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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang jing liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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A new study of neutrino energy loss of nuclides ^(53-60)Cr by electron capture in magnetars

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Research in Astronomy and Astrophysics 2013年第8期13卷 945-951页

作者： jing-jing liu College of Sciences and Technology Qiongzhou University

Following the theory of relativity, in the presence of an ultrastrong magnetic field （UMF） and utilizing a nuclear shell model, we carry out an estimation of the neutrino energy loss （NEL） rates of nuclides ^53-60Cr, which occur by electron capture in magnetars. The results show that the NEL rates greatly increase when a UMF is present, and can even exceed nine orders of magnitude at relatively lower density and temperature （e.g. ρ7 = 5.86, Ye = 0.47, T9 = 7.33） in the range from 1013 G to 1018 G. However, the increase in rates was no more than six orders of magnitude at relatively higher density and temperature （e.g.ρ7 = 4.86 × 10^8, Ye = 0.39, T9 = 14.35）.

关键词： physical data and processes: neutrinos nuclear reactions - stars: super- novae - stars: evolution

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Neutrino energy spectrum and electron capture of Nuclides^(56))Fe,^(56)Co,^(56)Ni,^(56)Mn,^(56)Cr and^(56)V in stellar interiors

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Research in Astronomy and Astrophysics 2014年第8期14卷 971-978页

作者： jing-jing liu College of Science and Technology Qiongzhou University

Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum （NES） and the electron capture （EC） of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure.

关键词： physical data and processes neutrinos, nuclear reactions -- stars super- novae -- stars evolution

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Strong screening effects on resonant nuclear reaction ^(23)Mg(p,γ) ^(24)Al in the surface of magnetars

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Research in Astronomy and Astrophysics 2016年第5期16卷 117-124页

作者： jing-jing liu College of Electronic and Communication Engineering Hainan Tropical Ocean University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University

Based on the theory of relativistic superstrong magnetic fields （SMFs）, by using the method of Thomas-Fermi-Dirac approximations, we investigate the problem of strong electron screening （SES） in SMFs and the influence of SES on the nuclear reaction of 23Mg （p, Y）24A1. Our calculations show that the nuclear reaction will be markedly effected by the SES in SMFs in the surface of magnetars. Our calculated screening rates can increase two orders of magnitude due to SES in SMFs.

关键词： physical data and processes: nuclear reactions nucleosynthesis abundances -- stars: neutron-- stars: magnetic fields

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稀土硼酸盐双折射材料的电子结构和光学性质的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 171-179页

作者：努尔比耶·图尔洪刘鸿涛崔秀花刘静姜轶井群新疆大学物理科学与技术学院乌鲁木齐830017

近年来,稀土(RE)硼酸盐材料因其丰富的结构和优异的光学性质,引起人们广泛关注.使用第一性原理高通量筛选工具获得五个性能优异的短波长稀土硼酸盐材料,并进一步研究了他们的电子结构和光学性质.研究结果表明,这些材料的紫外截止边和双... 详细信息

近年来,稀土(RE)硼酸盐材料因其丰富的结构和优异的光学性质,引起人们广泛关注.使用第一性原理高通量筛选工具获得五个性能优异的短波长稀土硼酸盐材料,并进一步研究了他们的电子结构和光学性质.研究结果表明,这些材料的紫外截止边和双折射率分别为:210 nm,0.0934@1064 nm(LaB_(3)O_(6))、246 nm,0.0880@1064 nm(LaBO_(3))、347 nm,0.0815@1064 nm(LuBO_(3))、272 nm,0.0914@1064 nm(ScBO_(3))、279 nm,0.0920@1064 nm(Sc_(3)B_(5)O_(12)).本文使用投影态密度、实空间原子实切割以及Born有效电荷分析了各原子及离子基团对双折射率的影响机制,结果表明RE-O基团和B-O多面体在决定光学性质方面做出了主要贡献.

关键词：稀土硼酸盐第一性原理双折射率

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The Infiuence of Velocity-dependent Correction Factor on Proton Decay Reactions in Massive White Dwarfs

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Research in Astronomy and Astrophysics 2024年第3期24卷 169-179页

作者： jing-jing liu Dong-Mei liu College of Science Hainan Tropical Ocean UniversitySanya 572022China

Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the *** find that a strong suppression controls the monopole catalysis of nucleon decay by the correction *** maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),*** luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.

