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iLIVER 2024年第1期3卷 30-37页

作者： Lin Han Huan Xie Xue-Mei Ma Xiao-Long Lu Jun Zhao Qing-Sheng Liang Zheng-Sheng Zou jing-feng bi Bo Jin Ying Sun Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China Graduate School Medical School of Chinese PLABeijing 100039China

Background and aims:Esophagogastric varices(EGV)are common complications of primary biliary cholangitis(PBC).We examined the risk factors for variceal bleeding-related liver transplantation(LT)or ***:This prospective observational cohort study involved PBC in our hospital from 1 January 2005 to 1 January *** clinical endpoints were variceal bleeding-related LT and *** analysis was performed using the Kaplan-Meier estimate,cox regression analysis was performed to investigate risk ***:PBC with EGV had significantly shorter survival than those without(p?0.002).Endoscopic prophylaxis significantly improved poor outcomes in PBC with EGV(p1.2ULN at baseline,total bilirubin of>1.2ULN,aspartate aminotransferase(AST)of>2.3ULN after 1 year of ursodeoxycholic acid(UDCA)treatment,non-biochemical responders according to the Paris criteria,and no history of endoscopic *** PBC without EGV,risk factors included AST of>2.3ULN,INR of>1.2ULN at baseline,CHE of***:This study provides evidence that AST,INR and CHE are major risk factors for variceal bleedingrelated poor outcomes in *** PBC with EGV,a good biochemical response to UDCA and endoscopic prophylaxis may improve *** findings can aid for guiding initial PBC risk stratification and screening endoscopy in patients without EGV.

关键词： Primary biliary cholangitis Esophagogastric varices Ursodeoxycholic acid Liver transplant-free survival Endoscopic therapy Risk factors

Absorption-dominant EMI shielding performance of multiple folded bi_(2)Se_(3)/PVDF nanocomposite films

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Journal of Materiomics 2024年第1期10卷 27-36页

作者： Xinyi Pu Zunpeng feng Siyuan Sun Ke bi Yanan Hao State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing100876China Chinese Academy of Engineering Innovation Strategy Beijing100088China

Absorption-dominant electromagnetic interference(EMI)shielding materials are promising in reducing electromagnetic radiation pollution,but their preparation processes are usually difficult and unsuitable for large-scale *** this work,multiple folded bi_(2)Se_(3)/PVDF nanocomposite films were fabri-cated by using a convenient tape-casting method and multiple folding,which can be easily extended in industrial *** EMI shielding effectiveness(SE)of the composite materials was investigated,which shows typical absorption-dominant behavior and can substantially reduce secondary ***,for the 35%(in volume)bi_(2)Se_(3)/PVDF nanocomposite film,the SE_(A)of single-layered film with a thickness of 60 mm reaches 20 dB while SE_(R)is lower than 5 *** folding the film into eight layers,the SE_(A)increased to 50 dB while SE_(R)remains below 5 *** method provides an effective way to the fabrication of absorption-dominant electromagnetic absorption(EMA)and EMI shielding material.

关键词： Electromagnetic interference shielding(EMI) Electromagnetic wave absorption bismuth selenide Composite

Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis

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World Journal of Gastroenterology 2020年第29期26卷 4316-4326页

作者： Bo Tu Yue-Ning Zhang jing-feng bi Zhe Xu Peng Zhao Lei Shi Xin Zhang Guang Yang En-Qiang Qin Department of Infectious Disease the Fifth Medical CenterChinese People's Liberation Army General HospitalBeijing 100039China Center of Hepatology and Gastroenterology Beijing Capital Medical University You’an HospitalBeijing 100039China Department of Clinical and Translational Medicine the Fifth Medical CenterChinese People's Liberation Army General HospitalBeijing 100039China

BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the *** establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with *** total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic *** in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP.

关键词： Spontaneous bacterial peritonitis Asymptomatic Ascites Multivariate predictive model Liver cirrhosis

Recent Advances in Deciphering the Mechanisms and biological Functions of DNA Demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang feng Sheng-Jun Chen bi-feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** DNA demethylation pathways possess critical functional implications and roles in biological *** Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms biological functions C—C bond cleavage Mass spectrometry

Experimental and numerical study on dynamic mechanical behaviors of shale under true triaxial compression at high strain rate

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International Journal of Mining Science and Technology 2024年第2期34卷 149-165页

作者： Xiaoping Zhou Linyuan Han jing bi Yundong Shou School of Civil Engineering Wuhan UniversityWuhan 430072China College of Civil Engineering Guizhou UniversityGuiyang 550025China

High-energy gas fracturing of shale is a novel,high efficacy and eco-friendly mining technique,which is a typical dynamic perturbing *** effectively extract shale gas,it is important to understand the dynamic mechanical properties of *** experiments on shale subjected to true triaxial compression at different strain rates are first conducted in this *** dynamic stress-strain curves,peak strain,peak stress and failure modes of shale are *** results of the study indicate that the intermediate principal stress and the minor principal stress have the significant influence on the dynamic mechanical behaviors,although this effect decreases as the strain rate *** characteristics of compression-shear failure primarily occur in shale subjected to triaxial compression at high strain rates,which distinguishes it from the fragmentation characteristics observed in shale under dynamic uniaxial ***,a numerical three-dimensional Split Hopkinson Pressure Bar(3D-SHPB),which is established by coupling PFC3D and FLAC3D methods,is validated to replicate the laboratory characteristics of *** dynamic mechanical characteristics of shale subjected to different confining stresses are systematically investigated by the coupling PFC3D and FLAC3D *** numerical results are in good agreement with the experimental data.

