检索结果-南通市图书馆

Palindrome-mediated DNA nanotubes with cell-specific aptamers to improve targeted antitumor effects and reduce toxicity on non-small cell lung cancer

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 454-466页

作者： Cheng Zheng Lanlan Song Chang Yu Lingye Zhu jing Zhang Ning wang Mengchu Liu Shini Li Liangxing wang Zhifa Shen Xiaoying Huang Division of Pulmonary Medicine the First Affiliated Hospital of Wenzhou Medical UniversityKey Laboratory of Interdiscipline and Translational MedicineWenzhou 325000China Intervention Department the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of Laboratory Medicine Ministry of Education of Chinaand Zhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China

Chemotherapy is regarded as a widely used and effective treatment strategy for lung cancer,although most conventional chemotherapeutics cause severe toxic side-effects due to their indiscriminate attacks on both cancerous and normal *** nucleic acid nanomaterials are emerging as a promising drug delivery strategy,their clinical applications are limited by rapid degradation by nucleases and difficulties in targeting cancer *** this study,we have developed a Rhein-loaded aptamer-based DNA nanotube(DNT-S6@Rhein)for the targeted and efficient therapy of non-small cell lung *** the palindrome segments,two specified oligonucleotides were hybridized and folded into the well-defined nanotubes(DNT-S6),with the S6 aptamer distributed *** obtained nanotubes exhibited excellent serum stability and targeting ability towards A549 cells due to the firm structure and decoration of the S6 ***,as an antitumor drug and DNA intercalator,can be effectively inserted into the *** drug-loaded nanotubes rapidly disassembled in intracellular environment and then the released Rhein was found to activate cellular apoptotic process and significantly suppress proliferation,migration and invasion of A549 ***,DNT-S6@Rhein could efficiently accumulate in tumor regions,offering compelling therapeutic efficacy and biocompatibility under both in vitro and in vivo *** findings of this study provide a promising strategy for mitigating the inevitable systemic side-effects of chemotherapy and expand the potential application of DNA nanostructure on targeted drug delivery.

关键词： DNA nanotube self-assembly Rhein targeted drug delivery cancer therapy

Latitudinal patterns of tree β-diversity and relevant ecological processes vary across spatial extents in forests of southeastern China

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2025年第1期47卷 89-97页

作者： Maochou Liu Wenxiang Wu Ke wang Xinshuai Ren Xueqin Zhang Lei wang jing Geng Bo Yang Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Department of Environment and Resources University of Chinese Academy of SciencesBeijing 100049China Zhai Mingguo Academician Work Station Sanya UniversitySanya 572022China

Latitudinal patterns of treeβ-diversity reveal important insights into the biogeographical processes that influence forest *** previous studies have extensively documentedβ-diversity within relatively small spatial extents,the potential drivers ofβ-diversity along latitudinal gradients are still not well understood at larger spatial *** this study,we determined whether treeβ-diversity is correlated with latitude in forests of southeastern China,and if so,what ecological processes contribute to these patterns of treeβ-*** specifically aimed to disentangle the relative contributions from interspecific aggregation and environmental filtering across various spatial *** delineated regional communities comprising multiple nearby national forest inventory(NFI)plots around random focal *** number of NFI plots in a regional community served as a surrogate for spatial *** also used a null model to simulate randomly assembled communities and quantify the deviation(β-deviation)between observed and expectedβ-*** found thatβ-diversity decreased along a latitudinal gradient and that this pattern was clearer at larger spatial *** addition,latitudinal patterns ofβ-deviation were explained by the degree of species spatial *** also identified environmental factors that driveβ-deviation in these forests,including precipitation,seasonality,and temperature *** larger spatial extents,these environmental variables explained up to 84%of theβ-*** results reinforce that ecological processes are scale-dependent and collectively contribute to theβ-gradient in subtropical *** recommend that conservation efforts maintain diverse forests and heterogeneous environments at multiple spatial extents to mitigate the adverse effects of climate change.

