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Optical Extinctions of Inter-Arm Molecular Clouds in M31:A Pilot Study for the Upcoming CSST Observations

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Research in Astronomy and Astrophysics 2024年第6期24卷 323-333页

作者： Cailing Chen zheng zheng Chao-Wei Tsai Sihan Jiao jing Tang jingwen Wu Di Li Yun zheng Linjing Feng Yujiao Yang Yuan Liang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China zhejiang Lab Hangzhou 311121China

Recent submillimeter dust thermal emission observations have unveiled a significant number of inter-arm massive molecular clouds in ***,the effectiveness of this technique is limited to its sensitivity,making it challenging to study more distant *** study introduces an alternative approach,utilizing optical extinctions derived from space-based telescopes,with a focus on the forthcoming China Space Station Telescope(CSST).We first demonstrate the capability of this method by constructing dust extinction maps for 17 inter-arm massive molecular clouds in M31 using the Panchromatic Hubble Andromeda Treasury *** analysis reveals that inter-arm massive molecular clouds with an optical extinction(A_(V)) greater than 1.6 mag exhibit a notable A_(V) excess,facilitating their *** majority of these inter-arm massive molecular clouds show an A_(V) around 1 mag,aligning with measurements from our JCMT *** validation using a mock CSST RGB star catalog confirms the method's *** show that the derived A_(V)values using CSST z and y photometries align more closely with the input *** clouds with A_(V)> 1.6 mag can also be identified using the CSST mock *** thus claim that future CSST observation clouds provide an effective way for the detection of inter-arm massive molecular clouds with significant optical extinction in nearby galaxies.

关键词： infrared:stars ISM:clouds Galaxy:structure

Properties and microstructure of copper–titanium alloys with magnesium additions

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Rare Metals 2024年第5期43卷 2290-2299页

作者： Lue Huang Li-Jun Peng Jiang Li Xu-Jun Mi Gang zhao Guo-Jie Huang Hao-Feng Xie Yi-Cheng Cao Wen-jing zhang zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. LtdBejing 101407China School of Materials Science and Engineering Northeastern UniversityShenyang110000China General Research Institute for Nonferrous Metals Beijing 100088China China Academy of Space Technology Beijing 100094China China Nonferrous Metals Mining Group(Tianjin)Co.Ltd Tianjin 3001llChina

The volume fractions and morphology of precipitates in precipitation-strengthened Cu-Ti alloys,which precipitate mainly as continuous and discontinuous precipitates,are important for the application of the *** study employed hardness and electrical conductivity tests transmission electron microscopy(TEM),atom probe tomography(APT),and first-principles calculations to demonstrate that the addition of Mg is effective for accelerating nanosized continuousβ'-Cu_(4)Ti precipitation as well as for suppressing the precipitation of coarse lamellar discontinuousβ-Cu_(4)Ti precipitates along the grain boundaries,resulting in Cu-Ti alloys with high yield strength and good electrical *** results showed that the continuous precipitation ofβ'-Cu_(4)Ti was accelerated by the Mg additions,which reduced the supersaturation of the matrix,thereby reducing the chemical driving force for the discontinuous *** the other hand,Mg additions increased the mismatch between the discontinuousβ-Cu_(4)Ti precipitates and matrix decreased the nucleation rate of the discontinuous precipitates,and increased the spacing of the discontinuous precipitation layer,resulting in a lower growth rate of the discontinuous ***,the addition of Mg to Cu-Ti alloys enhances the strength and improves the resistance to over-ageing.

关键词： Cu-Ti-Mg alloy Precipitation hardening Discontinuous precipitation Continuous precipitation Microstructure formation mechanism

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： zhan-Li Chen Chen Xie Wei zeng Rui-Qi Huang Jin-E Yang Jin-Yu Liu Ya-jing Chen Shi-Mei zhuang MOE Key Laboratory of Gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China Key Laboratory of Liver Disease of Guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTz),which inhibits the 20S catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not solid tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTz treatment,or silencing of PSMC5,a subunit of 19S regulatory particle of proteasome,causes G2-and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/GSDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1/PKMYT1(PD0166285),but not inhibitor of ATR,CHK1 or CHK2,abrogates the BTz-induced G2-phase arrest,thus exacerbates the BTz-induced mitotic arrest and *** BTz and PD0166285 treatment(named BP-Combo)selectively kills various types of solid tumor cells,and significantly lessens the IC50 of both BTz and PD0166285 compared to BTz or PD0166285 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTz or PD0166285 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.

