检索结果-南通市图书馆

The role of exosomes in adult neurogenesis:implications for neurodegenerative diseases

Neural Regeneration Research 2024年第2期19卷 282-288页

作者： Zhuoyang yu Yan Teng jing Yang Lu Yang Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Laboratory of Aging Research School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina

Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in *** are widely distributed in a range of body fluids,including urine,blood,milk,and *** exert biological function by transporting factors between different cells and by regulating biological pathways in recipient *** an important form of intercellular communication,exosomes are increasingly being investigated due to their ability to transfer bioactive molecules such as lipids,proteins,mRNAs,and microRNAs between cells,and because they can regulate physiological and pathological processes in the central nervous *** neurogenesis is a multistage process by which new neurons are generated and migrate to be integrated into existing neuronal *** the adult brain,neurogenesis is mainly localized in two specialized niches:the subventricular zone adjacent to the lateral ventricles and the subgranular zone of the dentate *** increasing body of evidence indicates that adult neurogenesis is tightly controlled by environmental conditions with the *** recent studies,exosomes released from different sources of cells were shown to play an active role in regulating neurogenesis both in vitro and in vivo,thereby participating in the progression of neurodegenerative disorders in patients and in various disease ***,we provide a state-of-the-art synopsis of existing research that aimed to identify the diverse components of exosome cargoes and elucidate the therapeutic potential of exosomal contents in the regulation of neurogenesis in several neurodegenerative *** emphasize that exosomal cargoes could serve as a potential biomarker to monitor functional neurogenesis in *** addition,exosomes can also be considered as a novel therapeutic approach to treat various neurodegenerative disorders by improving endogenous neurogenesis to mitigate neuronal loss in the central nervous system.

关键词： adult neurogenesis Alzheimer’s disease amyotrophic lateral sclerosis exosome Huntington’s disease neurodegenerative disease neurogenic niches Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RNF26 up-regulates PD-L1 to regulate the cancer immune response in ccRCC

引用

BIOCELL 2024年第9期48卷 1323-1330页

作者： WEIGANG REN jing LI RUIJIANG ZENG liang ZHU Department of Urology Hunan Provincial People’s HospitalHunan Normal UniversityChangsha410000China Department of Rehabilitation The Second Xiangya HospitalCentral South UniversityChangsha410000China Department of Urology The Second Xiangya HospitalCentral South UniversityChangsha410000China Uro-Oncology Institute of Central South University Changsha410000China

Background:Clear cell renal cell carcinoma(ccRCC)stands as the most prevalent form of kidney cancer,accounting for a significant proportion of malignancies affecting the *** is well known as a type of tumour with *** checkpoint inhibitors(ICIs)aim to enhance the anticancer immune response in ccRCC by blocking programmed cell death 1 ligand 1/programmed death 1(PD-L1/PD-1)*** a previous study,we showed that RING finger protein 26(RNF26)degrades chromobox 7(CBX7)to activate the tumor necrosis factor(TNF)in ***:We analyzed The Cancer Genome Atlas(TCGA)database using the R package ESTIMATE and found that RNF26 was significantly associated with ccRCC immune *** relationship between RNF26 and the PD1 checkpoint signaling pathway was detected by enrichment *** addition,the molecular mechanism of RNF26 up-regulation of PD-L1 was detected by transcriptome sequencing,RT-qPCR,and Western Blot in ccRCC cell lineages 786-O and A498 *** transplantation tumor experiments in C57BL/6 mice were used to test the efficacy of anti-PD1 and knockdown of RNF26 in ***:We showed that RNF26 suppressed the immune response to ***,we revealed that RNF26 activated the PD-1 checkpoint pathway to suppress the immune response to ccRCC,possibly via the CBX7/PD-L1 ***:The suggestion derived from our results is that targeting RNF26 holds the potential to amplify the efficacy of anticancer immunotherapies in the treatment of ccRCC.

