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Optimized online filter stack spectrometer for ultrashort X-ray pulses

Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma Ming-Hai Yu Yu-Chi Wu Yong-Hong Yan Shao-Yi Wang Huai-Zhong Gao Lu-Shan Wang Yu-Gang Zhou Qiang Li Yue yang fang Tan Xiao-Hui Zhang Jie Zhang Wen-Bo Mo jing-Qin Su Wei-Min Zhou Yu-Qiu Gu Ming Zeng Zong-Qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

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Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice

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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming GUO Jiatian ZHAO jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI fang CHEN Chong HOU Mingzhuang LV Nanning XU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic Surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)***(CSL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain *** study aimed to substantiate CSL’s chondroprotective effects and unravel its underlying *** investigated CSL’s impact on chondrocytes under both normal and inflammatory *** vitro,CSL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)*** vivo,intra-articular injection of CSL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA ***,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CSL-mediated antioxidative functions and exacerbated the progression of *** study is the first to elucidate the role of CSL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

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Efficacy and Safety of Sanjie Analgesic Capsule in Patients with Endometriosis-Associated Pain:A Multicenter,3:1 Randomized,Double-Blind,Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 780-787页

作者： LENG Jin-hua DUAN Hua GUAN Zheng ZHOU Ying-fang QU Hong XU Kai-hong ZHANG Shao-fen ZHANG Qin WANG Xin LIN Kai-qing LANG jing-he Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing100730China Department of Gynecology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing100006China Department of Gynecology Chinese PLA General HospitalBeijing100039China Department of Gynecology Peking University First HospitalBeijing100034China Department of Gynecology Beijing Chao-yang HospitalBeijing100020China Department of Gynecology Womens Hospital School of Medicine Zhejiang UniversityHangzhouZhejiang Province310006China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai200090China Department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310007China Department of Gynecology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110032China

Objective:To assess the efficacy and safety of Sanjie Analgesic Capsule(SAC)in Chinese patients with endometriosis-associated ***:This was a multicenter,randomized,double-blind,placebo-controlled trial conducted at 15 centers between November 2013 and July 2017 in *** 323 patients with endometriosis were randomized at a 3:1 ratio to the SAC group(241 cases)and placebo group(82 cases)by stratified block *** in the SAC or placebo groups were given SAC or placebo 1.6 g 3 times per day,orally,respectively since the first day of menstruation for 3 consecutive menstrual *** primary endpoint was clinical response to dysmenorrhea evaluated using a 10-point Visual Analogue Scale at 3 and 6 *** secondary endpoint was the pain score evaluated by VAS(chronic pelvic pain,defecation pain,and dyspareunia)at 3 and 6 months,and the pain recurrence rate at 6 *** events(AEs)were recorded during the ***:A total of 241 women were included in the SAC group,and 82 were in the placebo *** these women,217(90.0%)and 71(86.6%)completed the intervention,*** 3 months,overall response rate(ORR)was significantly higher in women administered SAC(80.1%)compared with those who received a placebo(30.5%,P<0.01).Six months after treatment,the ORR for dysmenorrhea was 62.7%in the SAC group and 31.7%in the placebo group(P<0.01).Chronic pelvic pain and defecation pain were significantly improved by SAC compared with placebo(both P<0.05).The incidence rates of total AEs events in the SAC and placebo groups were 6.6%and 9.8%,respectively,and no significant difference was shown between the two groups(P=0.339).Conclusion:SAC is well-tolerated and may improve dysmenorrhea in women with endometriosis-associated pain.

关键词： endometriosis pain Sanjie Analgesic Capsule randomized controlled trial Chinese medicine

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Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li Yi-Ming jing Xue Shen Ming-Yue Tang Hong-Hong Shen Xin-Wei Li Zi-Shu Wang fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

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Malignant myopericytoma originating from the colon: A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1918-1925页

作者： Heng-Li Zhang Min Zhang jing-Qiang Guo fang-Nan Wu Jin-De Zhu Chao-Yong Tu Xin-Liang Lv Kun Zhang Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Myopericytoma is a benign tumor that typically occurs within subcutaneous tissue and most often involves the distal extremities,followed by the proximal extremities,neck,thoracic vertebrae and oral *** resection is often *** myopericytoma is extremely rare and has a poor ***,we report for the first time a case of malignant myopericytoma originating from the *** SUMMARY A 69-year-old male was admitted to our hospital with right upper quadrant pain for five *** suggested a liver mass with hemorrhage.A malignant hepatic tumor was the initial *** resection was performed after a complete preoperative work *** postoperative pathology suggested that the mass was a malignant myoblastoma unrelated to the *** months after the first surgery,an enhanced computed tomography(CT)scan revealed a recurrence of the *** diagnosis of malignant myopericytoma derived from the colon was confirmed on histopathological examination of the specimen from the second *** patient did not return to the hospital regularly for *** first postoperative abdominal CT examination six months after the second surgery demonstrated multiple liver *** time between the diagnosis of the tumor to death was approximately one *** Malignant myopericytoma is a rare *** diagnosis may be *** to a lack of treatment options,prognosis is poor.

