检索结果-南通市图书馆

Machine learning for diagnosis of coronary artery disease in computed tomography angiography:A survey

Artificial Intelligence in Medical Imaging 2020年第1期1卷 31-39页

作者： Feng-Jun Zhao Si-Qi Fan jing-fang ren Karen M von Deneen Xiao-Wei He Xue-Li Chen School of Information Science and Technology Northwest UniversityXi’an 710069Shaanxi ProvinceChina Xi’an Key Lab of Radiomics and Intelligent Perception Northwest UniversityXi’an 710069Shaanxi ProvinceChina Engineering Research Center of Molecular and Neuro Imaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710126Shaanxi ProvinceChina

Coronary artery disease(CAD)has become a major illness endangering human *** mainly manifests as atherosclerotic plaques,especially vulnerable plaques without obvious symptoms in the early *** a rupture occurs,it will lead to severe coronary stenosis,which in turn may trigger a major adverse cardiovascular *** tomography angiography(CTA)has become a standard diagnostic tool for early screening of coronary plaque and stenosis due to its advantages in high resolution,noninvasiveness,and three-dimensional ***,manual examination of CTA images by radiologists has been proven to be tedious and time-consuming,which might also lead to intra-and interobserver ***,many machine learning algorithms have enabled the(semi-)automatic diagnosis of CAD by extracting quantitative features from CTA *** paper provides a survey of these machine learning algorithms for the diagnosis of CAD in CTA images,including coronary artery extraction,coronary plaque detection,vulnerable plaque identification,and coronary stenosis *** included articles were published within this decade and are found in the Web of *** wish to give readers a glimpse of the current status,challenges,and perspectives of these machine learning-based analysis methods for automatic CAD diagnosis.

关键词： Machine learning Deep learning Coronary artery disease Atherosclerotic plaque Vulnerability Stenosis Segmentation Computed tomography angiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang jing ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

引用

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui ren Yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Statistical analysis on the validity of the cold plasma approximation for chorus waves based on Van Allen Probe observations and their effects on radiation belt electrons

引用

Earth and Planetary Physics 2025年第1期9卷 159-170页

作者： AoJun ren Jiang Yu jing Wang ZuZheng Chen XiaoMan Liu Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai Guangdong 519000China

Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric *** quantitative analyses often simplified the chorus dispersion relation by using the cold plasma ***,the applicability of the cold plasma assumption is doubtful,especially during geomagnetic *** here present a systematic statistical analysis on the validity of the cold plasma dispersion relation of chorus waves based on observations from the Van Allen Probes over the period from 2012 to *** statistical results show that the observed magnetic field intensities deviate substantially from those calculated from the cold plasma dispersion relation and that they become more pronounced with an increase in geomagnetic activity or a decrease in background plasma *** region with large deviations is mainly concentrated in the nightside and expands in both the radial and azimuthal directions as the geomagnetic activity increases or the background plasma density *** addition,the bounce-averaged electron scattering rates are computed by using the observed and cold plasma dispersion relation of chorus *** with usage of the cold plasma dispersion relation,usage of the observed dispersion relation considerably lowers the minimum resonant energy of electrons and lowers the scattering rates of electrons above tens of kiloelectronvolts but enhances those ***,these differences are more pronounced with the enhancement of geomagnetic activity or the decrease in background plasma density.

关键词： chorus waves cold plasma approximation dispersion relations scattering rates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

引用

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lightweight Al-Nb-Ti-V-Cr high entropy alloys with high hardness and enhanced mechanical properties via doping Co

引用

China Foundry 2025年

作者： fang-dong Xu De-zhi Chen Rui-run Chen Bin Gan jing-yue Yu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of CoxAlNbTiVCr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti VCr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of Co changes the microstructure of LHEAs from a single B2 structure to a mixture dendrite structure,which consists of B2 phase,C14 and C15 Laves *** the C14 and C15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEC）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of B2 and Laves phase in *** the Co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti VCr alloy exhibits the maximum Vickers hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

引用

Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： fang Wu jing Jiao GuoTao Yang Lifang Du ZhengKuan Liu HaoRan Zheng JiXin Guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

宫颈癌HeLa细胞内SKP2结合蛋白的筛选和功能预测

引用

中国肿瘤生物治疗杂志 2018年第3期25卷 258-262页

作者：贾静方健飞任娟贾振宇王孝举浙江省医学科学院分子医学中心浙江杭州310013

目的:通过免疫共沉淀与质谱分析技术从宫颈癌HeLa细胞中获取与S期激酶相关蛋白2(S-phase kinase-associated protein 2,SKP2)结合的蛋白质群体并预测其生物功能。方法:以免疫共沉淀与Western blotting技术建立SKP2免疫共沉淀体系,以SDS-... 详细信息

