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托珠单抗治疗儿童难治性N-甲基-D-天冬氨酸受体抗体脑炎9例临床分析

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中华儿科杂志 2024年第6期62卷 559-564页

作者：韩洋彭镜何芳张慈柳杨丽芬毛蕾蕾中南大学湘雅医院小儿神经专科长沙410008

目的分析使用托珠单抗治疗的难治性N-甲基-D-天冬氨酸(NMDA)受体抗体脑炎患儿的临床特征。方法回顾性分析2021年8月至2023年9月中南大学湘雅医院儿科接受托珠单抗治疗的9例难治性NMDA受体抗体脑炎患儿的人口学数据、临床表现、辅助检查... 详细信息

目的分析使用托珠单抗治疗的难治性N-甲基-D-天冬氨酸(NMDA)受体抗体脑炎患儿的临床特征。方法回顾性分析2021年8月至2023年9月中南大学湘雅医院儿科接受托珠单抗治疗的9例难治性NMDA受体抗体脑炎患儿的人口学数据、临床表现、辅助检查、免疫治疗和预后资料。采用改良Rankin评分进行预后评估,分析治疗相关并发症及神经影像学和脑电图等资料。结果9例患儿中男6例、女3例,起病年龄4.2(2.8,8.7)岁。起病时改良Rankin评分均为5分,开始托珠单抗治疗时改良Rankin评分5分7例,4分2例。起病与开始托珠单抗治疗间隔12(5,27)个月,治疗次数8(5,13)次。随访时间2.8(1.5,3.7)年。末次随访时9例患儿运动障碍、睡眠障碍、意识障碍、语言缄默、自主神经功能紊乱等临床症状均不同程度好转,且均无癫痫发作。末次随访时改良Rankin评分0分4例,1分1例,3分2例,4分1例,5分1例,末次随访时改良Rankin评分较开始托珠单抗治疗时,差异有统计学意义(Z=-2.56,P=0.014)。治疗过程中9例患儿均未见严重不良反应。结论儿童难治性NMDA受体抗体脑炎使用托珠单抗治疗后运动障碍、睡眠障碍、意识障碍、语言缄默、自主神经功能紊乱等症状均不同程度好转,且均无癫痫发作,改良Rankin评分改善,治疗过程中安全性良好。

关键词：抗体,单克隆儿童受体,N-甲基-D-天冬氨酸难治性

Pregnancy and the disease recurrence of patients previously treated for differentiated thyroid cancer:A systematic review and meta analysis

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Chinese Medical Journal 2024年第5期137卷 547-555页

作者： Rui Shan Xin Li Ming Tao Wucai Xiao jing Chen fang Mei Shibing Song Bangkai Sun Chunhui Yuan Zheng Liu Department of Maternal and Child Health School of Public HealthPeking UniversityBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Pathology Peking University Third HospitalSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Information Management and Big Data Center Peking University Third HospitalBeijing 100191China

Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains *** study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for ***:We searched PubMed,Embase,Web of Science,Cochrane,and Scopus based on the prespecified protocol registered at PROSPERO(CRD42022367896).After study selection,two researchers independently extracted data from the included *** quantitative data synthesis,we used random-effects meta-analysis models to pool the proportion of recurrence(for pregnant women only)and odds ratio(OR;comparing the risk of recurrence between the pregnancy group and the nonpregnancy group),*** we conducted subgroup analyses to explore whether risk of recurrence differed by response to therapy status or duration of follow-up *** also assessed quality of the included ***:A total of ten studies were *** sample size ranged from 8 to 235,with participants’age at pregnancy or delivery ranging from 28 to 35 *** follow-up time varied from 0.1 to 36.0 *** pooled proportion of recurrence in all pregnant patients was 0.13(95%confidence intervals[CI]:0.06-0.25;I^(2):0.58).Among six included studies reporting response to therapy status before pregnancy,we observed a trend for increasingly higher risk of recurrence from excellent,indeterminate,and biochemically incomplete to structurally incomplete response to therapy(P trend0.05)or the OR of recurrence in studies with a comparison group(P>0.05).Two included studies t

关键词： Thyroid cancer Pregnancy Recurrence Women Systematic review Meta-analysis

深海静水压力对环氧涂层/907A低合金钢体系失效行为的影响

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表面技术 2024年第16期53卷 68-77,102页

作者：景超杰方博赵方超赵阳杨小奎陈雪晴周堃刘杰西南技术工程研究所国防科技工业自然环境试验研究中心重庆400039 烟台大学化学化工学院山东烟台264005 中国航空综合技术研究所北京100028

目的探究深海静水压力作为单一因素影响涂层/金属体系的失效过程。方法在深海环境模拟实验装置中开展环氧涂层/907A低合金钢体系的浸泡实验,从电化学阻抗谱、涂层湿附着力、涂层微观形貌及其化学结构等方面分析涂层的失效机理。结果当... 详细信息

