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Microbial community structure and dynamics of starch-fed and glucose-fed chemostats during two years of continuous operation

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 368-380页

作者： Min GOU jing zeng Huizhong WANG Yueqin TANG Toru SHIGEMATSU Shigeru MORIMURA Kenji KIDA College of Architecture and Environment Sichuan University Chengdu 610065 China Department of Food Science Faculty of Applied Life Sciences Niigata University of Pharmacy and Applied Life Sciences (NUPALS) Niigata 956-8603 Japan Graduate School of Science and Technology Kumamoto University Kumamoto 860-0862 Japan

The microbial community structures of two mesophilic anaerobic chemostats, one fed with glucose, the other with starch as sole carbon sources, were studied at various dilution rates （0.05-0.25 d-1 for glucose and 0.025-0.1 d-1 for starch） during two years continuous operation. In the glucose-fed chemostat, the aceticlastic methanogen Methanosaeta spp. and hydrogenotrophic methanogen Methanoculleus spp. predominated at low dilution rates, whereas Methanosaeta spp. and the hydrogenotrophic Methanobacterium spp. predominated together when dilution rates were greater than 0.1 d 1. Bacteria affiliated with the phyla Bacteroidetes, Spiro- chaetes, and Actinobacteria predominated at dilution rates of 0.05, 0.1, and 0.15 d-l, respectively, while Firmicutes predominated at higher dilution rates （0.2 and 0.25 d-l）. In the starch-fed chemostat, the aceticlastic and hydrogeno- trophic methanogens coexisted at all dilution rates. Although bacteria belonging to only two phyla were mainly responsible for starch degradation （Spirochaetes at the dilution rate of 0.08 d-1 and Firmicutes at other dilution rates）, different bacterial genera were identified at different dilution rates. With the exception of Archaea in the glucose-fed chemostat, the band patterns revealed by denaturing gradient gel electrophoresis （DGGE） of the microbial communities in the two chemostats displayed marked changes during long-term operation at a constant dilution rate. The bacterial community changed with changes in the dilution rate, and was erratic during long- term operation in both glucose-fed and starch-fed chemo- stats.

关键词： microbial community glucose degradation,starch degradation dilution rate continuous methanefermentation phylogenetic analysis

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Accelerated Infliximab Induction for Severe Lower Gastrointestinal Bleeding in a Young Patient with Crohn’s Disease:A Case Report

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World Journal of Clinical Cases 2022年第2期10卷 733-740页

作者： jing zeng Feng Shen Jian-Gao Fan Wen-Song Ge Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Severe lower gastrointestinal bleeding(SLGIB)is a rare complication of Crohn's disease(CD).The treatment of these patients is a clinical *** anti-TNFαantibody(IFX)can induce relatively fast mucosal *** has been reported for the treatment of SLGIB,but there are few reports on accelerated IFX induction in CD patients with *** SUMMARY A 16-year-old boy with a history of recurrent oral ulcers for nearly 1 year presented to the Gastroenterology Department of our hospital complaining of recurrent periumbilical pain for more than 1 mo and having bloody stool 4 times within 2 *** showed multiple areas of inflammation of the colon and a sigmoid colon ulcer with active *** was immediately performed under *** physical examination of the patient showed scattered small ulcers in the lower lip of the mouth and small cracks in the perianal *** with his medical history,physical examination,laboratory examinations with high C-reactive protein(CRP),platelet count(PLT),erythrocyte sedimentation rate(ESR)and fecal calprotectin levels,imaging examinations and pathology,a diagnosis of CD was taken into *** to the pediatric CD activity index 47.5,methylprednisolone(40 mg QD)was given *** abdominal pain disappeared,and CRP,PLT,and ESR levels decreased significantly after the ***,he had a large amount of bloody stool again after 1 wk of methylprednisolone treatment,and his hemoglobin level decreased *** infliximab(IFX)(5 mg/kg)was given as a combination therapy regimen,he still had bloody stool with his hemoglobin level decreasing from 112 g/L to 80 g/L in a short time,so-called *** informed consent,accelerated IFX(5 mg/kg)induction was given 7 days after initial *** bleeding then *** weeks after the treatment,repeat colonoscopy showed mucosal healing;thus far,no recurrent bleeding has occurred,and the patie

关键词： Crohn’s disease Severe lower gastrointestinal bleeding Steroid hormone Accelerated infliximab induction Case report

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Interface diffusion of sputtered CoZrNb films on silicon substrate

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Rare Metals 2006年第Z2期25卷 36-40页

