gross primary production(GPP)and precipitation in eastern China,the East Asian Summer Monsoon(EASM)plays a crucial role in shaping *** confirmation of the strong link between EASM and GPP,there remains a notable research gap in understanding the specific impact of the EASM on GPP in different regions of eastern *** we used simulations from Trends in Net Land-Atmosphere Carbon Exchanges(TRENDY)models from 1951 to 2010 and divided eastern China into five subregions for the *** also used the New East Asian Summer Monsoon Index(NEWI)as a quantitative metric to distinguish between periods of strong and weak *** on this,this study aims to investigate the response of GPP in different subregions of eastern ***,under strengthened EASM years(1954,1957,1965,1969,1977,1980,1983,1987,1993 and 1998),East China experienced the most pronounced increase in GPP at 12±21(mean±1 sigma)gC m^(-2) mon^(-1) compared to the weak EASM years(1958,1961,1972,1973,1978,1981,1985,1994,1997 and 2004).In contrast,Southwest China showed a decline in GPP at-4±10 gC m^(-2) mon^(-1).Moreover,GPP also increased in Northeast and North China when EASM strengthened,while South China showed a decline in *** indicated that GPP changed with monsoon *** to the mechanism analysis,during strong EASM,there was intense moisture convergence through alterations in the atmospheric circulation field over East China and abundant precipitation,which further contributed to the increase in *** solar radiation in Southwest China decreased with EASM enhancement,which suppressed GPP and hindered vegetation ***,the results highlight the importance of accurately predicting the impact of different EASM intensities of regional carbon fluxes.

关键词： Gross primary production Surface air temperature Precipitation Solar radiation Eastern China Carbon cycle

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Interface optimization of graphene paper-Cu composite prepared by electrodeposition

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Journal of Iron and Steel Research International 2024年第1期31卷 64-73页

作者： jing Guo Hai-jing Wang Shuang-juan Liu peng Zhang jing-yu Tang Wei-yang Zhang han-jie Guo peng-cheng Wang Cai Meng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Advanced Technology and Materials Co. Ltd.Beijing100083China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230027AnhuiChina

A room-temperature electrodeposition method with an organic electrolyte was developed to fabricate a HNO3-pretreated graphene paper Cu(GP'-Cu)*** improve the interfacial bonding of GP'-Cu composite,magnetron sputtering technology was used to create a"sandwich"structural gradient GP'-Cu *** selection of the intermediate transition layer metal was based on two-dimensional *** electron microscopy,X-ray photoelectron spectroscopy,and other analytical methods confirmed that the addition of an intermediate transition metal(Cr,Ni)layer reduced the gap distance and enhanced the interfacial bonding of the GP'and Cu deposited *** GP'-Ni-Cu composite exhibited the largest increase in tensile strength and *** addition,it had the highest thermal diffusivity and elongation at break among the GP'-Cu,GP'-Cr-Cu and GP'-Ni-Cu composites.

关键词： Graphene paper Two-dimensional disregistry Magnetron sputtering Metal composite

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Effect of slag composition on kinetic behavior of deep deoxidation of 5 wt.% Si high-silicon austenitic stainless steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1873-1885页

作者： Guan-xiong Dou han-jie Guo jing Guo Xue-cheng peng Qing-yun Chen School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing 100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing 100083China

Based on a thermodynamic study of 5 wt.%Si high-silicon austenitic stainless steel(SS-5Si)smelting using CaF_(2)-CaO-Al_(2)0_(3)-Mg-Si0_(2) slag to obtain a low oxygen content of less than 10×10^(-4) wt.%,a kinetic mass transfer model for deep deoxidation was established through laboratory studies,and the effects of slag components and temperature on deoxidation during the slag-steel reaction process of sS-5Si were systematically *** experimental data verified the accuracy of the model *** results showed that the final oxygen content in the steel at 1873 K was mainly controlled by the oxygen content derived from the activity of SiO_(2) regulated by the[Si]-[O]equilibrium reaction in the slag system;in particular,when the slag basicity R(R=w(CaO)/w(SiO2),where w(CaO)and w(SiO_(2))are the contents of CaO and SiO_(2) in the slag,respectively)is 3,the Al2O3 content in the slag needs to be less than 2.7%.The mass transfer rate equation for the kinetics of the deoxidation reaction revealed that the mass transfer of oxygen in the liquid metal is the rate-controlling step under different slag conditions at 1873 K,and the oxygen transfer coefficient ko.m increases with increasing the slag basicity from 4.0×10^(-6)m s^(-1)(R=1)to 4.3×10^(-5) m s^(-1)(R=3).ko.m values at R=2 and R=3 are almost the same,indicating that high slag basicity has little *** integral of the mass transfer rate equation for the deoxidation reaction of SS-5Si under different slag conditions is *** total oxygen content of the molten steel decreases with increasing basicity from an initial content of 22×10^(-4) to 3.2×10^(-4) wt.%(R=3),consistent with the change in ko.m with slag *** R=2,the slag-steel reaction takes 15 min to reach equilibrium(w[O]=5.5×10^(-4) wt.%),whereas at R=3,the slag-steel reaction takes 30 min to reach equilibrium(w[0]=3.2×10^(-4) wt.%).Considering the depth of deoxidation and reaction time of SS-5Si smelting,it is recommended the slag b

关键词： Slag-steel reaction Kinetics Rate-controlling step Deep deoxidation Transfer coefficient

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Sensing with extended gate negative capacitance ferroelectric field-effect transistors

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Chip 2024年第1期3卷 18-23页

作者： Honglei Xue Yue peng Qiushi jing Jiuren Zhou Genquan han Wangyang Fu Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China School of Microelectronics Xidian UniveristyXi’an 710071China

With major signal analytical elements situated away from the measurement environment,extended gate(EG)ion-sensitive fieldeffect transistors(ISFETs)offer prospects for whole chip circuit design and system integration of chemical *** this work,a highly sensitive and power-efficient ISFET was proposed based on a metal-ferroelectric-insulator gate stack with negative capacitance–induced super-steep subthreshold swing and ferroelectric memory *** with a remotely connected EG electrode,the architecture facilitates diverse sensing functions for future establishment of smart biochemical sensor platforms.