目的:通过免疫共沉淀与质谱分析技术从宫颈癌HeLa细胞中获取与S期激酶相关蛋白2(S-phase kinase-associated protein 2,SKP2)结合的蛋白质群体并预测其生物功能。方法:以免疫共沉淀与Western blotting技术建立SKP2免疫共沉淀体系,以SDS-PAGE和银染技术获得SKP2结合蛋白的特异条带,通过质谱分析技术获得可能与SKP2结合的蛋白群体,应用生物信息学技术对筛选得到的蛋白进行GO分析与KEGG分析。结果:HeLa细胞内存在一定水平的SKP2蛋白表达,可进行免疫共沉淀反应;成功建立了SKP2免疫共沉淀体系,并获得SKP2结合蛋白样品;针对差异的凝胶条带进行质谱分析,共鉴定出SKP2结合蛋白563个;设定筛选条件后,获得可信度较高的SKP2蛋白270个,进行GO分析与KEGG分析后初步预测了结合蛋白参与的细胞功能和信号通路。结论:从宫颈癌HeLa细胞中成功筛选获取SKP2结合蛋白,为后续筛选靶标结合蛋白和寻找细胞靶向药物奠定了基础。

关键词：细胞S期激酶相关蛋白2 免疫共沉淀宫颈癌结合蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三峡库区典型农业小流域土壤中抗生素的时空分布与生态风险

引用

环境科学 2024年第11期45卷 6583-6593页

作者：方镜人母悦唐柏彬郭春会黄纬斌雍晴王正张进忠西南大学资源环境学院重庆市农业资源与环境重点实验室重庆400715 重庆海关技术中心重庆400020

为了解三峡库区农业流域土壤中抗生素的时空分布与生态风险,于2022年分春、夏、秋、冬这4个季节在重庆市涪陵区王家沟小流域的26个样点采集表土样品,采用固相萃取、超高效液相色谱-串联质谱法测定土样中5类21种抗生素,分析抗生素的含量... 详细信息

为了解三峡库区农业流域土壤中抗生素的时空分布与生态风险,于2022年分春、夏、秋、冬这4个季节在重庆市涪陵区王家沟小流域的26个样点采集表土样品,采用固相萃取、超高效液相色谱-串联质谱法测定土样中5类21种抗生素,分析抗生素的含量水平和时空分布,探讨抗生素含量与土壤理化因子的相关关系,用风险商值法评估土壤中抗生素的潜在生态风险.结果表明,21种抗生素的检出率为0~100%,检出范围为ND~219.5μg·kg^(-1),其中四环素类(TCs)、喹诺酮类(FQs)和氯霉素类(CAPs)在4个季节的检出率均达到100%;抗生素总量范围为14.35~504.1μg·kg^(-1),含量平均值为149.7μg·kg^(-1),5类抗生素的含量平均值依次为:TCs(77.95μg·kg^(-1))>FQs(34.96μg·kg^(-1))>CAPs(28.14μg·kg^(-1))>磺胺类(7.15μg·kg^(-1))>大环类酯类(1.48μg·kg^(-1)).秋、冬季土壤中抗生素含量显著高于夏季土壤(P<0.05),抗生素含量总体上随季节呈现先降低后升高的变化趋势,并呈“西低东高”的分布态势,含量较高的点位主要集中在菜地、居民区和旱地.春季土壤中,泰乐菌素(TYL)(P<0.01)、四环素(TC)(P<0.01)、强力霉素(DXC)和磺胺甲嘧啶(SMR)含量(P<0.05)均与土壤pH呈显著负相关.夏季土壤中,总磷(TP)显著正影响磺胺异唑(SFZ)和TC含量(P<0.05),且对磺胺甲唑(SMX)、SMR和氧氟沙星(OFL)的正影响达到极显著水平(P<0.01);总氮(TN)对SMX(P<0.01)和SMR含量有显著正影响(P<0.05);土壤有机质(SOM)显著正影响TC和恩诺沙星(ENR)含量(P<0.05);而环丙沙星(CIP)(P<0.001)、磺胺吡啶(SPD)、诺氟沙星(NOR)和TYL含量(P<0.05)与土壤pH呈显著负相关.秋季土壤中,TN显著负影响CIP含量(P<0.05);pH显著负影响磺胺嘧啶(SDZ)、TC和DXC含量(P<0.05);阳离子交换量(CEC)显著正影响TC和SFZ含量(P<0.05).冬季土壤中,TP显著正影响TYL含量;TN显著正影响SFZ含量(P<0.05),且对磺胺间甲氧嘧啶(SMM)的正影响达到极显著水平(P<0.001);金霉素(CTC)(P<0.01)、CIP(P<0.01)、甲砜霉素(TAP)(P<0.001)、氯霉素(CAP)(P<0.001)、土霉素(OTC)(P<0.001)和磺胺二甲嘧啶(SM2)(P<0.05)均与土壤pH呈显著负相关;CEC显著负影响SDZ含量(P<0.05).王家沟农业小流域土壤主要受到SMX、SDZ、TC、DXC、红霉素、NOR、OFL、CIP和ENR的威胁,它们的生态风险不容忽视.

关键词：三峡库区农业小流域土壤抗生素时空分布生态风险

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

引用

World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue ren Ying Tang Qi Yang Tian-Tian Meng Song Li jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：