作者： LI Xiaowei WANG Leyun YANG jing zeng Fei PAN Feng Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The amorphous CoZrNb films were deposited by DC magnetron *** depth distributions of the elements were analyzed by Rutherford backscattering spectrometry(RBS).The results indicate that when the deposition time is longer than 37 min,the film composition keeps constant along the *** the deposition time is longer than 45 min,the Co concentration at the interface of the silicon substrate is higher than the average value in the whole *** the deposition time is longer than 52 min,the Co atoms diffuse into the substrate during the *** to the Co composition profile in the substrate,which were determined from the RBS spectra,the Co diffusion coefficients in the substrate were calculated using the solution of Fick′s second law corresponding to an infinite source with a constant diffusion *** calculated diffusion coefficients indicate an interstitial assisted diffusion mechanism.

关键词： CoZrNb films interface diffusion RBS

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Spatio-temporal variation in rock exhumation linked to large-scale shear zones in the southeastern Tibetan Plateau

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Science China Earth Sciences 2020年第4期63卷 512-532页

作者： Yukui GE jing LIU-zeng Jinyu ZHANG Wei WANG Yuntao TIAN Matthew FOX Lingsen zeng Xiaoming SHEN Heng WANG Ze SU Kejia XIE State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Surface-Earth System Science Tianjin UniversityTianjin 300072China Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityGuangzhou 510275China Department of Earth Sciences University College LondonWC1E 6BTUK Key Laboratory of Deep-Earth Dynamics Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of Crustal Dynamics Institute of Crustal DynamicsChina Earthquake AdministrationBeijing 100085China Henan Province Non-ferrous Metals Geological Mineral Resources Bureau Zhengzhou 450016.China

Crustal-scale shear zones are believed to have played an important role in the tectonic and landscape evolution of orogens. However, the variation of long-term rock exhumation between the interior of shear zones and adjacent regions has not been documented in detail. In this study, we obtained new zircon U-Pb, biotite ^(40)Ar/^(39)Ar, zircon and apatite(U-Th)/He data, and conducted inverse thermal history modeling from two age-elevation profiles(the Pianma and Tu'er profiles) in the southeastern Tibetan Plateau. Our goal is to constrain the exhumation history of the Gaoligong and Chongshan shear zones and adjacent regions, so as to explore the effect of the shear zones on exhumation and their thermal effect on cooling that should not be ignored. Our results suggest that during the interval of 18–11 Ma the exhumation rates of rocks within the Gaoligong shear zone are anomalously high compared with those outside of. The rapid cooling during 18–11 Ma appears to be restricted to the shear zone, likely due to localized thermal effects of shearing and exhumation. After 11 Ma, both the areas within and outside of the shear zones experienced a similar two-stage exhumation history: slower cooling until the early Pliocene, and then a rapid increase in cooling rate since the early Pliocene. Our results indicate a synchronized exhumation but with spatially varied exhumation rates. Our study also highlights the important role of large-scale shear zones in exposing rocks, and thus the importance of the structural context when interpreting thermochronological data in the southeastern margin of the Tibetan Plateau.

关键词： Southeastern Tibetan Plateau Exhumation (U-Th)/He Low-temperature thermochronometry Shear zone

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Mast Cells in Adjacent Normal Colon Mucosa rather than Those in Invasive Margin are Related to Progression of Colon Cancer

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Chinese Journal of Cancer Research 2011年第4期23卷 276-282页

作者： Qing Xia Ya Ding Xiao-jun Wu Rui-qing Peng Qiang Zhou jing zeng jing-hui Hou Xing Zhang Yi-xin zeng Xiao-shi Zhang Ying-bo Chen State Key Laboratory of Oncology in South China Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Biotherapy Center Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Colorectal Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology the First People Hospital of Yueyang Yueyang 414000 China Department of Pathology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Gastric and Pancreatic Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

Objective: Mast cells (MC) reside in the mucosa of the digestive tract as the first line against bacteria and toxins. Clinical evidence has implied that the infiltration of mast cells in colorectal cancers is related to malignant phenotypes and a poor prognosis. This study compared the role of mast cells in adjacent normal colon mucosa and in the invasive margin during the progression of colon cancer. Methods: Specimens were obtained from 39 patients with colon adenomas and 155 patients with colon cancers treated at the Sun Yat-sen University Cancer Center between January 1999 and July 2004. The density of mast cells was scored by an immunohistochemical assay. The pattern of mast cell distribution and its relationship with clinicopathologic parameters and 5-year survival were analyzed. Results: The majority of mast cells were located in the adjacent normal colon mucosa, followed by the invasive margin and least in the cancer stroma. Mast cell count in adjacent normal colon mucosa (MCCadjacent) was associated with pathologic classification, distant metastases and hepatic metastases, although it was not a prognostic factor. In contrast, mast cell count in the invasive margin (MCCinvasive) was associated with neither the clinicopathlogic parameters nor overall survival. Conclusion: Mast cells in the adjacent normal colon mucosa were related to the progression of colon cancer, suggesting that mast cells might modulate tumor progression via a long-distance mechanism.