关键词： Clear cell renal cell carcinoma Ring finger protein 26 chromobox 7 PD-L1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Li-current collector interface in lithium metal batteries

引用

Nano Research 2024年第10期17卷 8706-8728页

作者： Tian-yu Wang Dingyi Zhao Keyue liang yuzhang Li Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Interfaces within batteries,such as the widely studied solid electrolyte interface(SEI),profoundly influence battery *** these interfaces,the solid-solid interface between electrode materials and current collectors is crucial to battery performance but has received less discussion and *** review highlights the latest research advancements on the solid-solid interface between lithium metal(the next-generation anode)and current collectors(typically copper),focusing on factors affecting the Li-current collector interface and improvement strategies from perspectives of current collector substrate(lithiophilicity,crystal facets,mechanical properties,and topological structure),electrolyte chemistry,current density,stacking pressure,SEI,electric field and temperature,and provides a future directions and opportunities on this topic.

关键词： lithium metal anode current collectors Li-current collector interface solid-solid interface improvement strategies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solvothermal synthesis and adsorption performance of layered boehmite using aluminum chloride and high-alumina fly ash

引用

Chinese Journal of Chemical Engineering 2024年第6期70卷 280-290页

作者： jing Wen Ruirui yuan Tao Jiang Tangxia yu yufan Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China

High alumina fly ash(FAHAl)is a kind of bulk solid waste unique to China,whose availability of high-value aluminum and the threat to the environment makes its high-value utilization *** this work,the alumina containing leaching solution obtained from Na_(2)CO_(3) roasting and HCl leaching of FAHAl was used as the mother liquor to prepare layered boehmite in *** preparation process with AlCl_(3) as the raw material was also *** formation process and mechanism of boehmite,the choice of solvent,along with the adsorption capability of Congo red were analyzed by X-ray diffraction,scanning electron microscopy,Fourier transform infrared spectroscopy,Brunauer-Emmett-Teller method and adsorption *** showed that during the preparation of layered boehmite,the precursor Al(OH)_(3) from the reaction of Al^(3+) and OH-is transformed into boehmiteγ-*** existence of ethanol is beneficial to regulate and promote the growth of boehmite crystal *** water and ethanol are mixed with a volume ratio of 2:1 and used as the solvent,the maximum specific surface area of the boehmite is obtained at 135.7 m^(2)·g^(-1),and 99.16%of Congo red can be absorbed after 10 min when AlCl3 is used as a raw *** purified leaching solution is used as the mother liquid,the crystallinity of boehmite decreases slightly when the pH value decreases from 12.5 to *** pH is 11,the removal efficiency of Congo red reaches a maximum of 72.25%.This process not only achieves the extraction of aluminum and high-value utilization of FAHAl but also provides a thought to prepare layered boehmite with adsorption properties.

关键词： High-alumina fly ash Layered boehmite In-situ preparation Solvothermal synthesis Adsorption High-value utilization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Core shift limitation in investment casting process of hollow turbine blade

引用

Chinese Journal of Aeronautics 2024年第8期37卷 513-526页

作者： Kang CUI Lin jing Ruisong JIANG Longnv yu Xiao GAO Automation and Software Engineering Shanxi UniversityTaiyuan 030006China Key Laboratory of High Performance Manufacturing for Aero Engine Ministry of Industry and Information TechnologySchool of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Mechanical Engineering Sichuan UniversityChengdu 610065China

The deviation in wall thickness caused by core shift during the investment casting process significantly impacts the strength and service life of hollow turbine *** address this issue,a core shift limitation method is developed in this ***,a shift model is established based on computational fluid dynamics and motion simulation to predict the movement of the ceramic core in investment casting ***,utilizing this model,an optimization method for fixturing layout inside the refractory ceramic shell is devised for the ceramic *** casting experiment demonstrates that by utilizing the optimized fixture layout,not only can core shift during the investment casting pouring process be effectively controlled,but also the maximum wall thickness error of the blade can be reduced by 42.02%.In addition,the core shift prediction is also validated,with a prediction error of less than 26.9%.

