检索结果-南通市图书馆

江汉和洞庭盆地与周缘造山带盆山耦合研究进展

在线全文

学校读者我要写书评

暂无评论

地震地质 2019年第2期41卷 499-520页

作者：林旭刘静湖南文理学院洞庭湖生态经济区建设与发展湖南省协同创新中心中国地震局地质研究所

沉积盆地与造山带是大陆构造的2个重要的组成单元,具内在成因联系。对其耦合关系进行研究,可以恢复和重建岩石圈深部运动过程,了解近地表构造与气候之间的相互作用。江汉和洞庭盆地位于长江中游,与周缘造山带具有清晰的盆山边界,盆内河... 详细信息

沉积盆地与造山带是大陆构造的2个重要的组成单元,具内在成因联系。对其耦合关系进行研究,可以恢复和重建岩石圈深部运动过程,了解近地表构造与气候之间的相互作用。江汉和洞庭盆地位于长江中游,与周缘造山带具有清晰的盆山边界,盆内河流水系十分发育,是一个多物源沉积盆地,是探讨从山(源)到盆(汇)沉积过程的天然实验室。文中对江汉盆地盆山耦合的研究结果进行了总结和梳理,介绍了造山带基岩、盆地和河流沉积物低温热年代学的应用方法,提出了新的研究切入点,建议今后在江汉和洞庭盆地开展盆山耦合研究时,将造山带基岩和河流碎屑矿物低温热年代学结果相结合,同时开展同一目标矿物的物源示踪研究,综合分析造山带隆升信息与物源信息,并与周缘构造和沉积学研究结果相互检验,可得到详细的盆山耦合演化过程。

关键词：江汉盆地洞庭盆地盆山耦合低温热年代学

Lactate Decreases Bortezomib Sensitivity and Predicts Poor Clinical Outcomes of Multiple Myeloma

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第4期43卷 679-688页

作者： Na-ya MA Qiong LI Xin-lei LI Yun-jing zeng De-zhi HUANG Yi-shuo DUAN jing XIA Bang-dong LIU Ling-yi RAO Jun RAO Xi ZHANG Medical Center of Hematology Xinqiao HospitalArmy Medical UniversityChongqing 400037China State Key Laboratory of Trauma Burns and Combined InjuryArmy Medical UniversityChongqing 400037China National Clinical Research Center for Hematologic Diseases First Affiliated Hospital of Soochow UniversitySoochow 215031China

Objective:Metabolic disorders are regarded as hallmarks of multiple myeloma(MM)and are responsible for rapid cancer cell proliferation and tumor ***,the exact biological roles of metabolites in MM cells have not been fully *** study aimed to explore the feasibility and clinical significance of lactate for MM and investigate the molecular mechanism of lactic acid(Lac)in the proliferation of myeloma cells and cell sensitivity to bortezomib(BTZ).Methods:Metabolomic analysis of the serum was carried out to obtain metabolites expression and clinical characteristics in MM *** CCK8 assay and flow cytometry were used to detect cell proliferation,apoptosis,and cell cycle *** blotting was used to detect the potential mechanism and apoptosis-and cycle-related protein ***:Lactate was highly expressed in both the peripheral blood and bone marrow of MM *** was significantly correlated with Durie-Salmon Staging(DS Staging)and the International Staging System(ISS Staging)and the serum and urinary involved/uninvolved free light chain *** with relatively high lactate levels had a poor treatment ***,in vitro experiments showed that Lac could promote the proliferation of tumor cells and decrease the proportion of G0/G1-phase cells,which was accompanied by an increased proportion of S-phase *** addition,Lac could decrease tumor sensitivity to BTZ by disrupting the expression of nuclear factor kappa B subunit 2(NFκB2)and ***:Metabolic changes are important in MM cell proliferation and treatment response;lactate could be used as a biomarker in MM and as a therapeutic target to overcome cell resistance to BTZ.

