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The tumor-selective over-expression of the human Hsp 70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription

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Cell Research 2003年第2期13卷 93-109页

作者： LING CAI, jing de zhu,The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 25/2200, Xie-tu Road, Shanghai 200032, China Cancer Genetics and Gene Therapy The State-key Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Jiao Tong University LN 25/2200 Xie-tu Road Shanghai 200032 China

The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors, linked to the poor prognosis, being refractory to chemo- and radio-therapies as well as the advanced stage of tumorous lesions in particular. However, both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic. By comparing various upstream segments of the Hsp70 gene for each’s ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line, we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression. Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene, but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 a

关键词： Hsp 70 Tumor transcription elongation 5’ UTR. Over-expression.

Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

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Biomedical and Environmental Sciences 2024年第1期37卷 19-30页

作者： MENG Li Ying TAO Wen Fu LI jing zhu Min ZHONG de Bin ZHOU jing QIN Xue WEI Rong Guo department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Jiangsu Key Laboratory of Environmental Engineering Jiangsu Academy of Environmental SciencesNanjing 210000JiangsuChina

Objective The aim of this study was to assess the impact of bisphenol A(BPA)and its substitute,bisphenol F(BPF),on the colonic fecal community structure and function of *** We exposed 6–8-week-old male C57BL/6 mice to 5 mg/(kg∙day)and 50μg/(kg∙day)of BPA or BPF for 14 *** samples from the colon were analyzed using 16S rRNA *** Gut microbiome community richness and diversity,species composition,and function were significantly altered in mice exposed to BPA or *** change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and ***,pathways related to carbohydrate and amino acid metabolism showed substantial *** Mice exposed to different BP analogs exhibited distinct gut bacterial community richness,composition,and related metabolic *** the essential role of gut bacteria in maintaining intestinal homeostasis,our study highlights the intestinal toxicity of BPs in vertebrates.

关键词： Bisphenol A(BPA) Bisphenol F(BPF) 16S rRNA Microbiota

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A transfer learning enhanced physics-informed neural network for parameter identification in soft materials

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1685-1704页

作者： jing'ang zhu Yiheng XUE Zishun LIU International Center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University

Soft materials, with the sensitivity to various external stimuli, exhibit high flexibility and stretchability. Accurate prediction of their mechanical behaviors requires advanced hyperelastic constitutive models incorporating multiple parameters. However,identifying multiple parameters under complex deformations remains a challenge, especially with limited observed data. In this study, we develop a physics-informed neural network(PINN) framework to identify material parameters and predict mechanical fields,focusing on compressible Neo-Hookean materials and hydrogels. To improve accuracy, we utilize scaling techniques to normalize network outputs and material parameters. This framework effectively solves forward and inverse problems, extrapolating continuous mechanical fields from sparse boundary data and identifying unknown mechanical *** explore different approaches for imposing boundary conditions(BCs) to assess their impacts on accuracy. To enhance efficiency and generalization, we propose a transfer learning enhanced PINN(TL-PINN), allowing pre-trained networks to quickly adapt to new scenarios. The TL-PINN significantly reduces computational costs while maintaining accuracy. This work holds promise in addressing practical challenges in soft material science, and provides insights into soft material mechanics with state-of-the-art experimental methods.

关键词： 35Q74 74A20 74B20 74G75 inverse problem O242 O343 parameter identification physics-informed neural network (PINN) soft material transfer learning

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Old Pinus massoniana forests benefit more from recent rapid warming in humid subtropical areas of central-southern China

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Journal of Forestry Research 2024年第5期35卷 155-170页

作者： Wenxin Li Liangjun zhu Lianhua zhu Mengdan jing Censhi Qian Yu zhu Paolo Cherubini College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004People’s Republic of China Swiss Federal Institute for Forest Snow and Landscape Research WSL8903 BirmensdorfSwitzerland department of Forest and Conservation Sciences Faculty of ForestryUniversity of British Columbia2004-2424 Main MallVancouverBC V6T 1Z4Canada

