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双极电凝设备术中常见问题及应对措施

中国医疗器械信息 2024年第11期30卷 174-176页

作者：杨波冯夫禹张琦毕景涛巴磊徐州市检验检测中心江苏徐州221000 徐州市妇幼保健院江苏徐州221000 国家卫生健康委计划生育药具不良反应监测中心江苏南京210003

目的:探究双极电凝设备在妇科手术中遇到的常见问题并探讨应对的措施。方法:收集2022年9月~2023年6月本院收治的行妇科腹腔镜下手术的患者共125例,记录术中遇到的设备故障及出现的患者伤害情况。结果:双极电凝装置在妇科手术中最常见的... 详细信息

目的:探究双极电凝设备在妇科手术中遇到的常见问题并探讨应对的措施。方法:收集2022年9月~2023年6月本院收治的行妇科腹腔镜下手术的患者共125例,记录术中遇到的设备故障及出现的患者伤害情况。结果:双极电凝装置在妇科手术中最常见的不良事件包括:钳头粘连组织,导致撕开组织时出血;电凝烟雾过大,影响手术视野;电凝后钳头焦痂多,止血效果变差;电凝效果不佳;钳头变形等。故障产生的主要原因包括:手术中未及时清理焦痂;电凝击发时间过长;电凝操作时夹持过紧;夹取组织过多、过厚;以及一些产品质量问题,如产品阻值过大,钳头的涂层处理不到位等。此外,对患者的伤害主要包括:增加手术时长;电凝点出血;止血效果差等。结论:双极电凝装置是重要的止血器械,目前在临床使用中仍然存在一些问题,究其原因主要是器械使用者的操作不当和器械本身设计以及材质的缺陷,因此进一步规范医疗器械的使用,加大医疗器械的研发力度至关重要。

关键词：双极电凝设备妇科手术不良事件

Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study

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Pediatric Investigation 2021年第3期5卷 188-194页

作者： Huili Hu Huiling Deng jing bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu Key Laboratory of Major Diseases in Children Ministry of EducationResearch Unit of Critical Infection in ChildrenChinese Academy of Medical ScienceDepartment of Infectious DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Infectious Diseases Xi’an Children’s HospitalXi’anShaanxiChina Department of Infectious Diseases Baoding Children’s HospitalBaodingHebeiChina Guangzhou Women and Children’s Medical Center GuangzhouGuangdongChina Hepatology Center Hunan Children’s HospitalChangshaHunanChina Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:bited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis.

关键词： Infectious mononucleosis Antiviral Ganciclovir Acyclovir

Xuebijing alleviates LPS-induced acute lung injury by downregulating pro-inflammatory cytokine production and inhibiting gasdermin-E-mediated pyroptosis of alveolar epithelial cells

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中国天然药物:英文版 2023年第8期21卷 576-588页

作者： ZHANG Cuiping CHEN Xiaoyan WEI Tianchang SONG Juan TANG Xinjun bi jing CHEN Cuicui ZHOU Jian SU Xiao SONG Yuanlin Shanghai Key Laboratory of Lung Inflammation and Injury Department of Pulmonary MedicineZhongshan HospitalFudan UniversityShanghai 200032China The Unit of Respiratory Infection and Immunity Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Shanghai Institute of Infectious Disease and biosecurity Shanghai 200032China Shanghai Respiratory Research Institute Shanghai 200032China National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Jinshan Hospital of Fudan UniversityShanghai 201508China

Acute lung injury/acute respiratory distress syndrome(ALI/ARDS)is characterized by diffuse alveolar injury primarily caused by an excessive inflammatory response.Regrettably,the lack of effective pharmacotherapy currently available contributes to the high mortality rate in patients with this condition.Xuebijing(XBJ),a traditional Chinese medicine recognized for its potent anti-inflammatory properties,exhibits promise as a potential therapeutic agent for ALI/ARDS.This study aimed to explore the preventive effects of XBJ on ALI and its underlying mechanism.To this end,we established an LPS-induced ALI model and treated ALI mice with XBJ.Our results demonstrated that pre-treatment with XBJ significantly alleviated lung inflammation and increased the survival rate of ALI mice by 37.5%.Moreover,XBJ substantially suppressed the production of TNF-α,IL-6,and IL-1βin the lung tissue.Subsequently,we performed a network pharmacology analysis and identified identified 109 potential target genes of XBJ that were mainly involved in multiple signaling pathways related to programmed cell death and anti-inflammatory responses.Furthermore,we found that XBJ exerted its inhibitory effect on gasdermin-E-mediated pyroptosis of lung cells by suppressing TNF-αproduction.Therefore,this study not only establishes the preventive efficacy of XBJ in ALI but also reveals its role in protecting alveolar epithelial cells against gasdermin-E-mediated pyroptosis by reducing TNF-αrelease.

