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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Thermally triggered topological polymerization in diacetylene-functionalized covalent organic framework toward enhanced memristive properties

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Science China Chemistry 2025年

作者： Panke Zhou Yuxing Huang Ziyue Yu Cong Zhang Qian Chen Yiping li chao lin Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Advanced Carbon-Based Functional MaterialsCollege of Chemistry Fuzhou University

The development of stimuli-responsive switching memory devices and the elucidation of their switching mechanisms in specific environments are crucial for advancing the field of molecular electronics. Herein, we propose two distinct two-dimensional covalent organic frameworks (COFs), namely Py-EDA and Py-BDA, incorporating acetylene (-C≡C-) or diacetylene(-C≡C-C≡C-) moieties, respectively, targeting fabricate memory devices exhibiting stimuli-responsive switching *** findings demonstrate that the incorporation of acetylene units effectively modulates the electronic band structure and enhances the degree ofπ-conjugation, resulting in devices that exhibit typical bipolar nonvolatile memory performance. Notably,upon thermal treatment, the memory behavior of the ITO/Py-BDA/Ag device transitions to a write-once-read-many-times(WORM) mode, displaying decreased SET voltage, increased ON/OFF current ratio, and remarkable retention reliability and cycle stability. This switching behavior is attributed to the occurrence of interlayer solid-state topological polymerization at 350℃, leading to the transformation of diacetylene columnar arrays into enyne chains within Py-BDA, thereby further promoting interlayer charge transfer and separation.

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang jing-Shui Zhen Bo-Cheng li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年

作者： li Zhu JIA Zhenyang DONG jing liU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge ***-sourceremotesensingdata,thisstudyestablished decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong li Yuewei Chen Nian liu jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Leader-follower: Human-centered intention-guided controller for novel Superlimb with application to load-carrying scenarios

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Science China Technological Sciences 2025年第1期 325-338页

作者： Qinghua ZHANG Xianglong li Hongwei jing Kerui SUN Yuancheng li Sikai ZHAO Lele li Haotian JU Ziqi WANG Rui WU Tianjiao ZHENG Jie ZHAO Yanhe ZHU The State Key Laboratory of Robotics and System Harbin Institute of Technology The Learning Algorithms and Systems Laboratory School of Engineeringécole Polytechnique Fédérale de Lausanne

Supernumerary robotic arms(Superlimb) are a new type of wearable robot that works closely with humans as a third hand to augment human operation capability. Accurate conveyance of wearers' intentions, allocation of roles, and humancentered interaction considerations are the key points in the process of human–Superlimb collaboration. This paper proposes a human-centered intention-guided leader–follower controller that relies on the dynamic modeling of Superlimb with application to load-carrying scenarios. The proposed leader–follower controller takes the human as the leader and the Superlimb as the follower, achieving effective information communication, autonomous coordination, and good force compliance between Superlimb, humans, and the environment under human safety assurance. First, the human–Superlimb dynamic system is modeled to achieve force interaction with the environment and wearer. Second, to achieve the precise intention extraction of humans, pose data from five visual odometry sensors are fused to capture the human state, the generalized position, the velocity of hands, and the surface electromyography signals from two myoelectric bracelets sensors are processed to recognize the natural hand gestures during load-carrying scenarios by a designed Swin transformer network. Then, based on the real-time distance detection between human and mechanical limbs, the security assurance and force-compliant interaction of the human–Superlimb system are realized. Finally, the human hand muscle intention recognition, human–robot safety strategy verification,and comparative load-carrying experiments with and without the proposed method are conducted on the Superlimb *** showed that the task parameters are well estimated to produce more reasonable planning trajectories, and Superlimb could well understand the wearer's intentions to switch different Superlimb actions. The proposed sensor-based human–robot communication framework motivates future studies of o

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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang jingkai Wang Qixin Chen Chengzhen liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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新疆南天山榆树沟含石榴夕线石泥质麻粒岩的超高温变质作用及其构造意义

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岩石学报 2025年第1期41卷 215-236页

作者：荆彦清仝来喜刘兆李超大陆动力学国家重点实验室西北大学地质学系西安710069

天山造山带是中亚造山带的重要组成部分,新疆南天山造山带出露有橄榄岩-麻粒岩地体,其北部榆树沟地区麻粒岩超高温变质作用的确定及P-T-t轨迹的建立为南天山造山带增生造山过程的研究提供了重要依据。本文主要以榆树沟地区3个含石榴夕... 详细信息