关键词： Malignant myopericytoma Liver tumor Colonic neoplasms Abdominal pain

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病毒样蛋白纳米颗粒疫苗研究进展

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中华实验和临床病毒学杂志 2024年第3期38卷 343-350页

作者：杨静方谭玮徐涛岳阳市中心血站供血科岳阳414000 湖南省胸科医院Ⅰ期临床试验研究室长沙410013 长沙卫生职业学院基础医学部长沙410000

疫苗是应对传染病最有效的手段。有关疫苗及其技术的研究取得巨大的进展,其中,病毒样蛋白纳米颗粒疫苗(virus-like protein nanoparticle vaccine,VLPNV)以其独特的技术优势和良好抗感染免疫保护效果,成为疫苗研发热点,并取得了良好的... 详细信息

疫苗是应对传染病最有效的手段。有关疫苗及其技术的研究取得巨大的进展,其中,病毒样蛋白纳米颗粒疫苗(virus-like protein nanoparticle vaccine,VLPNV)以其独特的技术优势和良好抗感染免疫保护效果,成为疫苗研发热点,并取得了良好的应用效果。本文就VLPNV在引发免疫反应、表达技术以及防治病毒感染应用等方面的最新研究进展进行了综述,以期为VLPNV的未来设计和研发提供参考。

关键词：疫苗病毒样蛋白纳米颗粒疫苗免疫反应

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Quasinormal modes and isospectrality of Bardeen(Anti-)de Sitter black holes

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Chinese Physics C 2024年第3期48卷 191-202页

作者：赵莹刘文韬张超房熊俊荆继良 Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Educationand Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Department of Physics Faculty of ScienceTokyo University of Science1-3KagurazakaShinjuku-kuTokyo 162-8601Japan

Black holes(BHs)exhibiting coordinate singularities but lacking essential singularities throughout the spacetime are referred to as regular black holes(RBHs).The initial formulation of RBHs was presented by Bardeen,who considered the Einstein equation coupled with a nonlinear electromagnetic *** this study,we investigate the gravitational perturbations,including the axial and polar sectors,of the Bardeen(Anti-)de Sitter black *** derive the master equations with source terms for both axial and polar perturbations and subsequently compute the quasinormal modes(QNMs)through numerical *** the Bardeen de Sitter black hole,we employ the 6thorder WKB *** numerical results reveal that the isospectrality is broken in this ***,the QNM frequencies are calculated using the HH method for the Bardeen Anti-de Sitter black hole.

关键词： Bardeen quasinormal modes master equation

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Inflammatory response in gastrointestinal cancers:Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications

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World Journal of Clinical Oncology 2024年第1期15卷 9-22页

作者： Ze-Xuan fang Wen-Jia Chen Zheng Wu Yan-Yu Hou yang-Zheng Lan Hua-Tao Wu jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors *** lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory responses in vivo and likely to occur in hyperplasia and ***,due to the lack of effective therapeutic targets,the prognosis of patients with GICs is still ***,it is found that six transmembrane epithelial antigens of the prostate(STEAPs),a group of metal reductases,are significantly associated with the progression of malignancies,playing a crucial role in systemic metabolic homeostasis and inflammatory *** structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress,responding to inflammatory *** the imbalance status of abnormal oxidative stress,STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory *** review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms,with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.

关键词： Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation

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结核病mRNA疫苗的研制策略与展望

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中国防痨杂志 2024年第5期46卷 590-595页

作者：杨静肖丽娟方谭玮岳阳市中心血站供血科岳阳414000 湖南省胸科医院Ⅰ期临床试验研究室长沙410013

应对危害全球人类健康的重大传染性疾病——结核病流行的严峻挑战,迫切需要研制出有效的新型结核病疫苗。虽然目前开展了多种类型的新型结核病疫苗的研制,且一些疫苗已进入临床试验研究,但至今仍未能获得可以替代传统卡介苗(BCG)的更为... 详细信息

应对危害全球人类健康的重大传染性疾病——结核病流行的严峻挑战,迫切需要研制出有效的新型结核病疫苗。虽然目前开展了多种类型的新型结核病疫苗的研制,且一些疫苗已进入临床试验研究,但至今仍未能获得可以替代传统卡介苗(BCG)的更为有效的新型疫苗。随着mRNA疫苗研制技术的突破,其研发周期短、高效、安全和生产成本低等优点,使其成为一个非常有前景的疫苗研发新方向。笔者主要就mRNA疫苗的技术原理、优势、制备技术,以及结核病mRNA疫苗的研制策略和现状等方面的研究进展进行综述,以期为结核病mRNA疫苗的研制提供参考。

关键词：分枝杆菌,结核 RNA,细菌 RNA,信使疫苗,灭活策略,实验性综述

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Clinicopathological features of gastric glomus tumor

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World Journal of Gastroenterology 2010年第36期16卷 4616-4620页

作者： Hui-Qiong fang,jing yang,Fen-Fen Zhang,An-Jia Han,Department of Pathology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China Hui-Qiong fang,Department of Pathology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province,China jing yang,Department of Pathology,People’s Hospital of Zhu-hai City,Zhuhai 519000,Guangdong Province,China Yi Cui,Department of Gastroenterology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China Department of Pathology First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 Guangdong Province China

AIM:To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in ***:A case of gastric glomus tumor was *** findings in 56 cases of gastric glomus tumor were ***:Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:*** median age of the patients was 45 years(range 28-79 years).The patients often complained of epigastric pain and bloody *** tumor was located in antrum of the *** greatest diameter of the tumor was ***,the tumor was comprised of nests of glomus cells surrounding the *** cells were small,uniform and ***,smooth muscle actin and actin were expressed in the *** markers,including S-100 protein,CD34,CD117,desmin,CD56,synaptophysin,chromo-granin A,neuron specific enolase and cytokeratin were all ***:Gastric glomus tumor is a rare benign mesenchymal *** diagnosis depends on pathologic *** diagnosis includes gastrointestinal stromal tumor,paraganglioma and carcinoid tumor.

关键词： Stomach Glomus tumor Clinicopathology Immunohistochemistry

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