关键词： Hollow turbine blade Wall thickness Ceramic core Shift prediction Fixturing layout optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

引用

Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen Mao-Mao Zhang Wen-jing Xiao liang-Qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics,origins,and significance of pyrites in deep-water shales

引用

Science China Earth Sciences 2024年第2期67卷 313-342页

作者： Chao liang Shichao JI Yingchang CAO Keyu LIU jing WU Fang HAO National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580China School of Geosciences China University of PetroleumQingdao266000China Laboratory for Marine Mineral Resource Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao266590China

As important metal sulfides in the geochemical cycle of sulfur,the characteristics and formation processes of pyrites can provide useful clues regarding their *** on previous findings,shale pyrites were divided into three major classes(euhedral pyrites,framboidal pyrites(framboids)and metasomatic pyrites)and six sub-classes in this *** the microscopic scale,each type of pyrite is associated with a different formation *** are formed by burst nucleation in environments with a homogeneous distribution of nutrients while euhedral pyrites are usually formed on pre-existing sites(such as=FeS on the minerals surface)in the heterogeneous *** pyrites formed by the replacement of other ions in accountable material by iron ions and hydrogen sulfide ions in hydrothermal *** morphology and isotope value of pyrite provide information to track the origins of their nutrient and characteristics of sulfur and iron *** addition,the trace element content of pyrite can serve as a proxy for paleo-ocean trace element abundance,indicating changes in atmospheric oxygen ***,pyrite can also serves as an indicator of shale gas reservoirs.

关键词： Shale Pyrite Sulfate reduction reaction Isotope fractionation Pyrite element

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computational fluid dynamics modeling of rapid pyrolysis of solid waste magnesium nitrate hydrate under different injection methods

引用

Chinese Journal of Chemical Engineering 2024年第2期66卷 224-237页

作者： Wenchang Wu Kefan yu liang Zhao Hui Dong SEP Key Laboratory of Eco-industry School of MetallurgyNortheastern UniversityShenyang 110819China Liaoning Engineering Research Center of Energy Saving and Green Low Carbon Technology for Process Industry Northeastern UniversityShenyang 110819China

This study developed a numerical model to efficiently treat solid waste magnesium nitrate hydrate through multi-step chemical *** model simulates two-phase flow,heat,and mass transfer processes in a pyrolysis furnace to improve the decomposition rate of magnesium *** performance of multi-nozzle and single-nozzle injection methods was evaluated,and the effects of primary and secondary nozzle flow ratios,velocity ratios,and secondary nozzle inclination angles on the decomposition rate were *** indicate that multi-nozzle injection has a higher conversion efficiency and decomposition rate than single-nozzle injection,with a 10.3%higher conversion rate under the design *** decomposition rate is primarily dependent on the average residence time of particles,which can be increased by decreasing flow rate and velocity ratios and increasing the inclination angle of secondary *** optimal parameters are injection flow ratio of 40%,injection velocity ratio of 0.6,and secondary nozzle inclination of 30°,corresponding to a maximum decomposition rate of 99.33%.

关键词： Multi-nozzle Computational fluid dynamics Thermal decomposition reaction Pyrolysis furnace

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

引用

Computational Visual Media 2024年第1期10卷 161-186页

作者： yu Dong Christy Jie liang Yi Chen Jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of rail-bridge interaction of a high-speed railway suspension bridge under near-fault pulse-type earthquakes

引用

Transportation Safety and Environment 2024年第3期6卷 71-84页

作者： Xiangdong yu Bangzheng Jiang Haiquan jing School of Civil Engineering Central South UniversityChangsha 410075HunanChina

Due to the limitations of railway route selection,some high-speed railways are inevitably built near or across fault *** study the distribution of rail-bridge interaction under different load history states of suspension bridges under three types of near-fault pulse-type earthquakes,this paper takes China’s longest high-speed railway suspension bridge—Wufengshan Yangtze River Bridge-as the background and establishes a spatial model of the rail-bridge interaction of a suspension *** results show that:under the constant load state,the distribution of additional force under three types of pulse-type earthquakes is generally consistent,and pulse-type earthquakes produce more significant responses than non-pulse-type earthquakes;with fling-step pulse being the largest,it is advised to specifically consider the influence of the fling-step pulse in the *** the initial condition of the main beam temperature loading history,all rail-bridge additional forces increase significantly,particularly affecting the steel rail *** value of the rail-bridge interaction additional force under the near-fault earthquake in the initial state of the suspension bridge when the train deflection load is loaded from the tower to the mid-span is more significant and particularly *** initial effect of the braking load will weaken the effect of the deflection load loading *** results of the study indicate that the effect of the initial state of suspension bridges is an important factor influencing the rail-bridge interaction under near-fault pulse-type earthquakes,which needs to be considered in future seismic design.

关键词： rail-bridge interaction high-speed railway suspension bridge near-fault pulse-type earthquakes loading history initial state

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：