关键词： proteasome inhibiting catastrophe

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis:A Case-Control Study

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International Journal of Dermatology and Venereology 2024年第1期7卷 6-11页

作者： jing-jing Chen Xiao-Kai Fang Xiu-Mei Liu Xiao-Chun Liu Xu Yao Department of Allergy and Rheumatology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:To assess the relationship between the severity of atopic dermatitis(AD)in children of varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]***:The study population comprised 899 patients with AD and 854 age-and sex-matched *** Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups,and Spearman correlation analysis was used to test ***:The 25(OH)D level in the AD group was M(Q_(25),Q_(75)),24.0(19.7,28.4)ng/mL,which was significantly lower than the control group(26.4[23.6,29.9]ng/mL;z=-3.34,P=0.001).25(OH)D levels in children with AD were negatively correlated with body mass index(r=-0.30,P<0.001),Severity scoring of Atopic Dermatitis(SCORAD;r=-0.14,P<0.001),total immunoglobulin E(r=-0.13,P<0.001),and eosinophil(r=-0.08,P=0.017).There were statistically significant differences in 25(OH)D(H=18.46,P<0.001),total immunoglobulin E(H=9.13,P=0.010),eosinophil(H=67.17,P<0.001),and SCORAD(H=10.49,P=0.005)among groups with different body mass index *** 25(OH)D levels were 22.3(17.5,27.1)ng/mL in the overweight AD group and 22.3(17.6,25.7)ng/mL in the obese AD group,which were significantly lower than those in the normal-weight AD group(24.7[20.4,25.5]ng/mL;P=0.003,P=0.004).25(OH)D levels were negatively correlated with SCORAD in obese AD patients(r=-0.25,P=0.010).Conclusion:Vitamin D insufficient or deficient is obvious in children AD *** 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD *** D level is negatively correlated with SCORAD in obese children with AD.

关键词： atopic dermatitis vitamin D disease severity index immunoglobulin E body mass index eosinophil children overweight/obese

2001~2020年乌梁素海流域植被NPP时空变化及驱动因素分析

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环境科学 2024年第8期45卷 4744-4755页

作者：肖晶饶良懿北京林业大学水土保持学院北京100083 北京林业大学水土保持国家林业和草原局重点实验室北京100083

植被净初级生产力(NPP)表征植物对生态系统碳的固定能力,是决定生态系统健康状态和可持续发展程度的关键指标,其时空变化及驱动因素对于揭示植被恢复状况和指导生态修复工作具有重要作用.基于2001~2020年MODIS17A3 NPP数据、土地利用和... 详细信息

植被净初级生产力(NPP)表征植物对生态系统碳的固定能力,是决定生态系统健康状态和可持续发展程度的关键指标,其时空变化及驱动因素对于揭示植被恢复状况和指导生态修复工作具有重要作用.基于2001~2020年MODIS17A3 NPP数据、土地利用和气象数据等,采用变异系数、Theil-Sen Median趋势分析及Mann-Kendall检验、Hurst指数和地理探测器等方法,探究了内蒙古乌梁素海流域植被NPP的时空变化特征及驱动因素.结果表明:①2001~2020年乌梁素海流域植被NPP整体呈波动上升趋势,平均值(以C计)为141.03 g·(m^(2)·a)^(-1),平均上升速率为2.33g·(m^(2)·a)^(-1);植被NPP具有明显的空间分异规律,整体上呈现西南高、东北低,河套平原高、沙地和山区低的特征;②NPP主要呈增长趋势,增长、减少和无变化区域的面积占比分别约为80%、3%和17%;NPP的平均变异系数为0.149,主要呈低波动变化和较低波动变化,面积占比约为51%;NPP未来变化趋势主要呈反持续性特征,面积占比约为75%.③土地利用、海拔、最高温和坡度是乌梁素海流域植被NPP变化的主导驱动因素,q值均在0.200以上.海拔∩相对湿度对乌梁素海流域植被NPP空间分异的解释力最大;土地利用与除夜间灯光外的其他因子对乌梁素海流域植被NPP空间分异的解释力均存在显著性差异.根据研究结果,未来应加强乌梁素海流域生态系统管理,实行严格的生态保护和修复政策,综合考虑气候、地形和人类活动等因素,因地制宜开展生态综合治理工作,以提升生态系统服务质量.