关键词： Pyroptosis Gasdermin-E TNF-α Xuebijing Acute lung injury

Treatment patterns and survival outcomes in patients with nonmetastatic early-onset pancreatic cancer

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World Journal of Gastroenterology 2024年第12期30卷 1739-1750页

作者： Le-Tian Zhang Ying Zhang bi-Yang Cao Chen-Chen Wu jing Wang Graduate School Chinese PLA Medical SchoolBeijing 100853China Department of Radiation Oncology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Internal Medicine Hospital of University of Science and Technology BeijingBeijing 100083China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The incidence of patients with early-onset pancreatic cancer(EOPC;age≤50 years at diagnosis)is on the rise,placing a heavy burden on individuals,families,and society.The role of combination therapy including surgery,radiotherapy,and chemotherapy in non-metastatic EOPC is not well-defined.AIM To investigate the treatment patterns and survival outcomes in patients with non-metastatic EOPC.METHODS A total of 277 patients with non-metastatic EOPC who were treated at our institution between 2017 and 2021 were investigated retrospectively.Overall survival(OS),disease-free survival,and progression-free survival were estimated using the Kaplan-Meier method.Univariate and multivariate analyses with the Cox proportional hazards model were used to identify prognostic factors.RESULTS With a median follow-up time of 34.6 months,the 1-year,2-year,and 3-year OS rates for the entire cohort were 84.3%,51.5%,and 27.6%,respectively.The median OS of patients with localized disease who received surgery alone and adjuvant therapy(AT)were 21.2 months and 28.8 months,respectively(P=0.007).The median OS of patients with locally advanced disease who received radiotherapy-based combination therapy(RCT),surgery after neoadjuvant therapy(NAT),and chemotherapy were 28.5 months,25.6 months,and 14.0 months,respectively(P=0.002).The median OS after regional recurrence were 16.0 months,13.4 months,and 8.9 months in the RCT,chemotherapy,and supportive therapy groups,respectively(P=0.035).Multivariate analysis demonstrated that carbohydrate antigen 19-9 level,pathological grade,T-stage,N-stage,and resection were independent prognostic factors for non-metastatic EOPC.CONCLUSION AT improves postoperative survival in localized patients.Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.

关键词： Pancreatic cancer Early-onset Non-metastatic Multimodal treatment Radiotherapy Overall survival

Stercoral colonic diverticulum perforation with jejunal diverticulitis mimicking upper gastrointestinal perforation

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Chinese Medical Journal 2012年第3期125卷 536-538页

作者： bi jing-tao Guo Yan-tong Zhao jing-ming Zhang Zhong-tao Capital Med Univ Dept Gen Surg Beijing Friendship Hosp Beijing 100050 Peoples R China Peking Univ Dept Gen Surg Beijing Jishuitan Hosp Beijing 100035 Peoples R China

Stercoral perforation of the colon is an unusual pathological condition with fewer than 150 cases reported in the literature to date. We present a case of stercoral colonic perforation mimicking upper gastrointestinal perforation, which was diagnosed by computed tomography preoperatively. However, at laparotomy, stercoral colonic diverticulum perforation with jejunal diverticulitis became the most appropriate diagnosis.

关键词： intestinal perforation diverticulum constipation,＂ peritonitis

The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng Wang jing Hong Zhu-qian Tang bi-zhen Gong Xiao-rong Qi Han Jiang Bo Pan Qi Chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of life.To some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD patients.The purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.Methods:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the questionnaire.Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM therapy.Results:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use TCM.Multifactorial logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic regime.These included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;P<0.001,vs junior high school education),living in an urban setting(OR=8.022;95%CI:4.577–14.060;P<0.001,vs rural),having other underlying diseases(OR=5.126;95%CI:3.078–8.537;P<0.001,vs none),having previously used TCM(OR=3.083;95%CI:1.852–5.134;P<0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95%CI:1.446–8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95%CI:1.482–10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance,attitude,and independent predictors of TCM use

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

EFFECT　OF　PARTICULATE　SIZE　AND　CONTENT　ON　STRENGTH　OF　SiC_p／2024Al　COMPOSITE　AND　ITS　RELATIONSHIP　WITH　T6－TREATMENT

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中国有色金属学会会刊：英文版 1995年第3期5卷 127-132页

