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Chinese Journal of Polymer Science 2020年第2期38卷 143-150,I0006页

作者： Sheng-Qing Yang Jin-Nan zhao jing-bo zhao Zhi-Yuan Zhang Jun-Ying Zhang Key Laboratory of Carbon Fiber and Functional Polymers(Beijing University of Chemical Technology) Ministry of Education/College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Cross-linked polyamides(c PAs)were prepared through direct bulk Michael addition and subsequent *** mixed hexanediamine multi-esters(HDAMEs)were generated through the Michael addition of 1,6-hexanediamine(HDA)and methyl acrylate(MA)at50℃ with different HDA/MA molar *** polycondensation of HDAMEs then proceeded at 150 or 170℃ in flasks to obtain viscous fluids,and curing was continued in tetrafluoroethylene molds to obtain c PA *** Michael addition was monitored on the basis of FTIR and ESI-MS *** c PA films were characterized by DSC,TGA,dynamic mechanical analysis,and tensile *** directly prepared c PAs exhibited Tg of 1–39℃,tensile strength of up to 45 MPa,and strain at break from 18%to 40%.The c PAs with high tensile strength and good toughness were successfully synthesized through the direct bulk Michael addition from HDA and MA followed with polycondensation.

关键词： Michael addition Polycondensation Mechanical properties

Gastrointestinal tract modelling in health and disease

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World Journal of Gastroenterology 2009年第2期15卷 169-176页

作者： Dong-Hua Liao jing-bo zhao Hans Gregersen Hans Gregersen Mech-Sense Aalborg Hospital DK-9100 Aalborg Denmark Institute of Health Technology Aalborg University Denmark Haukeland University Hospital Bergen Norway

The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract function are generated by the integrated behaviour of multiple tissues and cell types. A thorough study of the GI tract requires understanding of the interactions between cells, tissues and gastrointestinal organs in health and disease. This depends on knowledge, not only of numerous cellular ionic current mechanisms and signal transduction pathways, but also of large scale GI tissue structures and the special distribution of the nervous network. A unique way of coping with this explosion in complexity is mathematical and computational modelling; providing a computational framework for the multilevel modelling and simulation of the human gastrointestinal anatomy and physiology. The aim of this review is to describe the current status of biomechanical modelling work of the GI tract in humans and animals, which can be further used to integrate the physiological, anatomical and medical knowledge of the GI system. Such modelling will aid research and ensure that medical professionals benefit, through the provision of relevant and precise information about the patient's condition and GI remodelling in animal disease models. It will also improve the accuracy and efficiency of medical procedures, which could result in reduced cost for diagnosis and treatment.

关键词： Gastrointestinal tract Computational modelling Biomechanics Remodelling Disease

Animal models of pancreatitis: Can it be translated to human pain study?

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World Journal of Gastroenterology 2013年第42期19卷 7222-7230页

作者： jing-bo zhao Dong-Hua Liao Thomas Dahl Nissen Mech-Sense Department of Gastroenterology and SurgeryAalborg University HospitalDK 9000 AalborgDenmark Institute of Clinical Medicine Aarhus UniversityDK 8200 Aarhus NDenmark The College of Bioengineering Chongqing University Biomedical Research Laboratory Aalborg University HospitalDK 9000 AalborgDenmark

Chronic pancreatitis affects many individuals around the world,and the study of the underlying mechanisms leading to better treatment possibilities are important ***,animal models are needed to illustrate the basic study of ***,animal models of acute and chronic pancreatitis have been thoroughly reviewed,but few reviews address the important aspect on the translation of animal studies to human *** is well known that pancreatitis is associated with epigastric pain,but the understanding regarding to mechanisms and appropriate treatment of this pain is still *** animal models to study pancreatitis associated visceral pain is difficult,however,these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral *** this review,the animal models of acute,chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.

关键词： Animal model Pancreatitis Visceral pain Mechanism

Time-dependent viscoelastic properties along rat small intestine

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World Journal of Gastroenterology 2005年第32期11卷 4974-4978页

作者： James B Smith jing-bo zhao Yan-Ling Dou Hans Gregersen Institute of Experimental Clinical Research Aarhus University Denmark Center of Excellence in Visceral Biomechanics and Pain Aalborg Hospital and Center of SMI Aalborg University Aalborg Denmark Department of Gastroenterology China-Japan Friendship Hospital Beijing 100029 China