目的探究深海静水压力作为单一因素影响涂层/金属体系的失效过程。方法在深海环境模拟实验装置中开展环氧涂层/907A低合金钢体系的浸泡实验,从电化学阻抗谱、涂层湿附着力、涂层微观形貌及其化学结构等方面分析涂层的失效机理。结果当静水压力为0.1 MPa和15 MPa时,涂层阻抗值分别下降至3.83×10^(6)Ω·cm^(2)和6.28×104Ω·cm^(2),涂层湿附着力分别下降至2.76 MPa和2.31 MPa。在不同静水压力下,水在涂层中的前期扩散形式均符合Fick扩散定律,而涂层下水的扩散系数从1.05×10^(-9) cm^(2)/s增加至2.39×10^(-9) cm^(2)/s。随着静水压力的升高,环氧涂层表面的孔隙以及裂纹不断发展并出现了鼓泡。在静水压力为0.1 MPa条件下腐蚀产物以γ-FeOOH为主,静水压力升高后腐蚀产物Fe_(3)O_(4)含量明显增加,除锈后的腐蚀坑直径由15μm增加至25μm。结论高静水压力可以加速腐蚀性介质向涂层内部以及涂层/金属界面的渗透,涂层湿附着力迅速下降,涂层失效更加严重。高静水压力能够促进腐蚀产物中高电化学活性Fe_(3)O_(4)的生成。此外,静水压力下涂层失效的主要原因是物理结构受到破坏。

关键词：环氧涂层深海静水压力水传输行为失效行为电化学阻抗谱

Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study

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Reproductive and Developmental Medicine 2024年第1期8卷 24-31页

作者： Lei Jia Pei-Gen Chen Li-Na Chen Cong fang jing Zhang Pan-Yu Chen Reproductive Medicine Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China GuangDong Engineering Technology Research Center ofFertility Preservation The Sixth Affiliated HospitalSun Yatsen UniversityGuangzhou 510275China Biomedical Innovation Center The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510275China

Objective:To develop a clinically applicable tool for predicting clinical pregnancy,providing individualized patient counseling,and helping couples with non-obstructive azoospermia(NOA)decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction(mTESE).Methods:A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection(ICSI):the fresh and cryopreserved *** evaluating several machine learning algorithms,logistic regression was *** LASSO regression and 10-fold cross-validation,the factors associated with clinical pregnancy were ***:The area under the curves(AUCs)for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759,*** with various modeling algorithms,Logistic Regression outperformed machine learning in both groups,with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved ***:The model accurately predicted clinical pregnancies in NOA couples.

关键词： Cryopreserved spermatozoa Fresh spermatozoa Logistic regression Microdissection testicular sperm extraction

聚氨酯弹性纤维面料在服装设计中的应用研究进展

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合成树脂及塑料 2024年第3期41卷 83-86页

作者：李芳李凤许亭玉彭晶杨琪重庆对外经贸学院重庆400000

综述了聚氨酯弹性纤维(氨纶)干法纺丝的工艺、氨纶性能的改进方法以及多功能氨纶面料的制备方法及性能。聚氨酯溶液中加入有机钛抗静电剂及其他助剂通过干法纺丝可制备抗静电氨纶。将含有聚氨酯-脲的原液熟化后添加抗黄变助剂得到的纺... 详细信息

综述了聚氨酯弹性纤维(氨纶)干法纺丝的工艺、氨纶性能的改进方法以及多功能氨纶面料的制备方法及性能。聚氨酯溶液中加入有机钛抗静电剂及其他助剂通过干法纺丝可制备抗静电氨纶。将含有聚氨酯-脲的原液熟化后添加抗黄变助剂得到的纺丝原液通过干法纺丝可制备耐黄变氨纶。以氨纶长丝为芯纱,棉纱与改性聚丙烯腈纤维混纺作为外包纱制备了包芯纱线,织成的蜂巢组织面料吸湿发热效果良好。使用3-氨丙基三乙氧基硅烷溶液将氨基接枝在氨纶表面,浸入到羧基化多壁碳纳米管分散液中得到碳纳米管涂层氨纶,纺入针织物中可用于实时医疗保健监测的可穿戴应变传感器。

关键词：聚氨酯弹性纤维阻燃抗静电可穿戴

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抗体片段在铂纳米粒子表面的构象重构

生物化学与生物物理进展 2024年第3期51卷 647-657页

作者：盛玲洁徐佳戴静静王海芳曹傲能上海大学环境与化学工程学院纳米化学与生物学研究所上海200444

目的最近在金纳米粒子(AuNPs)表面重构抗体片段的天然构象和功能的研究表明分子构象工程的可行性。本质上,分子构象工程就是要像蛋白质折叠一样,通过精确控制柔性非功能分子的构象使其产生新功能。本文在铂纳米粒子(PtNPs)表面重构抗体... 详细信息

