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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

超声在21-三体综合征产前筛查中的应用分析

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中国优生与遗传杂志 2016年第6期24卷 37-39页

作者：韩璐荆春丽王彦冯丽云顾颜大连市妇幼保健院产前诊断中心辽宁大连116033

目的探讨超声在21-三体综合征产前筛查中的应用价值。方法 2009年1月至2014年6月在大连市妇幼保健院被确诊为21-三体综合征的胎儿共77例,其中55例行超声筛查,分析其超声表现与21-三体综合征的关系。结果 55例接受产前超声筛查的21-三体... 详细信息

目的探讨超声在21-三体综合征产前筛查中的应用价值。方法 2009年1月至2014年6月在大连市妇幼保健院被确诊为21-三体综合征的胎儿共77例,其中55例行超声筛查,分析其超声表现与21-三体综合征的关系。结果 55例接受产前超声筛查的21-三体综合征病例中,10例进行了孕早期超声筛查,8例(80%)发现异常;45例进行了孕中晚期超声筛查,37例(82.2%)发现超声异常。孕早期常见的异常为NT增厚(80%)、鼻骨缺失(40%)和静脉导管α波倒置(30%)。孕中晚期常见的软指标异常为鼻骨缺失或发育不良(40.0%)、颈后皮肤皱褶增厚(26.7%)、肱骨或股骨短(17.8%)等;胎儿结构畸形主要为心血管畸形(33.3%)和十二指肠闭锁(13.3%)等。此外,21-三体综合征胎儿中晚期超声还可表现为羊水多(17.8%)和脐动脉血流异常(8.9%)。结论超声在21-三体综合征产前筛查中具有重要作用。

关键词：唐氏综合征超声检查产前诊断

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting Lv Hongfu li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

肾移植术后1年内贫血对患者远期存活率影响研究

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临床军医杂志 2018年第9期46卷 1004-1006页

作者：季敏莉高晶陈旭春李弘何龙沈阳军区总医院泌尿外科辽宁沈阳110016 沈阳军区总医院麻醉科辽宁沈阳110016

目的探讨肾移植术后1年内发生贫血(PTA)对慢性排斥反应及远期人、肾存活率的影响。方法回顾性分析自2012年1月至2014年12月收治的116例肾移植患者的临床资料。根据患者术后1年是否发生PTA,分为PTA组(n=27)和非PTA组(n=89)。比较两组患者... 详细信息

目的探讨肾移植术后1年内发生贫血(PTA)对慢性排斥反应及远期人、肾存活率的影响。方法回顾性分析自2012年1月至2014年12月收治的116例肾移植患者的临床资料。根据患者术后1年是否发生PTA,分为PTA组(n=27)和非PTA组(n=89)。比较两组患者1年内的慢性排斥反应发生率,以及人、肾存活率。结果 PTA组患者慢性排斥反应发生率为18. 5%(5/27),高于非PTA组的5. 6%(5/89),组间比较,差异有统计学意义(P <0. 05)。非PTA组移植术后1、3、5年的患者存活率及移植肾存活率均显著高于PTA组,组间比较,差异有统计学意义(P <0. 05)。结论肾移植术后1年PTA状态可明显增加移植后患者慢性排斥反应的发生率,并影响移植后人、肾存活率。

关键词：肾移植后贫血存活率慢性排斥反应

基于社会计算和深度学习的社交网络特定内容监控

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计算机科学 2016年第10期43卷 1-8页

作者：操晓春荆丽桦王蕊张锐董振江熊红凯中国科学院信息工程研究所信息安全国家重点实验室北京100093 中兴通讯股份有限公司深圳518057 上海交通大学电子工程系上海200240

社交网络极大地方便了人们的生活,加速了信息的共享,但同时也被用于不良和敏感信息的传播,内容安全问题亟待解决。针对此类问题,提出了一套基于社会计算和深度学习的社交网络特定内容监控体系,首先基于成对监督信息实现以内容为导向的... 详细信息

社交网络极大地方便了人们的生活,加速了信息的共享,但同时也被用于不良和敏感信息的传播,内容安全问题亟待解决。针对此类问题,提出了一套基于社会计算和深度学习的社交网络特定内容监控体系,首先基于成对监督信息实现以内容为导向的半监督社区发现,找到所关心的特定人群;然后对所挖掘的特定人群进行实时监控并获取其发布的内容,对图像和视频进行实时自动内容识别;同时针对实网数据误报多的问题提出面向多负类的误判修正方法,以达到收集实时信息,净化网络环境,在一定程度上预防犯罪的目的。

关键词：社会计算社区发现深度学习图像识别社交网络

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li Jun WANG Xianhui CAO Laifu GONG Jian li Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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吉林省西部苏打盐碱土改良研究

土壤通报 2001年第z1期32卷 91-96页

作者：赵兰坡王宇马晶李春林郄瑞卿韩兴吉林农业大学资源与环境学院吉林长春130118

通过盆栽及田间生物试验，结合室内分析，重点研　究了改良剂硫酸铝和地膜覆盖对盐碱地旱田的改良效果．结果表明：强碱性苏打盐碱土中添　加改良剂硫酸铝后，土壤平衡溶液的ｐＨ值明显下降，Ｃａ２＋＋Ｍｇ２＋、Ｋ＋及Ｎａ＋　离子浓... 详细信息

通过盆栽及田间生物试验，结合室内分析，重点研　究了改良剂硫酸铝和地膜覆盖对盐碱地旱田的改良效果．结果表明：强碱性苏打盐碱土中添　加改良剂硫酸铝后，土壤平衡溶液的ｐＨ值明显下降，Ｃａ２＋＋Ｍｇ２＋、Ｋ＋及Ｎａ＋　离子浓度明显增加，土壤的吸水量和吸水速度、毛管水上升高度和速度明显提高．旱田施用　硫酸铝后，大粒径微团聚体数量明显增多，土壤容重变小，孔隙度增大．盆栽条件下，随硫酸铝用量（０％－０．８％）的增加，作物出苗率及生长状况逐渐变好；田间条件下，施用改良　剂和覆膜对玉米出苗率及苗期生长均有良好作用，但玉米产量则以硫酸铝加覆膜的处理最高．

关键词：苏打盐碱土硫酸铝改良剂

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会计电算化对审计的影响

吉林商业高等专科学校学报 2003年第2期 61-62页

作者：马春静李立娟谷万芳吉林商业高等专科学校吉林长春130062

由于计算机技术和网络技术广泛应用于会计信息处理中,会计核算与监督已经同手工账务处理系统有极大的区别。会计实现电算化,对审计产生了很大影响。在数据处理程序、组织形态、内部控制、审计线索、信息等方面都对审计提出了更高的要求。

关键词：会计电算化审计工作内部控制审计线索数据处理程序组织形态