关键词： Environmental filtering Latitudinal pattern Forest beta diversity Spatial extent Species spatial aggregation Regional community

Nonsurgical treatment of postoperative intestinal obstruction caused by heterotopic ossification of the mesentery:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2025年第3期17卷 385-390页

作者： jing-Tian Chen Yao-Ping Li Shang-Qi Guo Jin-Sheng Huang Yong-gang wang Department of Colorectal and Anal Surgery Shanxi Provincial People’s HospitalShanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Among all forms of heterotopic ossification,heterotopic mesenteric ossification(HMO)is rare,with fewer than 100 reported cases to *** early small bowel obstruction caused by HMO is even rarer,presenting extremely high surgical risks,the potential for multiple surgeries,and a poor *** have been no reported cases of conservative treatment for resolving such early postoperative *** SUMMARY A 57-year-old male presented with severe postoperative small bowel obstruction shortly after undergoing open radical resection for transverse colon *** revealed extensive adhesions in the proximal jejunum and mesen-tery,making it too difficult to relieve without injuring the small ***-tionally,multiple fixed nodules were found in the mesentery during the *** confirmed the presence of heterotopic *** patient was treated with methylprednisolone on postoperative day 1,which gradually relieved his *** Hormone therapy may have a potential role in treating small bowel obstruction caused by early HMO after operative intervention.

关键词： Heterotopic mesenteric ossification Hormone therapy Bowel obstruction Methylprednisolone Surgery Case report

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu wang Xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-gang Zhao Ji-Luo Liu Jian wang jing-Han Guo Xiao-Mei Zhang Yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Tuning up of chromism,luminescence in cadmium-viologen complexes through polymorphism strategy:Inkless erasable printing application

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第1期36卷 322-325页

作者： Yanting Yang Guorong wang Kangjing Li Wen Yang jing Zhang Jian Zhang Shili Li Xianming Zhang Key Laboratory of Magnetic Molecules&Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China School of Chemistry Taiyuan University of TechnologyTaiyuan 030024China

In our work,polymorphism strategy has been successfully applied to tune up chromism and luminescence properties of viologen-based *** polymorphs of viologen-based complexes ofα-CdBr_(2)(PHSQ)_(2)(H_(2)O)_(2)(1)andβ-CdBr_(2)(PHSQ)_(2)(H_(2)O)_(2)(2)(PHSQ=N-(4-sulfophenyl)-4,4-bipyridinium)were synthesized by changing the *** can both respond to UV light and electricity in the manner of chromism visible to the naked eye and the coloration states have good reversibility,through which an inkless erasable printing model has been *** the coloration contrast of 1 is higher compared to ***,they both exhibit photoluminescence properties and the intensity of 1 is twice that of 2,which is accompanied by photoquenching upon continuous UV light *** only divergence of disordered/ordered O atoms in the two crystalline compounds leads to significantly different chromic and luminescent *** explorations simultaneously demonstrate that the different chromic performance between 1 and 2 should attribute to the alteration of stimulus-induced(light/electricity)electron transfer channels caused by the ordered/disordered O atoms in the complexes,which is achieved through C-H···O and O-H···O interactions to change crystal arrangement and structural rigidity,thus affect luminescent properties.

关键词： Polymorphs Photochromism Electrochromism Photoluminescence

Petrogenesis of rodingites along the northern margin of the North China Craton: Constraints from zirconology and whole-rock geochemistry