Trees progress through various growth stages,each marked by specific responses and adaptation strate-gies to environmental *** the importance of age-related growth responses on overall forest health and management policies,limited knowledge exists regarding age-related effects on dendroclimatic relationships in key subtropical tree *** this study,we employed a den-drochronological method to examine the impact of rapid warming on growth dynamics and climatic sensitivity of young(40–60 years)and old(100–180 years)Pinus mas-soniana forests across six sites in central-southern *** normalized log basal area increment of trees in both age groups increased significantly following rapid warming in *** in young forests further showed a distinct growth decline during a prolonged severe drought(2004–2013),whereas those in old forests maintained growth *** growth was more strongly influenced by temperature than by moisture,particularly in old *** tem-peratures strongly and positively impacted the growth of old trees but had a weaker effect on young *** forests had a significantly lower resistance to extreme drought but faster recovery compared to young ***“divergence problem”was more pronounced in younger forests due to their heightened sensitivity to warming-induced drought and heat *** ongoing warming,young forests also may initially experience a growth decline due to their heightened sensitivity to winter *** findings underscore the importance of considering age-dependent changes in forest/tree growth response to warming in subtropical forest man-agement,particularly in the context of achieving“Carbon Peak&Carbon Neutrality”goals in China.

关键词： Tree rings Pinus massoniana Age effects Drought resilience Subtropical forests Rapid warming

Transitional Revenue Scheme for High-cost Generator Unit in Guangdong Electricity Market Based on Government Authorized Contracts

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 208-221页

作者： Jisong zhu Baike Chen Tianyao Ji Zhaoxia jing School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China

High-cost generator units are at a cost disadvantage in electricity spot *** study focuses on revenue mechanisms of gas-fired units affected by power market reform in Guangdong province,*** the first time,we compare impacts on market indicators of five settlement mechanisms:feed-in tariff(FiT),location marginal price(LMP),contract for difference(CFD),direct subsidy(DS),and estimated revenue method(ERM).In particular,we design key parameters,including authorized CFD and ERM of two kinds of government authorized contracts based on traditional dispatching patterns to avoid significant profit fluctuations brought by market *** also analyze impact of factors such as climbing performance,seasonal load,and subsidy amount on the overall market and its *** of a case study show to directly subsidize gasfired units will lead higher-cost units to generate more electricity,with a resulting loss of social *** of market prices and provision of unreasonable incentives are fatal disadvantages of this subsidy *** government and policymakers should consider financial means to adjust benefits to reduce production costs and increase social ***,by case analysis,the ERM shows its stable performance in revenue of high-cost units,while we find that authorized CFD is not applicable for gas-fired units whose output is unstable as a marginal unit ***,we suggest government agencies adopt ERM to sign contracts with gas-fired units,to attain a balance between fairness and efficiency.

关键词： Guangdong electricity market high-cost generator unit settlement mechanism subsidy

Mutual Information Maximization via Joint Power Allocation in Integrated Sensing and Communications System

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China Communications 2024年第2期21卷 129-142页

作者： Jia zhu Junsheng Mu Yuanhao Cui Xiaojun jing School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ISAC, we propose a design scheme based on spectrum sharing, that is,to maximize the mutual information(MI) of radar sensing while ensuring certain communication rate and transmission power constraints. In the proposed scheme, three cases are considered for the scattering off the target due to the communication signals,as negligible signal, beneficial signal, and interference signal to radar sensing, respectively, thus requiring three power allocation schemes. However,the corresponding power allocation schemes are nonconvex and their closed-form solutions are unavailable as a consequence. Motivated by this, alternating optimization(AO), sequence convex programming(SCP) and Lagrange multiplier are individually combined for three suboptimal solutions corresponding with three power allocation schemes. By combining the three algorithms, we transform the non-convex problem which is difficult to deal with into a convex problem which is easy to solve and obtain the suboptimal solution of the corresponding optimization problem. Numerical results show that, compared with the allocation results of the existing algorithms, the proposed joint design algorithm significantly improves the radar performance.