关键词：净初级生产力(NPP) 乌梁素海流域气候变化人类活动驱动因素

Polymer electrolytes for flexible zinc-air batteries:Recent progress and future directions

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Nano Research 2024年第7期17卷 6058-6079页

作者： jing Wu Wen-Ya Wu Suxi Wang Dan Kai Enyi Ye Warintorn Thitsartarn Janet Beng Hoon Tan Jianwei Xu Qingyu Yan Qiang zhu Xian Jun Loh Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)1 Pesek RoadJurong IslandSingapore 627833Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Department of Material Science and Engineering National University of Singapore9 Engineering Drive 1#03-09 EASingapore 117575Singapore

This review article delves into the development of electrolytes for flexible zinc-air batteries(FzABs),a critical component driving the advancement of flexible *** started by surveying the current advancements in electrolyte technologies,including solid-state and gel-based types,and their contributions to enhance the flexibility,efficiency,and durability of ***,we explored the challenges in this domain,focusing on maintaining electrolyte stability under mechanical stress,ensuring compatibility with flexible substrates,optimizing ion conductivity,and under harsh environmental ***,the key issues regarding interface details between electrolyte and the electrodes are covered as *** then discussed the future of electrolyte development in FzABs,highlighting potential avenues such as materials development,sustainability,in-situ studies,and battery *** review offers an in-depth overview of the advancements,challenges,and potential breakthroughs in creating electrolytes for FzABs over the past five *** serves as a guide for both researchers and industry professionals in this dynamic area.

关键词： flexible zinc-air batteries electrolyte polymer hydrogel electrolyte-electrode interface

Multimodal Omics Approaches to Aging and Age‑Related Diseases

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Phenomics 2024年第1期4卷 56-71页

作者： Qianzhao Ji Xiaoyu Jiang Minxian Wang zijuan Xin Weiqi zhang jing Qu Guang‑Hui Liu State Key Laboratory of Membrane Biology Instituteof ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and ReproductiveBiology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academyof Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of ChineseAcademy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for GeriatricDisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Centerfor Aging and CancerXuanwu HospitalCapital MedicalUniversityBeijing 100053China

Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated *** increasing body of experimental evidence shows that aging is a complex biological process coordinately regulated by multiple factors at diferent molecular ***,it is difcult to delineate the overall systematic aging changes based on single-layer ***,multimodal omics approaches,in which data are acquired and analyzed using complementary omics technologies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise molecular regulatory mechanisms that trigger *** recent years,multimodal omics sequencing technologies that can reveal complex regulatory networks and specifc phenotypic changes have been developed and widely applied to decode aging and age-related *** review summarizes the classifcation and progress of multimodal omics approaches,as well as the rapidly growing number of articles reporting on their application in the feld of aging research,and outlines new developments in the clinical treatment of age-related diseases based on omics technologies.

关键词： Multimodal omics approaches Aging Genome Epigenome

A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei Chen jingyi Wang jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical Research Institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural ***,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and *** addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral ***,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque *** data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

Filamentous morphology engineering of bacteria by iron metabolism modulation through MagR expression

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Synthetic and Systems Biotechnology 2024年第3期9卷 522-530页

作者： Mengke Wei Chenyang Han Xiujuan zhou Tianyang Tong jing zhang Xinmiao Ji Peng zhang Yanqi zhang Yan Liu Xin zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui230032China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang310027China

The morphology is the consequence of evolution and *** coli is rod-shaped bacillus with regular dimension of about 1.5μm long and 0.5μm *** shape-related genes have been identified and used in morphology engineering of this ***,little is known about if specific metabolism and metal irons could modulate bacteria *** in this study,we discovered filamentous shape change of *** cells overexpressing pigeon MagR,a putative magnetoreceptor and extremely conserved iron-sulfur *** transcriptomic analysis strongly suggested that the iron metabolism change and iron accumulation due to the overproduction of MagR was the key to the morphological *** model was further validated,and filamentous morphological change was also achieved by supplement *** cells with iron in culture medium or by increase the iron uptake genes such as entB and *** study extended our understanding of morphology regulation of bacteria,and may also serves as a prototype of morphology engineering by modulating the iron metabolism.

关键词： Morphology regulation Iron accumulation Filamentous bacteria MagR overexpression