关键词： astroparticle physics-nuclear reactions-nucleosynthesis-abundances-(stars) white dwarfs

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Iron group nuclei electron capture in super-Chandrasekhar superstrong magnetic white dwarfs

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Research in Astronomy and Astrophysics 2021年第11期21卷 153-164页

作者： jing-jing liu Dong-Mei liu College of Science Hainan Tropical Ocean UniversitySanya 572022China

Using the theory of relativistic mean-field effective interactions,the influences of superstrong magnetic fields(SMFs)on electron Fermi energy,binding energy per nucleus and single-particle level structure are discussed in super-Chandrasekhar magnetic white *** on the relativistical SMFs theory model of Potekhin et al.,the electron chemical potential is corrected in SMFs,and the electron capture(EC)of iron group nuclei is investigated by using the Shell-Model Monte Carlo method and Random Phase Approximation *** EC rates can increase by more than three orders of magnitude due to the increase of the electron Fermi energy and the change of single-particle level structure by ***,the EC rates can decrease by more than four orders of magnitude due to increase of the nuclei binding energy by *** compare our results with those of FFNs(Fuller et al.),AUFDs(Aufderheide et al.)and Nabi(Nabi et al.).Our rates are higher by about four orders of magnitude than those of FFN,AUFD and Nabi due to *** study may have important reference value for subsequent studies of the instability,mass radius relationship,and thermal and magnetic evolution of super-Chandrasekhar magnetic white dwarfs.

关键词： nuclear reactions,nucleosynthesis,abundances stars:white dwarfs

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Integrating deep learning and logging data analytics for lithofacies classification and 3D modeling of tight sandstone reservoirs

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Geoscience Frontiers 2022年第1期13卷 350-363页

作者： jing-jing liu Jian-Chao liu School of Earth Science and Resources Chang’an UniversityXi’an 710064China

The lithofacies classification is essential for oil and gas reservoir exploration and *** traditional method of lithofacies classification is based on"core calibration logging"and the experience of *** approach has strong subjectivity,low efficiency,and high *** uncertainty may be one of the key factors affecting the results of 3 D modeling of tight sandstone *** recent years,deep learning,which is a cutting-edge artificial intelligence technology,has attracted attention from various ***,the study of deep-learning techniques in the field of lithofacies classification has not been ***,this paper proposes a novel hybrid deep-learning model based on the efficient data feature-extraction ability of convolutional neural networks(CNN)and the excellent ability to describe time-dependent features of long short-term memory networks(LSTM)to conduct lithological facies-classification *** results of a series of experiments show that the hybrid CNN-LSTM model had an average accuracy of 87.3%and the best classification effect compared to the CNN,LSTM or the three commonly used machine learning models(Support vector machine,random forest,and gradient boosting decision tree).In addition,the borderline synthetic minority oversampling technique(BSMOTE)is introduced to address the class-imbalance issue of raw *** results show that processed data balance can significantly improve the accuracy of lithofacies *** that,based on the fine lithofacies constraints,the sequential indicator simulation method is used to establish a three-dimensional lithofacies model,which completes the fine description of the spatial distribution of tight sandstone reservoirs in the study *** to this comprehensive analysis,the proposed CNN-LSTM model,which eliminates class imbalance,can be effectively applied to lithofacies classification,and is expected to improve the reality of the geologic

关键词： Deep learning Convolutional neural networks LSTM Lithological-facies classification 3D modeling Class imbalance

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Comparation of Activity against Aβ Aggregation between RR and LPFFD

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Chinese Journal of Polymer Science 2015年第7期33卷 1009-1017页

作者： jing liu 袁直 Key Laboratory of Functional Polymer Materials of Ministry of Education and Institute of Polymer Chemistry Nankai University and Collaborative Innovation Center of Chemical Science and Engineering

Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of Aβ with multiple weak interactions is better than those that only target a single region with the single driving force mainly.

关键词： Molecular docking Multiple weak interactions Affinity Inhibitory ability

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