作者： Ma, Zongyi Liang, Yanan Lu, Yuxiong bi, jing Chinese Acad of Sciences Shenyang China

ＥＦＦＥＣＴＯＦＰＡＲＴＩＣＵＬＡＴＥＳＩＺＥＡＮＤＣＯＮＴＥＮＴＯＮＳＴＲＥＮＧＴＨＯＦＳｉＣ_ｐ／２０２４ＡｌＣＯＭＰＯＳＩＴＥＡＮＤＩＴＳＲＥＬＡＴＩＯＮＳＨＩＰＷＩＴＨＴ６－ＴＲＥＡＴＭＥＮＴ￥Ｍａ，Ｚｏｎｇ... 详细信息

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关键词： composite particulate aluminum T6-treatment strength

EFFECT OF MATRIX STRENGTHENING ON SLIDING WEAR PROPERTIES OF SiCp/2024Al COMPOSITES

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中国有色金属学会会刊：英文版 1998年第4期8卷 25-30页

作者： Ma, Zongyi Liang, Yan'an Lu, Yuxiong bi, jing Inst of Metal Research Chinese Acad of Sciences Shenyang China

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｃｅｒａｍｉｃｐａｒｔｉｃｕｌａｔｅｓｒｅｉｎｆｏｒｃｅｄａｌｕｍｉｎｕｍａｌｏｙｃｏｍｐｏｓｉｔｅｓｅｘｈｉｂｉｔｈｉｇｈｓｐｅｃｉｆｉｃｍｏｄｕｌｕｓａｎｄｓｔｒｅｎｇｔｈ，ａｌｓ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｃｅｒａｍｉｃｐａｒｔｉｃｕｌａｔｅｓｒｅｉｎｆｏｒｃｅｄａｌｕｍｉｎｕｍａｌｏｙｃｏｍｐｏｓｉｔｅｓｅｘｈｉｂｉｔｈｉｇｈｓｐｅｃｉｆｉｃｍｏｄｕｌｕｓａｎｄｓｔｒｅｎｇｔｈ，ａｌｓｏｇｅｔａｓｉｇｎｉｆｉｃａｎｔｉ...

关键词： composite aluminum SiC wear particulate

Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease(GSD)mouse model

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Journal of Zhejiang University-Science B(biomedicine & biotechnology) 2024年第1期25卷 38-50页

作者： Dongfang ZHANG Hao XU Chi QIN Kangming CAI jing ZHANG Xinqiu XIA jingwen bi Li ZHANG Lianping XING Qianqian LIANG Wensheng WANG Laboratory of Molecular Medicine College of Life Science and State Key Laboratory of Cell Differentiation and RegulationHenan Normal UniversityXinxiang453007China Longhua Hospital&Spine Institute Shanghai University of Traditional Chinese MedicineShanghai200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai201203China Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochester14642USA

Gorham-Stout disease(GSD)is a sporadic chronic disease characterized by progressive bone dissolution,absorption,and disappearance along with lymphatic vessel infiltration in bone-marrow cavities.Although the osteolytic mechanism of GSD has been widely studied,the cause of lymphatic hyperplasia in GSD is rarely investigated.In this study,by comparing the RNA expression profile of osteoclasts(OCs)with that of OC precursors(OCPs)by RNA sequencing,we identified a new factor,semaphorin 3A(Sema3A),which is an osteoprotective factor involved in the lymphatic expansion of GSD.Compared to OCPs,OCs enhanced the growth,migration,and tube formation of lymphatic endothelial cells(LECs),in which the expression of Sema3A is low compared to that in OCPs.In the presence of recombinant Sema3A,the growth,migration,and tube formation of LECs were inhibited,further confirming the inhibitory effect of Sema3A on LECs in vitro.Using an LEC-induced GSD mouse model,the effect of Sema3A was examined by injecting lentivirus-expressing Sema3A into the tibiae in vivo.We found that the overexpression of Sema3A in tibiae suppressed the expansion of LECs and alleviated bone loss,whereas the injection of lentivirus expressing Sema3A short hairpin RNA(shRNA)into the tibiae caused GSD-like phenotypes.Histological staining further demonstrated that OCs decreased and osteocalcin increased after Sema3A lentiviral treatment,compared with the control.Based on the above results,we propose that reduced Sema3A in OCs is one of the mechanisms contributing to the pathogeneses of GSD and that expressing Sema3A represents a new approach for the treatment of GSD.

关键词： Semaphorin 3A Gorham-Stout disease Osteoclast Osteolysis Lymphatic endothelial cell