关键词： Mast cell Colon cancer Mucosa Invasive margin Prognosis

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Dys-psychological Stress Effect on Expressions of P53 and NFκBp65 in Human Ovarian Carcinoma In Vivo

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Chinese Journal of Cancer Research 2012年第3期24卷 245-248页

作者： Li-qun Yu Guo-lan Gao Fun-jun Liu Qiong-jing zeng Department of Gynecology Aviation General HospitalBeijing 200022Chine Department of Gynecology and Obstetrics First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Objective： To investigate the dys-psychological stress effect on the growth of subcutaneous xenotransplanted tumor in nude mice bearing human epithelium ovarian carcinoma, and the influence on P53 and NFκBp65 expressions. Methods： The subcutaneous tumor xenografts were established by implanting human epithelium ovarian carcinoma tissues into nude mice and the dys-psychological stress model was established with restraint. The mice were randomized into the following four treatment groups with each group six mice respectively： tumor group （group A）, normal saline intraperitoneal injection; tumor with stress group （group B）, normal saline intraperitoneal injection; tumor therapy group （group C）, cisplatin intraperitoneal injection; and tumor therapy with stress group （group D）, cisplatin intraperitoneal injection. The expressions of P53 and NFκBp65 in tumor tissues were determined by Western blotting. Results： The expressions of P53 and NFκBp65 in each restraint group were enhanced compared with the control groups （P0.05）. Conclusion： The dys-psychological stress may induce the high expressions of P53 and NFκBp65 proteins and further promote tumor growth.

关键词： Constraint stress Oncoprotein Ovarian cancer animal model

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3′-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion

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Neural Regeneration Research 2018年第9期13卷 1561-1567页

作者： Xiao Li Rui-Zhen Liu Qi zeng Zhi-Hua Huang Jian-Dong Zhang Zong-Liang Liu jing zeng Hai Xiao Gannan Medical University Ganzhou Jiangxi Province China Department of Ultrasound First Affiliated Hospital of Gannan Medical University Ganzhou liangxi Province China Department of Pathology First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi Province China

3′-Daidzein sulfonate sodium（DSS） is a new synthetic water-soluble compound derived from daidzein,a soya isoflavone that plays regulatory roles in *** this study,we hypothesized that the regulatory role of DSS in neurobiology exhibits therapeutic effects on hippocampal damage and memory *** validate this hypothesis,we established rat models of chronic cerebral hypoperfusion（CCH） by the permanent occlusion of the common carotid arteries using the two-vessel occlusion *** weeks after modeling,rat models were intragastrically administered 0.1,0.2,and 0.4 mg/kg DSS,once a day,for 5 successive *** Morris water maze test was performed to investigate CCH-induced learning and memory *** assay was used to analyze apoptosis in the hippocampal CA1,CA3 regions and dentate ***-eosin staining was performed to observe the morphology of neurons in the hippocampal CA1,CA3 regions and dentate *** blot analysis was performed to investigate the phosphorylation of PKA,ERK1/2 and CREB in the hippocampal PKA/ERK1/2/CREB signaling *** showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH,reduced apoptosis of neurons in the hippocampal CA1,CA3 regions and dentate gyrus,and increased the phosphorylation of PKA,ERK1/2,and CREB in the *** findings suggest that DSS protects against CCH-induced memory impairment and hippocampal damage possibly through activating the PKA/ERK1/2/CREB signaling pathway.

关键词： nerve regeneration learning and memory deficits chronic cerebral hypoperfusion 3'-daidzein sulfonate sodium PKAIERK1/2/CREB signaling pathway neuroprotection hippocampus neural regeneration

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Metal-organic interface engineering for boosting the electroactivity of Pt nanodendrites for hydrogen production

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Journal of Energy Chemistry 2020年第12期29卷 105-112页

作者： Juan Bai Nan Jia Pujun Jin Pei Chen Jia-Xing Jiang jing-Hui zeng Yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry(MOE)Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710062ShaanxiChina