关键词： Dynamic behaviors True triaxial compression High strain rates Dynamic failure mechanism PFC3D-FLAC3D coupled method

An optimized time-adaptive aerothermal coupling calculation method for aerothermal analysis of disc cavity system

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Chinese Journal of Aeronautics 2024年第9期37卷 164-177页

作者： Shuai bi Junkui MAO Lei WANG feng HAN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 20016China AECC Aeroengine Control System Institute Wuxi 214063China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In order to further achieve the balance between the calculation accuracy and efficiency of the transient analysis of the aero-engine disc cavity system,an Optimized Time-adaptive Aerother-mal Coupling calculation(OTAC)method has been *** combines one-dimensional tran-sient calculation of air system,Conventional Sequence Staggered(CSS)method,Time-adaptive Aerothermal Coupling calculation(TAC)method and differential evolution optimization algorithm to obtain an efficient and high-precision aerothermal coupling calculation method of air *** both the heat conduction in the solid domain and the flow in the fluid domain as unsteady states in the OTAC,the interaction of fluid-solid information within a single coupling time step size was implemented based on the CSS ***,the coupling time step size was automatically adjusted with the number of iterations by using the Proportional-Integral-Deri vative(PID)*** show that when compared with the traditional loosely coupling method with a fixed time step size,the computational accuracy and efficiency of the OTAC method are improved by 8.9%and 30%,*** with the tight coupling calculation,the OTAC method can achieve a speedup of 1 to 2 orders of magnitude,while the calculation error is maintained within 6.1%.

关键词： Air system 1D-3D coupling Conjugate heat transfer Transient calculation Adaptive time step size

An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

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Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-Da Zhu Yu-Zhe Han Xiao-bi jing School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using H_(2)O_(2)as the green *** was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb,Cu,Pd,Ag and *** of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material,which might facilitate its absorption to *** work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis,*** Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions,*** discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Surfaces Porous materials Rare metal concentration Adsorption Catalysis

Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： Huanhuan Yin Qiulin Tang Hongwei Xia feng bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

A modified 3D mean strain energy density criterion for predicting shale mixed-mode Ⅰ/Ⅲ fracture toughness

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2411-2428页

作者： Kun Zheng Chaolin Wang Yu Zhao jing bi Haifeng Liu College of Civil Engineering Guizhou UniversityGuiyang550025China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The fracture toughness of rocks is a critical fracturing parameter in geo-energy exploitation playing a significant role in fracture mechanics and hydraulic *** edge-notched disk bending(ENDB)specimens are employed to measure the entire range of mixed-modeⅠ/Ⅲfracture toughness of Longmaxi *** theoretically interpret the fracture mechanisms,this research first introduces the detailed derivations of three established fracture *** distinguishing the volumetric and distortional strain energy densities,an improved three-dimensional mean strain energy density(MSED)criterion is *** the critical volumetric to distortional MSED ratio decreases,the transition from tensiondominated fracture to shear-dominated fracture is *** results indicate that both peak load and applied energy increase significantly with the transition from pure mode I(i.e.,tension)to pure modeⅢ(i.e.,torsion or tearing)since mode-Ⅲcracking happens in a twisted manner and mode-Ⅰcracking occurs in a coplanar *** macroscopic fracture signatures are consistent with those of triaxial hydraulic *** average ratio of pure mode-Ⅲfracture toughness to pure mode-Ⅰfracture toughness is 0.68,indicating that the obtained mode-Ⅲfracture resistance for a tensionbased loading system is apparent rather than *** to the three mainstream fracture criteria,the present fracture criterion exhibits greater competitiveness and can successfully evaluate and predict mixed-modeⅠ/Ⅲfracture toughness of distinct materials and loading methods.

关键词： Longmaxi shale Hydraulic fracturing Fracture mechanisms Fracture criteria Mixed-modeⅠ/Ⅲfracture toughness Edge-notched disk bending

NMR-based analysis of the effect of moisture migration on sandstone pore structure under alternating wetting and drying conditions

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International Journal of Mining Science and Technology 2024年第8期34卷 1135-1150页

作者： Huasu Wang jing bi Yu Zhao Chaolin Wang Jiabao Ma College of Civil Engineering Guizhou UniversityGuiyang 550025China

The wetting-drying(W-D)cycle is a type of water–rock *** pore structure of rock,such as shape,size,distribution and pore throat,affects fluid storage and *** theory and experimental research on the evolution characteristics of pore damage during the wet-dry erosion process are highly important for determining W-D *** mass and velocity of liquid migration are related to the pore size,porosity,fluid properties,*** data show that the water absorption quality and velocity in rocks decrease with the number of wet-dry *** the same test time,the mass and velocity of the SI water absorption method are smaller than those of the FI *** these two conditions,the amount and rate of water absorption represent the degree of water–rock *** the pore evolution during the wet-dry cycling,an equation describing the motion of liquid in porous media was derived based on the imbibition-type separation *** experimental data are in excellent agreement with the calculated values of the *** characteristics can affect the area and degree of rock deterioration as well as the development rate of pores and *** on the interaction between permeability and pores,quantitative analysis of the weakening process(local damage)of rocks under W-D cycles can provide good reference indicators for evaluating the stability of geotechnical engineering.

关键词： W-D cycle Capillary absorption Pore characteristic Fractal theory Dynamic damage model