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第3期68卷 750-767页

作者： jing RAN Hao wang Jinhui YANG Yaoqi YAN Yusheng ZHU Baoquan ZHOU State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Rodingite is a metasomatic product formed from various rock types by aqueous fluids, providing a direct record of lithosphere-hydrosphere interactions and serving as a key carrier of surface water into Earth's deep interior（water content >1.5wt.%）. Determining the properties of metasomatic fluids is crucial for understanding the petrogenesis of rodingites. In this study,we conducted a detailed study of mineral inclusions, U-Pb ages, trace elements, and Hf-O isotopes of zircon, as well as wholerock geochemical and Sr-Nd-Hf isotopic data on rodingites and associated felsic alkaline veins/dikes along the northern margin of the North China Craton（NMNCC）, with aims to elucidate their formation ages, petrogenesis, and geodynamic settings. The results show that zircons from syenite and albite syenite veins/dikes exhibit clear oscillatory zoning, a wide range of Th/U ratios（0.0001–4.073）, low concentrations of rare-earth elements（REEs）, and low crystallization temperatures（<600°C）. These characteristics suggest that the zircons crystallized from fluids separated from late-stage melts during magma evolution. Consequently, the zircon U-Pb ages obtained through Secondary Ion Mass Spectrometry（SIMS） and Laser Ablation Inductively Coupled Plasma Mass Spectrometry（LA-ICPMS） analyses（389.1±3.5 to 390.2±1.6 Ma） record the timing of hydrothermal fluid activity. Zircons within the rodingites contain grandite, hematite, and aqueous fluid inclusions, indicating their formation during rodingitization, with an oxidizing, water-rich fluid acting as the metasomatic agent. SIMS and LA-ICPMS analyses of these zircons yielded U-Pb ages of 388.1±3.9 and 388.6±4.6 Ma, which register the formation ages of the rodingites. Both the syenite and albite syenite samples display high total alkali contents（9.9–13.9 wt.%）, consistent initial Sr isotopic ratios（0.7047–0.7051）,negative εNd（t）(-10.1 to-8.5) and εHf（t）(-13.9 to-13.7) values, and slightly elevated zircon δ18O values（6.20‰±0.18‰）compared to ma

关键词： North China Craton Rodingite Syenite Inclusions Zircon U-Pb age Sr-Nd-Hf-O isotopes

同方期刊数据库

Regulating crystallization and retarding oxidation in Sn-Pb perovskite via 1D cation engineering for high performance all-perovskite tandem solar cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 646-652页

作者： Ranran Liu Xin Zheng Zaiwei wang Miaomiao Zeng Chunxiang Lan Shaomin Yang Shangzhi Li Awen wang Min Li jing Guo Xuefei Weng Yaoguang Rong Xiong Li Michael Grätzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiChina Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina School of Chemistry Chemical Engineering and Life SciencesState Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of Technology430070HubeiChina Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO) Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570228HainanChina

All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization ***,the challenges encompass the oxidation of Sn^(2+)to Sn^(4+)and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational ***,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide (EMIMI) into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn^(2+)to Sn^(4+)and regulates the film-forming dynamics of Sn/Pb-based perovskite *** optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.

关键词： All-perovskite tandem solar cells Sn-Pb perovskite 1D Regulated crystallization Antioxidation

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le wang Wenwu Zhang gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Interfacial behaviors between ZG13Cr9Mo1VNbN stainless steel and chromite sand

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2025年第1期32卷 129-143页

作者： Shi-sen Li Xi-min Zang Ji-lin Chen Jie Yang Yu-an jing Zhi-ying wang Ling-zhong Kong School of Materials and Metallurgy University of Science and Technology LiaoningAnshan114051LiaoningChina School of Material Science and Engineering Shenyang University of TechnologyShenyang110870LiaoningChina Central Iron and Steel Research Institute Co. Ltd.Beijing100081China Xingtai Iron and Steel Co. Ltd.Xingtai054027HebeiChina

To elucidate the formation mechanisms of burn-on sand and metal penetration during sand casting,some laboratory experiments were carried out at different temperatures(1813,1833,1853,and 1873 K)and holding time(20,40,60,and 90 min)to simulate the interaction between ZG13Cr9Mo1VNbN stainless steel and chromite *** results demonstrate that the defects primarily consist of a mixture of the liquid phase,chromite,and *** main components of the liquid phase are SiO_(2),MnO,MgO,Cr_(2)O_(3),FeO,and Al_(2)O_(3),and the formation of Cr_(2)O_(3)through interfacial redox reactions has been *** presence of a liquid phase plays a pivotal role in influencing burn-on sand and metal *** reactions are prioritized,with burn-on sand maintaining a predominant *** the liquid phase quantity within the sand escalates,there is a corresponding incremental rise in the incidence of metal *** a minimal presence of the silicon element in steel can impact the liquid phase’s ***,the decomposition or dissolution of chromite sand is a significant factor in the development of burn-on sand and metal ***,a thorough investigation into the conditions and contributing factors of this phenomenon is essential for its effective management and mitigation.

关键词： Heat-resistant steel Chromite sand Interfacial reaction Burn-on sand Metal penetration Temperature Holding time