AIM： To measure the time-dependent （viscoelastic） behavior in the change of the small intestinal opening angle and to test how well the behavior could be described by the Kelvin model for a standard linear solid. METHODS： Segments from the duodenum, jejunum, and ileum were harvested from 10 female Wistar rats and the luminal diameter, wall thickness, and opening angle over time （θ（t）） were measured from rings cut from these segments. RESULTS： Morphometric variations were found along the small intestine with an increase in luminal area and a decrease in wall thickness from the duodenum to the ileum. The opening angle obtained after 60 rain was highest in the duodenum （220.8±12.9°）and decreased along the length of the intestine to 143.9±8.9° in the jejunum and 151.4±9.4° in the ileum. The change of opening angle as a function of time, fitted well to the Kelvin model using the equation θ（t）/θo = [1-ηexp （-λt）] after the ring was cut. The computed creep rate λ. did not differ between the segments. Compared to constant calculated from pig aorta and coronary artery, it showed that α agreed well （within 5%）, η was three times larger than that for vascular tissue, and λ ranged ±40% from the value of the pig coronary artery and was a third of the value of pig aorta. CONCLUSION： The change of opening angle over time for all the small intestine segments fits well to the standard linear spring-dashpot model. This viscoelastic constant of the rat small intestine is fairly homogenous along its length. The data obtained from this study add to a base set of biomechanical data on the small intestine and provide a reference state for comparison to other tissues,diseased intestinal tissue or intestinal tissue exposed to drugs or chemicals.

关键词： Biomechanics Standard linear solid Creep Opening angle

The hazardous effects of tobacco smoking on male ertility

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Asian Journal of Andrology 2015年第6期17卷 954-960,I0009页

作者： jing-bo Dai zhao-Xia Wang Zhong-Dong Qiao School of Life Sciences and Biotechnology Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University Shanghai 200240 China

The substantial harmful effects of tobacco smoking on fertility and reproduction have become apparent but are not generally appreciated. Tobacco smoke contains more than 4000 kinds of constituents, including nicotine, tar, carbonic monoxide, polycyclic aromatic hydrocarbons, and heavy metals. Because of the complexity of tobacco smoke components, the toxicological mechanism is notably complicated. Most studies have reported reduced semen quality, reproductive hormone system dysfunction and impaired spermatogenesis, sperm maturation, and spermatozoa function in smokers compared with nonsmokers. Underlying these effects, elevated oxidative stress, DNA damage, and cell apoptosis may play important roles collaboratively in the overall effect of tobacco smoking on male fertility. In this review, we strive to focus on both the phenotype of and the molecular mechanism underlying these harmful effects, although current studies regarding the mechanism remain insufficient.

关键词： DNA fragmentation heavy metals nicotine oxidative stress semen quality spermatogenesis

Effect of Kaiyu Qingwei Jianji on the morphometry and residual strain distribution of small intestine in experimental diabetic rats

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World Journal of Gastroenterology 2006年第44期12卷 7149-7154页

作者： Hong Sha jing-bo zhao Zhi-Yuan Zhang Shui-Ping Zhou Xiao-Lin Tong Feng-Yuan Zhuang Hans Gregersen China-Japan Friendship Hospital Beijing 100029 China Center of Excellence in Visceral Biomechanics and Pain Aalborg Hospital DK 9000 Aalborg Denmark Bioengineering Department Beijing University of Aeronautics and Astronautics 37 Xueyuan Rd. Beijing 100083 China

AIM： To investigate the effect of a Chinese medicine, Kaiyu Qingwei Jianji （KYQWJJ） used for diabetic treatment, on the morphometry and residual strain distribution of the small intestine in streptozotocin （STZ） -induced diabetic rats. Correlation analysis was also performed between the opening angle and residual strain with the blood glucose level. METHODS： Forty-two male Wistar rats weighing 220-240 g were included in this study. Thirty-two STZ- induced diabetic rats were subdivided into four groups （n = 8 in each group）, i.e. diabetic control group （DM）; high dose of KYQWJJ （T1, 36g/kg per day）; low dose of KYQWJJ （T2, 17 g/kg per day） and Gliclazide （T3, 50 mg/kg per day）. Another ten rats were used as nondiabetic control （CON）. The medicines were poured directly into stomach lumen by gastric lavage twice daily. The rats of CON and DM groups were only poured the physiological saline. Blood glucose and plasma insulin levels were measured. Experimental period was 35 d. At the end of experiment, three 5-cm long segments were harvested from the duodenum, jejunum and ileum. Three rings of 1-2 mm in length for no-load and zero-stress state tests were cut from the middle of different segments. The morphometric data, such as the circumferential length, the wall thickness and the opening angle were measured from the digitized images of intestinal segments in the no-load state and zerostress state. The residual strain was computed from the morphometry data. Furthermore, the linear regression analysis was performed between blood glucose level with morphometric and biomechanical data in the different intestinal segments. RESULTS： The blood glucose level of DM group was consistent 4-fold to 5-fold higher than those in CON group during the experiment （16.89 ± 1.11 vs 3.44 ± 0.15 mmol/L, P 〈 0.001）. The blood glucose level in the T1 （16.89 ± 1.11 vs 11.08 ± 2.67 mmol/L, P 〈 0.01） and T3 groups （16.89 ± 1.11 vs 13.54 ± 1.73 mmol/L, P 〈 0.05）, but not in T2 group （P 〉 0.05）