Recently, the surface chemical functionalization and morphology control of precious metal nanostructures have been recognized as two efficient strategies for improving their electroactivity and/or selectivity. In this work, 1, 10-phenanthroline monohydrate(PM) functionalized Pt nanodendrites(Pt-NDs) on carbon cloth(CC)(denoted as PM@Pt-NDs/CC) and polyethylenimine(PEI) functionalized Pt-NDs on CC(denoted as PEI@Pt-NDs/CC) are successfully achieved by immersing Pt-NDs/CC into PM and PEI aqueous solutions, respectively. PEI functionalization of Pt-NDs/CC improves its electroactivity for hydrogen evolution reaction(HER) due to local proton enrichment whereas PM functionalization of Pt-NDs/CC improves its electroactivity for formic acid oxidation reaction(FAOR) by facilitating dehydrogenation pathway. With such high activity, a two-electrode electrolyzer is assembled using PM@Pt-NDs/CC as the anodic electrocatalyst and PEI@Pt-NDs/CC as the cathodic electrocatalyst for electrochemical reforming of formic acid, which only requires 0.45 V voltage to achieve the current density of 10 mA cm^(-1) for highpurity hydrogen production, much lower than conventional water electrolysis(1.59 V). The work presents an example of interfacial engineering enhancing electrocatalytic activity and indicates that electrochemical reforming of formic acid is an energy-saving electrochemical method for high-purity hydrogen production.

关键词： Pt nanodendrites Chemical functionalization Catalytic activity Hydrogen evolution reaction Formic acid oxidation reaction

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Principle of Hydrogen Isotope Geochemistry Paleo-altimeter and its Potential in Reconstructing Paleo-elevation of the Southeastern Tibetan Plateau

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1051-1063页

作者： CUI Fengzhen LIU-zeng jing LI Yunshuai XU Qiang TANG Maoyun WANG Heng SUN Zhaotong School of Earth System Science Tianjin UniversityTianjin 300072China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China School of Earth Science and Technology Southwest Petroleum UniversityChengdu 610500China Chongqing Earthquake Agency Chongqing 401147China

The reconstruction of paleo-elevation serves a dual purpose to enhance our comprehension of geodynamic processes affecting terrestrial landforms and to contribute significantly to the interpretation of atmospheric circulation and *** oxygen(δ~(18)O_w)and deuterium(δD_w)isotopes in atmospheric precipitation are systematically depleted with the increase of altitude,which are typical and widely applicated *** utilization of hydrogen isotope of hydrous silicate minerals within the shear zone system,volcanic glass,and plant leaf wax alkanes offers valuable insights for addressing evaporation and *** this paper,we review the principle,application conditions,and influencing factors of the hydrogen isotope *** addition,we discuss the feasibility of utilizing this technique for quantitatively estimating the paleo-elevation of the southeastern Tibetan Plateau,where multiple shear zones extend over hundred kilometers parallel to the topographic gradient.

关键词： paleo-elevation hydrogen isotope hydrous silicate minerals volcanic glass Tibetan Plateau

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A stable artificial protective layer for high capacity dendrite-free lithium metal anode

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Nano Research 2019年第10期12卷 2535-2542页

作者： Zhipeng Wen Yueying Peng Jianlong Cong Haiming Hua Yingxin Lin Jian Xiong jing zeng Jinbao Zhao State Key Lab of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Energy&School cf Energy Research Xiamen UniversityXiamen 361102China

The metallic lithium(Li)is considered as the most promising anode material for high-e nergy ***,the uncon trollable growth of Li den drite and un stable electrolyte/electrode in terface still hin der the developme nt of Li-based *** this work,a no vel strategy has been proposed to stabilize Li anode by in-situ polymerizing polypyrrole(PPy)layer on Ni foam(PPy@Ni foam)as an artificial protective *** PPy protective layer can effectively decrease the contact between Li metal and electrolyte during *** addition,the morphology characterization shows that the PPy layer can help the even Li deposition undemeath the layer,leading to a dendrite-free Li *** a result,when deposited 2 mAh-cm-2 Li metal,the PPy@Ni foam can keep stable Coulombic efficiency(99%)during nearly 250 cycles,much better than the pure Ni foam(100 cycles).Even in the case of the Li capacity of 10 mAh-cm-2,the stable cycling performance for 60 cycles can still be ***,when assembled with LiFePO4 material as the cathode for a full cell,the PPy@Ni foam can keep high capacity retention of 85.5%at 500 *** our work,we provide a simple and effective method to enhanee the electrochemical performances of Li metal-based batteries,and reveal a new avenue to design three-dimensional(3D)metallic curre nt collector for protecting the Li metal ano de.

关键词： high capacity polypyrrole layer Li metal artificial protective layer dendrite-free anode

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