关键词： Extended gate Ion-sensitive field-effect transistors Negative capacitance Sub-60 mV/dec subthreshold swing Ferroelectric memory effect

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Mechanical and damping performances of TPMS lattice metamaterials fabricated by laser powder bed fusion

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China Foundry 2024年第4期21卷 327-333页

作者： Yan-peng Wei Huai-qian Li jing-jing han Ying-chun Ma Hao-ran Zhou jing-chang Cheng Jian Shi Zhi-quan Miao Bo Yu Feng Lin National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China

Lattice metamaterials based on three-period minimum surface(TPMS)are an effective means to achieve lightweight and high-strength materials which are widely used in various fields such as aerospace and ***,its vibration and noise reduction,and damping properties have not been fully ***,in this study,the TPMS structures with parameterization were designed by the method of surface migration,and the TPMS structures with high forming quality was manufactured by laser powder bed fusion(LPBF).The mechanical properties and energy absorption characteristics of the beam and TPMS structures were studied and compared by quasi-static *** modal shapes of the beam lattice structures and TPMS structures were obtained by the free modal analysis,and the damping properties of two structures were obtained by modal *** the two structures after heat treatment with the same porosity of 70%,the yield strength of the beam lattice structure reaches 40.76 MPa,elastic modulus is 20.38 GPa,the energy absorption value is 32.23 MJ·m^(-3),the damping ratio is 0.52%.The yield strength,elastic modulus,energy absorption value,and damping ratio of the TPMS structure are 50.74 MPa,25.37 GPa,47.34 MJ·m^(-3),and 0.99%,*** results show that TPMS structures exhibit more excellent mechanical properties and energy absorption,better damping performance,and obvious advantages in structural load and vibration and noise reduction compared with the beam lattice structures under the same porosity.

关键词： lattice metamaterials TPMS energy absorption damping laser powder bed fusion

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Jetting of a near-wall cavitation bubble induced by another tandem bubble

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Journal of Hydrodynamics 2024年第3期36卷 444-456页

作者： Hui han jing-zhu Wang Jian-lin Huang peng-bo Bai Yong-gang Chen Yi-wei Wang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China Guangdong Aerospace Research Academy Guangzhou511458China School of Future Technology University of Chinese Academy of SciencesBeijing100049China Jianghuai Advance Technology Center Hefei230088China

Double bubbles near a rigid wall surface collapse to produce a significant jet impact,with potential applications in surface cleaning and ultrasonic ***,the dynamic behaviors of near-wall bubbles remain *** this study,we investigate the jetting of a near-wall bubble induced by another tandem *** define two dimensionless standoff distances,γ_(1),γ_(2),to represent the distances from the center of the near-wall bubble to the rigid wall and the center of controlling bubble to the center of the near-wall bubble,*** observations reveal three distinct jetting regimes for the near-wall bubble:transferred jetting,double jetting,and directed *** further investigate the jetting mechanism,numerical simulations are conducted using the compressibleInterFoam solver in the open-source framework of OpenFOAM.A detailed analysis shows that the transferred jet flow is caused by the pinch-off resulting from the axial contraction velocity at the lower end of the near-wall bubble being greater than the vertical contraction velocity,leading to a maximum jet velocity of 682.58 m/*** the case of double jetting,intense stretching between the controlling bubble and the wall leads to a pinch-off and a double jetting with a maximum velocity of 1096.29 m/*** directed jet flow is caused by the downward movement of the high-pressure region generated by the premature collapse of the controlling bubble,with the maximum jet velocity reaching 444.62 m/s.

关键词： Jetting of near-wall bubble controlling bubble impact velocity

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Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： Zi-han Wang jing Guo han-jie Guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

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CFD-DEM study on the synergistic effect of coke consumption and particle dynamics in the blast furnace raceway

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Particuology 2024年第6期89卷 270-278页

作者： peng Xu peng han Zhijun He Xizhong An Kang Sun Lihua Gao Key Laboratory of Green Low-Carbon and Intelligent Metallurgy School of Materials and MetallurgyUniversity of Science and Technology LiaoningAnshan 114000China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang110819China

In this study,the gas-solid flow process in the blast furnace raceway is numerically simulated using coupled computational fluid dynamics and the discrete element method(CFD-DEM).The coke reaction kinetics data are imported into the DEM model to reproduce the consumption process of each coke *** effects of inlet gas velocity and angle on the morphology of the raceway,coke consumption rate,coke bed temperature,and particle size distribution in the blast process are systematically investigated and *** results show that the consumption of coke particles promotes the formation of raceways during the blast *** the same time,a coke mixture layer is produced at the edge of the *** higher the inlet gas velocity,the thicker the coke mixture layer in the middle and upper parts of the raceway region,and the larger the proportion of small particles in the coke mixture *** effect of the inlet gas angle on the raceway region is less than the inlet gas ***,with the increase in the inlet gas angle,the high-temperature region of the coke bed extends downward gradually,which is conducive to activating the hearth.

关键词： Blast furnace Raceway Multiphase flow CFD-DEM Modeling

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