关键词： coexistence communications multicarrier radar mutual information spectrum sharing

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An unexpected approach to enhance specific surface area and mesopore amount of polyaniline by Zn doping

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Rare Metals 2024年第9期43卷 4585-4594页

作者： Zhi-Da zhu Yu-Zhe Han Xiao-Bi jing School of Mechanical Engineering Yangzhou University School of Chemistry and Chemical Engineering Yangzhou University

Poly-p-anisidine could be easily fabricated via the oxidative polymerization reaction of p-anisidine using H2O2as the green oxidant. It was unexpectedly found that zinc doping could significantly improve the adsorption ability of the material versus heavy metals such as Pb, Cu,Pd, Ag and Hg. Results of nitrogen adsorption–desorption experiments demonstrated that Zn doping could enhance the specific surface area and mesopore amount of the prepared material, which might facilitate its absorption to metals. This work not only provides a novel material for the treatment of heavy metal-polluted water but also leads to a nice mesoporous catalyst support for environment protection and organic synthesis, i.e. the Zn-doped poly-panisidine can be employed as the catalyst support to prepare Cu@PANI-OMe/Zn or Pd@PANI-OMe/Zn for the oxidative degradation reaction of phenol or Suzuki–Miyaura coupling reactions, respectively. It discloses a new strategy for fabricating the mesoporous polyaniline materials with profound application potential.

关键词： Adsorption Catalysis Porous materials Rare metal concentration Surfaces

The posterior selection method for hyperparameters in regularized least squares method

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Control Theory and Technology 2024年第2期22卷 184-194页

作者： Yanxin Zhang jing Chen Yawen Mao Quanmin zhu School of Science Jiangnan UniversityWuxi214122JiangsuChina The Science and Technology on Near-Surface detection Laboratory Wuxi214122JiangsuChina department of Engineering design and Mathematics University of the West of EnglandBristolBS161QYUK

The selection of hyperparameters in regularized least squares plays an important role in large-scale system identification. The traditional methods for selecting hyperparameters are based on experience or marginal likelihood maximization method, which are inaccurate or computationally expensive. In this paper, two posterior methods are proposed to select hyperparameters based on different prior knowledge (constraints), which can obtain the optimal hyperparameters using the optimization theory. Moreover, we also give the theoretical optimal constraints, and verify its effectiveness. Numerical simulation shows that the hyperparameters and parameter vector estimate obtained by the proposed methods are the optimal ones.

关键词： Regularization method Hyperparameter System identification Least squares algorithm

Postoperative encapsulated hemoperitoneum in a patient with gastric stromal tumor treated by exposed endoscopic full-thickness resection: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 601-608页

作者： Hui-Fei Lu jing-jing Li de-Bin zhu Li-Qi Mao Li-Fen Xu jing Yu Lin-Hua Yao department of Gastroenterology the First People’s Hospital of HuzhouHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Gastric stromal tumors,originating from mesenchymal tissues,are one of the most common tumors of the digestive *** stromal tumors originating from the muscularis propria,compared with conventional endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR)can remove deep lesions and digestive tract wall tumors ***,this technique has major limitations such as perforation,postoperative bleeding,and post-polypectomy ***,we report a case of postoperative serous surface bleeding which formed an encapsulated hemoperitoneum in a patient with gastric stromal tumor that was treated with exposed *** treatment options to address this complication are *** SUMMARY A 47-year-old male patient had a hemispherical protrusion found during gastric endoscopic ultrasonography,located at the upper gastric curvature adjacent to the stomach fundus,with a smooth surface mucosa and poor *** lesion was 19.3 mm×16.1 mm in size and originated from the fourth ultrasound *** tomography(CT)revealed no significant evidence of lymph node enlargement or distant *** conventional ESD technology for mucosal pre-resection,exposed EFTR was performed to resect the intact tumor in order to achieve a definitive histopathological *** on its morphology and immunohistochemical expression of CD117 and DOG-1,the lesion was proven to be consistent with a gastric stromal *** days after exposed EFTR,CT showed a large amount of encapsulated fluid and gas accumulation around the *** addition,gastroscopy suggested intracavitary bleeding and abdominal puncture drainage indicated serosal *** on these findings,the patient was diagnosed with serosal bleeding resulting in encapsulated abdominal hemorrhage after exposed EFTR for a gastric stromal *** patient received combined treatments,such as hemostasis under gastroscopy,gastrointestinal decompression,and abdominal

关键词： Exposed endoscopic full-thickness resection Gastric stromal tumors Hemoperitoneum Abdominal infection Complication Postoperative bleeding Case report