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艾灸调节circ Pan3/mi R-667-5p/Ghrelin信号通路减轻膝骨关节炎大鼠的软骨病变

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中国组织工程研究 2025年第12期29卷 2475-2483页

作者：廖晴曾静陈峻袁立霞刘刚南方医科大学中医药学院广东省广州市510000 南方科技大学医院广东省深圳市518000 南方医科大学南方医院康复科广东省广州市510000

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghre... 详细信息

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghrelin信号通路探究艾灸对大鼠膝骨关节炎软骨的影响。方法:SD大鼠随机分为假手术组、模型组和艾灸组(n=10),对后2组大鼠行右后肢膝关节前交叉韧带横断和内侧半月板部分切除术建立膝骨关节炎大鼠模型;假手术组大鼠仅接受关节囊切开术。6周后,艾灸组大鼠每日艾灸“足三里”“肾俞”穴区20 min,持续4周,其余2组不予以特殊处理。4周后通过组织病理学染色观察膝关节滑膜病变和软骨损伤程度,通过酶联免疫吸附实验检测血清中炎症因子白细胞介素6和肿瘤坏死因子α的变化。此外,取上述3组大鼠右侧膝关节软骨细胞分为:正常对照组、模型组和艾灸组,通过Western blot和qRT-PCR检测各组细胞中软骨基质合成代谢分子(Ⅱ型胶原蛋白和Sox9)、基质降解分子(基质金属蛋白酶13和ADAMTS5)、自噬标志物(ATG5、Beclin-1、微管相关蛋白1轻链3)、Ghrelin、CircPan3以及miR-667-5P的表达水平。结果与结论:①治疗4周后,相对于假手术组,模型组大鼠滑膜显著增厚,炎症细胞浸润显著,关节间隙狭窄,软骨表面粗糙不平,变薄,软骨细胞数量减少,滑膜炎和OARSI评分显著升高,白细胞介素6和肿瘤坏死因子α水平明显上调(P<0.0001);与模型组相比,艾灸组滑膜增厚减轻,炎症细胞浸润减少,关节间隙增宽,软骨更光滑完整、变厚,软骨细胞数量增多,滑膜炎和OARSI评分降低,白细胞介素6和肿瘤坏死因子α水平显著降低(P<0.0001)。②体外实验结果表明,与正常对照组相比,模型组软骨细胞基质金属蛋白酶13、ADAMTS5和miR-667-5P表达增多,Ⅱ型胶原蛋白、Sox9、自噬标志物、Ghrelin和Circpan3表达减少(P<0.01);与模型组相比,艾灸可逆转上述指标改变(P<0.01)。③结果说明艾灸可能通过调节circPan3/miR-667-5p/Ghrelin信号通路增强软骨细胞自噬,抑制膝骨关节炎炎症和软骨破坏,对软骨发挥保护作用。

关键词：膝骨关节炎艾灸 ghrelin 软骨自噬大鼠信号通路

Effects of Bounding Potential on High-Order Harmonic Generation with H2＋

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Chinese Physics Letters 2010年第6期27卷 89-92页

作者： ZHAO jing ZHAO zeng-Xiu Department of Physics National University of Defense Technology Changsha 410073

We present harmonic spectra from hydrogen molecular ions with different ionization energy Ip. By comparing the recombination matrix element from helium ions and hydrogen molecular ions, we verify that the interference effect in high-order harmonic generation originates from the recombination interference. A numerical study on recombination matrix elements in 1D shows that w = Ek ＋ Ip holds only when an exact continuum wavefunction is used, and the positions of extrema in harmonic spectra can be predicted accurately. We demonstrate that the positions of extrema in harmonic spectra are mainly affected by bounding potential dependence of the recombination interference.

关键词： Recombination Ions Hydrogen Hydrogenation Elements

A Law of Large Numbers Under the Nonlinear Expectation

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 953-962页

作者： Miao ZHANG zeng-jing CHEN Qilu Securities Institute for Financial studies and Department of Mathematics Shandong University

In this paper, we derive a law of large numbers under the nonlinear expectation generated by backward stochastic differential equations driven by G-Brownian motion.