关键词： lactate biomarker multiple myeloma bortezomib NF-kappa B pathway

Spatial-temporal evolution of vegetation evapotranspiration in Hebei Province,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2018年第9期17卷 2107-2117页

作者： WANG Qian-feng TANG Jia zeng jing-yu QU Yan-ping ZHANG Qing SHUI Wei WANG Wu-lin YI Lin LENG Song Fujian Provincial Key Laboratory of Remote Sensing of Soil Erosion and Disaster Protection/College of Environment and Resources Fuzhou UniversityFuzhou 350116P.R.China Research Center on Flood and Drought Disaster Reduction China Institute of Water Resources and Hydropower Reseat'chBeijing 100038P.R.China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of ScienceBeijing 100094P.R.China Geospatial Information Center Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055P.R.China Climate Change Cluster University of Technology SydneyNew South Wales 2007Australia

Evapotranspiration （ET） is the sum of soil or water body evaporation and plant transpiration from the earth surface and ocean to the atmosphere, and thus plays a significant role in regulating carbon and water resource cycles. The time-series data set from the remote sensing MOLDS product （MOD16） was used to study the spatial-temporal evolution of vegetation evapotranspiration in salinized areas during 2000-2014 by analyzing the variability, spatial patterns and Mann-Kendall （MK） nonparametric trends for the time series. The results indicate that inter-annual and intra-annual variations of ET across various vegetated areas show seasonal changes, with the abnormal months identified. The Cultivated land displays a greater degree of spatial heterogeneity and the spatial pattern of ET in the area covered by broadleaved deciduous forests corresponds to a higher ET rate and increased water consumption. Awidespread decline of ET is observed only in cultivated areas. However, agricultural cultivation doesn＇t worsen water shortage and soil salinization problems in the region, and water shortage problems are worsening for other vegetated areas. This research provides a basis of reference for the reasonable allocation of water resources and restructuring of vegetation patterns in salinized areas.

关键词： evapotranspiration Hebei Province MODIS spatial pattern vegetation spatial-temporal evolution

列车系统蛇行运动稳定性分析及其与单车模型的比较

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2008年第4期44卷 184-188页

作者：罗仁曾京西南交通大学牵引动力国家重点实验室成都610031

建立拖车和动车的横—垂—纵向耦合动力学模型,考虑车间连接装置,组成三种列车编组。基于Hopf分叉和Poincare映射理论,采用数值积分方法研究列车编组中每辆车和列车整体的线性和非线性运动稳定性。仿真结果表明,直线轨道上列车中各车辆... 详细信息

建立拖车和动车的横—垂—纵向耦合动力学模型,考虑车间连接装置,组成三种列车编组。基于Hopf分叉和Poincare映射理论,采用数值积分方法研究列车编组中每辆车和列车整体的线性和非线性运动稳定性。仿真结果表明,直线轨道上列车中各车辆和相同参数单车的非线性临界速度相差不大;曲线轨道上列车的非线性临界速度比直线上低;列车编组方式对临界速度影响不大;车间横向连接阻尼和刚度对列车线性和非线性临界速度影响不大。研究直线和大半径曲线轨道上列车系统临界速度时,无论列车中各车辆的参数是否相同,列车的线性和非线性临界速度可以通过计算单车的最低线性和非线性临界速度分别近似得到。

关键词：动车组 Hopf分叉蛇行稳定性临界速度

Prevalence,clinical characteristics,risk factors,and indicators for lean Chinese adults with nonalcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第15期26卷 1792-1804页

作者： jing zeng Rui-Xu Yang Chao Sun Qin Pan Rui-Nan Zhang Guang-Yu Chen Ying Hu Jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Clinical Epidemiology Research Center Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Children’s Digestion and NutritionShanghai 200092China

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic diseases in the ***,the percentage of non-obese or lean patients with NAFLD is *** in non-obese populations,especially the lean subgroup with a normal waist circumference(WC),might lead to more problems than obese individuals,as these individuals may not visit clinics for NAFLD diagnosis or ignore the diagnosis of *** the precise characteristics of these populations,especially the lean subgroup,are identified,the clinicians would be able to provide more appropriate advice and treatment to these *** To investigate the prevalence,clinical characteristics,risk factors,and possible indicators for NAFLD in lean Chinese adults with a normal *** People without diabetes mellitus or significant alcohol consumption who underwent routine health examinations were *** fatty liver index(FLI),abdominal ultrasonography results,and controlled attenuation parameter were all *** for single-nucleotide polymorphisms associated with NAFLD was performed in another small group consisting of biopsy-proven NAFLD subjects and healthy *** A total of 2715 subjects who underwent routine health examinations were included in the *** 810 lean participants with a normal WC,142(17.5%)fulfilled the diagnostic criteria for ***-height ratio,hemoglobin,platelets,and triglycerides were significant factors associated with the presence of NAFLD in these *** appropriate cut-off value of the FLI score in screening for NAFLD in the lean subjects with a normal WC was 25.15,which had a 77.8%sensitivity and 75.9%*** was no significant difference in the single-nucleotide polymorphisms in the SIRT1,APOC3,PNPLA3,AGTR1,and PPARGC1A genes between lean subjects with and without NAFLD(P<0.05).CONCLUSION NAFLD is not uncommon in lean Chinese adults even with a normal *** factors,rather than genetic fa