关键词： Diabetes Intestine Kaiyu Qingwei Jianji Residual strain Rat

Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

Research on immune algorithm for mobile phone viruses detection

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通讯和计算机（中英文版） 2008年第6期5卷 31-34页

作者： ZHANG Li-jing zhao bo School of Computer Science and Technology North China Electric Power University Baoding 071003 China

Changes of phasic and tonic smooth muscle function of jejunum in type 2 diabetic Goto-Kakizaki rats

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World Journal of Diabetes 2013年第6期4卷 339-348页

作者： jing-bo zhao Peng-Min Chen Hans Gregersen Department of Gastroenterology and Surgery Aalborg University HospitalDK 9000 AalborgDenmark The College of Bioengineering Chongqing University Department of Molecular Biology Institute of Clinical MedicineChina-Japan Friendship Hospital The GIOME Institute GIOME FZERas AlKhaimah 6300United Arab Emirates

AIM:To generate phasic and tonic stress-strain curves for evaluation of intestinal smooth muscle function in type 2 diabetic rats during active and passive ***:Seven diabetic Goto-Kakizaki(GK)male rats,32-wk old(GK group),and 9 age-matched normal Wistar rats(Normal group)were included in the *** segments were distended up to a pressure of10 cm H2O in an organ bath containing 37℃Krebs solution with addition of carbachol(CA).The pressure and outer diameter changes were synchronously *** conditions were obtained using calcium-free Krebs solution containing ethylene glycol tetraacetic acid and *** phasic,tonic and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress state *** active phasic and tonic stresses were defined as the total phasic and tonic stresses minus the passive ***:Diabetes increased jejunal mucosa and muscle layer thicknesses compared to the Normal group(mucosa,755.8±63.3 vs 633.1±59.1μm,P0.05;stress,0.25±0.03 vs 0.35±0.06 kPa,P>0.05).The amplitude of total phasic,total tonic,active phasic and active tonic circumferential stresses did not differ for the distensions without CA application between the GK group and the Normal ***,the total phasic and total tonic stresses increased after CA application in the GK group compared those in the Normal *** normalized to muscle layer thickness,the amplitude of active stresses before CA application was lowest in the GK group compared with the Normal *** difference was

关键词： Intestine Diabetes Muscle function Stress-strain curves Carbachol Rat

Advanced glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats

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World Journal of Diabetes 2015年第4期6卷 662-672页

作者： Peng-Min Chen Hans Gregersen jing-bo zhao Department of Molecular Biology Institute of Clinical MedicineChina-Japan Friendship Hospital GIOME Center College of BioengineeringChongqing University Institute of Clinical Medicine Aarhus University

AIM:To investigate changes in advanced glycation end products(AGEs) and their receptor(RAGE) expression in the gastrointestinal(GI) tract in type 2 diabetic ***:Eight inherited type 2 diabetic rats GotoKakizak(GK) and ten age-matched normal rats were used in the *** 18 wk of age,the body weight and blood glucose were measured every week and 2 wk *** the rats reached 32 wk,twocentimeter segments of esophagus,duodenum,jejunum,ileum,and colon were excised and the wet weight was *** segments were fixed in 10% formalin,embedded in paraffin and five micron sections were *** layer thickness was measured in Hematoxylin and Eosin-stained *** [N epsilon-(carboxymethyl) lysine and N epsilon-(carboxyethyl)lysine] and RAGE were detected by immunohistochemistry staining and image analysis was done using Sigmascan Pro 4.0 image analysis ***:The blood glucose concentration(mmol/L) at 18 wk age was highest in the GK group(8.88 ± 1.87 vs 6.90 ± 0.43,P both in the striated muscle layer and mucosa layer(immuno-positive area/ total measuring area %:4.52 ± 0.89 vs 10.96 ± 1.34,P < 0.01 for muscle; 8.90 ± 2.62 vs

关键词： Diabetes mellitus Gastrointestinal complications Advanced glycation end products Receptor ofadvanced glycation end products