目的最近在金纳米粒子(AuNPs)表面重构抗体片段的天然构象和功能的研究表明分子构象工程的可行性。本质上,分子构象工程就是要像蛋白质折叠一样,通过精确控制柔性非功能分子的构象使其产生新功能。本文在铂纳米粒子(PtNPs)表面重构抗体互补决定簇区(CDR)片段的天然构象和功能,旨在探索分子构象工程的普适性及揭示蛋白质结构-功能机制。方法本文将抗溶菌酶抗体(cAB-lys3)中的CDR3片段(在单独存在时没有稳定构象和功能)通过两个Pt-S键偶联到PtNPs表面。CDR片段的天然构象和功能的恢复通过它对溶菌酶活性的抑制来表征。结果通过多肽密度优化和表面聚乙二醇修饰,制得基于PtNPs的抗溶菌酶人工抗体(简称铂抗体)。溶菌酶活性测试结果表明,铂抗体可以特异性结合溶菌酶并显著抑制其活性。结论本文第一次在PtNPs表面重构了蛋白质片段的天然构象并恢复了其功能,证明分子构象工程可作为一种通用方法制备基于纳米粒子的人工蛋白质。

关键词：抗体溶菌酶构象工程铂纳米粒子多肽

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基于多Agent传动关系的股市趋势预测

计算机工程 2024年第3期50卷 267-276页

作者：鲍志姚宏亮方帅杨静俞奎合肥工业大学计算机与信息学院安徽合肥230601

股市趋势预测是机器学习领域中一个具有挑战性的任务。由于一些因素对于股市的影响是动态且不确定的,导致股市趋势难以预测。针对已有方法在股市预测时存在的灵敏性差、适应力弱等问题,从快变量和慢变量的传动关系出发,利用Agent技术对... 详细信息

股市趋势预测是机器学习领域中一个具有挑战性的任务。由于一些因素对于股市的影响是动态且不确定的,导致股市趋势难以预测。针对已有方法在股市预测时存在的灵敏性差、适应力弱等问题,从快变量和慢变量的传动关系出发,利用Agent技术对股市中的快周期和慢周期进行联合建模,提出一种多Agent传动影响图(MATID)股市趋势预测方法。给出股市中快周期和慢周期的划分标准,并引入周期能量的概念;通过对相关趋势指标的特征融合,给出周期能量的量化计算方法;通过分析快周期和慢周期的动态作用过程,给出传动因子的表示方法;将快周期和慢周期分别对应成不同的Agent,利用多Agent影响图模型建模快周期和慢周期的传动过程;利用股市振子模型表示快Agent和慢Agent之间的传动效用,利用联合树的自动推理技术对股市趋势进行预测。在不同样本数量和不同股市趋势下进行实验,结果表明,与门控循环单元、S-LSTM和Hybrid-RNN预测方法相比,MATID方法预测精确率提升1.5%~7.0%,召回率提升5.4%~6.7%,F1值提升3.7%~6.2%,具有良好的灵敏性和适应力。

关键词：多Agent传动影响图周期传动振子模型效用函数联合树

New hybrid rice combination—Xieyou 46

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Chinese Rice Research Newsletter 1994年第1期2卷 1-1页

作者： YE,Fuchu,LI jing yang,and fang Hongming CNRRI,Hangzhou 310006,China

Hybrid rice combination Xieyou 46 was first bred by combining CMS line Xieqingzao A with restorer line Milyang 46 at CNRRI in 1983. It can be used as single season or late season new indica hybrid rice combination. Having passed provincial level yield trials in the following years, it was released in 1990 with the permission of Zhejiang Provincial Government, later on recommended as one of the top commercial hybrid rice combination by China State Science and Technology Commission. By the end of 1992, Xieyou 46 has been planted as a late season or single season hybrid ricc combination along the middle and lower reaches of the yangtze River, and the planting area has reached 3.35 million ha. It has become one of the most important late season hybrid rice combinations in Zhejiang Province. Characteristics of Xieyou 46: Xieyou 46 has a suitable growth duration of 125-130 d as late season rice or 127-134 d as single season rice, 2-3 d shorter than those of Shanyou 6. It bas a compact plant type, high tilleri

关键词： line high New hybrid rice combination Xieyou 46

Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy

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Food Science and Human Wellness 2024年

作者： Hong-Yu Pan Na Wang Qian-Wang Zheng Yuan Zou jing-Ru Zhong Guo-Zhao Luo Ming-Zhen Tu Li-Qiong Guo Jun-fang Lin College of Food Science， South China Agricultural University.Guangzhou Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province Faculty of Food Science and Engineering， Kunming University of Science and Technology Guangzhou Alchemy Biotechnology Co.， Ltd

Ergothioneine is a natural amino acid with powerful antioxidant activity. Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans， and enhance telomerase activity. In present study， the metagenomics sequencing and qRT-PCR analysis were employed to characterize the composition and diversity of gut microbiome in aging flies. And the alterations in the gut barrier， gut morphology， and other gut physiological indicators of aging flies were evaluated. Here， the results showed that EGT induced little variations in gut microbiota composition in flies at mid-life， and significant alterations in the gut microbiota populations were only observed in flies at late-life. And ergothioneine attenuated age-related gut injuries， including decreasing reactive oxygen species levels in intestinal enterocytes， reduction of intestinal cells death， and preservation of gut integrity in aging flies. Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy. And activation of intestinal autophagy also contributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.

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