关键词： Non-alcoholic fatty liver disease Lean Body max index Waist circumference Fatty liver index Triglyceride

Research on low-carbon development of electric power industry:from the perspectives of public policy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Economy 2010年第4期6卷 334-341页

作者： RAN jing-liang zeng Shao-lun School of Economics and Management Sichuan University of Science ＆ Engingering Zigong 643000 P. R. China

It is a fundamental way to achieve sustainable development and inclusive growth that China takes the low-carbon development *** low-carbon development is an effective way to respond to many threats,including global climate anomalies,environmental degradation,and energy ***-carbon economy is policy economy to a large *** the external environment demands low-carbon development of electric power industry,enterprises lack intrinsic *** power industry is the pillar industry of China,and is one of the key industries for China's low-carbon *** government needs to ensure its dominant position in the low-carbon development of electric power industry,and reform the government performance management system and promote the planning and management of electric power industry through appropriate public policy,in order to adjust the structure of the electric power industry and take a low-carbon development road with Chinese characteristics.

关键词： Electric power industry Energy saving and emission reduction Low-carbon development Public policy

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong Tang jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao Xueyuan Hu jing zeng Qin Xu Anguo Wu Jianming Wu Dalian Qin Xiaogang Zhou Betty Yuen-Kwan Law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s *** Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains *** the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first *** Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of *** addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo ***,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was *** importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease *** revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

Analysis of the evolutionary path and hotspots of innate lymphoid cells based on a knowledge map

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第12期133卷 1491-1492页

作者： Ying Liu Zuo-jing zeng Shun-Lin Peng Department of Otorhinolaryngology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan 610075China

To the Editor:Innate lymphoid cells(ILCs)are a heterogeneous population of lymphocytes that lack specific antigen receptors and yet produce effective cytokines to match the T helper cell subsets.[1]For the past decade,the discovery of these cells and research on this topic have revealed that ILCs are tissue resident cells that have multiple immune roles,such as regulating tissue inflammation,tissue remodeling and metabolic homeostasis,by the effector functions of their subsets and are involved in diseases such as asthma,allergic rhinitis,inflammatory bowel disease,and cancer.

关键词： lymphoid homeostasis inflammation

在线全文

学校读者我要写书评

暂无评论

轮轨横向碰撞引起的脱轨研究

振动与冲击 2009年第12期28卷 38-42页

作者：关庆华曾京西南交通大学牵引动力国家重点实验室成都610031

建立了车轮和钢轨的三维摩擦碰撞方程,根据刚体碰撞力学理论推导出碰撞后车轮的瞬时速度,讨论了摩擦碰撞过程中切向状态的变化。根据运动学关系和能量守恒定律推导出车轮横向碰撞钢轨的跳轨脱轨判别准则,包括车轮的横向碰撞临界速度和... 详细信息

建立了车轮和钢轨的三维摩擦碰撞方程,根据刚体碰撞力学理论推导出碰撞后车轮的瞬时速度,讨论了摩擦碰撞过程中切向状态的变化。根据运动学关系和能量守恒定律推导出车轮横向碰撞钢轨的跳轨脱轨判别准则,包括车轮的横向碰撞临界速度和以车轮横向力峰值、轮重和碰撞时间确定的判别公式。参数分析表明:增大轮缘角、摩擦系数和轮缘有效高度均能够提高跳轨脱轨限值;轮缘角越大出现粘滞状态的临界摩擦系数越小;车轮接触点纵向相对速度减弱了阻碍车轮跳轨的切向摩擦阻力,加大了脱轨的危险性。

关键词：轮轨摩擦碰撞跳轨脱轨判别准则