天山造山带是中亚造山带的重要组成部分,新疆南天山造山带出露有橄榄岩-麻粒岩地体,其北部榆树沟地区麻粒岩超高温变质作用的确定及P-T-t轨迹的建立为南天山造山带增生造山过程的研究提供了重要依据。本文主要以榆树沟地区3个含石榴夕线石泥质麻粒岩为研究对象,在详细岩相学研究的基础上进行了温压计算、相平衡模拟及锆石U-Pb年龄分析。结果显示其普遍保留了4个阶段的矿物组合:(1)峰前阶段(M1)主要是石榴子石核部与核部包裹体矿物Grt1+Bt1+Pl1+Ilm1+Rt1+Qz1±Ksp1;(2)峰期阶段(M2)由石榴子石幔部和基质矿物核部组成,Grt2+Sil2+Ksp2+Pl2+Ilm2+Rt2+Qz2+liq2,其温压条件为910~973℃和0.90~1.09GPa;(3)高压麻粒岩相阶段(M3)主要是石榴子石内边部和边部包裹体及基质中矿物的边部,Grt3+Bt3+Sil3+Ksp3+Pl3+Ilm3+Rt3+Qz3+liq3,其温压结果为845~869℃和1.01~1.14GPa;(4)角闪岩相退变质阶段(M4)以石榴子石的外边部及围绕石榴子石的矿物为代表,Grt4+Bt4+Sil4+Ksp4+Pl4+Ilm4+Qz4±Rt4,其温压条件为701~737℃和0.7~0.8GPa。温压结果指示泥质麻粒岩记录了一条逆时针P-T轨迹。锆石U-Pb年龄分析结果指示原岩沉积是在427Ma之后,超高温变质作用发生在397~409Ma,压力峰期变质作用年龄范围为381~395Ma,退变质年龄结果为355~387Ma。超高温变质作用的热源可能是泥盆纪弧岩浆侵入,随后麻粒岩及与之接触的橄榄岩被俯冲板片捕获并经历了高压变质作用,后期受挤压折返发生了退变质降压冷却。

关键词：泥质麻粒岩超高温变质作用 P-T轨迹榆树沟南天山

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基于熵权与集成学习的半监督小样本树种分类研究

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森林工程 2025年第1期41卷 151-161页

作者：王静李静河南机电职业学院信息工程学院郑州451191 河南科技大学信息工程学院河南洛阳471000

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论... 详细信息

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论上引入EL的思想,以熵权法作为基础理论设计按基分类器当前训练周期下的F1分数计算的信息熵作为计算权重因子,再依信息熵越大基分类器越不稳定思想设计权重,使集成分类器分类概率更集中,减少集成分类器偏向性。结果显示,EW-EL较传统半监督自训练方法能更有效地均衡数据分布,使新加入数据的伪标签样本类别更准确。EW-EL所得到的小样本树种分类总精度(OA)为0.97、召回率(Recall)为0.96及Kappa系数为0.97,3种指标均优于监督分类、传统半监督自训练方法及利用传统EL机制所构建的半监督自训练方法。其中,EW-EL方法较融合软投票机制的半监督自训练方法,OA与Recall均提升了1%。EW-EL联合简单线性迭代聚类所制成的树种图在所选测试区内达到了94%。此外,进一步分析证明,EW-EL能通过集成诸多分类器,来实现更佳的小样本树种分类结果,更适用于低成本下的相关部门进行林业资源统计的工作。

关键词：无人机影像熵权法深度学习集成学习半监督小样本分类树种分类树种制图 EW-EL

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四喷嘴气化炉烧嘴接管关键加工工艺技术研究

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压力容器 2017年第5期34卷 70-74页

作者：李文静蔡超李国骥哈尔滨锅炉厂有限责任公司黑龙江哈尔滨150046

根据四喷嘴气化炉烧嘴接管的结构特点与技术要求,分析烧嘴接管的装配和加工上的技术难点,将烧嘴接管的八角垫环槽精加工列为关键工序,通过工艺技术研究,选取合适的数控加工设备和设计专用非标刀具,并针对加工过程中发现的问题加以改进,... 详细信息

根据四喷嘴气化炉烧嘴接管的结构特点与技术要求,分析烧嘴接管的装配和加工上的技术难点,将烧嘴接管的八角垫环槽精加工列为关键工序,通过工艺技术研究,选取合适的数控加工设备和设计专用非标刀具,并针对加工过程中发现的问题加以改进,最终取得了较好的加工效果。

关键词：四喷嘴气化炉烧嘴接管加工工艺

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