关键词： law of large numbers nonlinear expectation backward stochastic differential equation

A Property of g-probabilities

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 567-574页

作者： Dong-mei Guo zeng-jing Chen School of Economics Central University of Finance and EconomicsBeijing 100081China School of Mathematics Shandong UniversityShandong 250100China Department of Financial Engineering Ajou UniversityKorea

Most work on capacities has focused on the 2-alternating and sub *** this paper we consider the capacities-g-probabilities derived from peng＇s *** g satisfies some conditions,we show that the g-probabilities fail to ... 详细信息

关键词： BSDEs g-expectations g-probabilities 2-alternating capacities sub 2-alternating capacities

Laws of Large Numbers of Negatively Correlated Random Variables for Capacities

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 749-760页

作者： Wen-juan LI zeng-jing CHEN School of Mathematics Shandong University Jinan 250100 China

Our aim is to present some limit theorems for capacities. We consider a sequence of pairwise negatively correlated random variables. We obtain laws of large numbers for upper probabilities and 2-alternating capacities, using some results in the classical probability theory and a non-additive version of Chebyshev＇s inequality and Boral-Contelli lemma for capacities.

关键词： law of large numbers 2-alternating capacity negatively correlated random variables upper probability

A New Comparison Theorem of Multidimensional BSDEs

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Acta Mathematicae Applicatae Sinica 2015年第1期31卷 131-138页

作者： Pan-yu WU zeng-jing CHEN Qilu Securities Institute for Financial Studies Shandong University School of Mathematics Shandong University

In this paper, we first study a property about the generator g of Backward Stochastic Differential Equation （BSDE） when the price of contingent claims can be represented by a multidimensional BSDE in the no-arbitrage financial market. Furthermore, motivated by the behavior of agents in finance market, we introduce a new total order q on Rn and obtain a necessary and sufficient condition for comparison theorem of multidimensional BSDEs under this order. We also give some further results for q

关键词： backward stochastic differential equation comparison theorem viability property

Recent progress on the synthesis of 2-deoxy glycosides

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Science China Chemistry 2017年第9期60卷 1162-1179页

作者： jing zeng Yang Xu Hao Wang Lingkui Meng Qian Wan 0030 China Institute of Brain Research Huazhong University of Science and TechnologyWuhan 410030China

2-Deoxy glycosides are widely presented in natural products and clinical *** presence of 2-deoxy glycosides is essential for bioactivities of these *** report provides an overview of the recent advances in the stereoselective synthesis of 2-deoxy ***,the contents of this review covered the work published since the earlier reviews on this topic by Marzabadi(2000),Lowary(2009),Ding(2012) and Nagorny(2012).

关键词： 2-deoxy glycosides, glycosylation, stereoselective synthesis, oligosaccharides

From NAFLD to MAFLD: Not just a change in the name

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 511-513页

作者： jing zeng Jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Lab of Pediatric Gastroenterology and Nutrition Shanghai 200092China

The names of many diseases have changed over time,and the criteria of successfully changing the name of a disease should make sense,be easy to say and write,get quick endorsement by professional societies,and keep the same *** general,a change in the name of a disease usually represents an improve-ment in the understanding of the disease,whether on clinical set-tings and natural history or pathophysiological *** suc-cessful renamed liver diseases in history include from non-A non-B hepatitis,non-B non-C hepatitis,primary biliary cirrhosis to hep-atitis C,hepatitis E and primary biliary cholangitis,***,the rename of the disease that is finally used usually clearly indicates its main characteristics.

关键词： diseases NAFLD clinical

Representation Theorems for Generators of BSDEs in L^p Spaces

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Acta Mathematicae Applicatae Sinica 2012年第2期28卷 255-264页

作者： Li SONG Feng HU zeng-jing CHENt School of Mathematics Shandong University Jinan 250100 China School of Finance Shandong Polytechnic University Jinan 250100 China Department of Mathematics Qufu Normal University Qufu 273165 China Department of Financial Engineering Ajou University Suwon 443749 Korea

In this paper, we prove that the generator g of a class of backward stochastic differential equations （BSDEs） can be represented by the solutions of the corresponding BSDEs at point （t, y, z）, when the terminal da... 详细信息

关键词： backward stochastic differential equation generator representation theorem